Majid Sheykhzade

Majid Sheykhzade

Associate Professor

Knowledge of languages

Danish (fluent), English (fluent), Persian / Farsi (mother tongue), Azerbaijanian (mother tongue) and Turkish (fluent)


Master of Science in Pharmacy (Cand. Pharm.), Royal Danish School of Pharmacy, September 1987 - February 1993.

Academic degree:

PhD, Royal Danish School of Pharmacy, 21. December 2000: "Characterization of calcitonin gene-related peptide (CGRP) receptor subtype and function in rat coronary arteries". PhD-study has resulted in 6 peer-reviewed publications in well-reputed journals. 

PhD-education was exclusively financed by external grants (self-financing):
June 1996, research grant covering lab running expenses (50.000 received from the Danish Heart Association (96-1-3-64-22386).
October 1996, research grant covering lab running expenses  (25.000 received from Novo Nordisk Foundation.
June 1997, research grant covering 6 months salary received from the Danish Heart Association (97-1-1-15-22503).
October 1998, research grant covering lab running expenses (30.000 received from Novo Nordisk Foundation.
December 1998, research grant covering 18 months salary received from the Danish Heart Association (98-2-2-19-22636).
December 1999, research grant covering lab running expenses (75.000 received from the Danish Heart Association (99-2-2-34-22741).

Current employment:

Associate Professor, Department of Pharmacology and Pharmacotherapy (New Name: Department of Drug Design and Pharmacology), Faculty of Pharmaceutical Sciences (New Name: Faculty of Health and Medical Sciences), University of Copenhagen, 1. April 2004 - present.

Previous employments:

1. February 2001 - 31. March 2004, Assistant Professor, Dept. of Pharmacology, Danish University of Pharmaceutical Sciences.

4. July 2000 - 31. January 2001, Amanuensis at the Dept. of Pharmacology, Royal Danish School of Pharmacy.

1. April 1997 - 29. February 1998, Student advisor for foreign students, Royal Danish School of Pharmacy.

1. July 1995 - 30. December 1995, Clinical data management and monitoring, Medical Department, IPSEN Scandinavia A/S

15. August 1994 - 30. June 1995, Department of Regulatory Affairs, IPSEN Scandinavia A/S

11. April 1994 - 11. August 1994, Pharmacist responsible for aseptic and sterile manufacturing of drugs, Bispebjerg Hospital Pharmacy.


Recipient of the award for the best teacher of the year in both 2005 and 2008 at the Faculty of Pharmaceutical Sciences, University of Copenhagen:



In November 2012, after the merger between FARMA and the Faculty of Health Science, I was nominated among top 10 candidates for receiving the annual HARALD teaching award (Årets Harald) at the University of Copenhagen.

The organizer of scientific meetings:

1- Coorganizer (together with associate prof. Bjarne Fjalland) of IUPHAR Teaching Section in Copenhagen, Denmark: Pre-Conference Satellite Meeting to WorldPharma 2010, Faculty of Pharmaceutical Sciences, University of Copenhagen, 17.-18. July 2010.

2- Coorganizer (together with prof. Lars Edvinsson and associate prof. Inger Jansen Olesen) of the 4th International Symposium on Calcitonin gene-related peptide (CGRP 2001), The Royal Danish School of Pharmacy, September 28-30, 2001. Meeting report has been published in TIPS: CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine? Trends in Pharmacological Sciences, 2002, vol. 23, No. 2, pp. 51-53.


Invited lectures (Scandinavia):

1- The Scandinavian Physiological Society - Annual Meeting, August 14-16, 2009, Uppsala, Sweden. The title of talk: calcitonin gene-related peptide (CGRP) receptors and signalling pathway in the vasculature.

2- DARC (Danish Arrhythmia Research Centre) Annual Symposium, November 2nd, 2006, Henrik Dam Auditorium, The Panum Institute, Copenhagen, Denmark, Organizer: Prof. Søren-Peter Olesen ( The title of talk: vascular tone in health and disease

3- Biologue Matchmaking meeting within the field of cardiovascular diseases held at NeuroSearch A/S and chaired by Prof. Søren-Peter Olesen, 25. November 2005. The title of talk: Calcitonin gene-related peptide (CGRP): Cardiovascular effects and potential therapeutic applications.

Expert referee work:


Member of Societies:

1- British Pharmacological Society (BPS)

2- Scandinavian Physiological Society (SPS)

3- The Danish Society of Toxicology and Pharmacology (DSTF).

4- Danish Cardiovascular Academy (DCAcademy).

5- Danish Heart association (Hjerteforeningen: 781694).

