Maiken Nedergaard

Maiken Nedergaard

Professor

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    1 - 50 out of 159Page size: 50
    1. 2024
    2. Published

      Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 “ISMRM Imaging Neurofluids Study group” Workshop in Rome

      Agarwal, N., Lewis, L. D., Hirschler, L., Rivera, L. R., Naganawa, S., Levendovszky, S. R., Ringstad, G., Klarica, M., Wardlaw, J., Iadecola, C., Hawkes, C., Carare, R. O., Wells, J., Bakker, E. N. T. P., Kurtcuoglu, V., Bilston, L., Nedergaard, M., Mori, Y., Stoodley, M., Alperin, N. & 2 others, de Leon, M. & van Osch, M. J. P., 2024, In: Journal of Magnetic Resonance Imaging. 59, 2, 19 p.

      Research output: Contribution to journal › Review › Research › peer-review

    3. Published

      Glymphatic fluid transport is suppressed by the aquaporin-4 inhibitor AER-271

      Giannetto, M. J., Gomolka, Ryszard Stefan, Gahn-Martinez, D., Newbold, E. J., Bork, Peter Aleksander Rousing, Chang, E., Gresser, M., Thompson, T., Mori, Yuki & Nedergaard, Maiken, 2024, In: Glia. 72, 5, p. 982-998 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. Published

      Glymphatic system dysfunction in neurodegenerative diseases

      Beschorner, Natalie & Nedergaard, Maiken, 2024, In: Current Opinion in Neurology. 37, 2, p. 182-188 7 p.

      Research output: Contribution to journal › Review › Research › peer-review

    5. Published

      Modeling of brain efflux: Constraints of brain surfaces

      Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Mori, Yuki, Møllgård, Kjeld, Hjorth, P. G. & Nedergaard, Maiken, 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 16, 12 p., e2318444121.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Oxygen imaging of hypoxic pockets in the mouse cerebral cortex

      Beinlich, Felix Ralf Michael, Asiminas, Antonios, Untiet, Verena, Bojarowska, Zuzanna, Pla Requena, Virginia Teresa, Sigurdsson, B., Timmel, V., Gehrig, L., Graber, M. H., Hirase, Hajime & Nedergaard, Maiken, 2024, In: Science (New York, N.Y.). 383, 6690, p. 1471-1478 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      The glymphatic system and Amyotrophic lateral sclerosis

      Eisen, A., Nedergaard, Maiken, Gray, E. & Kiernan, M. C., 2024, In: Progress in Neurobiology. 234, 10 p., 102571.

      Research output: Contribution to journal › Review › Research › peer-review

    8. Published

      Transient but not chronic hyperglycemia accelerates ocular glymphatic transport

      Delle, Christine, Wang, X., Giannetto, M., Newbold, E., Peng, W., Gomolka, Ryszard Stefan, Ladrón-de-Guevara, A., Cankar, Neza, Nielsen, Elise Schiøler, Kjærby, Celia, Weikop, Pia, Mori, Yuki & Nedergaard, Maiken, 2024, In: Fluids and Barriers of the CNS. 21, 1, 13 p., 26.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2023
    10. Published

      A SPECT-based method for dynamic imaging of the glymphatic system in rats

      Sigurdsson, B., Hauglund, Natalie Linea, Lilius, T. O., Mogensen, F. L. H., Mortensen, K. N., Beschorner, Natalie, Klinger, L., Bærentzen, S. L., Rosenholm, Marko, Shalgunov, Vladimir, Herth, Matthias Manfred, Mori, Yuki & Nedergaard, Maiken, 2023, In: Journal of Cerebral Blood Flow and Metabolism. 43, 7, 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      A mesothelium divides the subarachnoid space into functional compartments

      Møllgård, Kjeld, Beinlich, Felix Ralf Michael, Kusk, P., Miyakoshi, L. M., Delle, Christine, Pla Requena, Virginia Teresa, Hauglund, Natalie Linea, Esmail, Tina, Rasmussen, Martin Kaag, Gomolka, Ryszard Stefan, Mori, Yuki & Nedergaard, Maiken, 2023, In: Science. 379, 6627, p. 84-885

