Lona Louring Christrup

Lona Louring Christrup

Professor emeritus.


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  1. 2024
  2. Published

    Pharmacogenetic testing of CYP2D6, CYP2C19 and CYP2C9 in Denmark: Agreement between publicly funded genotyping tests and the subsequent phenotype classification

    Houlind, Morten Baltzer, Hansen, L., Iversen, E., Rasmussen, H. B., Larsen, J. B., Jørgensen, S., Dalhoff, Kim, Damkier, P., Walls, Anne Byriel, Vermehren, Charlotte, Andersen, T. R. H., Kallemose, T., Christrup, Lona Louring & Westergaard, N., 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 5, p. 756-763 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Use of drugs with pharmacogenomics (PGx)-based dosing guidelines in a Danish cohort of persons with chronic kidney disease, both on dialysis and not on dialysis: Perspectives for prescribing optimization

    Westergaard, N., Houlind, Morten Baltzer, Christrup, Lona Louring, Juul-Larsen, H. G., Strandhave, C. & Olesen, A. E., 2024, In: Basic and Clinical Pharmacology and Toxicology. 134, 4, p. 531-542

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2023
  5. Published

    The Sixth European Society of Pharmacogenomics and Personalised Therapy Congress

    Van Schaik, R. H. N., Manolopoulos, V. G., Daly, A. K., Niemi, M., Zukic, B., Patrinos, G. P., Primorac, D., Swen, J. J., Ingelman-Sundberg, M., Morris, T., Molden, E., Müller, D., Pavlovic, S., Russmann, S., Ansari, M., Henricks, L. M., Van Den Broek, W., Florindi, F., Bozina, N., Akin, D. & 4 others, Christrup, Lona Louring, Llerena, A., Sipeky, C. & Stankovic, S., 2023, In: Pharmacogenomics. 24, 5, p. 243-246 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. 2022
  7. Published

    Farmakogenetik kan blive supplement til fremtidens ordinationspraksis

    Clausen, E., Koch, N. E., Christrup, Lona Louring, Houlind, Morten Baltzer & Nørgaard, Lotte Stig, 2022, In: Best Practice Nordic.

    Research output: Contribution to journal › Journal article › Research

  8. 2021
  9. Published

    Effect of Roux-en-Y gastric bypass on the pharmacokinetic-pharmacodynamic relationships of liquid and controlled-release formulations of oxycodone

    Ladebo, L., Abuhelwa, A. Y., Foster, D. J. R., Kroustrup, J. P., Pacyk, G. J., Kongstad, Kenneth Thermann, Drewes, A. M., Christrup, Lona Louring & Olesen, A. E., 2021, In: Basic and Clinical Pharmacology and Toxicology. 129, 3, p. 232-245

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Oral absorption of oxycodone in patients with short bowel syndrome

    Ladebo, L., Vinter-Jensen, L., Hestvang, J., Mikkelsen, M. S., Rasmussen, H. H., Christrup, Lona Louring, Drewes, A. M. & Olesen, A. E., 2021, In: Scandinavian Journal of Gastroenterology. 56, 9, p. 1023-1029

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2020
  12. Published

    Opioider til kroniske nonmaligne smerter

    Licht, T. W., Bache, N. J., Bredahl, C., Christrup, Lona Louring, Drewes, A. M. & Arendt-Nielsen, L., 6 Jul 2020, In: Ugeskrift for Laeger. 182, 28, 9 p., V08190447.

