Mads Gyrd-Hansen

Mads Gyrd-Hansen

Professor

ORCID: 0000-0001-5641-5019

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  1. Published

    A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production

    Nachbur, U., Stafford, C. A., Bankovacki, A., Zhan, Y., Lindqvist, L. M., Fiil, B. K., Khakham, Y., Ko, H-J., Sandow, J. J., Falk, H., Holien, J. K., Chau, D., Hildebrand, J., Vince, J. E., Sharp, P. P., Webb, A. I., Jackman, K. A., Mühlen, S., Kennedy, C. L., Lowes, K. N. & 8 others, Murphy, J. M., Gyrd-Hansen, Mads, Parker, M. W., Hartland, E. L., Lew, A. M., Huang, D. C. S., Lessene, G. & Silke, J., 17 Mar 2015, In: Nature Communications. 6, 13 p., 6442.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. A new functional assay for the diagnosis of X-linked inhibitor of apoptosis (XIAP) deficiency

    Ammann, S., Elling, R., Gyrd-Hansen, Mads, Dückers, G., Bredius, R., Burns, S. O., Edgar, J. D. M., Worth, A., Brandau, H., Warnatz, K., zur Stadt, U., Hasselblatt, P., Schwarz, K., Ehl, S. & Speckmann, C., 2014, In: Clinical and Experimental Immunology. 176, 3, p. 394-400 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. All roads lead to ubiquitin

    Gyrd-Hansen, Mads, 2017, In: Cell Death and Differentiation. 24, 7, p. 1135-1136 2 p.

    Research output: Contribution to journal › Editorial › Research

  4. Published

    Apoptosome-independent activation of the lysosomal cell death pathway by caspase-9

    Gyrd-Hansen, Mads, Farkas, T., Fehrenbacher, N., Bastholm, L., Høyer-Hansen, M., Elling, F., Wallach, D., Flavell, R., Kroemer, G., Nylandsted, J. & Jaattela, Marja, 2006, In: Molecular and Cellular Biology. 26, 21, p. 7880-7891

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

    Prabakaran, T., Bodda, C., Krapp, C., Zhang, B-C., Christensen, M. H., Sun, C., Reinert, L., Cai, Y., Jensen, S. B., Skouboe, M. K., Nyengaard, J. R., Thompson, C. B., Lebbink, R. J., Sen, G. C., van Loo, G., Nielsen, R., Komatsu, M., Nejsum, L. N., Jakobsen, M. R., Gyrd-Hansen, M. & 1 others, Paludan, S. R., 13 Apr 2018, In: The EMBO Journal. 37, 8, e97858.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death

    Yde, C. W., Gyrd-Hansen, Mads, Lykkesfeldt, A. E., Issinger, O. & Stenvang, Jan, Jun 2007, In: Molecular Cancer Therapeutics. 6, 6, p. 1869-1876 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

    Hrdinka, M., Fiil, Berthe Katrine, Zucca, M., Leske, D., Bagola, K., Yabal, M., Elliott, P. R., Damgaard, R. B., Komander, D., Jost, P. J. & Gyrd-Hansen, Mads, 29 Mar 2016, In: Cell Reports. 14, 12, p. 2846-58 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Cell scientist to watch - Mads Gyrd-Hansen

    Gyrd-Hansen, Mads, 2017, In: Journal of Cell Science. 130, 12, p. 1981-1983 3 p.

    Research output: Contribution to journal › Comment/debate › Research

  9. Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling

    Nikhar, S., Siokas, I., Schlicher, L., Lee, S., Gyrd-Hansen, Mads, Degterev, A. & Cuny, G. D., 2021, In: European Journal of Medicinal Chemistry. 215, 113252.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Diarylurea compounds inhibit caspase activation by preventing the formation of the active 700-kilodalton apoptosome complex.

    Lademann, U., Cain, K., Gyrd-Hansen, Mads, Brown, D., Peters, D. & Jäättelä, M., 2003, In: Molecular and Cellular Biology. 23, 21, p. 7829-37 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Disease-causing mutations in the XIAP BIR2 domain impair NOD2-dependent immune signalling

    Damgaard, R. B., Fiil, Berthe Katrine, Speckmann, C., Yabal, M., Stadt, U. Z., Bekker-Jensen, Simon Holst, Jost, P. J., Ehl, S., Mailand, Niels & Gyrd-Hansen, Mads, 1 Jul 2013, In: E M B O Journal. 5, p. 1278-1295 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection

    Bodda, C., Reinert, L. S., Fruhwürth, S., Richardo, T., Sun, C., Zhang, B., Kalamvoki, M., Pohlmann, A., Mogensen, T. H., Bergström, P., Agholme, L., O'Hare, P., Sodeik, B., Gyrd-Hansen, Mads, Zetterberg, H. & Paludan, S. R., 2020, In: The Journal of Experimental Medicine. 217, 7

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Harnessing the potential of dystrophin-related proteins for ameliorating Duchenne's muscular dystrophy.