6- Pharmadanmark


Bibliography: Full bibliography (including contribution to book chapters) contains 104 academic publications of which 87 are Peer-reviewed scientific articles (Web of Science: H-index: 22; total citations (without self-citations): 1155. Number of first authorships = 13. Number of last authorships = 15. Number of corresponding authorships = 20.  





2. Sheykhzade, M. and Nyborg, N.C. (1998). Caliber dependent calcitonin gene-related peptide-induced relaxation in rat coronary arteries: effect of K+ on the tachyphylaxis. Eur. J. Pharmacol., 351: 53-59.

3. Sheykhzade, M. and Nyborg, N.C. (1998). Characterization of calcitonin gene-related peptide (CGRP) receptors in intramural coronary arteries from male and female Sprague Dawley rats. Br. J. Pharmacol., 123:1464-1470.



4. Nyborg, N.C. and Sheykhzade, M. (1999). Regulering af hjertets blodkar ved kredsløbslidelser. In Lægemiddelforskning edited by the Royal Danish School of Pharmacy, Copenhagen, pp. 16-17.



5. Sheykhzade, M., Dalsgaard, G.T., Johansen, T. and Nyborg, N.C. (2000). The effect of long-term streptozotocin-induced diabetes on contractile and relaxation responses of coronary arteries: selective attenuation of CGRP-induced relaxations. Br. J. Pharmacol., 129: 1212-1218.

6. Sheykhzade, M. and Nyborg, N.C.B. (2000). CGRP receptors in rat intra­mural left coronary arteries. In The CGRP Family: Calcitonin Gene-Related Peptide (CGRP), Amylin, and Adrenomedullin ed. Poyner, D., Marshall, I. & Brain, S.D. pp. 177-178. Texas: Landes Bioscience.

7. Sheykhzade, M. and Nyborg, N.C. (2000). Non-competitive antagonism of amylin on CGRP(1)-receptors in rat coronary small arteries. Br. J. Pharmacol., 130: 386-390.



8. Sheykhzade, M. and Nyborg, N.C. (2001). Mechanism of CGRP-induced relaxation in rat intramural coronary arteries. Br. J. Pharmacol., 132: 1235 - 1246.



9. Trautner, S., Amtorp, O., Boesgaard, S., Haunso, S., and Sheykhzade, M. (2002). Cytosolic Ca2+ and force in femoral small resistance arteries from rats with congestive heart failure. Effect of exogenous noradrenaline. European Heart Journal, 23 (Supplement S): 371-371.



10. Trautner, S. and Sheykhzade, M. (2003). Når kroppen overreagerer ved kronisk hjertesvigt. In Lægemiddelforskning edited by the Danish University of Pharmaceutical Sciences, Copenhagen, pp. 28-29.



11. Sheykhzade, M. and Nyborg, N.C.B. (2004). Homologous desensitization of calcitonin gene-related peptide-induced relaxation in rat intramural coronary arteries. Eur. J. Pharmacol., 484: 91-101.

12. Simonsen, A. H., Sheykhzade, M. and Nyborg, N.C. (2004). Age- and endothelium-dependent changes in coronary artery reactivity to serotonin and calcium. Vascular Pharmacology, 41: 43 - 49.

13. Sheykhzade, M., Lind, H. and Edvinsson, L. (2004). Noncompetitive antagonism of BIBN4096BS on CGRP-induced responses in human subcutaneous arteries. Br. J. Pharmacol., 143: 1066-1073.


14. Trautner, S., Amtorp, O., Boesgaard, S., Andersen, C.B., Galbo, H., Haunsø, S. and Sheykhzade, M. (2006). Ca(2+) sensitisation of force production by noradrenaline in femoral conductance and resistance arteries from rats with postinfarction congestive heart failure. Vascular Pharmacology, 44: 43 - 49.

15. Trautner, S., Amtorp, O., Boesgaard, S., Andersen, C.B., Galbo, H., Haunsø, S. and Sheykhzade, M. (2006). Noradrenaline-induced increases in calcium and tension in skeletal muscle conductance and resistance arteries from rats with post-infarction heart failure. Eur. J. Pharmacol., 537: 143 - 154.

16. Blom, I.V.D., Clausen, J.T., Hansen, A.J., Hasselager, E., Olsen, U.B., Sheykhzade, M. (2006). Effects of IL-20 concerning angiogenesis. Vascular Pharmacology, 45(3): e37 - e44.

17. Pedersen, S. H., Nielsen, L.B., Mortensen, A., Sheykhzade, M., Nilas, L. and Ottesen, B. (2006). Medroxyprogesterone acetate attenuates long-term effects of 17beta-estradiol in coronary arteries from hyperlipidemic rabbits. Steroids, 71: 834-842.