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Chronic abdominal pain and persistent opioid use after bariatric surgery

    Simoni, A. H., Ladebo, L., Christrup, Lona Louring, Drewes, A. M., Johnsen, S. P. & Olesen, A. E., 2020, In: Scandinavian Journal of Pain. 20, 2, p. 239-251

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Population pharmacokinetic-pharmacodynamic modelling of liquid and controlled-release formulations of oxycodone in healthy volunteers

    Ladebo, L., Foster, D. J. R., Abuhelwa, A. Y., Upton, R. N., Kongstad, Kenneth Thermann, Drewes, A. M., Christrup, Lona Louring & Olesen, A. E., 2020, In: Basic & Clinical Pharmacology & Toxicology. 126, 3, p. 263-276

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. 2019
  16. Published

    Differences in Kidney Function Estimates Based on Creatinine and/or Cystatin C in Non-Traumatic Amputation Patients and Their Impact on Drug Prescribing

    Aakjær, Mia, Houlind, M. B., Treldal, C., Ankarfeldt, M. Z., Jensen, P. S., Andersen, Ove, Iversen, E., Christrup, Lona Louring & Petersen, Janne, 2019, In: Journal of Clinical Medicine. 8, 1, 14 p., 89.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2018
  18. Published

    GENOMIC AIDED PHARMACOTHERAPY (GAP): A PILOT STUDY IN PATIENTS SUFFERING FROM CHRONIC NON-CANCER PAIN

    Houlind, M. B., Treldal, C., Vagn-Hansen, L., Hansen, R. W. & Christrup, Lona Louring, May 2018, p. 10-10.

    Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

  19. Published

    Association Between Genetic Polymorphisms and Pain Sensitivity in Patients with Hip Osteoarthritis

    Olesen, A. E., Nielsen, L. M., Feddersen, S., Erlenwein, J., Petzke, F., Przemeck, M., Christrup, Lona Louring & Drewes, A. M., 2018, In: Pain Practice. 18, 5, 587 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Creatinine-Based Renal Function Estimates and Dosage of Postoperative Pain Management for Elderly Acute Hip Fracture Patients

    Houlind, M. B., Petersen, K. K., wcr491, wcr491, Jorgensen, L. M., Aakjær, Mia, Christrup, Lona Louring, Petersen, Janne, Andersen, Ove & Treldal, C., 2018, In: Pharmaceuticals. 11, 3, 14 p., 88.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Healthcare professionals’ agreement on clinical relevance of drug-related problems among elderly patients

    Bech, C. F., Frederiksen, T., Villesen, C. T., Højsted, J., Nielsen, P. R., Kjeldsen, L. J., Nørgaard, Lotte Stig & Christrup, Lona Louring, 2018, In: International Journal of Clinical Pharmacy. 40, 1, p. 119-125

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Offset Analgesia and The Impact of Treatment with Oxycodone and Venlafaxine: A Placebo-Controlled, Randomized Trial in Healthy Volunteers

    Olesen, A. E., Nissen, T. D., Nilsson, M., Lelic, D., Brock, C., Christrup, Lona Louring & Drewes, A. M., 2018, In: Basic and Clinical Pharmacology and Toxicology. 123, 6, p. 727-731

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Recreational drug use at a major music festival: trend analysis of anonymised pooled urine

    Hoegberg, L., Christiansen, C., Søe, J. L., Telving, R., Andreasen, M. F., Stærk, Dan, Christrup, Lona Louring & Kongstad, Kenneth Thermann, 2018, In: Clinical Toxicology. 56, p. 245-255 1360496.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. 2017
  25. Published

    Analysis of opioid consumption in clinical trials: a simulation based analysis of power of four approaches

    Juul, R. V., Nyberg, J., Kreilgaard, M., Christrup, Lona Louring, Simonsson, U. S. H. & Lund, Trine Meldgaard, Aug 2017, In: Journal of Pharmacokinetics and Pharmacodynamics. 44, 4, p. 325-333 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Genetic Influences of OPRM1, OPRD1 and COMT on Morphine Analgesia in a Multi-Modal, Multi-Tissue Human Experimental Pain Model

    Nielsen, L. M., Christrup, Lona Louring, Sato, H., Drewes, A. M. & Olesen, A. E., Jul 2017, In: Basic & Clinical Pharmacology & Toxicology Online. 121, 1, p. 6-12

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Lack of genetic association between OCT1, ABCB1, and UGT2B7 variants and morphine pharmacokinetics

