Lene Juel Rasmussen

Lene Juel Rasmussen

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  1. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 4 Jun 2013, In: Proceedings of the National Academy of Science of the United States of America. 110, 23, p. 9403-8 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  2. Published

    Genome-wide screens for expressed hypothetical proteins

    Desler, Claus, Durhuus, J. A. & Rasmussen, Lene Juel, 2012, In: Methods in molecular biology (Clifton, N.J.). 815, p. 25-38 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions

    Martín-Pardillos, A., Tsaalbi-Shtylik, A., Chen, S., Lazare, S., Van Os, R. P., Dethmers-Ausema, A., Fakouri, N. B., Bosshard, M., Aprigliano, R., Van Loon, B., Salvatori, D. C. F., Hashimoto, K., Van Der Spek, C. D., Moriya, M., Rasmussen, Lene Juel, De Haan, G., Raaijmakers, M. H. G. P. & De Wind, N., 2017, In: Blood. 130, 13, p. 1523-1534 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Genomic instability and aging

    Li, Zhiquan, Anugula, Sharath & Rasmussen, Lene Juel, 2022, Aging: From Fundamental Biology to Societal Impact. Oliveira, P. J. & Malva, J. O. (eds.). Academic Press, p. 275-295 21 p.

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  5. Growth-rate-dependent transcription initiation from the dam P2 promoter

    Rasmussen, Lene Juel, Løbner-Olesen, Anders & Marinus, M. G., 1995, In: Gene. 157, 1-2, p. 213-215 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Helicobacter pylori infection generates genetic instability in gastric cells

    Machado, A. M. D., Figueiredo, C., Seruca, R. & Rasmussen, Lene Juel, 2010, In: BBA General Subjects. 1806, 1, p. 58-65 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells

    Machado, A. M. D., Figueiredo, C., Touati, E., Máximo, V., Sousa, S., Michel, V., Carneiro, F., Nielsen, Finn Cilius, Seruca, R. & Rasmussen, Lene Juel, 2009, In: Clinical Cancer Research. 15, 9, p. 2995-3002 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor

    Bisgaard, Hanne Cathrine, Holmskov, U., Santoni Rugiu, Eric, Nagy, P., Nielsen, O., Ott, P., Hage, E., Dalhoff, Kim, Rasmussen, Lene Juel & Tygstrup, N., 2002, In: American Journal of Pathology. 161, 4, p. 1187-1198 12 p., 64395.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Heterogeneity of ductular reactions in adult rat and human liver revealed by novel expression of deleted in malignant brain tumor

    Bisgaard, Hanne Cathrine, Holmskov, U., Santoni Rugiu, Eric, Nagy, P., Nielsen, O., Ott, P., Hage, E., Dalhoff, Kim, Rasmussen, Lene Juel & Tygstrup, N., 2002, In: American Journal of Pathology. 161, 4, p. 1187-1198 12 p., 64395.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro

    Liu, D., Frederiksen, J. H., Liberti, S. E., Lützen, Anne Hoff Kjeldsen, Keijzers, G., Pena-Diaz, J. & Rasmussen, Lene Juel, 19 Sep 2017, In: Nucleic Acids Research. 45, 16, p. 9427-9440 14 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, G., Bohr, Vilhelm & Rasmussen, Lene Juel, 2015, In: Bioscience Reports. 35, 3, 13 p., e00206.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Impact of bacterial infections on aging and cancer: Impairment of DNA repair and mitochondrial function of host cells

    Strickertsson, J. A. B., Desler, Claus & Rasmussen, Lene Juel, Aug 2014, In: Experimental Gerontology. 56, p. 164-174 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure

    Lauritzen, K. H., Kleppa, L., Aronsen, J. M., Eide, L., Carlsen, H., Haugen, O. P., Sjaastad, I., Klungland, A., Rasmussen, Lene Juel, Attramadal, H., Storm-Mathisen, J. & Bergersen, L. H., 1 Aug 2015, In: American Journal of Physiology: Heart and Circulatory Physiology. 309, 3, p. H434-H449 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    In Silico screening for functional candidates amongst hypothetical proteins

    Desler, Claus, Suravajhala, P., Sanderhoff, M., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In: BMC Bioinformatics. 10, p. 289

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

    Lopez-Contreras, Andres, Specks, J., Barlow, J. H., Ambrogio, C., Desler, Claus, Vikingsson, S., Rodrigo-Perez, S., Green, H., Rasmussen, Lene Juel, Murga, M., Nussenzweig, A. & Fernandez-Capetillo, O., 1 Apr 2015, In: Genes & Development. 29, 7, p. 690-5 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline

