Lona Louring Christrup

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• CV
• Research outputs
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Education & Degrees:

• M.Sc. (Pharm): The Royal Danish School of Pharmacy, 1978-1986           
• Ph.D.  The Royal Danish School of Pharmacy 1983-1986.

Former employment: (Current PharmaSchool)

• Assistant professor 1986-1990
• Associate professor 1990-2010

Research Abroad:

Dept. of Clinical Pharmacolo­gy, University of Adelaide, Australia. 1994 -1997

Dept. of Pharmaceuti­cal Sci­ence, Univer­sity of Notting­ham, Eng­land. 1988

Current Affiliations/Memberships

• EFIC (European Federation of IASP (International Association for the Study of Pain) Chapters) Task for Appropriate use of Opioids: 2014-
• Nordic OIC&OIBD (opioid induced constipation & opioid induced bowel dysfunction) Consensus Working Group: 2014-
• EFIC Task for Reimbursement Policies of Opioid Analgesics: 2011- (Chair)
• Steering committee for the MULTIPAIN research consort: 2011-
• Editorial board of European Journal of Hospital Pharmacy 2008- 

Scientific Work

Publications: 131 research papers, 26 dissemination papers (popular scientific, debate, etc.), 2 patent applications (1 patent granted) and 1 thesis, 1 expert report and editor of 1 book. Reviewer for more than 20 scientific journals Participation in more than 160 scientific meetings and conferences, presentation of more than 90 poster or free oral presentations and more than 40 invited lectures. 
Current research activities are focused on: 

• Influence of administration routes and delivery systems on the pharmacokinetic and pharmacodynamic behaviour of opioids with special focus on the dose-response of both wanted and unwanted effects. 
• PK/PD modeling of the effects of opioids. 
• Optimization of the pharmacological treatment of chronic pain disorders; with focus on the individual patient needs.
• MULTIPAIN; individualization of pharmacological pain treatment, by elucidation of the reasons for the differentiated effects of analgesics in human experimental pain models.
• Optimization of the pharmacological treatment of chronic pain disorders; with focus on the individual patient needs. 
• MULTIPAIN; individualization of pharmacological pain treatment, by elucidation of the reasons for the differentiated effects of analgesics in human experimental pain models. 

Supervisor Responsibilities and Teaching

Supervisor for a total of 26 Ph.D. students (currently 4), 8 pre graduate scholar students and more than 200 master students.  Member of the assessment committees for 13 PhD. theses.

Educational activities have included a broad spectrum of pharmaceutical disciplines, such a pharmaceutical technology, biopharmaceutics, drug delivery/formulation, pharmacotherapy, clinical pharmacy, social pharmacy, and pharmacology at both pre graduate and post-graduate level.

Activities have included lectures, laboratory exercises, work-shops, tutorials, supervision as well as  examnination, evaluation and course planning and managing.

Selected publications

1. Published

   Pain characteristics and management of inpatients admitted to a comprehensive cancer centre: a cross-sectional study

   Kurita, Geana Paula, Tange, U. B., Farholt, H., Sonne, N. M., Strömgren, A. S., Ankersen, L., Kristensen, L., Bendixen, L., Grønvold, Mogens, Petersen, M. A., Nordly, M., Christrup, Lona Louring, Niemann, C. & Sjøgren, P., 22 Jan 2013, In: Acta Anaesthesiologica Scandinavica. 57, p. 518-525

   Research output: Contribution to journal › Journal article › peer-review

2. Published

   Pharmacokinetic/pharmacodynamic relationships of tranddermal buprenorphine and fentanyl in experimental human pain models

   Andresen, T., Upton, R. N., Foster, D. J. R., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., Apr 2011, In: Basic & Clinical Pharmacology & Toxicology. 108, 4, p. 274-284

   Research output: Contribution to journal › Journal article › peer-review

3. Published

   Symptoms and side effects in chronic non-cancer pain:patient report vs. systematic assessment

   Jonsson, T., Christrup, Lona Louring, Højsted, J., Villlesen, H. H., Albjerg, T., Ravn-Nielsen, L. V. & Sjøgren, P., 2011, In: Acta Anaesthesiologica Scandinavica. 55

   Research output: Contribution to journal › Journal article › peer-review

4. Published

   Rationales behind the choice of administration form with fentanyl: Delphi survey among Danish general practitioners

   Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2010, In: Journal of Opioid Management. 6, 4, p. 259-68 9 p.

