Michael J. Davies
Professor
Inflammation, Metabolism and Oxidation
Blegdamsvej 3
2200 København N.
Degradation of matrix glycosaminoglycans by peroxynitrite/peroxynitrous acid: evidence for a hydroxyl-radical-like mechanism
Kennett, E. C. & Davies, Michael J., 15 Apr 2007, In: Free Radical Biology & Medicine. 42, 8, p. 1278-89 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains
Kennett, E. C., Rees, M. D., Malle, E., Hammer, A., Whitelock, J. M. & Davies, Michael J., 15 Jul 2010, In: Free Radical Biology & Medicine. 49, 2, p. 282-93 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid
Kennett, E. C. & Davies, Michael J., 1 Sep 2008, In: Free Radical Biology & Medicine. 45, 5, p. 716-25 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Special issue for the International Conference on Electron Paramagnetic Resonance Spectroscopy and Imaging of Biological Systems (EPR-2017)
Khramtsov, V. V. & Davies, Michael J., 2018, In: Free Radical Research. 52, 3, p. 305-306Research output: Contribution to journal › Editorial › Research
- Published
Biomedical, lifestyle and psychosocial characteristics of people newly diagnosed with type 2 diabetes: Baseline data from the DESMOND randomized controlled trial
Khunti, K., Skinner, Timothy, Heller, S., Carey, M. E., Dallosso, H. M. & Davies, Michael J., 1 Dec 2008, In: Diabetic Medicine. 25, 12, p. 1454-1461 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: Three year follow-up of a cluster randomised controlled trial in primary care
Khunti, K., Gray, L. J., Skinner, Timothy, Carey, M. E., Realf, K., Dallosso, H., Fisher, H., Campbell, M., Heller, S. & Davies, Michael J., 9 Jun 2012, In: BMJ (Online). 344, 7860, e2333.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study
Khunti, K., Taub, N., Tringham, J., Jarvis, J., Farooqi, A., Skinner, Timothy & Davies, Michael J., 1 Apr 2010, In: Primary Care Diabetes. 4, 1, p. 25-32 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The nitroxide radical TEMPOL prevents obesity, hyperlipidaemia, elevation of inflammatory cytokines, and modulates atherosclerotic plaque composition in apoE(-/-) mice
Kim, C. H. J., Mitchell, J. B., Bursill, C. A., Sowers, A. L., Thetford, A., Cook, J. A., van Reyk, D. M. & Davies, Michael J., May 2015, In: Atherosclerosis. 240, 1, p. 234-241 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Comparative time-courses of copper-ion-mediated protein and lipid oxidation in low-density lipoprotein
Knott, H. M., Baoutina, A., Davies, Michael J. & Dean, R. T., 15 Apr 2002, In: Archives of Biochemistry and Biophysics. 400, 2, p. 223-32 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glycation and glycoxidation of low-density lipoproteins by glucose and low-molecular mass aldehydes. Formation of modified and oxidized particles
Knott, H. M., Brown, B. E., Davies, Michael J. & Dean, R. T., Sep 2003, In: European Journal of Biochemistry. 270, 17, p. 3572-82 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations
Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, Clare Louise, Rees, M. D. & Davies, Michael J., 15 Apr 2010, In: Biochemical Pharmacology. 79, 8, p. 1156-64 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1
Kovacevic, Z., Sahni, S., Lok, K. H., Davies, Michael J., Wink, D. A. & Richardson, D. R., May 2017, In: B B A - Reviews on Cancer. 1861, 5 Pt A, p. 995-999 5 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Effect of Oxidation and Protein Unfolding on Cross-Linking of β-Lactoglobulin and α-Lactalbumin
Krämer, A. C., Torreggiani, A. & Davies, Michael J., 2017, In: Journal of Agricultural and Food Chemistry. 65, 47, p. 10258-10269 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of Methylglyoxal-Induced Glycation on the Composition and Structure of β-Lactoglobulin and α-Lactalbumin
Krämer, A. C. & Davies, Michael J., 2019, In: Journal of Agricultural and Food Chemistry. 67, 2, p. 699-710 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Key role of cysteine residues and sulfenic acids in thermal- and H2O2-mediated modification of β-lactoglobulin
Krämer, A. C., Thulstrup, Peter Waaben, Lund, Marianne N. & Davies, Michael J., 2016, In: Free Radical Biology & Medicine. 97, 8, p. 544–555 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Key role of cysteine residues in thermal- and H2O2-mediated modification of beta-lactoglobulin
Krämer, A. C., Thulstrup, Peter Waaben, Lund, Marianne N. & Davies, Michael J., 2016, In: Free Radical Biology & Medicine. 96, Suppl. 1, p. S16 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals
Lam, M. A., Pattison, D. I., Bottle, S. E., Keddie, D. J. & Davies, Michael J., Nov 2008, In: Chemical Research in Toxicology. 21, 11, p. 2111-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links
Lund, Marianne N., Luxford, C., Skibsted, Leif Horsfelt & Davies, Michael J., 2008, In: Biochemical Journal. 410, 3, p. 565-574Research output: Contribution to journal › Journal article › Research › peer-review