    Nielsen, L. M., Sverrisdóttir, E., Stage, T. B., Feddersen, S., Brøsen, K., Christrup, Lona Louring, Drewes, A. M. & Olesen, A. E., 1 Mar 2017, In: European Journal of Pharmaceutical Sciences. 99, p. 337-342 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Cortical and spinal assessment - a comparative study using encephalography and the nociceptive withdrawal reflex

    Fischer, I. W., Gram, M., Hansen, T. M., Brokjaer, A., Graversen, C., Malver, L. P., Mørch, C. D., Christrup, Lona Louring, Drewes, A. M. & Olesen, A. E., Mar 2017, In: Journal of Pharmacological and Toxicological Methods. 84, p. 37-43 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    European Pain Federation position paper on appropriate opioid use in chronic pain management

    O'Brien, T., Christrup, Lona Louring, Drewes, A. M., Fallon, M. T., Kress, H. G., McQuay, H. J., Mikus, G., Morlion, B. J., Perez-Cajaraville, J., Pogatzki-Zahn, E., Varrassi, G. & Wells, J. C. D., Jan 2017, In: European Journal of Pain. 21, 1, p. 3-19 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Objective methods for the assessment of the spinal and supraspinal effects of opioids

    Fischer, I. W., Hansen, T. M., Lelic, D., Brokjaer, A., Frøkjær, J., Christrup, Lona Louring & Olesen, A. E., Jan 2017, In: Scandinavian Journal of Pain. 14, p. 15-24 10 p.

    Research output: Contribution to journal › Review › Research › peer-review

  31. 2016
  32. Published

    Association between Gene Polymorphisms and Pain Sensitivity Assessed in a Multi-Modal Multi-Tissue Human Experimental Model - An Explorative Study

    Nielsen, L. M., Olesen, A. E., Sato, H., Christrup, Lona Louring & Drewes, A. M., Oct 2016, In: Basic & Clinical Pharmacology & Toxicology. 119, 4, p. 360-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

    Juul, R. V., Knøsgaard, K. R., Olesen, A. E., Pedersen, K. V., Kreilgaard, M., Christrup, Lona Louring, Osther, P. J., Drewes, A. M. & Lund, Trine Meldgaard, Jul 2016, In: A A P S Journal. 18, 4, p. 1013-1022 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    A Model-Based Approach for Joint Analysis of Pain Intensity and Opioid Consumption in Postoperative Pain

    Knøsgaard, K., Juul, R. V., Olesen, A. E., Pedersen, K. V., Kreilgaard, M., Christrup, Lona Louring, Osther, P. J. S., Drewes, A. M. & Lund, Trine Meldgaard, Jun 2016.

    Research output: Contribution to conference › Poster › Research

  35. Published

    Pharmacokinetic Metamodel of Morphine and Morphine-6-Glucuronide in Neonates and Adults

    Sverrisdóttir, E., Foster, D. J. R., Olesen, A. E., Lund, Trine Meldgaard, Drewes, A. M., Christrup, Lona Louring, Kreilgaard, M. & Upton, R. N., Jun 2016.

    Research output: Contribution to conference › Poster › Research

  36. Published

    A pharmacokinetic-pharmacodynamic model of morphine exposure and subsequent morphine consumption in postoperative pain

    Juul, R. V., Nyberg, J., Lund, Trine Meldgaard, Rasmussen, S., Kreilgaard, M., Christrup, Lona Louring & Simonsson, U. S. H., 2016, In: Pharmaceutical Research. 33, 5, p. 1093–1103 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Definition, diagnosis and treatment strategies for opioid-induced bowel dysfunction - Recommendations of the Nordic Working Group

    Drewes, A. M., Munkholm, Pia, Simrén, M., Breivik, H., Kongsgaard, U. E., Hatlebakk, J. G., Agreus, L., Friedrichsen, M. & Christrup, Lona Louring, 2016, In: Scandinavian Journal of Pain. 11, p. 111-122 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Short-term oxycodone treatment does not affect electrogenic ion transport in isolated mucosa from the human rectosigmoid colon

