Michael J. Davies

Michael J. Davies

Professor


  1. 2014
  2. Oxidation and modification of extracellular matrix and its role in disease

    Chuang, Christine, Degendorfer, G. & Davies, Michael J., Sep 2014, In: Free Radical Research. 48, 9, p. 970-89 20 p.

    Research output: Contribution to journalJournal articlepeer-review

  3. Oxidation modifies the structure and function of the extracellular matrix generated by human coronary artery endothelial cells

    Chuang, Christine, Degendorfer, G., Hammer, A., Whitelock, J. M., Malle, E. & Davies, Michael J., 15 Apr 2014, In: Biochemical Journal. 459, 2, p. 313-22 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. A critical role for thioredoxin-interacting protein in diabetes-related impairment of angiogenesis

    Dunn, L. L., Simpson, P. J. L., Prosser, H. C., Lecce, L., Yuen, G. S. C., Buckle, A., Sieveking, D. P., Vanags, L. Z., Lim, P. R., Chow, R. W. Y., Lam, Y. T., Clayton, Z., Bao, S., Davies, Michael J., Stadler, N., Celermajer, D. S., Stocker, R., Bursill, C. A., Cooke, J. P. & Ng, M. K. C., Feb 2014, In: Diabetes. 63, 2, p. 675-87 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  5. Detection, quantification, and total synthesis of novel 3-hydroxykynurenine glucoside-derived metabolites present in human lenses

    Gad, N. A., Mizdrak, J., Pattison, D. I., Davies, Michael J., Truscott, R. J. W. & Jamie, J. F., Feb 2014, In: Investigative Ophthalmology & Visual Science. 55, 2, p. 849-55 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  6. Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction

    Galougahi, K. K., Liu, C., Gentile, C., Kok, C., Nunez, A., Garcia, A., Fry, N. A. S., Davies, Michael J., Hawkins, Clare Louise, Rasmussen, H. H. & Figtree, G. A., 2014, In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 3, 2, p. e000731

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    A Novel Method for Isolating and Culturing Human Cardiomyocytes from Cryopreserved Tissues

    Gentile, C., Kuehn, B., Davies, Michael J. & dos Remedios, C. G., 2014, In: Biophysical Journal.

    Research output: Contribution to journalJournal articlepeer-review

  8. Detection and characterisation of radicals in biological materials using EPR methodology

    Hawkins, Clare Louise & Davies, Michael J., Feb 2014, In: B B A - Reviews on Cancer. 1840, 2, p. 708-21 14 p.

    Research output: Contribution to journalReviewpeer-review

  9. Published

    Competitive reduction of perferrylmyoglobin radicals by protein thiols and plant phenols

    Jongberg, S., Lund, Marianne N., Skibsted, Leif Horsfelt & Davies, Michael J., 2014, In: Journal of Agricultural and Food Chemistry. 62, 46, p. 11279-11288 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

    Kajer, T. B., Fairfull-Smith, K. E., Yamasaki, T., Yamada, K., Fu, S., Bottle, S. E., Hawkins, Clare Louise & Davies, Michael J., May 2014, In: Free Radical Biology & Medicine. 70, p. 96-105 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  11. The role of vascular-derived perlecan in modulating cell adhesion, proliferation and growth factor signaling

    Lord, M. S., Chuang, Christine, Melrose, J., Davies, Michael J., Iozzo, R. V. & Whitelock, J. M., Apr 2014, In: Matrix Biology. 35, p. 112-22 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Perturbation of human coronary artery endothelial cell redox state and NADPH generation by methylglyoxal

    Morgan, P. E., Sheahan, P. J. & Davies, Michael J., 2014, In: PloS one. 9, 1, 11 p., e86564.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction

    Nedoboy, P. E., Morgan, P. E., Mocatta, T. J., Richards, A. M., Winterbourn, C. C. & Davies, Michael J., Oct 2014, In: Free Radical Research. 48, 10, p. 1256-66 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. Published

    MODULATION OF ENDOTHELIAL CELL FUNCTION BY THE MYELOPEROXIDASE-DERIVED OXIDANT HYPOCHLOROUS ACID (HOCl) AND ITS CONTRIBUTION TO ATHEROSCLEROSIS

    Rayner, B. S., Lloyd, M. M., Summers, F. A., Davies, Michael J. & Hawkins, Clare Louise, 2014, In: Hypertension.

