Michael Gajhede

Michael Gajhede

Professor

ORCID: 0000-0001-9864-2287

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  1. Published

    Increased amylosucrase activity and specificity, and identification of regions important for activity, specificity and stability through molecular evolution

    van der Veen, B. A., Skov, L. K., Potocki-Véronèse, G., Gajhede, Michael, Monsan, P. & Remaud-Simeon, M., 2006, In: F E B S Journal. 273, 4, p. 673-81 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors

    Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, Stig, Tuelung, P. S., Narayanan, Dilip, Langkilde, Annette Eva, Gajhede, Michael, Pagano, P. J., Jaquet, V., Vilhardt, Frederik & Bach, Anders, 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Structure and binding properties of a cameloid nanobody raised against KDM5B

    Wiuf, A., Kristensen, L. H., Kristensen, O., Dorosz, J., Jensen, J. & Gajhede, Michael, 23 Sep 2015, In: Acta crystallographica. Section F, Structural biology communications. 71, Pt 10, p. 1235-1241 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

    Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Mirza, Osman Asghar, 2010, In: Protein Expression and Purification. 71, 2, p. 179-183

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist

    Vogensen, S. B., Frydenvang, Karla Andrea, Greenwood, J. R., Postorino, G., Nielsen, Birgitte, Pickering, Darryl S, Ebert, B., Bølcho, U., Egebjerg, J., Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2007, In: Journal of Medicinal Chemistry. 50, 10, p. 2408-2414

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The SAXS Solution Structure of RF1 Differs from Its Crystal Structure and Is Similar to Its Ribosome Bound Cryo-EM Structure

    Vestergaard, Bente, Sanyal, S., Roessle, M., Mora, L., Buckingham, R., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Svergun, D. I. & Ehrenberg, M., 2005, In: Molecular Cell. 20, p. 929-938

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

    Vestergaard, Bente, Jensen, M. G., Roessle, M., Kastrup, Jette Sandholm Jensen, van de Weert, Marco, Flink, J. M., Frøkjær, Sven, Gajhede, Michael & Svergun, D. I., 2007, In: PLoS - Biology. 5, 5, p. 1089-1097

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate

    Venskutonyte, R., Frydenvang, Karla Andrea, Gajhede, Michael, Bunch, Lennart, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, Dec 2011, In: Journal of Structural Biology. 176, 3, p. 307-314

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Corrigendum to "Binding site and interlobe interactions of the ionotropic glutamate receptor GluK3 ligand binding domain revealed by high resolution crystal structure in complex with (S)-glutamate" [J. Struct. Biol. 176 (2011) 307-314]

    Venskutonyte, R., Frydenvang, Karla Andrea, Gajhede, Michael, Bunch, Lennart, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, Nov 2013, In: Journal of Structural Biology. 184, 2, p. 381 1 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  10. Published

    Kainate induces various domain closures in AMPA and kainate receptors

    Venskutonyte, R., Frydenvang, Karla Andrea, Hald, H., Rabassa, A. C. D., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, Sep 2012, In: Neurochemistry International. 61, 4, p. 536-545

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

    Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Synthesis, pharmacology and biostructural characterization of novel a4ß2 nicotinic acetylcholine receptor agonists

    Ussing, C. A., Hansen, C. P., Petersen, J. G., Jensen, Anders A., Rohde, L. A. H., Ahring, P. K., Nielsen, E. Ø., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Frølund, Bente & Balle, T., 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 940-951

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region

    Tapken, D., Steffensen, T. B., Leth, R., Kristensen, L. B., Gerbola, A., Gajhede, Michael, Jørgensen, Flemming Steen, Olsen, L. & Kastrup, Jette Sandholm Jensen, 7 Apr 2017, In: Scientific Reports. 7, 12 p., 46145.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Cyclic lipoundecapeptide amphisin from Pseudomonas sp. strain DSS73

    Sørensen, D., Nielsen, T. H., Christophersen, C., Sørensen, J. & Gajhede, Michael, 2001, In: Acta Crystallographica Section C. Vol. C57, p. 1123-1124

