Michael Gajhede

Michael Gajhede

Professor

ORCID: 0000-0001-9864-2287

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  1. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, Azadeh, Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In: P L o S One. 7, 8, p. e40757

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

    Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In: Molecular Pharmacology. 88, 4, p. 697-707 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype

    Røder, G., Blicher, T., Justesen, S., Johannesen, B., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 11, p. 1300-10 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

    Røder, G., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt 6, p. 459-62 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    High resolution crystal structures of the p120 RasGAP SH3 domain

    Ross, B., Kristensen, O., Favre, D., Walicki, J., Kastrup, Jette Sandholm Jensen, Widmann, C. & Gajhede, Michael, 2007, In: Biochemical and Biophysical Research Communications. 353, 2, p. 463-468

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Få kræftcellen til at begå selvmord: en strukturel vinkel på kræft

    Ross, B., Borchorst, M., Gajhede, Michael & Kristensen, O., 2007, In: Lægemiddelforskning. p. 22-23

    Research output: Contribution to journal › Journal article › Communication

  7. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. O., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 14 Dec 2011

    Research output: Other contribution › Research

  9. Published

    Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

    Rasmussen, K. K., Kulahin, N., Kristensen, O., Poulsen, Jens-Christian Navarro, Sigurskjold, B. W., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 2008, In: Journal of Molecular Biology. 382, 5, p. 1113-20 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1

    Rafiq, M., Ernst, H. A., Aduri, N. G., Prabhala, B. K., Tufail, S., Rahman, M., Bloch, Magnus Borup, Mirza, N., Taylor, Nicholas M I, Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2022, In: Protein Expression and Purification. 190, 7 p., 105990.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

    Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

    Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network

    Petersson, B., Nielsen, B. B., Rasmussen, H., Larsen, I. K., Gajhede, Michael, Nielsen, Peter E. & Kastrup, Jette Sandholm Jensen, 9 Feb 2005, In: Journal of the American Chemical Society. 127, 5, p. 1424-30 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock

    Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, Henrik, Gajhede, Michael, Kongstad, Kenneth Thermann, Stenvang, Jan & Stærk, Dan, 2021, In: Biomolecules. 11, 10, 19 p., 1534.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit

    Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2008, In: Biochemistry. 47, 28, p. 7441-7451

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

    Pallesen, J. S., Narayanan, Dilip, Tran, K. T., Solbak, Sara Marie Øie, Marseglia, G., Sørensen, L. M. E., Høj, L. J., Munafò, F., Carmona, R. M. C., Garcia, A. D., Desu, H. L., Brambilla, R., Johansen, Tommy Nørskov, Popowicz, G. M., Sattler, M., Gajhede, Michael & Bach, Anders, 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4623–4661

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

    Owczarek, S., Kiryushko, D., Hald Larsen, M., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sandi, C., Berezin, V., Bock, E. & Soroka, V., 2010, In: The FASEB Journal. 24, 4, p. 1139-1150 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification.

    Ostergaard, L., Teilum, Kaare, Mirza, Osman Asghar, Mattsson, O., Petersen, M., Welinder, K. G., Mundy, J., Gajhede, Michael & Henriksen, A., 2000, In: Plant Molecular Biology. 44, 2, p. 231-43 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Hvad har varme at gøre med lægemidler?

    Olsen, L., Kasper, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Jørgensen, Flemming Steen, 2006, In: Lægemiddelforskning. p. 31-33

    Research output: Contribution to journal › Journal article › Communication

  20. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

    Olsen, J. A., Kastrup, Jette Sandholm Jensen, Peters, D., Gajhede, Michael, Balle, T. & Ahring, P. K., 13 Dec 2013, In: Journal of Biological Chemistry. 288, 50, p. 35997 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

    Olsen, J. A., Balle, T., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, 17 Mar 2014, In: PLOS ONE. 9, 3, p. e91232 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

    Olsen, J. A., Ahring, P. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Balle, T., 5 Sep 2014, In: The Journal of Biological Chemistry. 289, 36, p. 24911-21 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Differential Activity and Structure of Highly Similar Peroxidases. Spectroscopic, Crystallographic, and Enzymatic Analyses of Lignifying Arabidopsis thaliana Peroxidase A2 and Horseradish Peroxidase A2

    Nielsen, K. L., Indiani, C., Henriksen, A., Feis, A., Becucci, M., Gajhede, Michael, Smulevich, G. & Welinder, K. G., 2001, In: Biochemistry. 40, p. 11013-11021

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP

    Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Journal. 272, 7, p. 1639-48 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Identification of catechols as histone-lysine demethylase inhibitors

    Nielsen, A. L., Kristensen, L. H., Stephansen, K. B., Kristensen, J. B. L., Helgstrand, C., Lees, M., Cloos, P., Helin, K., Gajhede, Michael & Olsen, L., 2012, In: F E B S Letters. 586, 8, p. 1190-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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