   Research output: Contribution to journal › Journal article › peer-review

5. Published

   The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy:  a randomized controlled trial

   Christensen, A., Christrup, Lona Louring, Fabricius, P. E., Chrostowska, M., Wronka, M., Narkiewicz, K. & Hansen, E. H., 2010, In: Journal of Hypertension. 28, 1, p. 194-200

   Research output: Contribution to journal › Journal article › peer-review

6. Published

   A pharmacokinetic and pharmacodynamic study of oral oxycodone in a human experimental pain model of hyperalgesia

   Olesen, A. E., Upton, R., Staahl, C., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., 2010, In: Clinical Pharmacokinetics. 49, 12, p. 817-827

   Research output: Contribution to journal › Journal article › peer-review

7. Published

   The importance of the proper procedures in the implementation process of new guidelines

   Villesen, H. H., Faber, T., Skov, B., Bonde, J. & Christrup, Lona Louring, 2010, In: E J H P Practice. 16, 3

   Research output: Contribution to journal › Journal article

8. Published

   The Danish Barriers Questionnaire-II: preliminary validation in cancer pain patients

   Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, In: Pain Practice. 9, 4, p. 266-74 8 p.

   Research output: Contribution to journal › Journal article › peer-review

9. Published

   Barries to cancer management: a review of empirical research

   Jacobsen, R., Liubarskiene, Z., Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Samsanaviciene, J., 2009, In: Medicina. 45, 6, p. 427-432

   Research output: Contribution to journal › Review

10. Published

    Translational pain research: evaluating analgesic effect in experimental visceral pain models

    Olesen, A. E., Andresen, T., Christrup, Lona Louring & Upton, R. N., 2009, In: World Journal of Gastroenterology. 15, 2, p. 177-81

    Research output: Contribution to journal › Journal article › peer-review

11. Published

    Survey of patient and physician assessment of a compliance reminder device in the treatment of hypertension

    Christensen, A., Christrup, Lona Louring, Fabricius, P. E., Chrostowska, M., Wronka, M., Narkiewicz, K. & Hansen, E. H., 2009, In: Blood Pressure. 18, 5, p. 280-285

    Research output: Contribution to journal › Journal article › peer-review

12. Published

    Danish pain specialists' rationales behind the choice of fentanyl transdermal patches and oral transmucosal systems-A Delphi study

    Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2009, In: Pain Medicine. 10, 8, p. 1442-1451

    Research output: Contribution to journal › Journal article › peer-review

13. Published

    The Danish version of the questionnaire on pain communication: preliminary validation in cancer patients: preliminary validation in cancer patients

    Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, In: Acta Anaesthesiologica Scandinavica. 53, 6, p. 807-15 8 p.

    Research output: Contribution to journal › Journal article › peer-review

14. Published

    The Danish version of the Medication Adherence Report Scale: preliminary validation in cancer pain patients: preliminary validation in cancer pain patients

    Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring, Sjøgren, P. & Hansen, O. B., 2009, In: Pain Practice. 9, 1, p. 1-7 6 p.

    Research output: Contribution to journal › Journal article › peer-review

15. Published

    Role of active metabolites in the use of opioids

    Coller, J. K., Christrup, Lona Louring & Somogyi, A. A., 2009, In: European Journal of Clinical Pharmacology. 65, 2, p. 121-139

    Research output: Contribution to journal › Review

16. Published

    Patient-related barriers to cancer pain management: a systematic exploratory review: a systematic exploratory review

    Jacobsen, Ramune, Møldrup, C., Christrup, Lona Louring & Sjøgren, P., 2009, In: Scandinavian Journal of Caring Sciences. 23, 1, p. 190-208 18 p.