18. Hansen, C.S., Sheykhzade, M., Moller, P., Folkmann, J.K., Amtorp, O., Jonassen, T. and Loft, S. (2007). Diesel exhaust particles induce endothelial dysfunction in apoE-/- mice. Toxicol. Appl. Pharmacol., 219: 24 - 31.

19. Smajilovic, S., Sheykhzade, M., Holmegard, H.N., H., Haunsø, S. and Tfelft-Hansen, J. (2007). Calcimimetic, AMG 073, induces relaxation on isolated rat aorta. Vascular Pharmacology, 47: 222 - 228.

20. Kamp Nielsen, C., Sheykhzade, M., Heegaard, A.M., Bjerrum, O.J. (2007). Smerteforskning, chili con carne og fluorescerende stoffer. In Lægemiddelforskning edited by the Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, pp. 26-27.



21. Sheykhzade, M., Smajilovic, S., Issa, A., Haunsø, S., Christensen, S.B. and Tfelft-Hansen, J. (2008). S-petasin and butterbur lactones dilate vessels through blockage of voltage-gated calcium channels and block DNA synthesis. Eur. J. Pharmacol., 593: 79 - 86.

22. Ploug, K.B., Sørensen, M.A., Strøbech, L., Klaerke, D.A., Hay-Schmidt, A., Issa, A., Haunsø, S., Sheykhzade, M., Olesen, J., Jansen-Olesen, I. (2008). K ATP channels in pig and human intracranial arteries. Eur. J. Pharmacol., 601: 43 - 49.

23. Ghorbani , M.L.M., Fjalland, B., Sheykhzade, M., Nyborg, N.C.B. (2008). Ufølsomme hjerter i livsfare. In Lægemiddelforskning edited by the Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, pp. 49-51.



24. Vesterdal, L.K., Folkmann, J.K., Jacobsen, N.R., Sheykhzade, M., Wallin, H., Loft S., and Moller, P. (2009). Modest vasomotor dysfunction induced by low doses of C60 fullerenes in apolipoprotein E knockout mice with different degree of atherosclerosis. Particle and Fibre Toxicology, 6: 5.



25. Rode, F., Svalø, J., Sheykhzade, M., Rønn, L.C. (2010). Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder. Eur. J. Pharmacol., 638(1-3):121-127.

26. Ghorbani, B., Holmstrup, P., Edvinsson, L., Kristiansen, K.A., Sheykhzade, M. (2010). LPS from Porphyromonas gingivalis increases the sensitivity of contractile response mediated by endothelin-B (ET(B)) receptors in cultured endothelium-intact rat coronary arteries. Vascular Pharmacology, 53(5-6): 250-257.

27. Gupta, S., Amrutkar, D.V., Mataji, A., Salmasi, H., Hay-Schmidt, A., Sheykhzade, M., Messlinger, K., Olesen, J., Jansen-Olesen, I. (2010). Evidence for CGRP re-uptake in rat dura mater encephali. Br. J. Pharmacol., 161(8): 1885-1898.

28. Vesterdal, L.K., Folkmann, J.K., Jacobsen, N.R., Sheykhzade, M., Wallin, H., Loft, S., Moller, P. (2010). Pulmonary exposure to carbon black nanoparticles and vascular effects. Particle and Fibre Toxicology, 7(1): 33. 

29. Rasmussen, M.N.P., Hornbak, M., Edvinsson, L., and Sheykhzade, M. (2010). LOCAL ENHANCED CONTRACTILE RESPONSE OF ETB, 5-HT1B AND AT1 RECEPTORS FOLLOWING DISTAL FOCAL PERMANENT OCCLUSION. Hypertension, 56 (6): 1170-1170. 

30. Skovsted G.F., Pedersen, A.F., Sheykhzade, M., and Edvinsson, L. (2010). RAPID TRANSCRIPTIONAL UPREGULATION OF ETB RECEPTORS IN RAT CORONARY ARTERIES DURING MYOGRAPH STUDIES. Hypertension, 56 (6): 1170-1170. 



31. Sheykhzade, M., Gupta, S., Sørensen, T., Sørensen, O.A., Koch, H., Boonen, H.C., Back, O., Fjalland, B. (2011). Characterization of capsaicin-induced responses in mice vas deferens: evidence of CGRP uptake. Eur. J. Pharmacol., 667: 375-382.

32. Ghorbani, M.L., Qin, C., Wu, M., Farber, J.P., Sheykhzade, M., Fjalland, B., Nyborg, N.C., Foreman, R.D. (2011). Characterization of upper thoracic spinal neurons receiving noxious cardiac and/or somatic inputs in diabetic rats. Autonomic Neuroscience: Basic and Clinical, 165(2):168-177.