    Nilsson, M., Brock, C., Poulsen, J. L., Bindslev, Niels, Hansen, M. B., Christrup, Lona Louring & Drewes, A. M., 2016, In: Scandinavian Journal of Gastroenterology. 51, 5, p. 538-47 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. 2015
  40. Published

    Renal function and symptoms/adverse effects in opioid-treated patients with cancer

    Kurita, G. P., Lundström, S., Sjøgren, P., Ekholm, O., Christrup, Lona Louring, Davies, A., Kaasa, S., Klepstad, P. & Dale, O., Sep 2015, In: Acta Anaesthesiologica Scandinavica. 59, 8, p. 1049-59 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    Symptoms and side effects in chronic non-cancer pain patients: clinical implications and development of new assessment tools

    Olsen, T. S., Jonsson, T., Højsted, J., Sjøgren, P. & Christrup, Lona Louring, Sep 2015, In: Acta Anaesthesiologica Scandinavica. 59, 8, p. 1060-7 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Exploring the relationship between analgesic event rate and pain intensity in kidney stone surgery: A Repeated Time to Event Pilot Study

    Juul, R. V., Pedersen, K. V., Christrup, Lona Louring, Olesen, A. E., Drewes, A., Osther, P. J. S. & Lund, Trine Meldgaard, Jun 2015.

    Research output: Contribution to conference › Poster › Research › peer-review

  43. Published

    Altered Frequency Distribution in the Electroencephalogram is Correlated to the Analgesic Effect of Remifentanil

    Graversen, C., Malver, L. P., Kurita, G. P., Staahl, C., Christrup, Lona Louring, Sjøgren, P. & Drewes, A. M., May 2015, In: Basic & Clinical Pharmacology & Toxicology. 116, 5, p. 414-422 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The effects of morphine and methylnaltrexone on gastrointestinal pain in healthy male participants

    Brokjaer, A., Olesen, A. E., Christrup, Lona Louring, Dahan, A. & Drewes, A. M., May 2015, In: Neurogastroenterology and Motility. 27, 5, p. 693-704 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain

    Sverrisdóttir, E., Lund, Trine Meldgaard, Olesen, A. E., Drewes, A. M., Christrup, Lona Louring & Kreilgaard, M., 7 Apr 2015, In: European Journal of Pharmaceutical Sciences. 74, p. 45–62 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Objective markers of the analgesic response to morphine in experimental pain research

    Brokjær, A., Olesen, A. E., Kreilgaard, M., Graversen, C., Gram, M., Christrup, Lona Louring, Dahan, A. & Drewes, A. M., 7 Feb 2015, In: Journal of Pharmacological and Toxicological Methods. 73, p. 7-14 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Modelling concentration-analgesia relationships for morphine to evaluate experimental pain models

    Sverrisdóttir, E., Foster, D. J. R., Upton, R. N., Olesen, A. E., Lund, Trine Meldgaard, Gabel-Jensen, C., Drewes, A. M., Christrup, Lona Louring & Kreilgaard, M., 23 Jan 2015, In: European Journal of Pharmaceutical Sciences. 66, p. 50-58 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Exploratory survey study of long-term users of nicotine replacement therapy in Danish consumers

    Borup, G., Lyngby Mikkelsen, K., Tønnesen, P. & Christrup, Lona Louring, 19 Jan 2015, In: Harm Reduction Journal. 12, 2, p. 1-7 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    A cortical source localization analysis of resting EEG data after remifentanil infusion

    Khodayari-Rostamabad, A., Graversen, C., Malver, L. P., Kurita, G. P., Christrup, Lona Louring, Sjøgren, P. & Drewes, A. M., 2015, In: Clinical Neurophysiology. 126, 5, p. 898-905

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Association Between Human Pain-Related Genotypes and Variability in Opioid Analgesia: An Updated Review

