Michael Gajhede

Michael Gajhede

Professor

ORCID: 0000-0001-9864-2287

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  1. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface

    Ahring, P. K., Olsen, J. A., Nielsen, E. Ø., Peters, D., Pedersen, M. H. F., Rohde, L. A., Kastrup, Jette Sandholm Jensen, Shahsavar, A., Indurthi, D. C., Chebib, M., Gajhede, Michael & Balle, T., 2015, In: Neuropharmacology. 92, p. 135-45 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Epitope grafting, re-creating a conformational Bet v 1 antibody epitope on the surface of the homologous apple allergen Mal d 1

    Holm, J., Ferreras, M., Ipsen, H., Würtzen, P. A., Gajhede, Michael, Larsen, J. N., Lund, K. & Spangfort, M. D., 20 May 2011, In: Journal of Biological Chemistry. 286, 20, p. 17569-17578

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Erratum: Chemoenzymatic synthesis of new 2,4- syn -functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters (Journal of Medicinal Chemistry (2013) 56 (1614-1628))

    Assaf, Z., Larsen, A. P., Venskutonyteì, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, A. A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 25 Jul 2013, In: Journal of Medicinal Chemistry. 56, 14, p. 5985 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  5. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP

    Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Journal. 272, 7, p. 1639-48 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1

    Kulahin, N., Kasper, C., Gajhede, Michael, Berezin, V., Bock, E. & Kastrup, Jette Sandholm Jensen, Mar 2004, In: Acta Crystallographica. Section D: Biological Crystallography. 60, Pt 3, p. 591-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1

    Kulahin, N., Kasper, C., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. & Gajhede, Michael, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 9, p. 858-60 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1

    Rafiq, M., Ernst, H. A., Aduri, N. G., Prabhala, B. K., Tufail, S., Rahman, M., Bloch, Magnus Borup, Mirza, N., Taylor, Nicholas M I, Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2022, In: Protein Expression and Purification. 190, 7 p., 105990.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Expression, purification and characterization of the human MTA2-RBBP7 complex

    Brasen, C., Dorosz, J., Wiuf, A., Boesen, T., Mirza, Osman Asghar & Gajhede, Michael, 4 Feb 2017, In: Biochimica et biophysica acta. 1865, 5, p. 531-538 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine

    Frydenvang, Karla Andrea, Lash, L. L., Naur, P., Postila, P. A., Pickering, Darryl S, Smith, C. M., Gajhede, Michael, Sasaki, M., Sakai, R., Pentikäinen, O. T., Swanson, G. T. & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Biological Chemistry. 284, 21, p. 14219-14229

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Få kræftcellen til at begå selvmord: en strukturel vinkel på kræft

    Ross, B., Borchorst, M., Gajhede, Michael & Kristensen, O., 2007, In: Lægemiddelforskning. p. 22-23

    Research output: Contribution to journal › Journal article › Communication

  12. Published

    Gennembrud i forståelsen af insulinfibrillering

    Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In: Lægemiddelforskning. p. 10-11

    Research output: Contribution to journal › Journal article › Communication

  13. Published

    High resolution crystal structures of the p120 RasGAP SH3 domain

    Ross, B., Kristensen, O., Favre, D., Walicki, J., Kastrup, Jette Sandholm Jensen, Widmann, C. & Gajhede, Michael, 2007, In: Biochemical and Biophysical Research Communications. 353, 2, p. 463-468

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide

    Blicher, T., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2005, In: Acta Crystallographica. Section D: Biological Crystallography. 61, Pt 8, p. 1031-40 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Human proton coupled folic acid transporter is a monodisperse oligomer in the lauryl maltose neopentyl glycol solubilized state

    Aduri, N. G., Ernst, H. A., Prabhala, B. K., Bhatt, S., Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2018, In: Biochemical and Biophysical Research Communications. 495, 2, p. 1738-1743 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Hvad har varme at gøre med lægemidler?