33. Svaloe, J., Hansen, H.H., Rønn, L.C., Sheykhzade, M., Munro, G., Rode, F. (2011). K(v) 7 Positive Modulators Reduce Detrusor Overactivity and Increase Bladder Capacity in Rats. Basic & Clinical Pharmacology & Toxicology, 110:145-153, doi: 10.1111/j.1742-7843.2011.00765.x.

34. Mikkelsen, L, Sheykhzade, M., Jensen, K.A., Saber, A.T., Jacobsen, N.R., Vogel, U., Wallin, H., Loft, S., Moller, P. (2011). Modest effect on plaque progression and vasodilatory function in atherosclerosis-prone mice exposed to nanosized TiO2. Part Fibre Toxicol. 8(1):32.  

35. Skovsted, G.F., Sheykhzade, M., Trautner, S. and Edvinsson, L. (2011). Myocardial ischemia-reperfusion induces upregulation of contractile endothelin ETB receptor in rat coronary arteries. The Twelfth International Conference on Endothelin, Proceedings of the British Pharmacological Society. 



36. Munro, G., Storm, A., Hansen, M.K., Dyhr, H., Marcher, L., Erichsen, H.K., Sheykhzade, M.  (2012). The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function. Pharmacol Biochem Behav., 101(3):465-478. 

37. Skovsted, G.F., Pedersen, A..F, Larsen, R., Sheykhzade, M., Edvinsson, L. (2012). Rapid functional upregulation of vasocontractile endothelin ET(B) receptors in rat coronary arteries. Life Sci., 91(13-14):593-599. 

38. Ghoreishi, S.M., Rajaian, H., Sheykhzade, M., Alikhani, M., Rahmani, H.R., Hajipour, A.R., Khorvash, M., Khodaei, H.R. (2012). Pharmacokinetics of pioglitazone, a thiazolidinedione derivative, in male Naeini (Iranian fat-tailed) sheep. Journal of Applied Animal Research, 40 (3): 208-214. 

39. Folkmann, J.K., Vesterdal, L., Sheykhzade, M., Loft, S., Moller, P. (2012). Endothelial dysfunction in normal and prediabetic rats with metabolic syndrome exposed by oral gavage to carbon black nanoparticles. Toxicol Sci., 129(1):98-107. 

40. Blædel, M., Raun, K., Boonen, H.C., Sheykhzade, M., Sams, A. (2012). Early Onset Inflammation in Pre-Insulin-Resistant Diet-Induced Obese Rats Does Not Affect the Vasoreactivity of Isolated Small Mesenteric Arteries. Pharmacology, 90(3-4):125-132. 

41. Vesterdal, L.K., Mikkelsen, L., Folkmann, J.K.,  Sheykhzade, M., Cao, Y., Roursgaard, M., Loft, S., Moller, P. (2012)Carbon black nanoparticles and vascular dysfunction in cultured endothelial cells and artery segments. Toxicol Lett., 214(1):19-26. 

42. Sheykhzade, M., Simonsen, A.H., Boonen, H.C., Outzen, E.M., Nyborg, N.C. (2012). Effect of Ageing on the Passive and Active Tension and Pharmacodynamic Characteristics of Rat Coronary Arteries: Age-Dependent Increase in Sensitivity to 5-HT and K+. Pharmacology, 90 (3-4):160-168. 



43. Ghorbani, M.L., Nyborg, N.C., Fjalland, B., Sheykhzade, M. (2013). Calcium activity of upper thoracic dorsal root ganglion neurons in Zucker diabetic Fatty rats. International Journal of Endocrinology, 2013:532850. doi: 10.1155/2013/532850. 

44. Svaloe, J., Bille, M., Parameswaran, Theepakaran N., Sheykhzade, M., Nordling, J., Bouchelouche, P. (2013). Bladder contractility is modulated by Kv7 channels in pig detrusor. Eur. J. Pharmacol., 715(1-3):312-20. 

45. Rasmussen, M.N., Hornbak, M., Larsen, S.S., Sheykhzade, M., Edvinsson, L. (2013). Permanent Distal Occlusion of Middle Cerebral Artery in Rat Causes Local Increased ETB, 5-HT1B and AT1 Receptor-Mediated Contractility Downstream of Occlusion. J Vasc Res., 50(5):396-409. 

46. Erdling, A., Sheykhzade, M., Maddahi, A., Bari, F., Edvinsson, L. (2013). VIP/PACAP receptors in cerebral arteries of the rat: Characterization, localization and relation to intracellular calcium.  Neuropeptides, 47(2): 85-92. 