The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages
Lane, A. E., Tan, J. T. M., Hawkins, Clare Louise, Heather, A. K. & Davies, Michael J., 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 161-9 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites
Leinisch, F., Mariotti, M., Andersen, S. H., Lindemose, Søren, Hägglund, Per Mårten, Møllegaard, Niels Erik & Davies, Michael J., 2020, In: Scientific Reports. 10, 1, 11 p., 3106.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Peroxyl radical- and photo-oxidation of glucose 6-phosphate dehydrogenase generates cross-links and functional changes via oxidation of tyrosine and tryptophan residues
Leinisch, F., Mariotti, M., Rykaer, M., López-Alarcón, C., Hägglund, Per Mårten & Davies, Michael J., Nov 2017, In: Free Radical Biology & Medicine. 112, p. 240-252 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structural and functional changes in RNAse A originating from tyrosine and histidine cross-linking and oxidation induced by singlet oxygen and peroxyl radicals
Leinisch, F., Mariotti, M., Hägglund, Per Mårten & Davies, Michael J., Oct 2018, In: Free Radical Biology and Medicine. 126, p. 73-86Research output: Contribution to journal › Journal article › Research › peer-review
Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease
Leung, C., Herath, C. B., Jia, Z., Andrikopoulos, S., Brown, B. E., Davies, Michael J., Rivera, L. R., Furness, J. B., Forbes, J. M. & Angus, P. W., 21 Sep 2016, In: World Journal of Gastroenterology. 22, 35, p. 8026-8040 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Quinone-induced protein modifications: kinetic preference for reaction of 1,2-benzoquinones with thiol groups in proteins
Li, Y., Jongberg, S., Andersen, Mogens Larsen, Davies, Michael J. & Lund, Marianne N., 2016, In: Free Radical Biology & Medicine. 97, p. 148-157 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Protein oxidation and ageing
Linton, S., Davies, Michael J. & Dean, R. T., Sep 2001, In: Experimental Gerontology. 36, 9, p. 1503-18 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid
Lloyd, M. M., van Reyk, D. M., Davies, Michael J. & Hawkins, Clare Louise, 1 Sep 2008, In: Biochemical Journal. 414, 2, p. 271-80 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells
Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, Michael J. & Hawkins, Clare Louise, Dec 2013, In: Free Radical Biology & Medicine. 65, p. 1352-62 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling
Lord, M. S., Chuang, Christine, Melrose, J., Davies, Michael J., Iozzo, R. V. & Whitelock, J. M., Apr 2014, In: Matrix Biology. 35, p. 112-22 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Nitration alters laminin polymerization: [Meeting Abstract]
Lorentzen, Lasse Gøbel & Davies, Michael J., 2018, In: Free Radical Biology and Medicine. 120, S1, p. S127-S127 P-271.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Identification and quantification of sites of nitration and oxidation in the key matrix protein laminin and the structural consequences of these modifications
Lorentzen, Lasse Gøbel, Chuang, Christine, Rogowska-Wrzesinska, A. & Davies, Michael J., 2019, In: Redox Biology. 24, UNSP 101226.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analysis of the extracellular matrix of human atherosclerotic plaques shows marked changes between plaque types
Lorentzen, Lasse Gøbel, Yeung, K., Eldrup, Nikolaj, Eiberg, Jonas Peter, Sillesen, Henrik & Davies, Michael J., 2024, In: Matrix Biology Plus. 21, 14 p., 100141.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic Characterization of Atherosclerotic Lesions in Situ Using Percutaneous Coronary Intervention Angioplasty Balloons-Brief Report
Lorentzen, Lasse Gøbel, Hansen, G. M., Iversen, Kasper, Bundgård, Henning & Davies, Michael J., 2022, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 42, 7, p. 857-864Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages
Love, D., Barrett, T. J., White, M. Y., Cordwell, S. J., Davies, Michael J. & Hawkins, Clare Louise, 2016, In: Free Radical Biology & Medicine. 94, p. 88-98 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The immunoproteasome is induced by cytokines and regulates apoptosis in human islets
Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H., Wagner , B., Ghiasi, S. M., De Tata, V., Chen, Z., Lund, Marianne N., Davies, Michael J., Marchetti, P. & Mandrup-Poulsen, Thomas, 2017, In: Journal of Endocrinology. 233, 3, p. 369-379 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Radicals derived from histone hydroperoxides damage nucleobases in RNA and DNA
Luxford, C., Dean, R. T. & Davies, Michael J., Jul 2000, In: Chemical Research in Toxicology. 13, 7, p. 665-72 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Histone H1- and other protein- and amino acid-hydroperoxides can give rise to free radicals which oxidize DNA
