Mads Gyrd-Hansen

Mads Gyrd-Hansen

Professor

ORCID: 0000-0001-5641-5019

Publication year:
All
1 - 46 out of 46Page size: 500
  1. 2024
  2. E-pub ahead of print

    Mitochondrial outer membrane integrity regulates a ubiquitin-dependent and NF-κB-mediated inflammatory response

    Vringer, E., Heilig, R., Riley, J. S., Black, A., Cloix, C., Skalka, G., Montes-Gómez, A. E., Aguado, A., Lilla, S., Walczak, H., Gyrd-Hansen, Mads, Murphy, D. J., Huang, D. T., Zanivan, S. & Tait, S. W., 9 Feb 2024, (E-pub ahead of print) In: The EMBO Journal.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. 2022
  4. Published

    Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1

    Peng, R., Wang, Chris Kedong, Wang-Kan, X., Idorn, M., Kjær, M., Zhou, F. Y., Fiil, Berthe Katrine, Timmermann, F., Orozco, S. L., McCarthy, J., Leung, C. S., Lu, X., Bagola, K., Rehwinkel, J., Oberst, A., Maelfait, J., Paludan, S. R. & Gyrd-Hansen, Mads, 2022, In: EMBO Reports. 2022, 23, e55839.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. 2021

  6. Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling

    Nikhar, S., Siokas, I., Schlicher, L., Lee, S., Gyrd-Hansen, Mads, Degterev, A. & Cuny, G. D., 2021, In: European Journal of Medicinal Chemistry. 215, 113252.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. RIPK2 NODs to XIAP and IBD

    Topal, Y. & Gyrd-Hansen, Mads, 2021, In: Seminars in Cell and Developmental Biology. 109, p. 144-150 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

  8. Published

    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains

    Elliott, P. R., Leske, D., Wagstaff, J., Schlicher, L., Berridge, G., Maslen, S., Timmermann, F., Ma, B., Fischer, R., Freund, S. M. V., Komander, D. & Gyrd-Hansen, Mads, 2021, In: Cell Reports. 37, 1, 25 p., 109777.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The Met1-linked ubiquitin machinery in inflammation and infection

    Fiil, Berthe Katrine & Gyrd-Hansen, Mads, 2021, In: Cell Death and Differentiation. 28, p. 557–569

    Research output: Contribution to journal › Review › Research › peer-review

  10. Tryptophanemia is controlled by a tryptophan-sensing mechanism ubiquitinating tryptophan 2,3-dioxygenase

    Klaessens, S., Stroobant, V., Hoffmann, D., Gyrd-Hansen, Mads, Pilotte, L., Vigneron, N., De Plaen, E. & Van den Eynde, B. J., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 23, p. e2022447118

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2020

  12. Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Fenech, E. J., Lari, F., Charles, P. D., Fischer, R., Laétitia-Thézénas, M., Bagola, K., Paton, A. W., Paton, J. C., Gyrd-Hansen, Mads, Kessler, B. M. & Christianson, J. C., 2 Jul 2020, In: eLife. 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

    Bodda, C., Reinert, L. S., Fruhwürth, S., Richardo, T., Sun, C., Zhang, B., Kalamvoki, M., Pohlmann, A., Mogensen, T. H., Bergström, P., Agholme, L., O'Hare, P., Sodeik, B., Gyrd-Hansen, Mads, Zetterberg, H. & Paludan, S. R., 2020, In: The Journal of Experimental Medicine. 217, 7

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold

    Suebsuwong, C., Dai, B., Pinkas, D. M., Duddupudi, A. L., Li, L., Bufton, J. C., Schlicher, L., Gyrd-Hansen, Mads, Hu, M., Bullock, A. N., Degterev, A. & Cuny, G. D., 2020, In: European Journal of Medicinal Chemistry. 200, 21 p., 112417.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2018

  16. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

    Hrdinka, M., Schlicher, L., Dai, B., Pinkas, D. M., Bufton, J. C., Picaud, S., Ward, J. A., Rogers, C., Suebsuwong, C., Nikhar, S., Cuny, G. D., Huber, K. V., Filippakopoulos, P., Bullock, A. N., Degterev, A. & Gyrd-Hansen, Mads, 3 Sep 2018, In: The EMBO Journal. 37, 17