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      A sensitive and specific genetically-encoded potassium ion biosensor for in vivo applications across the tree of life

      Wu, S-Y., Wen, Y., Serre, N. B. C., Laursen, C. C. H., Dietz, A. G., Taylor, B. R., Drobizhev, M., Molina, R. S., Aggarwal, A., Rancic, V., Becker, M., Ballanyi, K., Podgorski, K., Hirase, H., Nedergaard, M., Fendrych, M., Lemieux, M. J., Eberl, D. F., Kay, A. R., Campbell, R. E. & 1 others, Shen, Y., 2023, In: PLOS Biology. 20, 9, 23 p., e3001772.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Age- and glaucoma-induced changes to the ocular glymphatic system

      Wang, X., Delle, Christine, Peng, W., Pla Requena, Virginia Teresa, Giannetto, M., Kusk, P., Sigurdsson, B., Sakurai, S., Sweeney, A., Sun, Q., Du, Ting, Libby, R. T. & Nedergaard, Maiken, 2023, In: Neurobiology of Disease. 188, 9 p., 106322.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Air pollution, glymphatic impairment, and Alzheimer's disease

      Hussain, R., Graham, U., Elder, A. & Nedergaard, Maiken, 2023, In: Trends in Neurosciences. 46, 11, p. 901-911 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    15. Published

      Astrocyte endfeet may theoretically act as valves to convert pressure oscillations to glymphatic flow

      Bork, Peter Aleksander Rousing, Ladrón-De-Guevara, A., Christensen, A. H., Jensen, K. H., Nedergaard, Maiken & Bohr, T., 2023, In: Journal of the Royal Society Interface. 20, 204, 5 p., 20230050.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Astrocytic GPCR-Induced Ca2+ Signaling Is Not Causally Related to Local Cerebral Blood Flow Changes

      Ozawa, K., Nagao, Masaki, Konno, A., Iwai, Y., Vittani, Marta, Kusk, P., Mishima, Tsuneko, Hirai, H., Nedergaard, Maiken & Hirase, Hajime, 2023, In: International Journal of Molecular Sciences. 24, 17, 12 p., 13590.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      Astrocytic chloride is brain state dependent and modulates inhibitory neurotransmission in mice

      Untiet, Verena, Beinlich, Felix Ralf Michael, Kusk, P., Kang, N., Ladrón-de-Guevara, A., Song, W., Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Bojarowska, Zuzanna, Sigurdsson, B., Deng, S., Hirase, Hajime, Petersen, Nicolas Caesar, Verkhratsky, A. & Nedergaard, Maiken, 2023, In: Nature Communications. 14, 1, 14 p., 1871.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Blood–brain barrier permeable β-blockers linked to lower risk of Alzheimer’s disease in hypertension

      Beaman, Emily Eufaula, Bonde, A. N., Larsen, S. M. U., Ozenne, Brice Maxime Hugues, Lohela, T. J., Nedergaard, Maiken, Gislason, Gunnar Hilmar, Knudsen, Gitte Moos & Holst, S. C., 2023, In: Brain. 146, 3, p. 1141–1151 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice

      Mathiesen, B. K., Miyakoshi, L. M., Cederroth, C. R., Tserga, E., Versteegh, C., Bork, Peter Aleksander Rousing, Hauglund, Natalie Linea, Gomolka, Ryszard Stefan, Mori, Yuki, Edvall, N. K., Rouse, S., Møllgård, Kjeld, Holt, J. R., Nedergaard, Maiken & Canlon, B., 2023, In: Science Translational Medicine. 15, 702, 13 p., eabq3916.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Development of 11C-labeled CRANAD-102 for positron emission tomography imaging of soluble Aβ-species

      Staudt, Markus, Shalgunov, Vladimir, Nedergaard, Maiken & Herth, Matthias Manfred, 2023, In: Journal of Labelled Compounds and Radiopharmaceuticals. 66, 12, p. 393-399

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Early impairments of visually-driven neuronal ensemble dynamics in the rTg4510 tauopathy mouse model