47. Hasbak, P., Sheykhzade, M., Schifter, S., Edvinsson, L. (2014). Potentiated adrenomedullin induced vasorelaxation during hypoxia in organ cultured porcine coronary arteries. J Cardiovasc Pharmacol., 63(1):58-67. doi: 10.1097/FJC.0000000000000025. 

48. Edvinsson, L., Ahnstedt, H., Larsen, R., Sheykhzade, M. (2014). Differential localization and characterization of functional calcitonin gene-related peptide receptors in human subcutaneous arteries. Acta Physiol (Oxf)., 210(4):811-22. doi: 10.1111/alpha.12213. 

49. Vesterdal, L.K., Jantzen, K., Sheykhzade, M., Roursgaard, M., Folkmann, J.K., Loft, S., Møller, P. (2014). Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice. Nanotoxicology, 8:61-71. doi: 10.3109/17435390.2012.750385. 

50. Skovsted, G.F., Kruse, L., Larsen, R., Pedersen, A.F., Trautner, S., Sheykhzade, M., Edvinsson, L. (2014). Heart ischemia-reperfusion induces local upregulation of vasoconstrictor endothelin receptor type B in rat coronary arteries downstream of the occlusion. Br J Pharmacol., 171(11):2726-38. doi: 10.1111/bph.12606. 

51. Boonen, H.C., Moesgaard, S.G., Birck, M.M., Christoffersen, B.O., Cirera, S., Heegaard, P.M., Højbøge, T.R., Jensen, L.J., Mortensen, A., Olsen, L.H., Sheykhzade, M., Tang, J., Lykkesfeldt, J. (2014). Functional network analysis of obese and lean Göttingen minipigs elucidates changes in oxidative and inflammatory networks in obese pigs. Pflugers Arch. 466(12):2167-76. doi: 10.1007/s00424-014-1486-2. 

52. Tang, J., Sheykhzade, M., Clausen, B.F., Boonen, H.C. (2014). Genetic fuzzy system predicting contractile reactivity patterns of small arteries. CPT Pharmacometrics Syst Pharmacol. 3:e108. doi: 10.1038/psp.2014.3. 



53. Kirchhoff, J.E., Goldin Diness, J., Sheykhzade, M., Grunnet, M., Jespersen, T. (2015). Synergistic anti-arrhythmic effect of combining inhibition of Ca2+activated K+ (SK) channels and voltage-gated Na+ channels in an isolated heart model of atrial fibrillation. Heart Rhythm. 12(2): 409-418. 

54. Svalø, J., Sheykhzade, M., Nordling, J., Matras, C., Bouchelouche, P. (2015). Functional and Molecular Evidence for Kv7 Channel Subtypes in Human Detrusor from Patients with and without Bladder Outflow Obstruction. PLoS One. 10(2):e0117350. doi: 10.1371/journal.pone.0117350. eCollection 2015. 

55. Løhr, M., Folkmann, J.K., Sheykhzade, M., Jensen, L.J., Kermanizadeh, A., Loft, S., Møller, P. (2015). Hepatic oxidative stress, genotoxicity and vascular dysfunction in lean or obese Zucker rats. PLoS One. 10(3):e0118773. doi: 10.1371/journal.pone.0118773. eCollection 2015. 

56. Taskin, B., von Schoubye, N.L., Sheykhzade, M., Bastlund, J.F., Grunnet, M., Jespersen T. (2015). Biophysical characterization of KV3.1 potassium channel activating compounds. Eur J Pharmacol. 758:164-70. doi: 10.1016/j.ejphar.2015.03.061. 

57. Diness, J.G., Kirchhoff, J.E., Sheykhzade, M., Jespersen, T., Grunnet, M. (2015). Anti-arrhythmic effect of either negative modulation or blockade of small conductance Ca2+ activated K+ channels on ventricular fibrillation in guinea pig Langendorff perfused heart. J Cardiovasc Pharmacol. 66(3):294-9. 

58. Outzen, E.M.,  Zaki, M.,  Abdolalizadeh, B.,  Sams, A., Boonen, H.C., Sheykhzade, M. (2015). Translational value of mechanical and vasomotor properties of mouse isolated mesenteric resistance-sized arteries. Pharmacology Research & Perspectives. 3(6): e00200. 



59. Blædel, M., Sams, A., Boonen, H.C., Sheykhzade, M. (2016). Increased Contractile Response to Noradrenaline Induced By Factors Associated with the Metabolic Syndrome in Cultured Small Mesenteric Arteries. Pharmacology. 97(1-2):48-56. 