    Research output: Contribution to journal › Journal article › peer-review

17. Published

    Novel formulations and routes of administration fro opioids in the treatment of breakthrough pain

    Christrup, Lona Louring, Lundorff, L. & Werner, M., 2009, In: Therapy. 6, 5

    Research output: Contribution to journal › Journal article

18. Published

    Generisk substitution af depotpraeparater indeholdende opioider

    Christrup, Lona Louring, Jensen, N., Jonsson, T., Kristensen, H. G., Sjøgren, P. & Steffansen, B., 4 May 2009, In: Ugeskrift for læger. 171, 19, p. 1624; author reply 1624

    Research output: Contribution to journal › Journal article › peer-review

19. Published

    Laegemiddelstyrelsen bør genoverveje tilladelsen til generisk substitution mellem fentanyldepotplastre

    Christrup, Lona Louring, Jensen, N., Jonsson, T., Sjøgren, P. & Steffansen, B., 2009, In: Ugeskrift for læger. 171, 44, p. 3215

    Research output: Contribution to journal › Comment/debate

20. Published

    Duplik til debatoplæg

    Christrup, Lona Louring, Jørgensen, N., Jonsson, T. & Sjøgren, P., 2009, In: Ugeskrift for læger. 171, 49, p. 3637

    Research output: Contribution to journal › Comment/debate

21. Published

    Pharmacokinetic-Pharmacodynamic modeling of morphine and oxycodone concentrations and analgesic effect in a multimodal experimental pain model

    Staahl, C., Upton, R., Foster, D. J. R., Christrup, Lona Louring, Kristensen, K., Hansen, S. H., Arendt-Nielsen, L. & Drewes, A. M., 2008, In: Journal of Clinical Pharmacology. 48, 5, p. 619-631

    Research output: Contribution to journal › Journal article › peer-review

22. Published

    Pharmacokinetic-Pharmacodynamic relationships of cognitive and psychomotor effects of intravenous buprenorphine infusion in human volunteers

    Jensen, M. L., Sjøgren, P., Upton, R. N., Foster, D. J. R., Bonde, P., Graae, C., Skram, U., Stevner, L. L. S. & Christrup, Lona Louring, 2008, In: Basic & Clinical Pharmacology & Toxicology. 103, 1, p. 94-101

    Research output: Contribution to journal › Journal article › peer-review

23. Published

    Pharmacokinetics and pharmacodynamics of intranasal versus intravenous fentanyl in patients with pain after oral surgery

    Foster, D., Upton, R., Christrup, Lona Louring & Popper, L., 2008, In: Annals of Pharmacotherapy. 42, 10, p. 1380-1387

    Research output: Contribution to journal › Journal article › peer-review

24. Published

    Clinical rationale for administering fentanyl to cancer pain patients: two Delphi surveys of pain management experts in Denmark

    Jacobsen, Ramune, Møldrup, C. & Christrup, Lona Louring, 2008, In: Journal of Opioid Management. 4, 6, p. 383-391

    Research output: Contribution to journal › Journal article › peer-review

25. Published

    Pharmacokinetics, efficacy, and tolerability of fentanyl following intranasal versus intravenous administration in adults undergoing third-molar extraction: A randomized, double-blind, double-dummy, two-way, crossover study

    Christrup, Lona Louring, Foster, D., Popper, L. D., Troen, T. & Upton, R., 2008, In: Clinical Therapeutics. 30, 3, p. 469-481

    Research output: Contribution to journal › Journal article › peer-review

26. Published

    Pharmakonetics of morphine and oxycodone following intravenous administration in elderly patients