    Desler, Claus, Frederiksen, J. H., Olsen, M. N. A., Maynard, S., Keijzers, G., Fagerlund, Birgitte, Mortensen, Erik Lykke, Osler, Merete, Lauritzen, Martin, Bohr, Vilhelm & Rasmussen, Lene Juel, Nov 2015, In: Mitochondrion. 25, p. 34-7 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours

    Harpelunde Poulsen, K., Nielsen, J. E., Grønkær Toft, B., Joensen, Ulla Nordström, Rasmussen, Lene Juel, Blomberg Jensen, M., Mitchell, R. T., Juul, Anders, Rajpert-De Meyts, E. & Jørgensen, Anders, 2020, In: BMC Cancer. 20, 1, 14 p., 349.

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Information, involvement, self-care and support—The needs of caregivers of people with stroke: A grounded theory approach

    Lobo, E. H., Frølich, Anne, Abdelrazek, M., Rasmussen, Lene Juel, Grundy, J., Livingston, P. M., Islam, S. M. S. & Kensing, Finn, 2023, In: PLoS ONE. 18, 1, p. 1-25 25 p., e0281198.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus

    Thomsen, Kirsten Joan, Yokota, T., Hasan-Olive, M. M., Sherazi, N., Fakouri, N. B., Desler, Claus, Regnell, C. E., Larsen, S., Rasmussen, Lene Juel, Dela, Flemming, Bergersen, L. H. & Lauritzen, Martin, 2018, In: Neurobiology of Aging. 61, p. 215-224 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, S., Han, X., Akbari, M., Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In: Nucleic Acids Research. 48, 12, p. 6530–6546

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Interactions between mitochondrial dysfunction and other hallmarks of aging: Paving a path toward interventions that promote healthy old age

    Li, Yuan, Berliocchi, Laura, Li, Zhiquan & Rasmussen, Lene Juel, 2024, In: Aging Cell. 23, 1, 12 p., e13942.

    Research output: Contribution to journal › Review › Research › peer-review

  22. Published

    Interventions for age-related diseases: Shifting the paradigm

    Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, Andres, Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, Lene Juel, Xapelli, S., Ellam, T. & Bellantuono, I., Dec 2016, In: Mechanisms of Ageing and Development. 160, p. 69-92 24 p.

    Research output: Contribution to journal › Review › Research › peer-review

  23. Published

    Introducing the hypothome: a way to integrate predicted proteins in interactomes

    Desler, Claus, Zambach, S., Suravajhala, P. & Rasmussen, Lene Juel, 2014, In: International Journal of Bioinformatics Research and Applications. 10, 6, p. 647-52 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours

    Rudolph, C., Melau, C., Nielsen, J. E., Jensen, K. V., Liu, D., Pena-Diaz, J., Meyts, E. R., Rasmussen, Lene Juel & Jorgensen, A., 2017, In: Cellular Oncology. 40, 4, p. 341-355

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

    Hansen, T. L., Rasmussen, Lene Juel, Desler, Claus, Frederiksen, J. B., Espersen, M. L. M. & Singh, K. K., 2012, In: Journal of Aging Research. 2012, p. 192503 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Is hEXO1 a cancer predisposing gene?

    Liberti, S. E. & Rasmussen, Lene Juel, Aug 2004, In: Molecular Cancer Research. 2, 8, p. 427-32 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction

    Christensen, Christa Lykke, Helge, Jørn Wulff, Krasnik, Allan, Kriegbaum, Margit, Rasmussen, Lene Juel, Hickson, Ian David, Liisberg, Kasper Bering, Oxlund, Bjarke, Bruun, B., Lau, Sofie Rosenlund, Olsen, M. N. A., Andersen, John Sahl, Heltberg, Andreas Søndergaard, Kuhlman, A. C. B., Morville, T. H., Dohlmann, T. L., Larsen, Steen & Dela, Flemming, 2016, In: Scandinavian Journal of Public Health. 44, 5, p. 534-539 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    MERTK Acts as a costimulatory receptor on human cd8 t cells

    Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, Mads Hald, Olofsson, G. H., Svane, Inge Marie, Rasmussen, Lene Juel, Met, Özcan, Becker, J. C., dqp123, dqp123, Desler, Claus & Straten, P. T., 2019, In: Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    MRE11A: a novel negative regulator of human DNA mismatch repair

    Du, D., Yang, Y., Wang, G., Chen, L., Guan, X., Rasmussen, Lene Juel & Liu, D., 2023, bioRxiv, 34 p.

