Matthias Mann

Matthias Mann

Professor, head of research, Professor


  1. 2019
  2. A mass spectrometry guided approach for the identification of novel vaccine candidates in gram-negative pathogens

    Hornburg, D., Kruse, T., Anderl, F., Daschkin, C., Semper, R. P., Klar, K., Guenther, A., Mejías-Luque, R., Schneiderhan-Marra, N., Mann, Matthias, Meissner, F. & Gerhard, M., 22 Nov 2019, In: Scientific Reports. 9, 1, p. 17401

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease

    Ravell, J. C., Matsuda-Lennikov, M., Chauvin, S. D., Zou, J., Biancalana, M., Deeb, S. J., Price, S., Su, H. C., Notarangelo, G., Jiang, P., Morawski, A., Kanellopoulou, C., Binder, K. W., Mukherjee, R., Anibal, J. T., Sellers, B., Zheng, L., He, T., George, A. B., Pittaluga, S. & 34 others, Powers, A., Kleiner, D. E., Kapuria, D., Ghany, M., Hunsberger, S., Cohen, J. I., Uzel, G., Bergerson, J., Wolfe, L., Toro, C., Gahl, W., Folio, L. R., Matthews, H., Angelus, P., Chinn, I. K., Orange, J. S., Trujillo-Vargas, C. M., Franco, J. L., Orrego-Arango, J., Gutiérrez-Hincapié, S., Patel, N. C., Raymond, K., Patiroglu, T., Unal, E., Karakukcu, M., Day, A. G., Mehta, P., Masutani, E., De Ravin, S. S., Malech, H. L., Altan-Bonnet, G., Rao, V. K., Mann, Matthias & Lenardo, M. J., 5 Nov 2019, (E-pub ahead of print) In: The Journal of Clinical Investigation.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Interconversion between Anticipatory and Active GID E3 Ubiquitin Ligase Conformations via Metabolically Driven Substrate Receptor Assembly

    Qiao, S., Langlois, C. R., Chrustowicz, J., Sherpa, D., Karayel, O., Hansen, F. M., Beier, V., von Gronau, S., Bollschweiler, D., Schäfer, T., Alpi, A. F., Mann, Matthias, Prabu, J. R. & Schulman, B. A., 1 Nov 2019, (E-pub ahead of print) In: Molecular Cell.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The Atherosclerosis Risk Variant rs2107595 Mediates Allele-Specific Transcriptional Regulation of HDAC9 via E2F3 and Rb1

    Prestel, M., Prell-Schicker, C., Webb, T., Malik, R., Lindner, B., Ziesch, N., Rex-Haffner, M., Röh, S., Viturawong, T., Lehm, M., Mokry, M., den Ruijter, H., Haitjema, S., Asare, Y., Söllner, F., Najafabadi, M. G., Aherrahrou, R., Civelek, M., Samani, N. J., Mann, M. & 2 others, Haffner, C. & Dichgans, M., Oct 2019, In: Stroke. 50, 10, p. 2651-2660 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Plasma proteome profiling discovers potential biomarkers of non-alcoholic fatty liver disease

    Niu, Lili, Gupta, R., Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Mueller, T. D., Tschoep, M. H., Hofmann, S. M. & Mann, Matthias, Aug 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S71 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  7. Key Features Relevant to Select Antigens and TCR From the MHC-Mismatched Repertoire to Treat Cancer

    Audehm, S., Glaser, M., Pecoraro, M., Bräunlein, E., Mall, S., Klar, R., Effenberger, M., Albers, J., Bianchi, H. D. O., Peper, J., Yusufi, N., Busch, D. H., Stevanović, S., Mann, Matthias, Antes, I. & Krackhardt, A. M., 28 Jun 2019, In: Frontiers in Immunology. 10, 1485.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesis

    Marinkovic, M., Fuoco, C., Sacco, F., Cerquone Perpetuini, A., Giuliani, G., Micarelli, E., Pavlidou, T., Petrilli, L. L., Reggio, A., Riccio, F., Spada, F., Vumbaca, S., Zuccotti, A., Castagnoli, L., Mann, Matthias, Gargioli, C. & Cesareni, G., Jun 2019, In: Life Science Alliance. 2, 3

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency

    Yang, P., Humphrey, S. J., Cinghu, S., Pathania, R., Oldfield, A. J., Kumar, D., Perera, D., Yang, J. Y. H., James, D. E., Mann, Matthias & Jothi, R., 22 May 2019, In: Cell Systems. 8, 5, p. 427-445.e10

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Cortical circuit alterations precede motor impairments in Huntington's disease mice

    Burgold, J., Schulz-Trieglaff, E. K., Voelkl, K., Gutiérrez-Ángel, S., Bader, J. M., Hosp, F., Mann, Matthias, Arzberger, T., Klein, R., Liebscher, S. & Dudanova, I., 29 Apr 2019, In: Scientific Reports. 9, 1, p. 6634

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets

    Sacco, F., Seelig, A., Humphrey, S. J., Krahmer, N., Volta, F., Reggio, A., Marchetti, P., Gerdes, J. & Mann, Matthias, 7 Mar 2019, (E-pub ahead of print) In: Cell Metabolism.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape

    Hubel, P., Urban, C., Bergant, V., Schneider, W. M., Knauer, B., Stukalov, A., Scaturro, P., Mann, A., Brunotte, L., Hoffmann, H. H., Schoggins, J. W., Schwemmle, M., Mann, Matthias, Rice, C. M. & Pichlmair, A., 4 Mar 2019, (E-pub ahead of print) In: Nature Immunology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

    Angelidis, I., Simon, L. M., Fernandez, I. E., Strunz, M., Mayr, C. H., Greiffo, F. R., Tsitsiridis, G., Ansari, M., Graf, E., Strom, T., Nagendran, M., Desai, T., Eickelberg, O., Mann, Matthias, Theis, F. J. & Schiller, H. B., 27 Feb 2019, In: Nature Communications. 10, 1, p. 963

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    A spatially resolved proteomic atlas of human skin and its associated immune system

    Dyring-Andersen, Beatrice, Coscia, F., Santos, A., Løvendorf, M. B., Sørensen, L. B. P., Niu, Lili, Andersen, J. L., Clark, R., Skov, L., Teunissen, M. B. & Mann, Matthias, 2019, In: Journal of Investigative Dermatology. 139, 9, suppl., p. S259 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  15. Published

    A spatially resolved proteomic atlas of psoriatic skin

    Dyring-Andersen, Beatrice, Lovendorf, M. B., Santos, A., Coscia, F., Sørensen, L. B. P., Niu, Lili, Andersen, J. L., Teunissen, M. B., Skov, L. & Mann, Matthias, 2019, In: Journal of Investigative Dermatology. 139, 9, suppl., p. S260 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  16. Published

    Catching Lipid Droplet Contacts by Proteomics

    Krahmer, N. & Mann, Matthias, 2019, In: Contact. 2, p. 1-8 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Development, use, application of novel TIMS-Tof system

    Mann, Matthias, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S20 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  18. Published

    Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

    Zhang, G., Kruse, Thomas, Guasch Boldú, C., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: E M B O Journal. 38, 7, e100977.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Hepatic Rab24 controls blood glucose homeostasis via improving mitochondrial plasticity

    Seitz, S., Kwon, Y., Hartleben, G., Juelg, J., Sekar, R., Krahmer, N., Najafi, B., Loft, A., Gancheva, S., Stemmer, K., Feuchtinger, A., de Angelis, M. H., Mueller, T. D., Mann, M., Blueher, M., Roden, M., Diaz, M. B., Behrends, C., Gilleron, J., Herzig, S. & 1 others, Zeigerer, A., 2019, In: Nature Metabolism. 1, p. 1009-1026