    Research output: Contribution to journalJournal articlepeer-review

  15. Mechanisms of degradation of the natural high-potency sweetener (2R,4R)-monatin in mock beverage solutions

    Storkey, C., Pattison, D. I., Gaspard, D. S., Hagestuen, E. D. & Davies, Michael J., 16 Apr 2014, In: Journal of Agricultural and Food Chemistry. 62, 15, p. 3476-87 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Reevaluation of the rate constants for the reaction of hypochlorous acid (HOCl) with cysteine, methionine, and peptide derivatives using a new competition kinetic approach

    Storkey, C., Davies, Michael J. & Pattison, D. I., Aug 2014, In: Free Radical Biology & Medicine. 73, p. 60-6 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. The smoking-associated oxidant hypothiocyanous acid induces endothelial nitric oxide synthase dysfunction

    Talib, J., Kwan, J., Suryo Rahmanto, A., Witting, P. K. & Davies, Michael J., 1 Jan 2014, In: Biochemical Journal. 457, 1, p. 89-97 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  18. 2013
  19. Chemical modification of lysozyme, glucose 6-phosphate dehydrogenase, and bovine eye lens proteins induced by peroxyl radicals: role of oxidizable amino acid residues

    Arenas, A., López-Alarcón, C., Kogan, M., Lissi, E., Davies, Michael J. & Silva, E., 18 Jan 2013, In: Chemical Research in Toxicology. 26, 1, p. 67-77 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  20. Apolipoprotein A-I glycation by glucose and reactive aldehydes alters phospholipid affinity but not cholesterol export from lipid-laden macrophages

    Brown, B. E., Nobecourt, E., Zeng, J., Jenkins, A. J., Rye, K. & Davies, Michael J., 2013, In: PLOS ONE. 8, 5, p. e65430

    Research output: Contribution to journalJournal articlepeer-review

  21. The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

    Graham, G. G., Davies, Michael J., Day, R. O., Mohamudally, A. & Scott, K. F., Jun 2013, In: Inflammopharmacology. 21, 3, p. 201-32 32 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl)

    Hadfield, K. A., Pattison, D. I., Brown, B. E., Hou, L., Rye, K., Davies, Michael J. & Hawkins, Clare Louise, 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 531-42 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Biomarkers of oxidative stress study V: ozone exposure of rats and its effect on lipids, proteins, and DNA in plasma and urine

    Kadiiska, M. B., Basu, S., Brot, N., Cooper, C., Saari Csallany, A., Davies, Michael J., George, M. M., Murray, D. M., Jackson Roberts, L., Shigenaga, M. K., Sohal, R. S., Stocker, R., Van Thiel, D. H., Wiswedel, I., Hatch, G. E. & Mason, R. P., Aug 2013, In: Free Radical Biology & Medicine. 61, p. 408-15 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  24. Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

    Lloyd, M. M., Grima, M. A., Rayner, B. S., Hadfield, K. A., Davies, Michael J. & Hawkins, Clare Louise, Dec 2013, In: Free Radical Biology & Medicine. 65, p. 1352-62 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Methylglyoxal-induced modification of arginine residues decreases the activity of NADPH-generating enzymes

    Morgan, P. E., Sheahan, P. J., Pattison, D. I. & Davies, Michael J., Aug 2013, In: Free Radical Biology & Medicine. 61, p. 229-42 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  26. Targeting the AGE-RAGE axis improves renal function in the context of a healthy diet low in advanced glycation end-product content

    Thallas-Bonke, V., Coughlan, M. T., Tan, A. L., Harcourt, B. E., Morgan, P. E., Davies, Michael J., Bach, L. A., Cooper, M. E. & Forbes, J. M., Jan 2013, In: Nephrology. 18, 1, p. 47-56 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  27. Superoxide radicals have a protective role during H2O2 stress