60. Spray, S., Rasmussen, M.N., Skovsted, G.F., Warfvinge, K., Sheykhzade, M., Edvinsson, L. (2016). Reduced Mechanical Stretch Induces Enhanced Endothelin B Receptor-mediated Contractility via Activation of Focal Adhesion Kinase and Extra Cellular-regulated Kinase 1/2 in Cerebral Arteries from Rat. Basic Clin Pharmacol Toxicol. 119(1): 68-77. doi: 10.1111/bcpt.12553.

61. Christophersen, D.V., Jacobsen, N.R., Jensen, D.M., Kermanizadeh, A., Sheykhzade, M., Loft, S., Vogel, U., Møller, P. (2016). Inflammation and Vascular Effects after Repeated Intratracheal Instillations of Carbon Black and Lipopolysaccharide. PLoS One. 11(8):e0160731. doi: 10.1371/journal.pone.0160731.

62. Kirchhoff, J.E., Diness, J.G., Abildgaard, L., Sheykhzade, M., Grunnet, M., Jespersen, T.(2016). Antiarrhythmic effect of the Ca2+-activated K+ (SK) channel inhibitor ICA combined with either amiodarone or dofetilide in an isolated heart model of atrial fibrillation. Pflugers Arch. 468(11-12):1853-1863.



63. Outzen, E.M.,  Zaki, M.,  Mehryar, R., Abdolalizadeh, B., Sajid, W., Boonen, H.C., Sams, A., Sheykhzade, M. (2017). LPS, but not Angiotensin ll, induces Direct Pro-inflammatory Effects in Cultured Mouse Arteries and Human Endothelial and Vascular Smooth Muscle Cells. Basic Clin Pharmacol Toxicol. 120(4):335-347.

64. Eriksen, V.R., Abdolalizadeh, B.,  Trautner, S., Greisen, G., Sheykhzade, M. (2017). Mechanical and vasomotor properties of piglet isolated middle cerebral artery. Pharmacology Research & Perspectives. 5(1): e00279.

65. Sekeroglu, A., Jacobsen, J.M., Jansen-Olesen, I., Gupta, S., Sheykhzade, M., Olesen, J., Bhatt, D.K. (2017). Effect of PGD2 on the middle meningeal artery and mRNA expression profile of L-PGD2 synthase and DP receptors in the trigeminovascular system and other pain processing structures in the rat brain. Pharmacol Rep. 69(1):50-56.

66. Sheykhzade, M., Amandi, N., Pla, M.V., Abdolalizadeh, B., Sams, A., Warfvinge, K., Edvinsson, L., Pickering, D.S. (2017). Binding and functional pharmacological characteristics of gepant-type antagonists in rat brain and mesenteric arteries. Vascul Pharmacol. 90:36-43.

67. Erdling, A., Sheykhzade, M., Edvinsson, L. (2017). Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca2+ levels in the perfused and non-perfused isolated rat middle cerebral artery. J Headache Pain. 18(1):61.

68. Kristiansen, S.B., Haanes, K.A., Sheykhzade, M., Edvinsson, L. (2017). Endothelin receptor-mediated Ca2+ signalling in coronary arteries after experimentally induced ischemia/reperfusion injury in the rat. J Mol Cell Cardiol. 111:1-9.

69. Kristiansen, S.B., Sheykhzade, M., Edvinsson, L., Haanes, K.A. (2017). Changes in vasodilation following myocardial ischemia/reperfusion in rats. Nitric Oxide 70:68-75.



70. Jensen, D.M., Christophersen, D.V., Sheykhzade, M., Skovsted, G.F., Lykkesfeldt, J., Münter, R., Roursgaard, M., Loft, S., Møller, P. (2018). Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles. Part Fibre Toxicol. 15(1):12. doi: 10.1186/s12989-018-0248-2.

71. Sheykhzade, M., Abdolalizadeh, B,. Koole, C., Pickering, D.S., Dreisig, K,. Johansson, S.E., Abboud, B.K,. Dreier, R., Berg, J.O., Jeppesen, J.L., Sexton, P.M., Edvinsson, L., Wootten, D., Sams, A. (2018). Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX. Eur J Pharmacol. 829:85-92. 

72. Jensen, D.M., Skovsted, G.F., Lykkesfeldt, J.,  Dreier, R., Berg, J.O., Jeppesen, J.L., Sheykhzade, M., Loft, S., Møller, P. (2018). Vasomotor dysfunction in human subcutaneous arteries exposed ex vivo to food-grade titanium dioxide. Food Chem Toxicol. 120:321-327. doi: 10.1016/j.fct.2018.07.015.

73. Kristiansen, S.B., Skovsted, G.F., Berchtold, L.A., Radziwon-Balicka, A., Dreisig, K., Edvinsson, L., Sheykhzade, M., Haanes, K.A. (2018). Role of Pannexin and adenosine triphosphate (ATP) following myocardial ischemia/reperfusion. Scand Cardiovasc J. 52(6):340-343. doi: 10.1080/14017431.2018.1552793.