Luxford, C., Morin, B., Dean, R. T. & Davies, Michael J., 15 Nov 1999, In: Biochemical Journal. 344 Pt 1, p. 125-34 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Induction of DNA damage by oxidised amino acids and proteins
Luxford, C., Dean, R. T. & Davies, Michael J., 2002, In: Biogerontology. 3, 1-2, p. 95-102 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Azocompounds as generators of defined radical species: Contributions and challenges for free radical research
López-Alarcón, C., Fuentes-Lemus, E., Figueroa, J. D., Dorta, E., Schöneich, C. & Davies, Michael J., 2020, In: Free Radical Biology and Medicine. 160, p. 78-91Research output: Contribution to journal › Review › Research › peer-review
Peroxidase catalysed cross-linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima
Mai, K., Smith, N. C., Feng, Z., Katrib, M., Slapeta, J., Slapetova, I., Wallach, M. G., Luxford, C., Davies, Michael J., Zhang, X., Norton, R. S. & Belli, S. I., Sep 2011, In: International Journal for Parasitology (Online). 41, 11, p. 1157-64 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chasing Great Paths of Helmut “Oxidative Stress” Sies
Majima, H., Indo, H., Nakanishi, I., Suenaga, S., Matsumoto, K., Matsui, H., Minamiyami, Y., Ichikawa, H., Yen, H., Hawkins, C., Davies, Michael J., Ozawa, T. & St. Clair, D., 2016, In: Archives of Biochemistry and Biophysics. 595, p. 54-60 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid
Malle, E., Marsche, G., Arnhold, J. & Davies, Michael J., Apr 2006, In: B B A - Reviews on Cancer. 1761, 4, p. 392-415 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mass-Spectrometry-Based Identification of Cross-Links in Proteins Exposed to Photo-Oxidation and Peroxyl Radicals Using 18O Labeling and Optimized Tandem Mass Spectrometry Fragmentation
Mariotti, M., Leinisch, F., Leeming, D. J., Svensson, B., Davies, Michael J. & Hägglund, Per Mårten, 2018, In: Journal of Proteome Research. 17, 6, p. 2017-2027Research output: Contribution to journal › Journal article › Research › peer-review
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Cross-linking and modification of fibronectin by peroxynitrous acid: Mapping and quantification of damage provides a new model for domain interactions
Mariotti, M., Rogowska-Wrzesinska, A., Hägglund, Per Mårten & Davies, Michael J., 2021, In: Journal of Biological Chemistry. 296, 100360.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Absence of synproportionation between oxy and ferryl leghemoglobin. off
Mathieu, C., Swaraj, K., Davies, Michael J., Trinchant, J. C. & Puppo, A., Aug 1997, In: Free Radical Research. 27, 2, p. 165-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Direct detection of radicals in intact soybean nodules: presence of nitric oxide-leghemoglobin complexes
Mathieu, C., Moreau, S., Frendo, P., Puppo, A. & Davies, Michael J., 1998, In: Free Radical Biology & Medicine. 24, 7-8, p. 1242-9 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation
Mertens, K., Lowes, D. A., Webster, N. R., Talib, J., Hall, L., Davies, Michael J., Beattie, J. H. & Galley, H. F., 2015, In: British Journal of Anaesthesia. 114, 6, p. 990-999 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage
Mizdrak, J., Hains, P. G., Truscott, R. J. W., Jamie, J. F. & Davies, Michael J., 15 Mar 2008, In: Free Radical Biology & Medicine. 44, 6, p. 1108-19 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: possible links between diabetes and atherosclerosis
Moheimani, F., Morgan, P. E., van Reyk, D. M. & Davies, Michael J., Jun 2010, In: B B A - Reviews on Cancer. 1802, 6, p. 561-71 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Effect of exposure of human monocyte-derived macrophages to high, versus normal, glucose on subsequent lipid accumulation from glycated and acetylated low-density lipoproteins
Moheimani, F., Tan, J. T. M., Brown, B. E., Heather, A. K., van Reyk, D. M. & Davies, Michael J., 2011, In: Journal of Diabetes Research. 2011, p. 851280Research output: Contribution to journal › Journal article › Research › peer-review
Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: a potential contributory factor in diabetes-associated atherosclerosis
Moheimani, F., Kim, C. H. J., Rahmanto, A. S., van Reyk, D. M. & Davies, Michael J., Jul 2012, In: Atherosclerosis. 223, 1, p. 144-51 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 38036205
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Protein oxidation and peroxidation
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Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes
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Cardiac spheroids as promising in vitro models to study the human heart microenvironment
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