    Thorpe, G. W., Reodica, M., Davies, Michael J., Heeren, G., Jarolim, S., Pillay, B., Breitenbach, M., Higgins, V. J. & Dawes, I. W., Sep 2013, In: Molecular Biology of the Cell. 24, 18, p. 2876-84 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  28. 2012
  29. Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

    Barrett, T. J., Pattison, D. I., Leonard, S. E., Carroll, K. S., Davies, Michael J. & Hawkins, Clare Louise, 15 Mar 2012, In: Free Radical Biology & Medicine. 52, 6, p. 1075-85 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Myeloperoxidase-derived oxidants inhibit sarco/endoplasmic reticulum Ca2+-ATPase activity and perturb Ca2+ homeostasis in human coronary artery endothelial cells

    Cook, N. L., Viola, H. M., Sharov, V. S., Hool, L. C., Schöneich, C. & Davies, Michael J., 1 Mar 2012, In: Free Radical Biology & Medicine. 52, 5, p. 951-61 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. Myeloperoxidase-derived oxidants rapidly oxidize and disrupt zinc-cysteine/histidine clusters in proteins

    Cook, N. L., Pattison, D. I. & Davies, Michael J., 1 Dec 2012, In: Free Radical Biology & Medicine. 53, 11, p. 2072-80 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  32. Myeloperoxidase-Derived Oxidants Rapidly and Efficiently Oxidise Protein Zinc-Thiol Clusters

    Cook, N. L., Pattison, David & Davies, Michael J., 2012, In: Free Radical Biology and Medicine. 53, Supl. 2, p. S146 1 p., 355.

    Research output: Contribution to journalConference abstract in journal

  33. Free Radical Research origins

    Davies, Michael J., Jan 2012, In: Free Radical Research. 46, 1, p. 1

    Research output: Contribution to journalJournal article

  34. Computational design of effective, bioinspired HOCl antioxidants: the role of intramolecular Cl+ and H+ shifts

    Karton, A., O'Reilly, R. J., Pattison, D. I., Davies, Michael J. & Radom, L., 21 Nov 2012, In: Journal of the American Chemical Society. 134, 46, p. 19240-5 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Effectiveness of a diabetes education and self management programme (DESMOND) for people with newly diagnosed type 2 diabetes mellitus: Three year follow-up of a cluster randomised controlled trial in primary care

    Khunti, K., Gray, L. J., Skinner, Timothy, Carey, M. E., Realf, K., Dallosso, H., Fisher, H., Campbell, M., Heller, S. & Davies, Michael J., 9 Jun 2012, In: BMJ (Online). 344, 7860, e2333.

    Research output: Contribution to journalJournal articlepeer-review

  36. Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: a potential contributory factor in diabetes-associated atherosclerosis

    Moheimani, F., Kim, C. H. J., Rahmanto, A. S., van Reyk, D. M. & Davies, Michael J., Jul 2012, In: Atherosclerosis. 223, 1, p. 144-51 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  37. Quantification of hydroxyl radical-derived oxidation products in peptides containing glycine, alanine, valine, and proline

    Morgan, P. E., Pattison, D. I. & Davies, Michael J., 15 Jan 2012, In: Free Radical Biology & Medicine. 52, 2, p. 328-39 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  38. Photo-oxidation of proteins

    Pattison, D. I., Rahmanto, A. S. & Davies, Michael J., Jan 2012, In: Photochemical & Photobiological Sciences. 11, 1, p. 38-53 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  39. Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids

    Pattison, D. I., Davies, Michael J. & Hawkins, Clare Louise, Aug 2012, In: Free Radical Research. 46, 8, p. 975-95 21 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. The nitroxide TEMPO is an efficient scavenger of protein radicals: cellular and kinetic studies

    Pattison, D. I., Lam, M., Shinde, S. S., Anderson, R. F. & Davies, Michael J., 1 Nov 2012, In: Free Radical Biology & Medicine. 53, 9, p. 1664-74 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Selenium-containing amino acids as direct and indirect antioxidants