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis

    Sprogøe, D., van den Broek, L. A. M., Mirza, Osman Asghar, Kastrup, Jette Sandholm Jensen, Voragen, A. G. J., Gajhede, Michael & Skov, L., 10 Feb 2004, In: Biochemistry. 43, 5, p. 1156-62 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Dominating IgE-binding epitope of Bet v 1, the major allergen of birch pollen, characterized by X-ray crystallography and site-directed mutagenesis

    Spangfort, M. D., Mirza, Osman Asghar, Ipsen, H., Van Neerven, R. J. J., Gajhede, Michael & Larsen, J., 2003, In: Journal of Immunology. 171, 6, p. 3084-90 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Crystallization and preliminary X-ray analysis of birch-pollen allergen Bet v 1 in complex with a murine monoclonal IgG Fab' fragment

    Spangfort, M. D., Mirza, Osman Asghar & Gajhede, Michael, Dec 1999, In: Acta Crystallographica. Section D: Biological Crystallography. 55, Pt 12, p. 2035-6 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Crystal structure of the Glu328Gln mutant of Neisseria polysaccharea amylosucrase in complex with sucrose and maltoheptaose

    Skov, L. K., Mirza, Osman Asghar, Sprogøe, D., van der Veen, B., Remaud-Simeon, M., Albenne, C., Monsan, P. & Gajhede, Michael, 1 Jan 2006, In: Biocatalysis and Biotransformation. 24, 1-2, p. 99-105 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Structure of recombinant Ves v 2 at 2.0 Angstrom resolution: structural analysis of an allergenic hyaluronidase from wasp venom

    Skov, L. K., Seppälä, U., Coen, J. J. F., Crickmore, N., King, T. P., Monsalve, R., Kastrup, Jette Sandholm Jensen, Spangfort, M. D. & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 6, p. 595-604 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    The structure of amylosucrase from Deinococcus radiodurans has an unusual open active-site topology

    Skov, L. K., Pizzut-Serin, S., Remaud-Simeon, M., Ernst, H. A., Gajhede, Michael & Mirza, Osman Asghar, Sep 2013, In: Acta Crystallographica. Section F: Structural Biology and Crystallization Communications Online. 69, Pt 9, p. 973-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Oligosaccharide and sucrose complexes of amylosucrase. Structural implications for the polymerase activity

    Skov, L. K., Mirza, Osman Asghar, Sprogøe, D., Dar, I., Remaud-Simeon, M., Albenne, C., Monsan, P. & Gajhede, Michael, 6 Dec 2002, In: Journal of Biological Chemistry. 277, 49, p. 47741-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Amylosucrase, a glucan-synthesizing enzyme from the alpha-amylase family

    Skov, L. K., Mirza, Osman Asghar, Henriksen, A., De Montalk, G. P., Remaud-Simeon, M., Sarçabal, P., Willemot, R. M., Monsan, P. & Gajhede, Michael, 6 Jul 2001, In: Journal of Biological Chemistry. 276, 27, p. 25273-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Crystallization and preliminary X-ray studies of recombinant amylosucrase from Neisseria polysaccharea

    Skov, L. K., Mirza, O. A., Henriksen, A., Potocki de Montalk, G., Remaud-Simeon, M., Sarcabal, P., Willemot, R. M., Monsan, P. & Gajhede, Michael, Feb 2000, In: Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 2, p. 203-5 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Snegleprotein øger forståelsen af vigtige receptorer i hjernen

    Shahsavar, Azadeh, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael, Balle, T. & Kastrup, Jette Sandholm Jensen, 2012, In: Lægemiddelforskning. 2012, p. 48-50 3 p.