      Parka, A., Degel, C., Dreyer, J., Richter, U., Hall, B., Bastlund, J. F., Laursen, B., Nedergaard, Maiken, Sotty, F. & Botta, P., 2023, In: Neurobiology of Disease. 178, 13 p., 106012.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      Glymphatic influx and clearance are accelerated by neurovascular coupling: [Inkl. Correction]

      Holstein-Rønsbo, Stephanie, Gan, Y., Giannetto, M. J., Rasmussen, Martin Kaag, Sigurdsson, B., Beinlich, Felix Ralf Michael, Rose, Laura, Untiet, Verena, Hablitz, L. M., Kelley, D. H. & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, p. 1042–1053

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles

      Lilius, T. O., Mortensen, K. N., Deville, C., Lohela, T. J., Stæger, Frederik Filip Vinggaard, Sigurdsson, B., Fiordaliso, E. M., Rosenholm, Marko, Kamphuis, C., Beekman, F. J., Jensen, A. I. & Nedergaard, Maiken, 2023, In: Journal of Controlled Release. 355, p. 135-148 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

      Nasu, Y., Aggarwal, A., Le, G. N. T., Vo, C. T., Kambe, Y., Wang, X., Beinlich, F. R. M., Lee, A. B., Ram, T. R., Wang, F., Gorzo, K. A., Kamijo, Y., Boisvert, M., Nishinami, S., Kawamura, G., Ozawa, T., Toda, H., Gordon, G. R., Ge, S., Hirase, H. & 5 others, Nedergaard, Maiken, Paquet, M. E., Drobizhev, M., Podgorski, K. & Campbell, R. E., 2023, In: Nature Communications. 14, 1, 17 p., 6598.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      Local extracellular K+ in cortex regulates norepinephrine levels, network state, and behavioral output

      Dietz, Andrea Grostøl, Weikop, Pia, Hauglund, Natalie Linea, Andersen, Mie, Petersen, Nicolas Caesar, Rose, Laura, Hirase, Hajime & Nedergaard, Maiken, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 40, 9 p., e2305071120.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Locomotion Induces Fundamentally Different Patterns of Ca2+Signaling in Astrocytes and Neurons

      Hirase, Hajime & Nedergaard, Maiken, 2023, In: Function. 4, 4, 2 p., zqad028.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    27. Published

      Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

      Delle, Christine, Cankar, Neza, Digebjerg Holgersson, C., Hvorup Knudsen, H., Nielsen, Elise Schiøler, Kjærby, Celia, Mori, Yuki, Nedergaard, Maiken & Weikop, Pia, 2023, In: Scientific Reports. 13, 1, 11 p., 4137.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation

      Gomolka, Ryszard Stefan, Hablitz, L. M., Mestre, H., Giannetto, M., Du, Ting, Hauglund, Natalie Linea, Xie, L., Peng, W., Martinez, P. M., Nedergaard, Maiken & Mori, Yuki, 2023, In: eLife. 12, 36 p., e82232.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism

      Gan, Y., Holstein-Rønsbo, Stephanie, Nedergaard, Maiken, Boster, K. A. S., Thomas, J. H. & Kelley, D. H., 2023, In: Journal of the Royal Society, Interface. 20, 206, 17 p., 20230288.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      Potentiating glymphatic drainage minimizes post-traumatic cerebral oedema

      Hussain, R., Tithof, J., Wang, W., Cheetham-West, A., Song, W., Peng, W., Sigurdsson, B., Kim, D., Sun, Q., Peng, S., Pla Requena, Virginia Teresa, Kelley, D. H., Hirase, Hajime, Castorena-Gonzalez, J. A., Weikop, Pia, Goldman, Steven Alan, Davis, M. J. & Nedergaard, Maiken, 2023, In: Nature. 623, p. 992–1000 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Protocol to study molecule exchange between venous blood and CSF in live mice using transcranial bioluminescence imaging

      Esmail, Tina, Nedergaard, Maiken & Beinlich, Felix Ralf Michael, 2023, In: STAR Protocols. 4, 4, 18 p., 102652.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Reply to: 'Do all norepinephrine surges disrupt sleep?'

      Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Ding, F., Hirase, Hajime & Nedergaard, Maiken, 2023, In: Nature Neuroscience. 26, 3 p.

      Research output: Contribution to journal › Comment/debate › Research › peer-review

    33. Published

      SDREAMER: Self-distilled Mixture-of-Modality-Experts Transformer for Automatic Sleep Staging

      Chen, J., Yao, Y., Anderson, M., Hauglund, Natalie Linea, Kjærby, Celia, Untiet, Verena, Nedergaard, Maiken & Luo, J., 2023, p. 131-142. 12 p.

      Research output: Contribution to conference › Paper › Research › peer-review

    34. Published

      Structural characterization of SLYM—a 4th meningeal membrane

      Pla Requena, Virginia Teresa, Bitsika, S., Giannetto, M. J., Ladron-de-Guevara, A., Gahn-Martinez, D., Mori, Yuki, Nedergaard, Maiken & Møllgård, Kjeld, 2023, In: Fluids and Barriers of the CNS. 20, 1, 18 p., 93.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      The Alzheimer's disease 5xFAD mouse model is best suited to investigate pretargeted imaging approaches beyond the blood-brain barrier

      Lopes van den Broek, S. I., Sehlin, D., Andersen, Jens Velde, Aldana, Blanca, Beschorner, Natalie, Nedergaard, Maiken, Knudsen, Gitte Moos, Syvanen, S. & Herth, Matthias Manfred, 2023, In: Frontiers in Nuclear Medicine. 2, 7 p., 1001722.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      The state of brain activity modulates cerebrospinal fluid transport

      Miyakoshi, L. M., Stæger, Frederik Filip Vinggaard, Li, Q., Pan, C., Xie, L., Kang, H., Pavan, C., Dang, J., Sun, Q., Ertürk, A. & Nedergaard, Maiken, 2023, In: Progress in Neurobiology. 229, 11 p., 102512.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Using Fiber Photometry in Mice to Estimate Fluorescent Biosensor Levels During Sleep

      Andersen, Mie, Tsopanidou, Anastasia, Radovanovic, Tessa, Compere, V. N., Hauglund, Natalie Linea, Nedergaard, Maiken & Kjærby, Celia, 2023, In: Bio-protocol. 13, 15, 17 p., e4734.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Visual Evoked Potentials as an Early-Stage Biomarker in the rTg4510 Tauopathy Mouse Model

      Parka, A., Volbracht, C., Hall, B., Bastlund, J. F., Nedergaard, Maiken, Laursen, B., Botta, P. & Sotty, F., 2023, In: Journal of Alzheimer's Disease. 93, 1, p. 247-262 16 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. 2022
    40. Published

      A network model of glymphatic flow under different experimentally-motivated parametric scenarios

      Tithof, J., Boster, K. A. S., Bork, Peter Aleksander Rousing, Nedergaard, Maiken, Thomas, J. H. & Kelley, D. H., 2022, In: iScience. 25, 5, 24 p., 104258.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      A real-time in vivo clearance assay for quantification of glymphatic efflux

      Plá, V., Bork, Peter Aleksander Rousing, Harnpramukkul, A., Olveda, G., Ladrón-de-Guevara, A., Giannetto, M. J., Hussain, R., Wang, W., Kelley, D. H., Hablitz, L. M. & Nedergaard, Maiken, 2022, In: Cell Reports. 40, 11, 20 p., 111320.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      An unnoticed player overseeing CSF flux

      Pla Requena, Virginia Teresa & Nedergaard, Maiken, 2022, In: Nature Cardiovascular Research. 1, 2 p.

      Research output: Contribution to journal › Comment/debate › Research

    43. Published

      Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema

      Du, T., Mestre, H., Kress, B. T., Liu, G., Sweeney, A. M., Samson, A. J., Rasmussen, M. K., Mortensen, K. N., Bork, P. A. R., Peng, W., Olveda, G. E., Bashford, L., Toro, E. R., Tithof, J., Kelley, D. H., Thomas, J. H., Hjorth, P. G., Martens, E. A., Mehta, R. I., Hirase, H. & 2 others, Mori, Yuki & Nedergaard, Maiken, 2022, In: Brain. 145, 2, p. 787–797 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Could dexmedetomidine be repurposed as a glymphatic enhancer?