    Rahmanto, A. S. & Davies, Michael J., Nov 2012, In: I U B M B Life. 64, 11, p. 863-71 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage

    Skaff, O., Pattison, D. I., Morgan, P. E., Bachana, R., Jain, V. K., Priyadarsini, K. I. & Davies, Michael J., 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 305-16 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Reduced metal ion concentrations in atherosclerotic plaques from subjects with type 2 diabetes mellitus

    Stadler, N., Heeneman, S., Vöö, S., Stanley, N., Giles, G. I., Gang, B. P., Croft, K. D., Mori, T. A., Vacata, V., Daemen, M. J. A. P., Waltenberger, J. & Davies, Michael J., Jun 2012, In: Atherosclerosis. 222, 2, p. 512-8 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  44. Preventing protein oxidation with sugars: scavenging of hypohalous acids by 5-selenopyranose and 4-selenofuranose derivatives

    Storkey, C., Pattison, D. I., White, J. M., Schiesser, C. H. & Davies, Michael J., 19 Nov 2012, In: Chemical Research in Toxicology. 25, 11, p. 2589-99 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  45. Photo-oxidation-induced inactivation of the selenium-containing protective enzymes thioredoxin reductase and glutathione peroxidase

    Suryo Rahmanto, A., Pattison, D. I. & Davies, Michael J., 15 Sep 2012, In: Free Radical Biology & Medicine. 53, 6, p. 1308-16 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  46. High plasma thiocyanate levels modulate protein damage induced by myeloperoxidase and perturb measurement of 3-chlorotyrosine

    Talib, J., Pattison, D. I., Harmer, J. A., Celermajer, D. S. & Davies, Michael J., 1 Jul 2012, In: Free Radical Biology & Medicine. 53, 1, p. 20-9 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  47. Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?

    Truscott, R. J. W., Mizdrak, J., Friedrich, M. G., Hooi, M. Y., Lyons, B., Jamie, J. F., Davies, Michael J., Wilmarth, P. A. & David, L. L., Jun 2012, In: Experimental Eye Research. 99, p. 48-54 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  48. 2011
  49. Published

    The association between anxiety and measures of glycaemia in a population-based diabetes screening programme

    Aujla, N., Davies, Michael J., Skinner, Timothy, Gray, L. J., Webb, D. R., Srinivasan, B. & Khunti, K., 1 Jul 2011, In: Diabetic Medicine. 28, 7, p. 785-788 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Multifactorial intervention in individuals with type 2 diabetes and microalbuminuria: The Microalbuminuria Education and Medication Optimisation (MEMO) study

    Crasto, W., Jarvis, J., Khunti, K., Skinner, Timothy, Gray, L. J., Brela, J., Troughton, J., Daly, H., Lawrence, I. G., McNally, P. G., Carey, M. E. & Davies, Michael J., 1 Sep 2011, In: Diabetes Research and Clinical Practice. 93, 3, p. 328-336 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Dityrosine, 3,4-dihydroxyphenylalanine (DOPA), and radical formation from tyrosine residues on milk proteins with globular and flexible structures as a result of riboflavin-mediated photo-oxidation

    Dalsgaard, T. K., Nielsen, J. H., Brown, B. E., Stadler, N. & Davies, Michael J., 27 Jul 2011, In: Journal of Agricultural and Food Chemistry. 59, 14, p. 7939-47 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. Myeloperoxidase-derived oxidation: mechanisms of biological damage and its prevention

    Davies, Michael J., Jan 2011, In: Journal of Clinical Biochemistry and Nutrition. 48, 1, p. 8-19 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  53. Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

    Gracanin, M., Lam, M. A., Morgan, P. E., Rodgers, K. J., Hawkins, Clare Louise & Davies, Michael J., 15 Jan 2011, In: Free Radical Biology & Medicine. 50, 2, p. 389-99 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  54. Mechanisms and consequences of oxidative damage to extracellular matrix

    Kennett, E. C., Chuang, Christine, Degendorfer, G., Whitelock, J. M. & Davies, Michael J., Oct 2011, In: Biochemical Society Transactions. 39, 5, p. 1279-87 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  55. Peroxidase catalysed cross-linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima

    Mai, K., Smith, N. C., Feng, Z., Katrib, M., Slapeta, J., Slapetova, I., Wallach, M. G., Luxford, C., Davies, Michael J., Zhang, X., Norton, R. S. & Belli, S. I., Sep 2011, In: International Journal for Parasitology (Online). 41, 11, p. 1157-64 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Effect of exposure of human monocyte-derived macrophages to high, versus normal, glucose on subsequent lipid accumulation from glycated and acetylated low-density lipoproteins

    Moheimani, F., Tan, J. T. M., Brown, B. E., Heather, A. K., van Reyk, D. M. & Davies, Michael J., 2011, In: Journal of Diabetes Research. 2011, p. 851280

    Research output: Contribution to journalJournal articlepeer-review

  57. High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

    Morgan, P. E., Pattison, D. I., Talib, J., Summers, F. A., Harmer, J. A., Celermajer, D. S., Hawkins, Clare Louise & Davies, Michael J., 1 Nov 2011, In: Free Radical Biology & Medicine. 51, 9, p. 1815-22 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  58. One-electron reduction of N-chlorinated and N-brominated species is a source of radicals and bromine atom formation

    Pattison, D. I., O'Reilly, R. J., Skaff, O., Radom, L., Anderson, R. F. & Davies, Michael J., 21 Mar 2011, In: Chemical Research in Toxicology. 24, 3, p. 371-82 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    Comparison of illness representations dimensions and illness representation clusters in predicting outcomes in the first year following diagnosis of type 2 diabetes: Results from the DESMOND trial

    Skinner, Timothy, Carey, M. E., Cradock, S., Dallosso, H. M., Dalyb, H., Davies, Michael J., Doherty, Y., Heller, S., Khunti, K. & Olivere, L., 1 Mar 2011, In: Psychology and Health. 26, 3, p. 321-335 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  60. Synthesis and antioxidant capacity of 5-selenopyranose derivatives

    Storkey, C., Davies, Michael J., White, J. M. & Schiesser, C. H., 14 Sep 2011, In: Chemical communications (Cambridge, England). 47, 34, p. 9693-5 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  61. Catalytic activity of selenomethionine in removing amino acid, peptide, and protein hydroperoxides

    Suryo Rahmanto, A. & Davies, Michael J., 15 Dec 2011, In: Free Radical Biology & Medicine. 51, 12, p. 2288-99 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. 2010
  63. Published

    Ethnic differences in the prevalence and recognition of depression in a primary care population with and without type 2 diabetes

    Ali, S., Taub, N. A., Stone, M. A., Davies, Michael J., Skinner, Timothy & Khunti, K., 1 Sep 2010, Diabetologia.

    Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

  64. Published

    The association between depression and health-related quality of life in people with type 2 diabetes: A systematic literature review

    Ali, S., Stone, M., Skinner, Timothy, Robertson, N., Davies, Michael J. & Khunti, K., 1 Feb 2010, In: Diabetes/Metabolism Research and Reviews. 26, 2, p. 75-89 15 p.

    Research output: Contribution to journalReviewpeer-review

  65. Published

    The prevalence of depressive symptoms in a white European and South Asian population with impaired glucose regulation and screen-detected Type 2 diabetes mellitus: A comparison of two screening tools

    Aujla, N., Skinner, Timothy, Khunti, K. & Davies, Michael J., 1 Aug 2010, In: Diabetic Medicine. 27, 8, p. 896-905 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  66. Published

    Delivering the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: Cost effectiveness analysis

    Gillett, M., Dallosso, H. M., Dixon, S., Brennan, A., Carey, M. E., Campbell, M. J., Heller, S., Khunti, K., Skinner, Timothy & Davies, Michael J., 26 Aug 2010, In: BMJ (Online). 341, 7770, c4093.