    Villesen, H. H., Banning, A., Petersen, R. H., Weinelt, S., Poulsen, J. B., Hansen, S. H. & Christrup, Lona Louring, 2007, In: Therapeutics and Clinical Risk Management. 3, 5

    Research output: Contribution to journal › Journal article › peer-review

27. Published

    Pharmacokinetics of morphine-6-glucuronide following oral administration in healthy volunteers

    Villesen, H. H., Kristensen, K., Hansen, S. H., Jensen, N., Skram, U. & Christrup, Lona Louring, 2007, In: European Journal of Clinical Pharmacology. 63, 8, p. 761-767

    Research output: Contribution to journal › Journal article › peer-review

28. Published

    Patient acceptance of a tablet reminder device

    Christensen, A., Christrup, Lona Louring, Fabricius, P. E. & Hansen, E. H., 2007, In: Journal of Medical Marketing (Print Edition). 7, 2, p. 152-161

    Research output: Contribution to journal › Journal article › peer-review

29. Published

    A new intelligent tablet reminder device - do health professionals find it of therapeutic value?

    Christensen, A., Christrup, Lona Louring, Fabricius, P. E. & Hansen, E. H., 2007, In: Journal of Medical Marketing (Print Edition). 7, 3, p. 235-243

    Research output: Contribution to journal › Journal article › peer-review

30. Published

    Forskelle på ordinationsmønstret af analgetika ved behandling af cancersmerter på seks danske smertebehandlingsenheder

    Olesen, A. E., Jarvig, L., Hansen, O. B., Højsted, J., von Holstein-Rathlou, Niels-Henrik, Jonsson, T., Sjøgren, P., Sonne, N. M., Sørensen, J. T. & Christrup, Lona Louring, 2007, In: Ugeskrift for læger. 169, 21, p. 2024-9

    Research output: Contribution to journal › Journal article › peer-review

31. Published

    Differential effect of opioids in patients with chronic pancreatitis: an experimental pain study

    Staahl, C., Dimcevski, G., Andersen, S. D., Thorsgaard, N., Christrup, Lona Louring, Arendt-Nielsen, L. & Drewes, A. M., 2007, In: Scandinavian Journal of Gastroenterology. 42, 3, p. 383-90

    Research output: Contribution to journal › Journal article › peer-review

32. Published

    Population pharmacokinetics of buprenorphine following a two-stage intravenous infusion in healthy volunteers

    Jensen, M. L., Foster, D. J. R., Upton, R. N., Kristensen, K., Hansen, S. H., Jensen, N., Nielsen, B. N., Skram, U., Villesen, H. H. & Christrup, Lona Louring, 2007, In: European Journal of Clinical Pharmacology. 63, 12, p. 1153-1159

    Research output: Contribution to journal › Journal article › peer-review

33. Published

    Lack of influence of CYP2D6 genotype on the clearance of (R)-, (S)- and racemic-methadone.

    Coller, J. K., Jørgensen, Carsten, Foster, D. J. R., James, H., Gillis, D., Christrup, Lona Louring & Somogyi, A. A., 2007, In: International Journal of Clinical Pharmacology and Therapeutics. 45, 7, p. 410-7

    Research output: Contribution to journal › Journal article › peer-review

34. Published

    Physician-related barriers to cancer pain management with opioid analgesics: a systematic review

    Jacobsen, Ramune, Sjøgren, P., Møldrup, C. & Christrup, Lona Louring, 2007, In: Journal of Opioid Management. 3, 4, p. 207-14

    Research output: Contribution to journal › Journal article › peer-review

35. Published

    Effect of liquid volume and food intake on the absolute bioavailability of danazol, a poorly soluble drug

    Sunesen, V. H., Vedelsdal, R., Kristensen, H. G., Christrup, Lona Louring & Mullertz, Anette , 2005, In: European Journal of Pharmaceutical Sciences. 24, 4, p. 297-303 6 p.

    Research output: Contribution to journal › Journal article › peer-review