Michael Gajhede

Michael Gajhede

Professor

ORCID: 0000-0001-9864-2287

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  1. Published

    Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity

    Johannessen, B. R., Skov, L., Kastrup, Jette Sandholm Jensen, Kristensen, O., Bolwig, C., Larsen, J., Spangfort, M., Lund, K. & Gajhede, Michael, 2005, In: F E B S Letters. 579, 5, p. 1208-12 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity

    Jones, S. E., Olsen, L. & Gajhede, Michael, 2018, In: Biochemistry. 57, 5, p. 585–592

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes

    Jones, S. E., Olsen, L., Dorosz, J., Seger, S. T., Andersson, J. L., Kristensen, L. H. & Gajhede, Michael, 4 Sep 2018, In: ChemBioChem. 19, 17, p. 1817-1822

    Research output: Contribution to journal › Letter › Research › peer-review

  4. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution

    Jørgensen, A. D., Nøhr, J., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sigurskjold, B. W., Sauer, J., Svergun, D. I., Svensson, B. & Vestergaard, Bente, 2008, In: Journal of Biological Chemistry. 283, 21, p. 14772-14780

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Conformational stability of calreticulin

    Jørgensen, C. S., Trandum, C., Larsen, N. B., Ryder, L. R., Gajhede, Michael, Skov, L., Højrup, P., Barkholt, V. & Houen, G., 2005, In: Protein and Peptide Letters. 12, 7, p. 687-93 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Cyclic Acetals. Structural Analysis of 1,3‐Dioxepine and Related Compounds

    Jørgensen, Flemming Steen, Gajhede, Michael & Frei, B., 1 Jan 1985, In: Helvetica Chimica Acta. 68, 8, p. 2148-2157 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

    Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In: Chemistry & Biology. 14, 11, p. 1294-303 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209

    Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In: Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

    Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: FEBS Letters. 582, 29, p. 4089-4094

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism

    Kobberø, S. D., Gajhede, Michael, Mirza, Osman Asghar, Kløverpris, S., Kjær, T. R., Mikkelsen, J. H., Boesen, T. & Oxvig, C., 2022, In: Nature Communications. 13, 1, 16 p., 6084.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2

    Krintel, C., Dorosz, J., Larsen, A. H., Thorsen, T. S., Venskutonytė, R., Mirza, Osman Asghar, Gajhede, Michael, Boesen, T. & Kastrup, Jette Sandholm Jensen, 2021, In: The FEBS Journal. 288, p. 995-1007 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Zachariassen, L. G., Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

    Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

    Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

    Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, Jette Sandholm Jensen, Helin, K., Olsen, L. & Gajhede, Michael, Jun 2012, In: F E B S Journal. 279, 11, p. 1905-1914

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Chaperone binding at the ribosomal exit tunnel

    Kristensen, O. & Gajhede, Michael, 2003, In: Structure. 11, 12, p. 1547-56 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Crystallization of a stringent response factor from Aquifex aeolicus

    Kristensen, O., Laurberg, M. & Gajhede, Michael, 2002, In: Acta Crystallographica. Section D: Biological Crystallography. 58, Pt 7, p. 1198-200 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp

    Kristensen, O., Ross, B. & Gajhede, Michael, 2008, In: Journal of Molecular Biology. 375, 5, p. 1469-1476

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    A unique set of SH3-SH3 interactions controls IB1 homodimerization

    Kristensen, O., Guenat, S., Dar, I., Allaman-Pillet, N., Abderrahmani, A., Ferdaoussi, M., Roduit, R., Maurer, F., Beckmann, J. S., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Bonny, C., 2006, In: E M B O Journal. 25, 4, p. 785-97 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family

    Kristensen, O., Laurberg, M., Liljas, A., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2004, In: Biochemistry. 43, 28, p. 8894-900 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Crystal structure of NCAM2 IgIV-Fn3I

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual form › Dataset › Research

  26. Published

    Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1

    Kulahin, N., Kasper, C., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. & Gajhede, Michael, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 9, p. 858-60 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Crystal Structure of NCAM2 Ig1-2

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual form › Dataset › Research

  28. Published

    Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit)

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Poulsen, Jens-Christian Navarro, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual form › Dataset › Research

  29. Published

    Structure of rat acidic fibroblast growth factor at 1.4 A resolution.

    Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2007, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 63, Pt2, p. 65-68 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Dimerization effect of sucrose octasulfate on rat FGF1.

    Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt6, p. 448-452 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Crystal structure of NCAM2 IgIV-Fn3II

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual form › Dataset › Research

  32. Published

    Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1

    Kulahin, N., Kasper, C., Gajhede, Michael, Berezin, V., Bock, E. & Kastrup, Jette Sandholm Jensen, Mar 2004, In: Acta Crystallographica. Section D: Biological Crystallography. 60, Pt 3, p. 591-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Crystal Structure of NCAM2 Ig2-3

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual form › Dataset › Research

  34. Published

    Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule

    Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, Bente, Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 9 Feb 2011, In: Structure. 19, 2, p. 203-211

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Crystal Structure of NCAM2 Ig34

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual form › Dataset › Research

  36. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner, Hans, 2013, In: The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Lipid-bound ApoE3 self-assemble into elliptical disc-shaped particles

    Nørgrd Larsen, Andreas, Johansen, Nicolai Tidemand, Gajhede, Michael, Arleth, Lise & Midtgaard, S. R., 2021, In: B B A - Biomembranes. 1863, 1, 10 p., 183495.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Inhibitors of histone demethylases

    Lohse, B., Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, K., Helin, K., Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  40. Published

    The metal binding site of the major house dust mite allergen Der p 1

    Meno, K., Thorsted, P. B., Ipsen, H., Kristensen, O., Larsen, J., Spangfort, M. D., Gajhede, Michael & Lund, K., 2006, In: Journal of Allergy and Clinical Immunology. 118, 4, p. 971

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  41. Published

    The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen

    Meno, K., Thorsted, P. B., Ipsen, H., Kristensen, O., Larsen, J., Spangfort, M. D., Gajhede, Michael & Lund, K., 2005, In: Journal of Immunology. 175, 6, p. 3835-45 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1

    Meno, K. H., Kastrup, Jette Sandholm Jensen, Kuo, I., Chua, K. Y. & Gajhede, Michael, 1 Apr 2017, In: Allergy. 72, 4, p. 665-670 6 p., 13111.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion

    Mirza, Osman Asghar, Henriksen, L. S., Sprogøe, D., van den Broek, L. A. M., Beldman, G., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2006, In: Journal of Biological Chemistry. 281, 46, p. 35576-84 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Crystal Structures of Amylosucrase from Neisseria polysaccharea in Complex with D-Glucose and the Active Site Mutant Glu328Gln in Complex with the Natural Substrate Sucrose

    Mirza, O., Skov, L. K., Remaud-Simeon, M., Potocki de Montalk, G., Albenne, C., Monsan, P. & Gajhede, Michael, 2001, In: Biochemistry. 40, p. 9032-9039

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Arabidopsis thaliana peroxidase N: structure of a novel neutral peroxidase

    Mirza, Osman Asghar, Henriksen, A., Ostergaard, L., Welinder, K. G. & Gajhede, Michael, Mar 2000, In: Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 3, p. 372-5 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1

    Mirza, Osman Asghar, Henriksen, A., Ipsen, H., Larsen, J. N., Wissenbach, M., Spangfort, M. D. & Gajhede, Michael, 1 Jul 2000, In: Journal of Immunology. 165, 1, p. 331-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose

    Mirza, O. A., Skov, L. K., Remaud-Simeon, M., Potocki de Montalk, G., Albenne, C., Monsan, P. & Gajhede, Michael, 31 Jul 2001, In: Biochemistry. 40, 30, p. 9032-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery

    Narayanan, Dilip, Tran, K. T., Pallesen, J. S., Solbak, S. M. Ø., Qin, Y., Mukminova, E., Luchini, M., Vasilyeva, K. O., González Chichón, D., Goutsiou, G., Poulsen, C., Haapanen, N., Popowicz, G. M., Sattler, M., Olagnier, D., Gajhede, Michael & Bach, Anders, 2022, In: Journal of Medicinal Chemistry. 65, 21, p. 14481-14526

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Jagten på et signalstof til hjernens delta2-receptor

    Naur, P., Olsen, L., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Lægemiddelforskning. p. 32-33

    Research output: Contribution to journal › Journal article › Communication

  50. Published

    Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

    Naur, P., Vestergaard, Bente, Skov, L., Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Letters. 579, p. 1154-60

    Research output: Contribution to journal › Journal article › Research › peer-review

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