Michael Gajhede
Professor
Structural Biology
Universitetsparken 2
2100 København Ø
- Published
STRUCTURE OF 1-DIMETHYLAMINO-2,2,3,4,4-PENTAMETHYL-1-LAMBDA-5-PHOSPHETANE 1-SULFIDE, C10H22NPS, AT 105 K
Gajhede, Michael, DAHL, O. & Nielsen, J., 1985, In: Acta Crystallographica. Section C: Crystal Structure Communications. 41, JUN, p. 935-937Research output: Contribution to journal › Journal article › peer-review
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Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR
Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449Research output: Contribution to journal › Journal article › peer-review
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Site-directed mutagenesis of key amino acids in the active site of amylosucrase from Neisseria polysaccharea
Albenne, C., Potocki De Montalk, G., Monsan, P., Skov, L., Mirza, Osman Asghar, Gajhede, Michael & Remaud-Simeon, M., 1 Dec 2002, In: Biologia - Section Cellular and Molecular Biology. 57, SUPPL. 11, p. 119-128 10 p.Research output: Contribution to journal › Journal article › peer-review
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Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution
Jørgensen, A. D., Nøhr, J., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sigurskjold, B. W., Sauer, J., Svergun, D. I., Svensson, B. & Vestergaard, Bente, 2008, In: Journal of Biological Chemistry. 283, 21, p. 14772-14780Research output: Contribution to journal › Journal article › peer-review
- Published
Small-molecule modulators of tumor necrosis factor signaling
Chédotal, H., Narayanan, Dilip, Povlsen, K., Gotfredsen, C. H., Brambilla, R., Gajhede, Michael, Bach, Anders & Clausen, M. H., 2023, In: Drug Discovery Today. 28, 6, 103575.Research output: Contribution to journal › Review › peer-review
- Accepted/In press
Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure
Bay, Yasmin, Venskutonytė, R., Frantsen, S. M., Thorsen, T. S., Musgaard, M., Frydenvang, Karla Andrea, Francotte, P., Pirotte, B., Biggin, P. C., Kristensen, Anders Skov, Boesen, T., Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2023, (Accepted/In press) In: FEBS Journal.Research output: Contribution to journal › Journal article › peer-review
- Published
- Published
Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity
Jones, S. E., Olsen, L. & Gajhede, Michael, 2018, In: Biochemistry. 57, 5, p. 585–592Research output: Contribution to journal › Journal article › peer-review
- Published
Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate
Shahsavar, A., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 17 Nov 2015, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 6, p. 399–407 9 p.Research output: Contribution to journal › Journal article › peer-review
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Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain
Krintel, C., Harpsøe, Kasper, Zachariassen, L. G., Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.Research output: Contribution to journal › Journal article › peer-review
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Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors
Olsen, J. A., Ahring, P. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Balle, T., 5 Sep 2014, In: The Journal of Biological Chemistry. 289, 36, p. 24911-21 11 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family
Kristensen, O., Laurberg, M., Liljas, A., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2004, In: Biochemistry. 43, 28, p. 8894-900 7 p.Research output: Contribution to journal › Journal article › peer-review
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Structural interactions between horseradish peroxidase C and the substrate benzhydroxamic acid determined by X-ray crystallography
Henriksen, A., Schuller, D. J., Meno, K., Welinder, K. G., Smith, A. T. & Gajhede, Michael, 1998, In: Biochemistry. 37, p. 8054-8060Research output: Contribution to journal › Journal article › peer-review
- Published
Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule
Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, Bente, Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 9 Feb 2011, In: Structure. 19, 2, p. 203-211Research output: Contribution to journal › Journal article › peer-review
- Published
Structural mutations of C-domains in members of the Ig superfamily. Consequences for the interactions between the T cell antigen receptor and the zeta 2 homodimer
Geisler, Carsten, Rubin, B., Caspar-Bauguil, S., Champagne, E., Vangsted, A., Hou, X. & Gajhede, Michael, 1992, In: Journal of Immunology. 148, 11, p. 3469-77 8 p.Research output: Contribution to journal › Journal article › peer-review
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Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites
Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In: Chemistry & Biology. 14, 11, p. 1294-303 10 p.Research output: Contribution to journal › Journal article › peer-review
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Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion
Mirza, Osman Asghar, Henriksen, L. S., Sprogøe, D., van den Broek, L. A. M., Beldman, G., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2006, In: Journal of Biological Chemistry. 281, 46, p. 35576-84 9 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structure and binding properties of a cameloid nanobody raised against KDM5B