    Krag, T. O., Gyrd-Hansen, Mads & Khurana, T. S., 2001, In: Acta Physiologica (Print Edition). 171, 3, p. 349-58 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Heat shock protein 70 promotes cancer cell viability by safeguarding lysosomal integrity.

    Gyrd-Hansen, Mads, Nylandsted, J. & Jäättelä, M., 2004, In: Cell Cycle. 3, 12, p. 1484-5 1 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization.

    Nylandsted, J., Gyrd-Hansen, Mads, Danielewicz, A., Fehrenbacher, N., Lademann, U., Høyer-Hansen, M., Weber, E., Multhoff, G., Rohde, M. & Jäättelä, M., 2004, In: Journal of Experimental Medicine. 200, 4, p. 425-435 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Heregulin-induced epigenetic regulation of the utrophin-A promoter.

    Basu, U., Gyrd-Hansen, Mads, Baby, S. M., Lozynska, O., Krag, T. O. B., Jensen, C. J., Frödin, Morten & Khurana, T. S., 2007, In: FEBS Letters. 581, 22, p. 4153-8 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1

    Peng, R., Wang, Chris Kedong, Wang-Kan, X., Idorn, M., Kjær, M., Zhou, F. Y., Fiil, Berthe Katrine, Timmermann, F., Orozco, S. L., McCarthy, J., Leung, C. S., Lu, X., Bagola, K., Rehwinkel, J., Oberst, A., Maelfait, J., Paludan, S. R. & Gyrd-Hansen, Mads, 2022, In: EMBO Reports. 2022, 23, e55839.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

    Gyrd-Hansen, Mads, Darding, M., Miasari, M., Santoro, M. M., Zender, L., Xue, W., Tenev, T., da Fonseca, P. C. A., Zvelebil, M., Bujnicki, J. M., Lowe, S., Silke, J. & Meier, P., 2008, In: Nature Cell Biology. 10, 11, p. 1309-17 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    IAPs: From caspase inhibitors to modulators of NF-κB, inflammation and cancer

    Gyrd-Hansen, Mads & Meier, P., 2010, In: Nature Reviews Cancer.

    Research output: Contribution to journal › Journal article › Commissioned › peer-review

  20. Published

    IAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancer

    Gyrd-Hansen, Mads & Meier, P., 2010, In: Nature Reviews. Cancer. 10, 8, p. 561-74 13 p.

    Research output: Contribution to journal › Review › Research › peer-review

  21. Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease

    Schwerd, T., Pandey, S., Yang, H-T., Bagola, K., Jameson, E., Jung, J., Lachmann, R. H., Shah, N., Patel, S. Y., Booth, C., Runz, H., Düker, G., Bettels, R., Rohrbach, M., Kugathasan, S., Chapel, H., Keshav, S., Elkadri, A., Platt, N., Muise, A. M. & 8 others, Koletzko, S., Xavier, R. J., Marquardt, T., Powrie, F., Wraith, J. E., Gyrd-Hansen, Mads, Platt, F. M. & Uhlig, H. H., Jun 2017, In: Gut. 66, 6, p. 1060-1073 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors

    Canning, P., Ruan, Q., Schwerd, T., Hrdinka, M., Maki, J. L., Saleh, D., Suebsuwong, C., Ray, S., Brennan, P. E., Cuny, G. D., Uhlig, H. H., Gyrd-Hansen, Mads, Degterev, A. & Bullock, A. N., 17 Sep 2015, In: Cell Chemical Biology. 22, 9, p. 1174-84 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Inhibitor of apoptosis (IAP) proteins in regulation of inflammation and innate immunity

    Damgaard, R. B. & Gyrd-Hansen, Mads, 2011, In: Discovery Medicine. 11, 58, p. 221-31 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  24. Interaction mapping of endoplasmic reticulum ubiquitin ligases identifies modulators of innate immune signalling

    Fenech, E. J., Lari, F., Charles, P. D., Fischer, R., Laétitia-Thézénas, M., Bagola, K., Paton, A. W., Paton, J. C., Gyrd-Hansen, Mads, Kessler, B. M. & Christianson, J. C., 2 Jul 2020, In: eLife. 9

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. JNK2 mediates TNF-induced cell death in mouse embryonic fibroblasts via regulation of both caspase and cathepsin protease pathways.

    Dietrich, N., Thastrup, J., Holmberg, C., Gyrd-Hansen, Mads, Fehrenbacher, N., Lademann, U., Lerdrup, M., Herdegen, T., Jäättelä, M. & Kallunki, T., 2004, In: Cell Death and Differentiation. 11, 3, p. 301-13 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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