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

    Prabakaran, T., Bodda, C., Krapp, C., Zhang, B-C., Christensen, M. H., Sun, C., Reinert, L., Cai, Y., Jensen, S. B., Skouboe, M. K., Nyengaard, J. R., Thompson, C. B., Lebbink, R. J., Sen, G. C., van Loo, G., Nielsen, R., Komatsu, M., Nejsum, L. N., Jakobsen, M. R., Gyrd-Hansen, M. & 1 others, Paludan, S. R., 13 Apr 2018, In: The EMBO Journal. 37, 8, e97858.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. 2017

  19. The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

    Hrdinka, M. & Gyrd-Hansen, Mads, 19 Oct 2017, In: Molecular Cell. 68, 2, p. 265-280 16 p.

    Research output: Contribution to journal › Review › Research › peer-review

  20. Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

    Schwerd, T., Pandey, S., Yang, H-T., Bagola, K., Jameson, E., Jung, J., Lachmann, R. H., Shah, N., Patel, S. Y., Booth, C., Runz, H., Düker, G., Bettels, R., Rohrbach, M., Kugathasan, S., Chapel, H., Keshav, S., Elkadri, A., Platt, N., Muise, A. M. & 8 others, Koletzko, S., Xavier, R. J., Marquardt, T., Powrie, F., Wraith, J. E., Gyrd-Hansen, Mads, Platt, F. M. & Uhlig, H. H., Jun 2017, In: Gut. 66, 6, p. 1060-1073 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. All roads lead to ubiquitin

    Gyrd-Hansen, Mads, 2017, In: Cell Death and Differentiation. 24, 7, p. 1135-1136 2 p.

    Research output: Contribution to journal › Editorial › Research

  22. Cell scientist to watch - Mads Gyrd-Hansen

    Gyrd-Hansen, Mads, 2017, In: Journal of Cell Science. 130, 12, p. 1981-1983 3 p.

    Research output: Contribution to journal › Comment/debate › Research

  23. 2016
  24. Published

    OTULIN deficiency causes auto-inflammatory syndrome

    Fiil, Berthe Katrine & Gyrd-Hansen, Mads, Nov 2016, In: Cell Research. 26, 11, p. 1176-1177 2 p.

    Research output: Contribution to journal › Journal article › Commissioned

  25. SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

    Elliott, P. R., Leske, D., Hrdinka, M., Bagola, K., Fiil, Berthe Katrine, McLaughlin, S. H., Wagstaff, J., Volkmar, N., Christianson, J. C., Kessler, B. M., Freund, S. M. V., Komander, D. & Gyrd-Hansen, Mads, 15 Sep 2016, In: Molecular Cell. 63, 6, p. 990-1005 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

    Hrdinka, M., Fiil, Berthe Katrine, Zucca, M., Leske, D., Bagola, K., Yabal, M., Elliott, P. R., Damgaard, R. B., Komander, D., Jost, P. J. & Gyrd-Hansen, Mads, 29 Mar 2016, In: Cell Reports. 14, 12, p. 2846-58 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. 2015

  28. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

    Canning, P., Ruan, Q., Schwerd, T., Hrdinka, M., Maki, J. L., Saleh, D., Suebsuwong, C., Ray, S., Brennan, P. E., Cuny, G. D., Uhlig, H. H., Gyrd-Hansen, Mads, Degterev, A. & Bullock, A. N., 17 Sep 2015, In: Cell Chemical Biology. 22, 9, p. 1174-84 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Symptomatic Males and Female Carriers in a Large Caucasian Kindred with XIAP Deficiency

    Dziadzio, M., Ammann, S., Canning, C., Boyle, F., Hassan, A., Cale, C., Elawad, M., Fiil, Berthe Katrine, Gyrd-Hansen, Mads, Salzer, U., Speckmann, C. & Grimbacher, B., 25 Jul 2015, In: Journal of Clinical Immunology. 35, 5, p. 439-444 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

    Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H-J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L., Lowes, K. N. & 8 others, Murphy, J. M., Gyrd-Hansen, Mads, Parker, M. W., Hartland, E. L., Lew, A. M., Huang, D. C. S., Lessene, G. & Silke, J., 17 Mar 2015, In: Nature Communications. 6, 13 p., 6442.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. 2014
  32. Published

    Met1-linked Ubiquitination in Immune Signalling

    Fiil, Berthe Katrine & Gyrd-Hansen, Mads, Oct 2014, In: F E B S Journal. 81, 19, p. 4337-50 14 p.

    Research output: Contribution to journal › Review › Research › peer-review

  33. Published

    XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

    Yabal, M., Müller, N., Adler, H., Knies, N., Groß, C. J., Damgaard, R. B., Kanegane, H., Ringelhan, M., Kaufmann, T., Heikenwälder, M., Strasser, A., Groß, O., Ruland, J., Peschel, C., Gyrd-Hansen, Mads & Jost, P. J., 26 Jun 2014, In: Cell Reports. 7, 6, p. 1796-1808

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency

    Ammann, S., Elling, R., Gyrd-Hansen, Mads, Dückers, G., Bredius, R., Burns, S. O., Edgar, J. D. M., Worth, A., Brandau, H., Warnatz, K., zur Stadt, U., Hasselblatt, P., Schwarz, K., Ehl, S. & Speckmann, C., 2014, In: Clinical and Experimental Immunology. 176, 3, p. 394-400 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Molecular basis and regulation of OTULIN-LUBAC interaction

    Elliott, P. R., Al-Saoudi, S. V., Marco-Casanova, P., Fiil, Berthe Katrine, Keusekotten, K., Mailand, Niels, Freund, S. M. V., Gyrd-Hansen, Mads & Komander, D., 2014, In: Molecular Cell. 54, 3, p. 335-348 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 2013
  37. Published

    X-linked inhibitor of apoptosis (XIAP) deficiency: The spectrum of presenting manifestations beyond hemophagocytic lymphohistiocytosis

    Speckmann, C., Lehmberg, K., Albert, M. H., Damgaard, R. B., Fritsch, M., Gyrd-Hansen, M., Rensing-Ehl, A., Vraetz, T., Grimbacher, B., Salzer, U., Fuchs, I., Ufheil, H., Belohradsky, B. H., Hassan, A., Cale, C. M., Elawad, M., Strahm, B., Schibli, S., Lauten, M., Kohl, M. & 10 others, Meerpohl, J. J., Rodeck, B., Kolb, R., Eberl, W., Soerensen, J., von Bernuth, H., Lorenz, M., Schwarz, K., zur Stadt, U. & Ehl, S., 1 Oct 2013, In: Clinical Immunology. 149, 1, p. 133-141 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

    Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

    Fiil, Berthe Katrine, Damgaard, R. B., Wagner, S. A., Keusekotten, K., Fritsch, M., Bekker-Jensen, Simon Holst, Mailand, Niels, Choudhary, Chunaram, Komander, D. & Gyrd-Hansen, Mads, 27 Jun 2013, In: Molecular Cell. 50, 6, p. 818-30 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    OTULIN antagonizes LUBAC signaling by specifically hydrolyzing met1-linked polyubiquitin

    Keusekotten, K., Elliott, P. R., Kulathu, Y., Wauer, T., Hospenthal, M. K., Komander, D., Glockner, L., Krappmann, D., Fiil, Berthe Katrine, Damgaard, R. B., Gyrd-Hansen, Mads & Hofmann, K., 6 Jun 2013, In: Cell. 153, 6, p. 1312-1326 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. 2012
  42. Published

    The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

    Damgaard, R. B., Nachbur, U., Yabal, M., Wong, W. W., Fiil, Berthe Katrine, Kastirr, M., Rieser, E., Rickard, J. A., Bankovacki, A., Peschel, C., Ruland, J., Bekker-Jensen, Simon Holst, Mailand, Niels, Kaufmann, T., Strasser, A., Walczak, H., Silke, J., Jost, P. J. & Gyrd-Hansen, Mads, 2012, In: Molecular Cell. 46, 6, p. 746-58 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. 2011
  44. Published

    Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity

    Damgaard, R. B. & Gyrd-Hansen, Mads, 2011, In: Discovery Medicine. 11, 58, p. 221-31 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  45. 2010
  46. Published

    IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer

    Gyrd-Hansen, Mads & Meier, P., 2010, In: Nature Reviews Cancer.