    Research output: Contribution to journal › Journal article › Communication

  25. Published

    Structural Studies of Nicotinic Acetylcholine Receptors: Using Acetylcholine Binding Protein as a Structural Surrogate

    Shahsavar, A., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 17 Nov 2015, In: Basic & Clinical Pharmacology & Toxicology Online. 118, 6, p. 399–407 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, Azadeh, Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In: P L o S One. 7, 8, p. e40757

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

    Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In: Molecular Pharmacology. 88, 4, p. 697-707 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype

    Røder, G., Blicher, T., Justesen, S., Johannesen, B., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 11, p. 1300-10 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Structure of a SARS coronavirus-derived peptide bound to the human major histocompatibility complex class I molecule HLA-B*1501

    Røder, G., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt 6, p. 459-62 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    High resolution crystal structures of the p120 RasGAP SH3 domain

    Ross, B., Kristensen, O., Favre, D., Walicki, J., Kastrup, Jette Sandholm Jensen, Widmann, C. & Gajhede, Michael, 2007, In: Biochemical and Biophysical Research Communications. 353, 2, p. 463-468

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Få kræftcellen til at begå selvmord: en strukturel vinkel på kræft

    Ross, B., Borchorst, M., Gajhede, Michael & Kristensen, O., 2007, In: Lægemiddelforskning. p. 22-23

    Research output: Contribution to journal › Journal article › Communication

  32. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. O., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 14 Dec 2011

    Research output: Other contribution › Research

  34. Published

    Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

    Rasmussen, K. K., Kulahin, N., Kristensen, O., Poulsen, Jens-Christian Navarro, Sigurskjold, B. W., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 2008, In: Journal of Molecular Biology. 382, 5, p. 1113-20 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Expression, purification and characterization of human proton-coupled oligopeptide transporter 1 hPEPT1

    Rafiq, M., Ernst, H. A., Aduri, N. G., Prabhala, B. K., Tufail, S., Rahman, M., Bloch, Magnus Borup, Mirza, N., Taylor, Nicholas M I, Boesen, T., Gajhede, Michael & Mirza, Osman Asghar, 2022, In: Protein Expression and Purification. 190, 7 p., 105990.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Several hPepT1-transported drugs are substrates of the Escherichia coli proton-coupled oligopeptide transporter YdgR

    Prabhala, B. K., Aduri, N. G., Iqbal, M., Rahman, M., Gajhede, Michael, Hansen, Paul Robert & Mirza, Osman Asghar, 16 Feb 2017, In: Research in Microbiology. 168, 5, p. 443-449

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    The prototypical proton-coupled oligopeptide transporter YdgR from Escherichia coli facilitates chloramphenicol uptake into bacterial cells

    Prabhala, B. K., Aduri, N. G., Sharma, N., Shaheen, A., Sharma, A., Iqbal, M., Hansen, Paul Robert, Brasen, C., Gajhede, Michael, Rahman, M. & Mirza, Osman Asghar, 2018, In: The Journal of Biological Chemistry. 293, p. 1007-1017

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network

    Petersson, B., Nielsen, B. B., Rasmussen, H., Larsen, I. K., Gajhede, Michael, Nielsen, Peter E. & Kastrup, Jette Sandholm Jensen, 9 Feb 2005, In: Journal of the American Chemical Society. 127, 5, p. 1424-30 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock

    Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, Henrik, Gajhede, Michael, Kongstad, Kenneth Thermann, Stenvang, Jan & Stærk, Dan, 2021, In: Biomolecules. 11, 10, 19 p., 1534.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The structure of the complex between a branched pentasaccharide and Thermobacillus xylanilyticus GH-51 arabinofuranosidase reveals xylan-binding determinants and induced fit

    Paës, G., Skov, L. K., O'Donohue, M. J., Rémond, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Mirza, Osman Asghar, 2008, In: Biochemistry. 47, 28, p. 7441-7451

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds

    Pallesen, J. S., Narayanan, Dilip, Tran, K. T., Solbak, Sara Marie Øie, Marseglia, G., Sørensen, L. M. E., Høj, L. J., Munafò, F., Carmona, R. M. C., Garcia, A. D., Desu, H. L., Brambilla, R., Johansen, Tommy Nørskov, Popowicz, G. M., Sattler, M., Gajhede, Michael & Bach, Anders, 2021, In: Journal of Medicinal Chemistry. 64, 8, p. 4623–4661

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

    Owczarek, S., Kiryushko, D., Hald Larsen, M., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sandi, C., Berezin, V., Bock, E. & Soroka, V., 2010, In: The FASEB Journal. 24, 4, p. 1139-1150 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Arabidopsis ATP A2 peroxidase. Expression and high-resolution structure of a plant peroxidase with implications for lignification.