Wiuf, A., Kristensen, L. H., Kristensen, O., Dorosz, J., Jensen, J. & Gajhede, Michael, 23 Sep 2015, In: Acta crystallographica. Section F, Structural biology communications. 71, Pt 10, p. 1235-1241 7 p.Research output: Contribution to journal › Journal article › peer-review
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Structure of Barley Grain Peroxidase Refined at 1.9 A Resolution. A plant Peroxidase Reversibly Inactived at Neutral pH
Henriksen, A., Welinder, K. G. & Gajhede, Michael, 1998, In: Journal of Biological Chemistry. 273, p. 2241-2248Research output: Contribution to journal › Journal article
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Structure of HLA-A*1101 in complex with a hepatitis B peptide homologue
Blicher, T., Kastrup, Jette Sandholm Jensen, Pedersen, L. Ø., Buus, Søren & Gajhede, Michael, 2006, In: Acta Crystallographica Section F-Structural Biology and Crystallization Communications. 62, Pt 12, p. 1179-84 5 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501
Røder, G., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt 6, p. 459-62 3 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2007, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 63, Pt2, p. 65-68 4 p.Research output: Contribution to journal › Journal article › peer-review
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Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom
Skov, L. K., Seppälä, U., Coen, J. J. F., Crickmore, N., King, T. P., Monsalve, R., Kastrup, Jette Sandholm Jensen, Spangfort, M. D. & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 6, p. 595-604 10 p.Research output: Contribution to journal › Journal article › peer-review
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Structure of soybean seed coat peroxidase: a plant peroxidase with unusual stability and haem-apoprotein interactions
Henriksen, A., Mirza, Osman Asghar, Indiani, C., Teilum, Kaare, Smulevich, G., Welinder, K. G. & Gajhede, Michael, 2001, In: Protein Science. 10, 1, p. 108-15 7 p.Research output: Contribution to journal › Journal article › peer-review
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Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp
Kristensen, O., Ross, B. & Gajhede, Michael, 2008, In: Journal of Molecular Biology. 375, 5, p. 1469-1476Research output: Contribution to journal › Journal article › peer-review
- Published
Structure of the first PDZ domain of human PSD-93
Fiorentini, M., Nielsen, A. K., Kristensen, O., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2009, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 65, 12, p. 1254-1257Research output: Contribution to journal › Journal article › peer-review
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Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity
Johannessen, B. R., Skov, L., Kastrup, Jette Sandholm Jensen, Kristensen, O., Bolwig, C., Larsen, J., Spangfort, M., Lund, K. & Gajhede, Michael, 2005, In: F E B S Letters. 579, 5, p. 1208-12 5 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism
Kobberø, S. D., Gajhede, Michael, Mirza, Osman Asghar, Kløverpris, S., Kjær, T. R., Mikkelsen, J. H., Boesen, T. & Oxvig, C., 2022, In: Nature Communications. 13, 1, 16 p., 6084.Research output: Contribution to journal › Journal article › peer-review
- Published
Structure-Based Design of a New Scaffold for Cell-Penetrating Peptidic Inhibitors of the Histone Demethylase PHF8
Dorosz, J., Olsen, L., Seger, S. T., Steinhauer, C., Bouras, G., Helgstrand, C., Wiuf, A. & Gajhede, Michael, 18 Jul 2017, In: ChemBioChem. 18, 14, p. 1369-1375 7 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency
Beich-Frandsen, M., Pickering, Darryl S, Mirza, Osman Asghar, Johansen, Tommy Nørskov, Greenwood, J., Vestergaard, Bente, Schousboe, Arne, Gajhede, Michael, Liljefors, T. & Kastrup, Jette Sandholm Jensen, 2008, In: Journal of Medicinal Chemistry. 51, 5, p. 1459-63Research output: Contribution to journal › Journal article › peer-review
- Published
Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor
Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, Jette Sandholm Jensen, Helin, K., Olsen, L. & Gajhede, Michael, Jun 2012, In: F E B S Journal. 279, 11, p. 1905-1914Research output: Contribution to journal › Journal article › peer-review
- Published
Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists
Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 940-951Research output: Contribution to journal › Journal article › peer-review
- Published
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors
Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, Stig, Tuelung, P. S., Narayanan, Dilip, Langkilde, Annette Eva, Gajhede, Michael, Pagano, P. J., Jaquet, V., Vilhardt, Frederik & Bach, Anders, 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005Research output: Contribution to journal › Journal article › peer-review
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Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors
Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103Research output: Contribution to journal › Journal article › peer-review
- Published
The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP
Ambjørner, S. E. B., Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, Lasse, Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, N. & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.Research output: Contribution to journal › Journal article › peer-review