    Research output: Contribution to journalJournal articlepeer-review

  67. Published

    Screening for type 2 diabetes in a multiethnic setting using known risk factors to identify those at high risk: A cross-sectional study

    Gray, L. J., Tringham, J. R., Davies, Michael J., Webb, D. R., Jarvis, J., Skinner, Timothy, Farooqi, A. M. & Khunti, K., 1 Dec 2010, In: Vascular Health and Risk Management. 6, 1, p. 837-842 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  68. Peroxynitrite modifies the structure and function of the extracellular matrix proteoglycan perlecan by reaction with both the protein core and the heparan sulfate chains

    Kennett, E. C., Rees, M. D., Malle, E., Hammer, A., Whitelock, J. M. & Davies, Michael J., 15 Jul 2010, In: Free Radical Biology & Medicine. 49, 2, p. 282-93 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    Screening for the metabolic syndrome using simple anthropometric measurements in south Asian and white Europeans: A population-based screening study. The Leicester Ethnic Atherosclerosis and Diabetes Risk (LEADER) Study

    Khunti, K., Taub, N., Tringham, J., Jarvis, J., Farooqi, A., Skinner, Timothy & Davies, Michael J., 1 Apr 2010, In: Primary Care Diabetes. 4, 1, p. 25-32 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  70. Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

    Koelsch, M., Mallak, R., Graham, G. G., Kajer, T., Milligan, M. K., Nguyen, L. Q., Newsham, D. W., Keh, J. S., Kettle, A. J., Scott, K. F., Ziegler, J. B., Pattison, D. I., Fu, S., Hawkins, Clare Louise, Rees, M. D. & Davies, Michael J., 15 Apr 2010, In: Biochemical Pharmacology. 79, 8, p. 1156-64 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  71. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

    Lane, A. E., Tan, J. T. M., Hawkins, Clare Louise, Heather, A. K. & Davies, Michael J., 15 Aug 2010, In: Biochemical Journal. 430, 1, p. 161-9 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  72. Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: possible links between diabetes and atherosclerosis

    Moheimani, F., Morgan, P. E., van Reyk, D. M. & Davies, Michael J., Jun 2010, In: B B A - Reviews on Cancer. 1802, 6, p. 561-71 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  73. Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I

    Nobécourt, E., Tabet, F., Lambert, G., Puranik, R., Bao, S., Yan, L., Davies, Michael J., Brown, B. E., Jenkins, A. J., Dusting, G. J., Bonnet, D. J., Curtiss, L. K., Barter, P. J. & Rye, K., Apr 2010, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 30, 4, p. 766-72 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  74. Removal of amino acid, peptide and protein hydroperoxides by reaction with peroxiredoxins 2 and 3

    Peskin, A. V., Cox, A. G., Nagy, P., Morgan, P. E., Hampton, M. B., Davies, Michael J. & Winterbourn, C. C., 1 Dec 2010, In: Biochemical Journal. 432, 2, p. 313-21 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  75. Cellular effects of peptide and protein hydroperoxides

    Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael J., 15 Apr 2010, In: Free Radical Biology & Medicine. 48, 8, p. 1071-8 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  76. Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts

    Rahmanto, A. S., Morgan, P. E., Hawkins, Clare Louise & Davies, Michael J., 30 Nov 2010, In: Free Radical Biology & Medicine. 49, 10, p. 1505-15 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  77. Myeloperoxidase-derived oxidants selectively disrupt the protein core of the heparan sulfate proteoglycan perlecan

    Rees, M. D., Whitelock, J. M., Malle, E., Chuang, Christine, Iozzo, R. V., Nilasaroya, A. & Davies, Michael J., Jan 2010, In: Matrix Biology. 29, 1, p. 63-73 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  78. Published

    Depressive symptoms in the first year from diagnosis of Type 2 diabetes: Results from the DESMOND trial

    Skinner, Timothy, Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Davies, Michael J., Doherty, Y., Heller, S., Khunti, K. & Oliver, L., 1 Aug 2010, In: Diabetic Medicine. 27, 8, p. 965-967 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  79. Modulation of the cellular expression of circulating advanced glycation end-product receptors in type 2 diabetic nephropathy