    Ostergaard, L., Teilum, Kaare, Mirza, Osman Asghar, Mattsson, O., Petersen, M., Welinder, K. G., Mundy, J., Gajhede, Michael & Henriksen, A., 2000, In: Plant Molecular Biology. 44, 2, p. 231-43 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Hvad har varme at gøre med lægemidler?

    Olsen, L., Kasper, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Jørgensen, Flemming Steen, 2006, In: Lægemiddelforskning. p. 31-33

    Research output: Contribution to journal › Journal article › Communication

  45. Published

    Two distinct allosteric binding sites at α4β2 nicotinic acetylcholine receptors revealed by NS206 and NS9283 give unique insights to binding activity-associated linkage at Cys-loop receptors.

    Olsen, J. A., Kastrup, Jette Sandholm Jensen, Peters, D., Gajhede, Michael, Balle, T. & Ahring, P. K., 13 Dec 2013, In: Journal of Biological Chemistry. 288, 50, p. 35997 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

    Olsen, J. A., Balle, T., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, 17 Mar 2014, In: PLOS ONE. 9, 3, p. e91232 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Structural and functional studies of the modulator NS9283 reveal agonist-like mechanism of action at α4β2 nicotinic acetylcholine receptors

    Olsen, J. A., Ahring, P. K., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Balle, T., 5 Sep 2014, In: The Journal of Biological Chemistry. 289, 36, p. 24911-21 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Differential Activity and Structure of Highly Similar Peroxidases. Spectroscopic, Crystallographic, and Enzymatic Analyses of Lignifying Arabidopsis thaliana Peroxidase A2 and Horseradish Peroxidase A2

    Nielsen, K. L., Indiani, C., Henriksen, A., Feis, A., Becucci, M., Gajhede, Michael, Smulevich, G. & Welinder, K. G., 2001, In: Biochemistry. 40, p. 11013-11021

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP

    Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Journal. 272, 7, p. 1639-48 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Identification of catechols as histone-lysine demethylase inhibitors

    Nielsen, A. L., Kristensen, L. H., Stephansen, K. B., Kristensen, J. B. L., Helgstrand, C., Lees, M., Cloos, P., Helin, K., Gajhede, Michael & Olsen, L., 2012, In: F E B S Letters. 586, 8, p. 1190-4 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Jagten på et signalstof til hjernens delta2-receptor

    Naur, P., Olsen, L., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Lægemiddelforskning. p. 32-33

    Research output: Contribution to journal › Journal article › Communication

  52. Published

    Ionotropic glutamate-like receptor d2 binds D-serine and glycine.

    Naur, P., Hansen, K. B., Kristensen, Anders Skov, Dravid, S. M., Pickering, Darryl S, Olsen, L., Vestergaard, Bente, Egebjerg, J., Gajhede, Michael, Traynelis, S. F. & Kastrup, Jette Sandholm Jensen, 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 35, p. 14116-14121

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

    Naur, P., Vestergaard, Bente, Skov, L., Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Letters. 579, p. 1154-60

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. Published

    Development of Noncovalent Small-Molecule Keap1-Nrf2 Inhibitors by Fragment-Based Drug Discovery

    Narayanan, Dilip, Tran, K. T., Pallesen, J. S., Solbak, S. M. Ø., Qin, Y., Mukminova, E., Luchini, M., Vasilyeva, K. O., González Chichón, D., Goutsiou, G., Poulsen, C., Haapanen, N., Popowicz, G. M., Sattler, M., Olagnier, D., Gajhede, Michael & Bach, Anders, 2022, In: Journal of Medicinal Chemistry. 65, 21, p. 14481-14526

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Arabidopsis thaliana peroxidase N: structure of a novel neutral peroxidase

    Mirza, Osman Asghar, Henriksen, A., Ostergaard, L., Welinder, K. G. & Gajhede, Michael, Mar 2000, In: Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 3, p. 372-5 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    Dominant epitopes and allergic cross-reactivity: complex formation between a Fab fragment of a monoclonal murine IgG antibody and the major allergen from birch pollen Bet v 1