- Published
The SAXS Solution Structure of RF1 Differs from Its Crystal Structure and Is Similar to Its Ribosome Bound Cryo-EM Structure
Vestergaard, Bente, Sanyal, S., Roessle, M., Mora, L., Buckingham, R., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Svergun, D. I. & Ehrenberg, M., 2005, In: Molecular Cell. 20, p. 929-938Research output: Contribution to journal › Journal article › peer-review
- Published
The Structures of the Horseradish Peroxidase C-Ferulic Acid Complex and the Ternary Comples with Cyanide Suggest How Peroxidases Oxidize Small Phenolic Substrates
Henriksen, A., Smith, A. T. & Gajhede, Michael, 1999, In: J. of Biol. Chem.. 49, p. 35005-34011Research output: Contribution to journal › Journal article
- Published
The apo structure of sucrose hydrolase from Xanthomonas campestris pv. campestris shows an open active-site groove
Champion, E., Remaud-Simeon, M., Skov, L. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2009, In: Acta Crystallographica. Section D: Biological Crystallography. 65, 12, p. 1309-1314Research output: Contribution to journal › Journal article › peer-review
- Published
The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen
Meno, K., Thorsted, P. B., Ipsen, H., Kristensen, O., Larsen, J., Spangfort, M. D., Gajhede, Michael & Lund, K., 2005, In: Journal of Immunology. 175, 6, p. 3835-45 11 p.Research output: Contribution to journal › Journal article › peer-review
- Published
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization
Clausen, Rasmus Prætorius, Naur, P., Kristensen, Anders Skov, Greenwood, J. R., Strange, M., Bräuner, Hans, Jensen, Anders A., Nielsen, A. S. T., Geneser, U., Ringgaard, L. M., Nielsen, Birgitte, Pickering, Darryl S, Brehm, L., Gajhede, Michael, Krogsgaard-Larsen, Povl & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Medicinal Chemistry. 52, 15, p. 4911-4922Research output: Contribution to journal › Journal article › peer-review
- Published
The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region
Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, Michael, Jørgensen, Flemming Steen, Olsen, L. & Kastrup, Jette Sandholm Jensen, 7 Apr 2017, In: Scientific Reports. 7, 12 p., 46145.Research output: Contribution to journal › Journal article › peer-review
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The metal binding site of the major house dust mite allergen Der p 1
Meno, K., Thorsted, P. B., Ipsen, H., Kristensen, O., Larsen, J., Spangfort, M. D., Gajhede, Michael & Lund, K., 2006, In: Journal of Allergy and Clinical Immunology. 118, 4, p. 971Research output: Contribution to journal › Comment/debate › peer-review
- Published
The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells
Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017Research output: Contribution to journal › Journal article › peer-review
- Published
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209
Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In: Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.Research output: Contribution to journal › Journal article › peer-review
- Published
The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology
Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, Michael & Mirza, Osman Asghar, Sep 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.Research output: Contribution to journal › Journal article › peer-review
- Published
The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit
Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2008, In: Biochemistry. 47, 28, p. 7441-7451Research output: Contribution to journal › Journal article › peer-review
- Published
The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1
Meno, K. H., Kastrup, Jette Sandholm Jensen, Kuo, I., Chua, K. Y. & Gajhede, Michael, 1 Apr 2017, In: Allergy. 72, 4, p. 665-670 6 p., 13111.Research output: Contribution to journal › Journal article › peer-review
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Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2
Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178Research output: Contribution to journal › Journal article › peer-review
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Towards the molecular understanding of glycogen elongation by amylosucrase
Albenne, C., Skov, L. K., Tran, V., Gajhede, Michael, Monsan, P., Remaud-Siméon, M. & André-Leroux, G., 2007, In: Proteins - Structure Function and Bioinformatics. 66, 1, p. 118-126Research output: Contribution to journal › Journal article › peer-review
- Published
Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.
Olsen, J. A., Kastrup, Jette Sandholm Jensen, Peters, D., Gajhede, Michael, Balle, T. & Ahring, P. K., 13 Dec 2013, In: Journal of Biological Chemistry. 288, 50, p. 35997 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2
Frandsen, A., Pickering, Darryl S, Vestergaard, Bente, Kasper, C., Nielsen, B. B., Greenwood, J. R., Campiani, G., Fattorusso, C., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: Molecular Pharmacology. 67, 3, p. 703-13 10 p.Research output: Contribution to journal › Journal article › peer-review
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Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
Research output: Contribution to journal › Journal article › peer-review
Published