    Nielsen, L. M., Olesen, A. E., Branford, R., Christrup, Lona Louring, Sato, H. & Drewes, A. M., 2015, In: Pain Practice. 15, 6, p. 580–594 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Disruption of Cortical Connectivity during Remifentanil Administration Is Associated with Cognitive Impairment but Not with Analgesia

    Khodayari-Rostamabad, A., Olesen, S. S., Graversen, C., Malver, L. P., Kurita, G. P., Sjøgren, P., Christrup, Lona Louring & Drewes, A. M., 2015, In: Anesthesiology. 122, p. 140-49 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Does mutual compensation of the cognitive effects induced by pain and opioids exist? An experimental study

    Kurita, Geana Paula, Malver, L. P., Andresen, T., Polianskis, R., Drewes, A. M., Christrup, Lona Louring, Højsted, J. & Sjøgren, P., 2015, In: Psychopharmacology. 232, 8, p. 1373-1381 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. Published

    Management of non-malignant chronic pain conditions with opioids; cross-sectional challenges

    Villesen, C. T., Højsted, J., Nørgaard, Lotte Stig, Kjeldsen, L. J., Nielsen, P. R. & Christrup, Lona Louring, 2015, In: International Journal of Clinical Pharmacy. 37, 1, p. 255 1 p., HP-CE022.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  54. Published

    Modelling drug-drug interactions between morphine and methylnaltrexone

    Sverrisdóttir, E., Kreilgaard, M., Brokjær, A., Miltersen, K. K., Olesen, A. E., Christrup, Lona Louring & Drewes, A., 2015.

    Research output: Contribution to conference › Poster › Research

  55. Published

    PS-109 Barriers and facilitators to implementing drug changes caused by drug tenders and shortages

    Rishøj, R. M., Christrup, Lona Louring & Clemmensen, M. H., 2015, In: European Journal of Hospital Pharmacy - Science and Practice. 22, p. A185-A186 2 p.

    Research output: Contribution to journal › Journal article › Research

  56. Published

    Repeated Time-to-event Analysis of Consecutive Analgesic Events in Postoperative Pain

    Juul, R. V., Rasmussen, S., Kreilgaard, M., Christrup, Lona Louring, Simonsson, U. S. H. & Lund, Trine Meldgaard, 2015, In: Anesthesiology. 123, 12, p. 1411-1419 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  57. 2014
  58. Published

    Population Pharmacokinetics of Morphine and Morphine-6-Glucuronide following Rectal Administration -A Dose Escalation Study

    Brokjær, A., Kreilgaard, M., Olesen, A. E., Simonsson, U. S. H., Christrup, Lona Louring, Dahan, A. & Drewes, A. M., 5 Dec 2014, In: European Journal of Pharmaceutical Sciences. 68, p. 78-86 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  59. Published

    Corrigendum: Pharmacokinetic-Pharmacodynamic Modelling of the Analgesic and Anti-hyperalgesic Effects of Morphine after Intravenous Infusion in Human Volunteers (vol 115, pg 257, 2014)

    Ravn, P., Foster, D. J. R., Kreilgaard, M., Christrup, Lona Louring, Werner, M., Secher, E., Skram, U. & Upton, R., Nov 2014, In: Basic & Clinical Pharmacology & Toxicology Online. 115, 5, p. 476-476 1 p.

    Research output: Contribution to journal › Journal article › Research

  60. Published

    Being a long-term user of nicotine replacement therapy: Interpretative phenomenological analysis of former smokers’ experience of continued nicotine dependence

    Borup, G., Nørgaard, Lotte Stig, Tønnesen, P. & Christrup, Lona Louring, 18 Sep 2014.

    Research output: Contribution to conference › Poster › Research

  61. Published

    Exploratory survey study of long-term users of nicotine replacement therapy in Danish consumers

    Borup, G., Christrup, Lona Louring, Lyngby Mikkelsen, K. & Tønnesen, P., 18 Sep 2014.

    Research output: Contribution to conference › Poster › Research

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ID: 1301280