74. Johansson, S.E., Abdolalizadeh, B., Sheykhzade, M., Edvinsson, L., Sams, A. (2019). Vascular pathology of large cerebral arteries in experimental subarachnoid haemorrhage: Vasoconstriction, functional CGRP depletion and maintained CGRP sensitivity. Eur J Pharmacol. 846:109-118. doi: 10.1016/j.ejphar.2019.01.007.

75. Jensen, D.M., Løhr, M., Sheykhzade, M., Lykkesfeldt, J., Wils, R.S., Loft, S., Møller, P. (2019). Telomere length and genotoxicity in the lung of rats following intragastric exposure to food-grade titanium dioxide and vegetable carbon particles. Mutagenesis. 34(2):203-214. doi: 10.1093/mutage/gez003.

76. Arildsen, L., Andersen, J.V., Waagepetersen, H.S., Nissen, J.B.D., Sheykhzade, M. (2019). Hypermetabolism and impaired endothelium-dependent vasodilation in mesenteric arteries of type 2 diabetes mellitus db/db mice. Diab Vasc Dis Res. 16(6):539-548. doi: 10.1177/1479164119865885.

77. Warfvinge, K., Edvinsson, L., Pickering, D.S., Sheykhzade, M. (2019). The Presence of Calcitonin Gene-Related Peptide and Its Receptors in Rat, Pig and Human Brain: Species Differences in Calcitonin Gene-Related Peptide Pharmacology. Pharmacology. 104:332-341. doi: 10.1159/000502471.

78. Edvinsson, J.C.A., Warfvinge, K., Krause, D.N., Blixt, F.W., Sheykhzade, M., Edvinsson, L., Haanes, K.A. (2019). C-fibres may modulate adjacent Aδ-fibers through axon-axon CGRP signalling at nodes of Ranvier in the trigeminal system. J Headache Pain. 20(1):105. doi: 10.1186/s10194-019-1055-3.



79: Zhu, J., Pedersen, M.D., Ahmed, L.S., Abdolalizadeh, B., Grell, A.S., Berg, J.O., Thulstrup, P.W., Franzyk, H., Edvinsson, L., Sams, A., Sheykhzade, M., Hansen, P.R. (2020). Fluorescent Analogues of Human α-Calcitonin Gene-Related Peptide with Potent Vasodilator Activity. Int J Mol Sci. 21(4):E1343. doi: 10.3390/ijms21041343.

80. Le, T.L., Jagd Grell, A.S., Sheykhzade, M., Warfvinge, K., Edvinsson, L., Sams, A. (2020). CGRP in rat mesenteric artery and vein - receptor expression, CGRP presence and potential roles. Eur J Pharmacol. 875:173033. doi: 10.1016/j.ejphar.2020.173033.

81. Sohn, I., Sheykhzade, M., Edvinsson, L., Sams, A. (2020). The effects of CGRP in vascular tissue - classical vasodilation, shadowed effects and systemic dilemmas. Eur J Pharmacol. 881:173205. doi: 10.1016/j.ejphar.2020.173205.

82. Edvinsson, J.C.A., Grell, A.S., Warfvinge, K., Sheykhzade, M., Edvinsson, L., Haanes, K.A. (2020).  Differences in pituitary adenylate cyclase-activating peptide and calcitonin gene-related peptide release in the trigeminovascular system. Cephalalgia. 40(12):1296-1309. doi: 10.1177/0333102420929026. 

83. Dreier, R., Abdolalizadeh, B., Asferg, C.L., Hölmich, L.R., Buus, N.H., Forman, J.L., Andersen, U.B., Egfjord, M., Sheykhzade, M., Jeppesen, J.L. (2020). Effect of increased potassium intake on the renin-angiotensin-aldosterone system and subcutaneous resistance arteries: a randomized crossover study. Nephrol Dial Transplant. 2020 Jun 29:gfaa114. doi: 10.1093/ndt/gfaa114. 

84. Beck, L., Su, J., Comerma-Steffensen, S., Pinilla, E., Carlsson, R., Hernanz, R., Sheykhzade, M., Danielsen, C.C., Simonsen, U. (2020). Endothelial Dysfunction and Passive Changes in the Aorta and Coronary Arteries of Diabetic db/db Mice. Front. Physiol. 11:667. doi: 10.3389/fphys.2020.00667. eCollection 2020.

85. Ramshini, E., Sheykhzade, M., Dabiri, S., Shabani, M. (2020). Cannabinoid CB1 receptor mediates METH-induced electrophysiological and morphological alterations in cerebellum Purkinje cells. Hum Exp Toxicol. 2020 Nov 28:960327120975448. doi: 10.1177/0960327120975448.



