Marianne Halberg Larsen
Food Safety and Zoonoses
Stigbøjlen 4, 1870 Frederiksberg C, 1-20, Building: 215
Main research interest is the adaptation of bacterial food borne pathogens mainly Listeria moncytogenes to stress including influence of stress conditions on virulence. This includes studies of stress signal transduction and the role of general metabolism such as carbon utilization on stress tolerance and virulence, response to biocides, and characterizations of persistent strains of L. monocytogenes with respect to risk assessment. Studies of host-pathogen interactions include use of mice, fish, mucus, macrophages, epithelial cell lines, Drosophila. The last years a major focus has been role of carbohydrates including chitin for virulence and ecology of L monocytogenes: how is expression of virulence genes influenced by changes in carbohydrate composition; will certain environments influence (prevent) virulence, and will the ability to hydrolyze the carbohydrate chitin facilitate survival of L. monocytogenes in the environment and promotes transmission into food? My main research has been focused on L. monocytogenes but I´ve also worked with Vibrio anguillarum, Staphyloccous aureus, Salmonella Typhimurium and Yersinia enterocolitica.