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    MaxQuant.Live enables global targeting of more than 25,000 peptides

    Wichmann, C., Meier, F., Virreira Winter, S., Brunner, A., Cox, J. & Mann, Matthias, 2019, In: Molecular and Cellular Proteomics. 18, 5, p. 982-994 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Mesothelial Cell HIF1α Expression Is Metabolically Downregulated by Metformin to Prevent Oncogenic Tumor-Stromal Crosstalk

    Hart, P. C., Kenny, H. A., Grassl, N., Watters, K. M., Litchfield, L. M., Coscia, F., Blaženović, I., Ploetzky, L., Fiehn, O., Mann, Matthias, Lengyel, E. & Romero, I. L., 2019, In: Cell Reports. 29, 12, p. 4086-4098.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

    Nordgaard, C., Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Mobi-DIK (Ion Mobility DIA Analysis Kit): Targeted analysis software for diaPASEF data improves proteome coverage

    Ha, A., Frank, M., Meier, F., Brunner, A., Kaspar-Schoenefeld, S., Koch, S., Lubeck, M., Raether, O., Collins, B. C., Aebersold, R., Mann, Matthias & Rost, H., 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S17 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  24. Published

    Myosin binding protein H-like (MYBPHL): a promising biomarker to predict atrial damage

    Lahm, H., Dressen, M., Beck, N., Doppler, S., Deutsch, M., Matsushima, S., Neb, I., Koenig, K. C., Sideris, K., Voss, S., Eschenbach, L., Puluca, N., Deisenhofer, I., Doll, S., Holdenrieder, S., Mann, Matthias, Lange, R. & Krane, M., 2019, In: Scientific Reports. 9, 8 p., 9986.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Neurodevelopmental deficits in human isogenic fragile x syndrome neurons

    Utami, K., Skotte, N. H., Colaco, A. R. -., Yusof, N. A. B. M., Sim, B., Yeo, X. Y., Bae, H., Garcia-Miralles, M., Radulescu, C., Jung, S., Mann, Matthias & Pouladi, M., 2019, In: Journal of Neurochemistry. 150, p. 103 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  26. Published

    Parallel accumulation - serial fragmentation combined with data-independent acquisition (diaPASEF)

    Meier, F., Brunner, A., Frank, M., Ha, A., Voytik, E., Kaspar-Schoenefeld, S., Lubeck, M., Raether, O., Aebersold, R., Collins, B. C., Roest, H. L. & Mann, Matthias, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S17 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  27. Published

    Plasma Proteome Profiling to detect and avoid sample-related biases in biomarker studies

    Geyer, P. E., Voytik, E., Treit, P. V., Doll, S., Kleinhempel, A., Niu, Lili, Müller, J. B., Buchholtz, M., Bader, J. M., Teupser, D., Holdt, L. M. & Mann, Matthias, 2019, In: EMBO Molecular Medicine. 11, 11, e10427.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Plasma proteome profiling discovers novel proteins associated with non-alcoholic fatty liver disease

    Niu, Lili, Geyer, P. E., Albrechtsen, Nicolai Jacob Wewer, Gluud, Lise Lotte, Santos, A., Doll, S., Treit, P. V., Holst, Jens Juul, Knop, Filip Krag, Vilsbøll, Tina, Junker, A., Sachs, S., Stemmer, K., Müller, T. D., Tschöp, M. H., Hofmann, S. M. & Mann, Matthias, 2019, In: Molecular Systems Biology. 15, 16 p., e8793.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Proteomics of Cytochrome c Oxidase-Negative versus -Positive Muscle Fiber Sections in Mitochondrial Myopathy

    Murgia, M., Tan, J., Geyer, P. E., Doll, S., Mann, Matthias & Klopstock, T., 2019, In: Cell Reports. 29, 12, p. 3825-3834 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Proteomics reveals NNMT as a master metabolic regulator of cancer-associated fibroblasts