      Persson, N. D. Å., Uusalo, P., Nedergaard, Maiken, Lohela, T. J. & Lilius, T. O., 2022, In: Trends in Pharmacological Sciences. 43, 12, p. 1030-1040 11 p.

      Research output: Contribution to journal › Review › Research › peer-review

    45. Published

      Does Long-Duration Exposure to Microgravity Lead to Dysregulation of the Brain and Ocular Glymphatic Systems?

      Wostyn, P., Mader, T. H., Gibson, C. R. & Nedergaard, Maiken, 2022, In: Eye and Brain. 14, p. 49-58 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    46. Published

      Fluid Transport in the Brain

      Rasmussen, Martin Kaag, Mestre, H. & Nedergaard, Maiken, 2022, In: Physiological Reviews. 102, p. 1025-1151 27 p.

      Research output: Contribution to journal › Review › Research › peer-review

    47. Published

      Glymphatic system and Spaceflight Associated Neuro-Ocular Syndrome

      Wostyn, P. & Nedergaard, Maiken, 2022, Spaceflight Associated Neuro-Ocular Syndrome. Elsevier, p. 67-76 10 p.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    48. Published

      Human NREM Sleep Promotes Brain-Wide Vasomotor and Respiratory Pulsations

      Helakari, H., Korhonen, V., Holst, S. C., Piispala, J., Kallio, M., Väyrynen, T., Huotari, N., Raitamaa, L., Tuunanen, J., Kananen, J., Järvelä, M., Tuovinen, T., Raatikainen, V., Borchardt, V., Kinnunen, H., Nedergaard, Maiken & Kiviniemi, V., 2022, In: Journal of Neuroscience. 42, 12, p. 2503-2515 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Increased interictal synchronicity of respiratory related brain pulsations in epilepsy

      Kananen, J., Järvelä, M., Korhonen, V., Tuovinen, T., Huotari, N., Raitamaa, L., Helakari, H., Väyrynen, T., Raatikainen, V., Nedergaard, Maiken, Ansakorpi, H., Jacobs, J., LeVan, P. & Kiviniemi, V., 2022, In: Journal of Cerebral Blood Flow and Metabolism. 42, 10, p. 1840-1853 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Liver-secreted fluorescent blood plasma markers enable chronic imaging of the microcirculation

      Wang, Xiaowen, Delle, Christine, Asiminas, Antonios, Akther, S., Vittani, Marta, Brøgger, Peter, Kusk, P., Vo, C. T., Radovanovic, Tessa, Konno, A., Hirai, H., Fukuda, M., Weikop, Pia, Goldman, Steven Alan, Nedergaard, Maiken & Hirase, Hajime, 2022, In: Cell Reports Methods. 2, 10, 16 p., 100302.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. Published

      Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies

      Liu, G., Ladrón-de-Guevara, A., Izhiman, Y., Nedergaard, Maiken & Du, Ting, 2022, In: Fluids and Barriers of the CNS. 19, 1, 24 p., 101.

      Research output: Contribution to journal › Review › Research › peer-review

    52. Published

      Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine

      Kjærby, Celia, Andersen, Mie, Hauglund, Natalie Linea, Untiet, Verena, Dall, C., Sigurdsson, B., Ding, F., Feng, J., Li, Y., Weikop, Pia, Hirase, Hajime & Nedergaard, Maiken, 2022, In: Nature Neuroscience. 25, p. 1059–1070 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    53. Published

      Periarteriolar spaces modulate cerebrospinal fluid transport into brain and demonstrate altered morphology in aging and Alzheimer’s disease

      Mestre, H., Verma, N., Greene, T. D., Lin, L. J. A., Ladron-de-Guevara, A., Sweeney, A. M., Liu, G., Thomas, V. K., Galloway, C. A., de Mesy Bentley, K. L., Nedergaard, Maiken & Mehta, R. I., 2022, In: Nature Communications. 13, 1, 8 p., 3897.

      Research output: Contribution to journal › Journal article › Research › peer-review

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