    Sourris, K. C., Harcourt, B. E., Penfold, S. A., Yap, F. Y. T., Morley, A. L., Morgan, P. E., Davies, Michael J., Baker, S. T., Jerums, G. & Forbes, J. M., 2010, In: Journal of Diabetes Research. 2010, p. 974681

    Research output: Contribution to journalJournal articlepeer-review

  80. Site-specific hypochlorous acid-induced oxidation of recombinant human myoglobin affects specific amino acid residues and the rate of cytochrome b5-mediated heme reduction

    Szuchman-Sapir, A. J., Pattison, D. I., Davies, Michael J. & Witting, P. K., 1 Jan 2010, In: Free Radical Biology & Medicine. 48, 1, p. 35-46 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  81. 2009
  82. Published

    The prevalence of depression in White-European and South-Asian people with impaired glucose regulation and screen-detected type 2 diabetes mellitus

    Aujla, N., Abrams, K. R., Davies, Michael J., Taub, N., Skinner, Timothy & Khunti, K., 9 Nov 2009, In: PLoS ONE. 4, 11, e7755.

    Research output: Contribution to journalJournal articlepeer-review

  83. Hypobromous acid and bromamine production by neutrophils and modulation by superoxide

    Chapman, A. L. P., Skaff, O., Senthilmohan, R., Kettle, A. J. & Davies, Michael J., 1 Feb 2009, In: Biochemical Journal. 417, 3, p. 773-81 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  84. Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products

    Gracanin, M., Hawkins, Clare Louise, Pattison, D. I. & Davies, Michael J., 1 Jul 2009, In: Free Radical Biology & Medicine. 47, 1, p. 92-102 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  85. Quantification of protein modification by oxidants

    Hawkins, Clare Louise, Morgan, P. E. & Davies, Michael J., 15 Apr 2009, In: Free Radical Biology & Medicine. 46, 8, p. 965-88 24 p.

    Research output: Contribution to journalJournal articlepeer-review

  86. Glycosaminoglycans are fragmented by hydroxyl, carbonate, and nitrogen dioxide radicals in a site-selective manner: implications for peroxynitrite-mediated damage at sites of inflammation

    Kennett, E. C. & Davies, Michael J., 15 Aug 2009, In: Free Radical Biology & Medicine. 47, 4, p. 389-400 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  87. Evidence for chronically elevated serum protein oxidation in systemic lupus erythematosus patients

    Morgan, P. E., Sturgess, A. D. & Davies, Michael J., Feb 2009, In: Free Radical Research. 43, 2, p. 117-27 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach

    Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., May 2009, In: Chemical Research in Toxicology. 22, 5, p. 807-17 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  89. Inhibition of myeloperoxidase-mediated hypochlorous acid production by nitroxides

    Rees, M. D., Bottle, S. E., Fairfull-Smith, K. E., Malle, E., Whitelock, J. M. & Davies, Michael J., 1 Jul 2009, In: Biochemical Journal. 421, 1, p. 79-86 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  90. Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance

    Skaff, O., Pattison, D. I. & Davies, Michael J., 15 Aug 2009, In: Biochemical Journal. 422, 1, p. 111-7 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  91. 2008
  92. Published

    Effectiveness of the diabetes education and self management for ongoing and newly diagnosed (DESMOND) programme for people with newly diagnosed type 2 diabetes: Cluster randomised controlled trial

    Davies, Michael J., Heller, S., Skinner, Timothy, Campbell, M. J., Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Doherty, Y., Eaton, S., Fox, C., Oliver, L., Rantell, K., Rayman, G. & Khunti, K., 1 Mar 2008, In: BMJ. 336, 7642, p. 491-495 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    The DESMOND educational intervention

    Davies, Michael J., Heller, S., Khunti, K. & Skinner, Timothy, 1 Mar 2008, In: Chronic Illness. 4, 1, p. 38-40 3 p.

    Research output: Contribution to journalComment/debatepeer-review

  94. Mammalian heme peroxidases: from molecular mechanisms to health implications

    Davies, Michael J., Hawkins, Clare Louise, Pattison, D. I. & Rees, M. D., Jul 2008, In: Antioxidants & Redox Signaling. 10, 7, p. 1199-234 36 p.