    Mirza, Osman Asghar, Henriksen, A., Ipsen, H., Larsen, J. N., Wissenbach, M., Spangfort, M. D. & Gajhede, Michael, 1 Jul 2000, In: Journal of Immunology. 165, 1, p. 331-8 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. Crystal structures of amylosucrase from Neisseria polysaccharea in complex with D-glucose and the active site mutant Glu328Gln in complex with the natural substrate sucrose

    Mirza, O. A., Skov, L. K., Remaud-Simeon, M., Potocki de Montalk, G., Albenne, C., Monsan, P. & Gajhede, Michael, 31 Jul 2001, In: Biochemistry. 40, 30, p. 9032-9 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Published

    Structural rearrangements of sucrose phosphorylase from Bifidobacterium adolescentis during sucrose conversion

    Mirza, Osman Asghar, Henriksen, L. S., Sprogøe, D., van den Broek, L. A. M., Beldman, G., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2006, In: Journal of Biological Chemistry. 281, 46, p. 35576-84 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Crystal Structures of Amylosucrase from Neisseria polysaccharea in Complex with D-Glucose and the Active Site Mutant Glu328Gln in Complex with the Natural Substrate Sucrose

    Mirza, O., Skov, L. K., Remaud-Simeon, M., Potocki de Montalk, G., Albenne, C., Monsan, P. & Gajhede, Michael, 2001, In: Biochemistry. 40, p. 9032-9039

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Published

    The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1

    Meno, K. H., Kastrup, Jette Sandholm Jensen, Kuo, I., Chua, K. Y. & Gajhede, Michael, 1 Apr 2017, In: Allergy. 72, 4, p. 665-670 6 p., 13111.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. Published

    The metal binding site of the major house dust mite allergen Der p 1

    Meno, K., Thorsted, P. B., Ipsen, H., Kristensen, O., Larsen, J., Spangfort, M. D., Gajhede, Michael & Lund, K., 2006, In: Journal of Allergy and Clinical Immunology. 118, 4, p. 971

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  62. Published

    The crystal structure of recombinant proDer p 1, a major house dust mite proteolytic allergen

    Meno, K., Thorsted, P. B., Ipsen, H., Kristensen, O., Larsen, J., Spangfort, M. D., Gajhede, Michael & Lund, K., 2005, In: Journal of Immunology. 175, 6, p. 3835-45 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. Published

    Targeting histone lysine demethylases by truncating the histone 3 tail to obtain selective substrate-based inhibitors

    Lohse, B., Nielsen, A. L., Kristensen, J. B. L., Helgstrand, C., Cloos, P. A. C., Olsen, L., Gajhede, Michael, Clausen, Rasmus Prætorius & Kristensen, Jesper Langgaard, 19 Sep 2011, In: Angewandte Chemie International Edition. 50, 39, p. 9100-9103

    Research output: Contribution to journal › Journal article › Research › peer-review

  64. Published

    Inhibitors of histone demethylases

    Lohse, B., Kristensen, Jesper Langgaard, Kristensen, L. H., Agger, K., Helin, K., Gajhede, Michael & Clausen, Rasmus Prætorius, 1 Feb 2011, In: Bioorganic & Medicinal Chemistry. 19, 12, p. 3625-3636 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  65. Published

    Lipid-bound ApoE3 self-assemble into elliptical disc-shaped particles

    Nørgrd Larsen, Andreas, Johansen, Nicolai Tidemand, Gajhede, Michael, Arleth, Lise & Midtgaard, S. R., 2021, In: B B A - Biomembranes. 1863, 1, 10 p., 183495.

    Research output: Contribution to journal › Journal article › Research › peer-review

  66. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner, Hans, 2013, In: The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  67. Published

    Crystal structure of NCAM2 IgIV-Fn3I

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual form › Dataset › Research

  68. Published

    Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1

    Kulahin, N., Kasper, C., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. & Gajhede, Michael, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 9, p. 858-60 2 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  69. Published

    Crystal Structure of NCAM2 Ig1-2

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual form › Dataset › Research

  70. Published

    Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit)

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Poulsen, Jens-Christian Navarro, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual form › Dataset › Research

  71. Published

    Structure of rat acidic fibroblast growth factor at 1.4 A resolution.

    Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2007, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 63, Pt2, p. 65-68 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  72. Published

    Dimerization effect of sucrose octasulfate on rat FGF1.

    Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt6, p. 448-452 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  73. Published

    Crystal structure of NCAM2 IgIV-Fn3II

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual form › Dataset › Research

  74. Published

    Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1

    Kulahin, N., Kasper, C., Gajhede, Michael, Berezin, V., Bock, E. & Kastrup, Jette Sandholm Jensen, Mar 2004, In: Acta Crystallographica. Section D: Biological Crystallography. 60, Pt 3, p. 591-3 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  75. Published

    Crystal Structure of NCAM2 Ig2-3

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual form › Dataset › Research

  76. Published

    Structural model and trans-interaction of the entire ectodomain of the olfactory cell adhesion molecule

    Kulahin, N., Kristensen, O., Rasmussen, K. K., Olsen, L., Rydberg, P., Vestergaard, Bente, Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 9 Feb 2011, In: Structure. 19, 2, p. 203-211

    Research output: Contribution to journal › Journal article › Research › peer-review

  77. Published

    Crystal Structure of NCAM2 Ig34

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual form › Dataset › Research

  78. Published

    Chaperone binding at the ribosomal exit tunnel

    Kristensen, O. & Gajhede, Michael, 2003, In: Structure. 11, 12, p. 1547-56 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  79. Published

    Crystallization of a stringent response factor from Aquifex aeolicus

    Kristensen, O., Laurberg, M. & Gajhede, Michael, 2002, In: Acta Crystallographica. Section D: Biological Crystallography. 58, Pt 7, p. 1198-200 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  80. Published

    Structure of the PPX/GPPA phosphatase from Aquifex aeolicus in complex with the alarmone ppGpp

    Kristensen, O., Ross, B. & Gajhede, Michael, 2008, In: Journal of Molecular Biology. 375, 5, p. 1469-1476

    Research output: Contribution to journal › Journal article › Research › peer-review

  81. Published

    A unique set of SH3-SH3 interactions controls IB1 homodimerization

    Kristensen, O., Guenat, S., Dar, I., Allaman-Pillet, N., Abderrahmani, A., Ferdaoussi, M., Roduit, R., Maurer, F., Beckmann, J. S., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Bonny, C., 2006, In: E M B O Journal. 25, 4, p. 785-97 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  82. Published

    Structural characterization of the stringent response related exopolyphosphatase/guanosine pentaphosphate phosphohydrolase protein family

    Kristensen, O., Laurberg, M., Liljas, A., Kastrup, Jette Sandholm Jensen & Gajhede, Michael, 2004, In: Biochemistry. 43, 28, p. 8894-900 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  83. Published

    Studies of H3K4me3 demethylation by KDM5B/Jarid1B/PLU1 reveals strong substrate recognition in vitro and identifies 2,4-pyridine-dicarboxylic acid as an in vitro and in cell inhibitor

    Kristensen, L. H., Nielsen, A. L., Helgstrand, C., Lees, M., Cloos, P., Kastrup, Jette Sandholm Jensen, Helin, K., Olsen, L. & Gajhede, Michael, Jun 2012, In: F E B S Journal. 279, 11, p. 1905-1914

    Research output: Contribution to journal › Journal article › Research › peer-review

  84. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journal › Journal article › Research › peer-review

  85. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

    Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  86. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  87. Published

    Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2

    Krintel, C., Dorosz, J., Larsen, A. H., Thorsen, T. S., Venskutonytė, R., Mirza, Osman Asghar, Gajhede, Michael, Boesen, T. & Kastrup, Jette Sandholm Jensen, 2021, In: The FEBS Journal. 288, p. 995-1007 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  88. Published

    Structural analysis of the positive AMPA receptor modulators CX516 and Me-CX516 in complex with the GluA2 ligand-binding domain