    Eckert, M. A., Coscia, F., Chryplewicz, A., Chang, J. W., Hernandez, K. M., Pan, S., Tienda, S. M., Nahotko, D. A., Li, G., Blaženović, I., Lastra, R. R., Curtis, M., Yamada, S. D., Perets, R., McGregor, S. M., Andrade, J., Fiehn, O., Moellering, R. E., Mann, Matthias & Lengyel, E., 2019, In: Nature. 569, 7758, p. 723-728

    Research output: Contribution to journalLetterResearchpeer-review

  31. Published

    Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine

    Deshmukh, A. S., Peijs, L., Beaudry, J. L., Jespersen, N. Z., Nielsen, C. H., Ma, T., Brunner, A. D., Larsen, T. J., Bayarri-Olmos, R., Prabhakar, B. S., Helgstrand, C., Severinsen, M. C. K., Holst, B., Kjaer, A., Tang-Christensen, M., Sanfridson, A., Garred, P., Privé, G. G., Pedersen, B. K., Gerhart-Hines, Z. & 4 others, Nielsen, S., Drucker, D. J., Mann, Matthias & Schéele, Camilla Charlotte Nielsen, 2019, In: Cell Metabolism. 30, 5, p. 963-975.e7 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Quick and clean: Cracking sentences encoded in E. coli by LC-MS/MS, de novo sequencing, and dictionary search

    Niu, Lili & Mann, Matthias, 2019, In: EuPA Open Proteomics. 22-23, p. 30-35 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts

    Larsen, N. B., Gao, A. O., Sparks, J. L., Gallina, I., Wu, R. A., Mann, Matthias, Räschle, M., Walter, J. C. & Duxin, Julien, 2019, In: Molecular Cell. 73, 3, p. 574-588.e7 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Response to Raaijmakers & Medema

    Zhang, G., Kruse, Thomas, Boldú, C. G., Garvanska, Dimitriya Hristoforova, Coscia, F., Mann, Matthias, Barisic, Marin & Nilsson, Jakob, 2019, In: The EMBO Journal. 38, 22, 5 p., e103547.

    Research output: Contribution to journalComment/debateResearch

  35. Published

    SILAC-based quantitative mass spectrometry-based proteomics quantifies endoplasmic reticulum stress in whole HeLa cells

    Itzhak, D. N., Sacco, F., Nagaraj, N., Tyanova, S., Mann, Matthias & Murgia, M., 2019, In: Disease Models & Mechanisms. 12, 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Sleep-wake cycles drive daily dynamics of synaptic phosphorylation

    Brüning, F., Noya, S. B., Bange, T., Koutsouli, S., Rudolph, J. D., Tyagarajan, S. K., Cox, J., Mann, Matthias, Brown, S. A. & Robles, M. S., 2019, In: Science (New York, N.Y.). 366, 6462, eaav3617 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair

    Sparks, J. L., Chistol, G., Gao, A. O., Räschle, M., Larsen, N. B., Mann, Matthias, Duxin, Julien & Walter, J. C., 2019, In: Cell. 176, 1-2, p. 167-181.e21

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The Case for Proteomics and Phospho-Proteomics in Personalized Cancer Medicine

    Doll, S., Gnad, F. & Mann, Matthias, 2019, In: Proteomics - Clinical Applications. 13, 2, 10 p., e1800113.

    Research output: Contribution to journalReviewResearchpeer-review

  39. Published

    The ever expanding scope of electrospray mass spectrometry-a 30 year journey

    Mann, Matthias, 2019, In: Nature Communications. 10, 3744.

    Research output: Contribution to journalComment/debateResearch

  40. Published

    The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep

    Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, Matthias, Tyagarajan, S. K., Robles, M. S. & Brown, S. A., 2019, In: Science. 366, 6462, eaav2642 .

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 5650809