Lona Louring Christrup
Professor emeritus.
Translational Pharmacology
Jagtvej 160
2100 København Ø
Education & Degrees:
- M.Sc. (Pharm): The Royal Danish School of Pharmacy, 1978-1986
- Ph.D. The Royal Danish School of Pharmacy 1983-1986.
Former employment: (Current PharmaSchool)
- Assistant professor 1986-1990
- Associate professor 1990-2010
Research Abroad:
Dept. of Clinical Pharmacology, University of Adelaide, Australia. 1994 -1997
Dept. of Pharmaceutical Science, University of Nottingham, England. 1988
Current Affiliations/Memberships
- EFIC (European Federation of IASP (International Association for the Study of Pain) Chapters) Task for Appropriate use of Opioids: 2014-
- Nordic OIC&OIBD (opioid induced constipation & opioid induced bowel dysfunction) Consensus Working Group: 2014-
- EFIC Task for Reimbursement Policies of Opioid Analgesics: 2011- (Chair)
- Steering committee for the MULTIPAIN research consort: 2011-
- Editorial board of European Journal of Hospital Pharmacy 2008-
Scientific Work
Publications: 131 research papers, 26 dissemination papers (popular scientific, debate, etc.), 2 patent applications (1 patent granted) and 1 thesis, 1 expert report and editor of 1 book. Reviewer for more than 20 scientific journals Participation in more than 160 scientific meetings and conferences, presentation of more than 90 poster or free oral presentations and more than 40 invited lectures.
Current research activities are focused on:
- Influence of administration routes and delivery systems on the pharmacokinetic and pharmacodynamic behaviour of opioids with special focus on the dose-response of both wanted and unwanted effects.
- PK/PD modeling of the effects of opioids.
- Optimization of the pharmacological treatment of chronic pain disorders; with focus on the individual patient needs.
- MULTIPAIN; individualization of pharmacological pain treatment, by elucidation of the reasons for the differentiated effects of analgesics in human experimental pain models.
- Optimization of the pharmacological treatment of chronic pain disorders; with focus on the individual patient needs.
- MULTIPAIN; individualization of pharmacological pain treatment, by elucidation of the reasons for the differentiated effects of analgesics in human experimental pain models.
Supervisor Responsibilities and Teaching
Supervisor for a total of 26 Ph.D. students (currently 4), 8 pre graduate scholar students and more than 200 master students. Member of the assessment committees for 13 PhD. theses.
Educational activities have included a broad spectrum of pharmaceutical disciplines, such a pharmaceutical technology, biopharmaceutics, drug delivery/formulation, pharmacotherapy, clinical pharmacy, social pharmacy, and pharmacology at both pre graduate and post-graduate level.
Activities have included lectures, laboratory exercises, work-shops, tutorials, supervision as well as examnination, evaluation and course planning and managing.
Selected publications
- Published
Pain characteristics and management of inpatients admitted to a comprehensive cancer centre: a cross-sectional study
Kurita, Geana Paula, Tange, U. B., Farholt, H., Sonne, N. M., Strömgren, A. S., Ankersen, L., Kristensen, L., Bendixen, L., Grønvold, Mogens, Petersen, M. A., Nordly, M., Christrup, Lona Louring, Niemann, C. & Sjøgren, P., 22 Jan 2013, In: Acta Anaesthesiologica Scandinavica. 57, p. 518-525Research output: Contribution to journal › Journal article › peer-review
- Published
Pharmacokinetic/pharmacodynamic relationships of tranddermal buprenorphine and fentanyl in experimental human pain models
Andresen, T., Upton, R. N., Foster, D. J. R., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., Apr 2011, In: Basic & Clinical Pharmacology & Toxicology. 108, 4, p. 274-284Research output: Contribution to journal › Journal article › peer-review
- Published
Symptoms and side effects in chronic non-cancer pain:patient report vs. systematic assessment
Jonsson, T., Christrup, Lona Louring, Højsted, J., Villlesen, H. H., Albjerg, T., Ravn-Nielsen, L. V. & Sjøgren, P., 2011, In: Acta Anaesthesiologica Scandinavica. 55Research output: Contribution to journal › Journal article › peer-review
- Published
Rationales behind the choice of administration form with fentanyl: Delphi survey among Danish general practitioners
Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2010, In: Journal of Opioid Management. 6, 4, p. 259-68 9 p.Research output: Contribution to journal › Journal article › peer-review
- Published
The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial
Christensen, A., Christrup, Lona Louring, Fabricius, P. E., Chrostowska, M., Wronka, M., Narkiewicz, K. & Hansen, E. H., 2010, In: Journal of Hypertension. 28, 1, p. 194-200Research output: Contribution to journal › Journal article › peer-review
- Published
A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia
Olesen, A. E., Upton, R., Staahl, C., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., 2010, In: Clinical Pharmacokinetics. 49, 12, p. 817-827Research output: Contribution to journal › Journal article › peer-review
- Published
The importance of the proper procedures in the implementation process of new guidelines
Villesen, H. H., Faber, T., Skov, B., Bonde, J. & Christrup, Lona Louring, 2010, In: E J H P Practice. 16, 3Research output: Contribution to journal › Journal article
- Published
The Danish Barriers Questionnaire-II: preliminary validation in cancer pain patients
Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, In: Pain Practice. 9, 4, p. 266-74 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Barries to cancer management: a review of empirical research
Jacobsen, R., Liubarskiene, Z., Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Samsanaviciene, J., 2009, In: Medicina. 45, 6, p. 427-432Research output: Contribution to journal › Review
- Published
Translational pain research: evaluating analgesic effect in experimental visceral pain models
Olesen, A. E., Andresen, T., Christrup, Lona Louring & Upton, R. N., 2009, In: World Journal of Gastroenterology. 15, 2, p. 177-81Research output: Contribution to journal › Journal article › peer-review
- Published
Survey of patient and physician assessment of a compliance reminder device in the treatment of hypertension
Christensen, A., Christrup, Lona Louring, Fabricius, P. E., Chrostowska, M., Wronka, M., Narkiewicz, K. & Hansen, E. H., 2009, In: Blood Pressure. 18, 5, p. 280-285Research output: Contribution to journal › Journal article › peer-review
- Published
Danish pain specialists' rationales behind the choice of fentanyl transdermal patches and oral transmucosal systems-A Delphi study
Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2009, In: Pain Medicine. 10, 8, p. 1442-1451Research output: Contribution to journal › Journal article › peer-review
- Published
The Danish version of the questionnaire on pain communication: preliminary validation in cancer patients: preliminary validation in cancer patients
Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, In: Acta Anaesthesiologica Scandinavica. 53, 6, p. 807-15 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
The Danish version of the Medication Adherence Report Scale: preliminary validation in cancer pain patients: preliminary validation in cancer pain patients
Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, In: Pain Practice. 9, 1, p. 1-7 6 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Role of active metabolites in the use of opioids
Coller, J. K., Christrup, Lona Louring & Somogyi, A. A., 2009, In: European Journal of Clinical Pharmacology. 65, 2, p. 121-139Research output: Contribution to journal › Review
- Published
Patient-related barriers to cancer pain management: a systematic exploratory review: a systematic exploratory review
Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring & Sjøgren, P., 2009, In: Scandinavian Journal of Caring Sciences. 23, 1, p. 190-208 18 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Novel formulations and routes of administration fro opioids in the treatment of breakthrough pain
Christrup, Lona Louring, Lundorff, L. & Werner, M., 2009, In: Therapy. 6, 5Research output: Contribution to journal › Journal article
- Published
Generisk substitution af depotpraeparater indeholdende opioider
Christrup, Lona Louring, Jensen, N., Jonsson, T., Kristensen, H. G., Sjøgren, P. & Steffansen, B., 4 May 2009, In: Ugeskrift for læger. 171, 19, p. 1624; author reply 1624Research output: Contribution to journal › Journal article › peer-review
- Published
Laegemiddelstyrelsen bør genoverveje tilladelsen til generisk substitution mellem fentanyldepotplastre
Christrup, Lona Louring, Jensen, N., Jonsson, T., Sjøgren, P. & Steffansen, B., 2009, In: Ugeskrift for læger. 171, 44, p. 3215Research output: Contribution to journal › Comment/debate
- Published
Duplik til debatoplæg
Christrup, Lona Louring, Jørgensen, N., Jonsson, T. & Sjøgren, P., 2009, In: Ugeskrift for læger. 171, 49, p. 3637Research output: Contribution to journal › Comment/debate
- Published
Pharmacokinetic-Pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model
Staahl, C., Upton, R., Foster, D. J. R., Christrup, Lona Louring, Kristensen, K., Hansen, S. H., Arendt-Nielsen, L. & Drewes, A. M., 2008, In: Journal of Clinical Pharmacology. 48, 5, p. 619-631Research output: Contribution to journal › Journal article › peer-review
- Published
Pharmacokinetic-Pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers
Jensen, M. L., Sjøgren, P., Upton, R. N., Foster, D. J. R., Bonde, P., Graae, C., Skram, U., Stevner, L. L. S. & Christrup, Lona Louring, 2008, In: Basic & Clinical Pharmacology & Toxicology. 103, 1, p. 94-101Research output: Contribution to journal › Journal article › peer-review
- Published
Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery
Foster, D., Upton, R., Christrup, Lona Louring & Popper, L., 2008, In: Annals of Pharmacotherapy. 42, 10, p. 1380-1387Research output: Contribution to journal › Journal article › peer-review
- Published
Clinical rationale for administering fentanyl to cancer pain patients: two Delphi surveys of pain management experts in Denmark
Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2008, In: Journal of Opioid Management. 4, 6, p. 383-391Research output: Contribution to journal › Journal article › peer-review
- Published
Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: A randomized, double-blind, double-dummy, two-way, crossover study
Christrup, Lona Louring, Foster, D., Popper, L. D., Troen, T. & Upton, R., 2008, In: Clinical Therapeutics. 30, 3, p. 469-481Research output: Contribution to journal › Journal article › peer-review
- Published
Pharmakonetics of morphine and oxycodone following intravenous administration in elderly patients
Villesen, H. H., Banning, A., Petersen, R. H., Weinelt, S., Poulsen, J. B., Hansen, S. H. & Christrup, Lona Louring, 2007, In: Therapeutics and Clinical Risk Management. 3, 5Research output: Contribution to journal › Journal article › peer-review
- Published
Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers
Villesen, H. H., Kristensen, K., Hansen, S. H., Jensen, N., Skram, U. & Christrup, Lona Louring, 2007, In: European Journal of Clinical Pharmacology. 63, 8, p. 761-767Research output: Contribution to journal › Journal article › peer-review
- Published
Patient acceptance of a tablet reminder device
Christensen, A., Christrup, Lona Louring, Fabricius, P. E. & Hansen, E. H., 2007, In: Journal of Medical Marketing (Print Edition). 7, 2, p. 152-161Research output: Contribution to journal › Journal article › peer-review
- Published
A new intelligent tablet reminder device - do health professionals find it of therapeutic value?
Christensen, A., Christrup, Lona Louring, Fabricius, P. E. & Hansen, E. H., 2007, In: Journal of Medical Marketing (Print Edition). 7, 3, p. 235-243Research output: Contribution to journal › Journal article › peer-review
- Published
Forskelle på ordinationsmønstret af analgetika ved behandling af cancersmerter på seks danske smertebehandlingsenheder
Olesen, A. E., Jarvig, L., Hansen, O. B., Højsted, J., von Holstein-Rathlou, Niels-Henrik, Jonsson, T., Sjøgren, P., Sonne, N. M., Sørensen, J. T. & Christrup, Lona Louring, 2007, In: Ugeskrift for læger. 169, 21, p. 2024-9Research output: Contribution to journal › Journal article › peer-review
- Published
Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study
Staahl, C., Dimcevski, G., Andersen, S. D., Thorsgaard, N., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., 2007, In: Scandinavian Journal of Gastroenterology. 42, 3, p. 383-90Research output: Contribution to journal › Journal article › peer-review
- Published
Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers
Jensen, M. L., Foster, D. J. R., Upton, R. N., Kristensen, K., Hansen, S. H., Jensen, N., Nielsen, B. N., Skram, U., Villesen, H. H. & Christrup, Lona Louring, 2007, In: European Journal of Clinical Pharmacology. 63, 12, p. 1153-1159Research output: Contribution to journal › Journal article › peer-review
- Published
Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.
Coller, J. K., Jørgensen, Carsten, Foster, D. J. R., James, H., Gillis, D., Christrup, Lona Louring & Somogyi, A. A., 2007, In: International Journal of Clinical Pharmacology and Therapeutics. 45, 7, p. 410-7Research output: Contribution to journal › Journal article › peer-review
- Published
Physician-related barriers to cancer pain management with opioid analgesics: a systematic review
Jacobsen, Ramune, Sjøgren, P., Møldrup, C. & Christrup, Lona Louring, 2007, In: Journal of Opioid Management. 3, 4, p. 207-14Research output: Contribution to journal › Journal article › peer-review
- Published
Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug
Sunesen, V. H., Vedelsdal, R., Kristensen, H. G., Christrup, Lona Louring & Mullertz, Anette , 2005, In: European Journal of Pharmaceutical Sciences. 24, 4, p. 297-303 6 p.Research output: Contribution to journal › Journal article › peer-review
ID: 1301280
Most downloads
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787
downloads
Being a long-term user of nicotine replacement therapy: Interpretative phenomenological analysis of former smokers’ experience of continued nicotine dependence
Research output: Contribution to conference › Poster › Research
Published -
775
downloads
Exploratory survey study of long-term users of nicotine replacement therapy in Danish consumers
Research output: Contribution to conference › Poster › Research
Published -
695
downloads
GENOMIC AIDED PHARMACOTHERAPY (GAP): A PILOT STUDY IN PATIENTS SUFFERING FROM CHRONIC NON-CANCER PAIN
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published