    Olsen, L., Kasper, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Jørgensen, Flemming Steen, 2006, In: Lægemiddelforskning. p. 31-33

    Research output: Contribution to journal › Journal article › Communication

  17. Published

    Identification of catechols as histone-lysine demethylase inhibitors

    Nielsen, A. L., Kristensen, L. H., Stephansen, K. B., Kristensen, J. B. L., Helgstrand, C., Lees, M., Cloos, P., Helin, K., Gajhede, Michael & Olsen, L., 2012, In: F E B S Letters. 586, 8, p. 1190-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Increased amylosucrase activity and specificity, and identification of regions important for activity, specificity and stability through molecular evolution

    van der Veen, B. A., Skov, L. K., Potocki-Véronèse, G., Gajhede, Michael, Monsan, P. & Remaud-Simeon, M., 2006, In: F E B S Journal. 273, 4, p. 673-81 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Inhibitors of histone demethylases

    Lohse, B., Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, K., Helin, K., Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

    Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

    Research output: Contribution to journal › Journal article › Research

  21. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Ionotropic glutamate-like receptor d2 binds D-serine and glycine.

    Naur, P., Hansen, K. B., Kristensen, Anders Skov, Dravid, S. M., Pickering, Darryl S, Olsen, L., Vestergaard, Bente, Egebjerg, J., Gajhede, Michael, Traynelis, S. F. & Kastrup, Jette Sandholm Jensen, 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 35, p. 14116-14121

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Jagten på et signalstof til hjernens delta2-receptor

    Naur, P., Olsen, L., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Lægemiddelforskning. p. 32-33

    Research output: Contribution to journal › Journal article › Communication

  24. Published

    Kainate induces various domain closures in AMPA and kainate receptors

    Venskutonyte, R., Frydenvang, Karla Andrea, Hald, H., Rabassa, A. C. D., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, Sep 2012, In: Neurochemistry International. 61, 4, p. 536-545

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Lipid-bound ApoE3 self-assemble into elliptical disc-shaped particles

    Nørgrd Larsen, Andreas, Johansen, Nicolai Tidemand, Gajhede, Michael, Arleth, Lise & Midtgaard, S. R., 2021, In: B B A - Biomembranes. 1863, 1, 10 p., 183495.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Lysine demethylase inhibition protects pancreatic β cells from apoptosis and improves β-cell function

    Backe, M. B., Andersson, J. L., Bacos, K., Christensen, D. P., Hansen, J. B., Dorosz, J. J., Gajhede, Michael, Dahlby, T., Bysani, M., Kristensen, L. H., Ling, C., Olsen, L. & Mandrup-Poulsen, Thomas, 15 Jan 2018, In: Molecular and Cellular Endocrinology. 460, p. 47-56 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Major venom allergen of yellow jackets, Ves v 5: structural characterization of a pathogenesis-related protein superfamily

    Henriksen, A., King, T. P., Mirza, O., Monsalve, R. I., Meno, K., Ipsen, H., Larsen, J. N., Gajhede, Michael & Spangfort, M. D., 2001, In: Proteins: Structure, Function, and Bioinformatics. 45, 4, p. 438-48 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Maltooligosaccharide disproportionation reaction: an intrinsic property of amylosucrase from Neisseria polysaccharea

    Albenne, C., Skov, L. K., Mirza, Osman Asghar, Gajhede, Michael, Potocki-Véronèse, G., Monsan, P. & Remaud-Simeon, M., 11 Sep 2002, In: F E B S Letters. 527, 1-3, p. 67-70 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium

    Hansen, K. B., Naur, P., Kurtkaya, N. L., Kristensen, Anders Skov, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., 2009, In: Journal of Neuroscience. 29, 4, p. 907-917

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Molecular Dynamics Simulations Reveal the Proton:Peptide Coupling Mechanism in the Bacterial Proton-Coupled Oligopeptide Transporter YbgH

    Aduri, N. G., Montefiori, M., Khalil, R., Gajhede, Michael, Jørgensen, Flemming Steen & Mirza, Osman Asghar, 31 Jan 2019, In: ACS Omega. 4, 1, p. 2040-2046 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Molecular architecture of the Jumonji C family histone demethylase KDM5B