    Research output: Contribution to journal › Journal article › Commissioned › peer-review

  47. Published

    IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

    Gyrd-Hansen, Mads & Meier, P., 2010, In: Nature Reviews. Cancer. 10, 8, p. 561-74 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  48. 2008
  49. Published

    Lysosomes and Nonapoptotic Pathways

    Kirkegaard-Sørensen, T., Fehrenbacher, N., Gyrd-Hansen, Mads & Jüüttelü, M., 26 May 2008, Apoptosis and Cancer Therapy: From Cutting-edge Science to Novel Therapeutic Concepts. John Wiley and Sons, Inc., Vol. 1. p. 599-622 24 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  50. Published

    IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

    Gyrd-Hansen, Mads, Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C. A., Zvelebil, M., Bujnicki, J. M., Lowe, S., Silke, J. & Meier, P., 2008, In: Nature Cell Biology. 10, 11, p. 1309-17 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. 2007
  52. Published

    Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death

    Yde, C. W., Gyrd-Hansen, Mads, Lykkesfeldt, A. E., Issinger, O. & Stenvang, Jan, Jun 2007, In: Molecular Cancer Therapeutics. 6, 6, p. 1869-1876 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Heregulin-induced epigenetic regulation of the utrophin-A promoter.

    Basu, U., Gyrd-Hansen, Mads, Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, Morten & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  54. 2006
  55. Published

    Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9

    Gyrd-Hansen, Mads, Farkas, T., Fehrenbacher, N., Bastholm, L., Høyer-Hansen, M., Elling, F., Wallach, D., Flavell, R., Kroemer, G., Nylandsted, J. & Jaattela, Marja, 2006, In: Molecular and Cellular Biology. 26, 21, p. 7880-7891

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. 2004

  57. Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.

    Gyrd-Hansen, Mads, Nylandsted, J. & Jäättelä, M., 2004, In: Cell Cycle. 3, 12, p. 1484-5 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  58. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.

    Nylandsted, J., Gyrd-Hansen, Mads, Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M. & Jäättelä, M., 2004, In: Journal of Experimental Medicine. 200, 4, p. 425-435 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

    Dietrich, N., Thastrup, J., Holmberg, C., Gyrd-Hansen, Mads, Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jäättelä, M. & Kallunki, T., 2004, In: Cell Death and Differentiation. 11, 3, p. 301-13 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  60. Sensitization to the lysosomal cell death pathway upon immortalization and transformation.

    Fehrenbacher, N., Gyrd-Hansen, Mads, Poulsen, B., Felbor, U., Kallunki, T., Boes, M., Weber, E., Leist, M. & Jäättelä, M., 2004, In: Cancer Research. 64, 15, p. 5301-10 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  61. 2003

  62. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.

    Lademann, U., Cain, K., Gyrd-Hansen, Mads, Brown, D., Peters, D. & Jäättelä, M., 2003, In: Molecular and Cellular Biology. 23, 21, p. 7829-37 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  63. 2002

  64. Sp1 and the ets-related transcription factor complex GABP alpha/beta functionally cooperate to activate the utrophin promoter.

    Gyrd-Hansen, Mads, Krag, T. O. B., Rosmarin, A. G. & Khurana, T. S., 2002, In: Journal of the Neurological Sciences. 197, 1-2, p. 27-35 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  65. 2001

  66. Harnessing the potential of dystrophin-related proteins for ameliorating Duchenne's muscular dystrophy.

    Krag, T. O., Gyrd-Hansen, Mads & Khurana, T. S., 2001, In: Acta Physiologica (Print Edition). 171, 3, p. 349-58 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 4000197