86. Beck, L., Pinilla, E., Arcanjo, D.D.R., Hernanz, R., Prat-Duran, J., Petersen, A.G., Köhler, R., Sheykhzade, M., Comerma-Steffensen S, Simonsen U. (2021). Pirfenidone Is a Vasodilator: Involvement of KV7 Channels in the Effect on Endothelium-Dependent Vasodilatation in Type-2 Diabetic Mice. Front Pharmacol. 2021 Jan 12; 11:619152. doi: 10.3389/fphar.2020.619152. eCollection 2020. 

87. Dreier, R., Andersen, U.B., Forman, J.L., Sheykhzade, M., Egfjord, M., Jeppesen, J.L. (2021). Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study. J Am Heart Assoc. 2021 Apr 19:e018716. doi: 10.1161/JAHA.120.018716.

88. Dreier, R., Abdolalizadeh B, Asferg CL, Hölmich LR, Buus NH, Forman, J.L., Andersen, U.B., Egfjord, M., Sheykhzade, M., Jeppesen, J.L. (2021). Effect of increased potassium intake on the renin-angiotensin-aldosterone system and subcutaneous resistance arteries: a randomized crossover study. Nephrol Dial Transplant. 2021 May 27; 36(6):1139. doi: 10.1093/ndt/gfaa292.

89. Ramshini, E., Sheykhzade, M., Dabiri, S., Shabani, M. (2021). Cannabinoid CB1 receptor mediates METH-induced electrophysiological and morphological alterations in cerebellum Purkinje cells. Hum Exp Toxicol. 2021 Jun; 40(6):940-951. doi: 10.1177/0960327120975448.

90. Coskun., H., Elbahi, F.A., Al-Karagholi, M.A., Ghanizada, H., Sheykhzade, M. and Ashina, M. (2021). The Effect of KATP Channel Blocker Glibenclamide on CGRP-Induced Headache and Hemodynamic in Healthy Volunteers. Front Physiol. 2021 Jun 11;12:652136. doi: 10.3389/fphys.2021.652136. eCollection 2021.

91. Edvinsson, J.C., Reducha, P.V., Sheykhzade, M., Warfvinge, K., Haanes, K.A., Edvinsson, L. (2021). Neurokinins and their receptors in the rat trigeminal system: Differential localization and release with implications for migraine pain. Mol Pain. 2021 Jan-Dec; 17:17448069211059400. doi: 10.1177/17448069211059400.

92. Lassen, M.L., Byrne, C., Sheykhzade, M., Wissenberg, M., Hurry, P.K., Schmedes, A.V., Kjaer, A., Hasbak, P. (2021). Sex differences and caffeine impact in adenosine-induced hyperemia. J Nucl Med. 2022 Mar; 63(3):431-437. doi: 10.2967/jnumed.121.261970.
93. Lassen, M.L., Wissenberg, M., Byrne, C., Sheykhzade, M., Hurry, P.K., Schmedes, A.V., Kjær, A., Hasbak, P. (2022). Image-derived and physiological markers to predict adequate adenosine-induced hyperemic response in Rubidium-82 myocardial perfusion imaging.  J Nucl Cardiol. 2022 Feb 11. doi: 10.1007/s12350-022-02906-9.
94. Edvinsson, J.C.A., Maddahi, A., Christiansen, I.M., Reducha, P.V., Warfvinge, K., Sheykhzade, M., Edvinsson, L., Haanes, K.A. (2022). Lasmiditan and 5-Hydroxytryptamine in the rat trigeminal system; expression, release and interactions with 5-HT1 receptors. J Headache Pain. 2022 Feb 17;23(1):26. doi: 10.1186/s10194-022-01394-z.
95. Sams, A., Haanes, K.A., Holm, A., Kazantzi, S., Mikkelsen, L.F., Edvinsson, L., Brain, S., Sheykhzade, M. Heterogeneous vasomotor responses in segments from Göttingen Minipigs coronary, cerebral, and mesenteric artery: A comparative study. Vascul Pharmacol. 2023 Sep 18:107231. doi: 10.1016/j.vph.2023.107231.
Review of books:

1. Review of "Patologi og Farmakologi" 3. udgave, 1. oplag 2010, forfatter: Mogens Vyberg, Farmakologisk konsulent: Majid Sheykhzade, Forlag: Munksgaard Danmark, Kapitel 11 (Almen Farmakologi) og Kapitel 12 (Speciel Farmakologi), ISBN: 978-8762809536.


M. Sci. in pharmacy, PhD

ID: 1299979