    Krintel, C., Harpsøe, Kasper, Zachariassen, L. G., Peters, D., Frydenvang, Karla Andrea, Pickering, Darryl S, Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2013, In: Acta Crystallographica Section D: Structural Biology. 69, Pt 9, p. 1645-1652 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  89. Published

    Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2

    Krintel, C., Frydenvang, Karla Andrea, Olsen, L., Kristensen, M. T., de Barrios, O., Naur, P., Francotte, P., Pirotte, B., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 1 Jan 2012, In: Biochemical Journal. 441, 1, p. 173-178

    Research output: Contribution to journal › Journal article › Research › peer-review

  90. Published

    Realizing integration in structural biology: The 2022 ISBUC Annual Meeting

    Kragelund, Birthe Brandt, Loland, Claus Juul, Montoya, Guillermo, Hatzakis, Nikos, Martinez, Karen Laurence, Gajhede, Michael, Christensen, Caspar Elo & Holt, Lucy, 2023, In: Structure. 31, 7, p. 747-754

    Research output: Contribution to journal › Journal article › Research › peer-review

  91. Published

    Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism

    Kobberø, S. D., Gajhede, Michael, Mirza, Osman Asghar, Kløverpris, S., Kjær, T. R., Mikkelsen, J. H., Boesen, T. & Oxvig, C., 2022, In: Nature Communications. 13, 1, 16 p., 6084.

    Research output: Contribution to journal › Journal article › Research › peer-review

  92. Published

    The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209

    Kasper, C., Pickering, Darryl S, Mirza, Osman Asghar, Olsen, L., Kristensen, Anders Skov, Greenwood, J. R., Liljefors, T., Schousboe, Arne, Wätjen, F., Gajhede, Michael, Sigurskjold, B. W. & Kastrup, Jette Sandholm Jensen, 2006, In: Journal of Molecular Biology. 357, 4, p. 1184-201 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  93. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

    Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: FEBS Letters. 582, 29, p. 4089-4094

    Research output: Contribution to journal › Journal article › Research › peer-review

  94. Published

    Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites

    Kaae, B. H., Harpsøe, Kasper, Kastrup, Jette Sandholm Jensen, Sanz, A. C., Pickering, Darryl S, Metzler, B., Clausen, Rasmus Prætorius, Gajhede, Michael, Sauerberg, P., Liljefors, T. & Madsen, Ulf, 2007, In: Chemistry & Biology. 14, 11, p. 1294-303 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  95. Published

    Cyclic Acetals. Structural Analysis of 1,3‐Dioxepine and Related Compounds

    Jørgensen, Flemming Steen, Gajhede, Michael & Frei, B., 1 Jan 1985, In: Helvetica Chimica Acta. 68, 8, p. 2148-2157 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  96. Published

    Conformational stability of calreticulin

    Jørgensen, C. S., Trandum, C., Larsen, N. B., Ryder, L. R., Gajhede, Michael, Skov, L., Højrup, P., Barkholt, V. & Houen, G., 2005, In: Protein and Peptide Letters. 12, 7, p. 687-93 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  97. Published

    Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution

    Jørgensen, A. D., Nøhr, J., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sigurskjold, B. W., Sauer, J., Svergun, D. I., Svensson, B. & Vestergaard, Bente, 2008, In: Journal of Biological Chemistry. 283, 21, p. 14772-14780

    Research output: Contribution to journal › Journal article › Research › peer-review

  98. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journal › Journal article › Research › peer-review

  99. Published

    Peptides Derived from Histone 3 and Modified at Position 18 Inhibit Histone Demethylase KDM6 Enzymes

    Jones, S. E., Olsen, L., Dorosz, J., Seger, S. T., Andersson, J. L., Kristensen, L. H. & Gajhede, Michael, 4 Sep 2018, In: ChemBioChem. 19, 17, p. 1817-1822

    Research output: Contribution to journal › Letter › Research › peer-review

  100. Published

    Structural Basis of Histone Demethylase KDM6B Histone 3 Lysine 27 Specificity

    Jones, S. E., Olsen, L. & Gajhede, Michael, 2018, In: Biochemistry. 57, 5, p. 585–592

    Research output: Contribution to journal › Journal article › Research › peer-review

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