    Research output: Contribution to journalJournal articlepeer-review

  95. Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation

    Hawkins, Clare Louise, Pattison, D. I., Stanley, N. R. & Davies, Michael J., 15 Dec 2008, In: Biochemical Journal. 416, 3, p. 441-52 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  96. Degradation of extracellular matrix by peroxynitrite/peroxynitrous acid

    Kennett, E. C. & Davies, Michael J., 1 Sep 2008, In: Free Radical Biology & Medicine. 45, 5, p. 716-25 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  97. Published

    Biomedical, lifestyle and psychosocial characteristics of people newly diagnosed with type 2 diabetes: Baseline data from the DESMOND randomized controlled trial

    Khunti, K., Skinner, Timothy, Heller, S., Carey, M. E., Dallosso, H. M. & Davies, Michael J., 1 Dec 2008, In: Diabetic Medicine. 25, 12, p. 1454-1461 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  98. Nitric oxide and nitroxides can act as efficient scavengers of protein-derived free radicals

    Lam, M. A., Pattison, D. I., Bottle, S. E., Keddie, D. J. & Davies, Michael J., Nov 2008, In: Chemical Research in Toxicology. 21, 11, p. 2111-9 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. Published

    Oxidation of myosin by haem proteins generates myosin radicals and protein cross-links

    Lund, Marianne N., Luxford, C., Skibsted, Leif Horsfelt & Davies, Michael J., 2008, In: Biochemical Journal. 410, 3, p. 565-574

    Research output: Contribution to journalJournal articlepeer-review

  100. Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

    Lloyd, M. M., van Reyk, D. M., Davies, Michael J. & Hawkins, Clare Louise, 1 Sep 2008, In: Biochemical Journal. 414, 2, p. 271-80 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  101. Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage

    Mizdrak, J., Hains, P. G., Truscott, R. J. W., Jamie, J. F. & Davies, Michael J., 15 Mar 2008, In: Free Radical Biology & Medicine. 44, 6, p. 1108-19 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  102. Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins

    Morgan, P. E., Pattison, D. I., Hawkins, Clare Louise & Davies, Michael J., 1 Nov 2008, In: Free Radical Biology & Medicine. 45, 9, p. 1279-89 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  103. Published

    Effects of cross-link breakers, glycation inhibitors and insulin sensitisers on HDL function and the non-enzymatic glycation of apolipoprotein A-I

    Nobecourt, E., Zeng, J., Davies, Michael J., Brown, B. E., Yadav, S., Barter, P. J. & Rye, K. -., Jun 2008, In: Diabetologia. 51, 6, p. 1008-1017 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  104. Oxidative damage to extracellular matrix and its role in human pathologies

    Rees, M. D., Kennett, E. C., Whitelock, J. M. & Davies, Michael J., 15 Jun 2008, In: Free Radical Biology & Medicine. 44, 12, p. 1973-2001 29 p.

    Research output: Contribution to journalJournal articlepeer-review

  105. The vinyl ether linkages of plasmalogens are favored targets for myeloperoxidase-derived oxidants: a kinetic study

    Skaff, O., Pattison, D. I. & Davies, Michael J., 5 Aug 2008, In: Biochemistry. 47, 31, p. 8237-45 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  106. Published

    'Educator talk' and patient change: Some insights from the DESMOND (Diabetes Education and Self Management for Ongoing and Newly Diagnosed) randomized controlled trial

    Skinner, Timothy, Carey, M. E., Cradock, S., Dallosso, H. M., Daly, H., Davies, Michael J., Doherty, Y., Heller, S., Khunti, K. & Oliver, L., 1 Sep 2008, In: Diabetic Medicine. 25, 9, p. 1117-1120 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  107. Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation

    Stadler, N., Stanley, N., Heeneman, S., Vacata, V., Daemen, M. J. A. P., Bannon, P. G., Waltenberger, J. & Davies, Michael J., May 2008, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 28, 5, p. 1024-30 7 p.

    Research output: Contribution to journalJournal articlepeer-review

ID: 38036205