    Dorosz, J., Kristensen, L. H., Aduri, N. G., Mirza, Osman Asghar, Lousen, R., Bucciarelli, S., Mehta, V., Sellés Baiget, Selene, Solbak, Sara Marie Øie, Bach, Anders, Mesa, Pablo, Hernandez, P. A., Montoya, Guillermo, Nguyen, T. T. T. N., Rand, Kasper Dyrberg, Boesen, T. & Gajhede, Michael, 2019, In: Scientific Reports. 9, 13 p., 4019.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Molecular basis of allergic cross-reactivity between group 1 major allergens from birch and apple

    Holm, J., Bærentzen, G., Gajhede, Michael, Ipsen, H., Larsen, J. N., Løwenstein, H., Wissenbach, M. & Spangfort, M. D., 2001, In: Journal of Chromatography - B. 756, 1-2, p. 307-313 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Molecular basis of the amylose-like polymer formation catalyzed by Neisseria polysaccharea amylosucrase

    Albenne, C., Skov, L., Mirza, Osman Asghar, Gajhede, Michael, Feller, G., D'Amico, S., André, G., Potocki-Véronèse, G., van der Veen, B. A., Monsan, P. & Remaud-Simeon, M., 2 Jan 2004, In: Journal of Biological Chemistry. 279, 1, p. 726-34 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

    Harpsøe, Kasper, Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Ahring, P. K., 25 Jan 2013, In: Journal of Biological Chemistry. 288, 4, p. 2559-2570 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

    Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: FEBS Letters. 582, 29, p. 4089-4094

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

    Olsen, J. A., Balle, T., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, 17 Mar 2014, In: PLOS ONE. 9, 3, p. e91232 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

    Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

    Owczarek, S., Kiryushko, D., Hald Larsen, M., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sandi, C., Berezin, V., Bock, E. & Soroka, V., 2010, In: The FASEB Journal. 24, 4, p. 1139-1150 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Oligosaccharide and sucrose complexes of amylosucrase. Structural implications for the polymerase activity

    Skov, L. K., Mirza, Osman Asghar, Sprogøe, D., Dar, I., Remaud-Simeon, M., Albenne, C., Monsan, P. & Gajhede, Michael, 6 Dec 2002, In: Journal of Biological Chemistry. 277, 49, p. 47741-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

    Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Mirza, Osman Asghar, 2010, In: Protein Expression and Purification. 71, 2, p. 179-183

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

    Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Journal of Biological Chemistry. 282, 35, p. 25726-25736

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes

    Jones, S. E., Olsen, L., Dorosz, J., Seger, S. T., Andersson, J. L., Kristensen, L. H. & Gajhede, Michael, 4 Sep 2018, In: ChemBioChem. 19, 17, p. 1817-1822

    Research output: Contribution to journal › Letter › Research › peer-review

  44. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

    Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Plant peroxidases: Substrate complexes with mechanistic implications

    Gajhede, Michael, 2001, In: Biochemical Society Transactions. 29, p. 91-99

    Research output: Contribution to journal › Journal article › Research

  47. Published

    Rational and combinatorial engineering of the glucan synthesizing enzyme amylosucrase

    Albenne, C., Van Der Veen, B. A., Potocki-Véronèse, G., Joucla, G., Skov, L., Mirza, Osman Asghar, Gajhede, Michael, Monsan, P. & Remaud-Simeon, M., 1 Aug 2003, In: Biocatalysis and Biotransformation. 21, 4-5, p. 271-277 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock

    Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, Henrik, Gajhede, Michael, Kongstad, Kenneth Thermann, Stenvang, Jan & Stærk, Dan, 2021, In: Biomolecules. 11, 10, 19 p., 1534.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Role of CD3 gamma in T cell receptor assembly

    Dietrich, J., Neisig, A., Hou, X., Wegener, A. M., Gajhede, Michael & Geisler, Carsten, 1996, In: Journal of Cell Biology. 132, 3, p. 299-310 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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