    Research output: Working paper › Preprint › Research

  30. Published

    Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies

    Wang, H. L., Siow, R., Schmauck-Medina, T., Zhang, J., Sandset, P. M., Filshie, C., Lund, Ø., Partridge, L., Bergersen, L. H., Juel Rasmussen, L., Palikaras, K., Sotiropoulos, I., Storm-Mathisen, J., Rubinsztein, D. C., Spillantini, M. G., De Zeeuw, C. I., Watne, L. O., Vyhnalek, M., Veverova, K., Liang, K. X. & 18 others, Tavernarakis, N., Bohr, Vilhelm, Yokote, K., Saarela, J., Nilsen, H., Gonos, E. S., Scheibye-Knudsen, Morten, Chen, G., Kato, H., Selbæk, G., Fladby, T., Nilsson, P., Simonsen, A., Aarsland, D., Lautrup, S., Ottersen, O. P., Cox, L. S. & Fang, E. F., 2024, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 79, 4, 10 p., glae029.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Mitochondria as determinant of nucleotide pools and chromosomal stability

    Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S., Kulawiec, M., Singh, K. K. & Rasmussen, Lene Juel, 1 Dec 2007, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Mitochondria in biology and medicine

    Desler, Claus & Rasmussen, Lene Juel, Jul 2012, In: Mitochondrion. 12, 4, p. 472-6 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Mitochondria in biology and medicine--2012

    Desler, Claus & Rasmussen, Lene Juel, May 2014, In: Mitochondrion. 16, p. 2-6 5 p.

    Research output: Contribution to journal › Review › Research › peer-review

  34. Published

    Mitochondria in health and disease: 3rd annual conference of society for mitochondrial research and medicine - 19-20 december 2013 - bengaluru, India

    Durhuus, J. A., Desler, Claus & Rasmussen, Lene Juel, Jan 2015, In: Mitochondrion. 20, p. 7-12 6 p.

    Research output: Contribution to journal › Conference article › Research › peer-review

  35. Published

    Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

    Bjerregaard, Victoria Alexandra, Schönewolf-Greulich, B., Rasmussen, Lene Juel, Desler, Claus & Tümer, Asuman Zeynep, 2020, In: Frontiers in Neurology. 11, 9 p., 163.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Mitochondrial dysfunction induced by variation in the non-coding genome – A proposed workflow to improve diagnostics

    du Mee, D. J. M., Bak, M., Østergaard, Elsebet & Rasmussen, Lene Juel, 2020, In: Mitochondrion. 53, p. 255-259

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Mitochondrial oxidative phosphorylation capacity of cryopreserved cells

    Lauridsen, P. E., Rasmussen, Lene Juel & Desler, Claus, 2019, In: Mitochondrion. 47, p. 47-53 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules

    Peeters, M. J. W., Aehnlich, P., Pizzella, A., Mølgaard, K., Seremet, T., Met, Özcan, Rasmussen, Lene Juel, thor Straten, P. & Desler, Claus, 2021, In: Frontiers in Immunology. 12, 718863.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis

    Kermanizadeh, A., Jantzen, K., Ward, M. B., Durhuus, J. A., Rasmussen, Lene Juel, Loft, Steffen & Møller, Peter, Mar 2017, In: Nanotoxicology. 11, 2, p. 184-200 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Natural selection of mitochondria during somatic lifetime promotes healthy aging

    Rodell, A., Rasmussen, Lene Juel, Bergersen, L. H., Singh, K. K. & Gjedde, Albert, 2013, In: Frontiers in Neuroenergetics. 5, p. 1-6 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary

    Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., Li, Z., Shiloh, Y., Opresko, P. L., Egly, J. M., Kirkwood, T., Verdin, E., Bohr, V. A., Cox, L. S., Stevnsner, T., Rasmussen, L. J. & 1 others, Fang, E. F., 2022, In: Aging. 14, 16, p. 6829-6839 11 p.

    Research output: Contribution to journal › Review › Research › peer-review

  42. Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

    de Souza-Pinto, N. C., Mason, P. A., Hashiguchi, K., Weissman, L., Tian, J., Guay, D., Lebel, M., Stevnsner, T. V., Rasmussen, Lene Juel & Bohr, V. A., 2009, In: DNA Repair. 8, 6, p. 704-19 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Novel growth rate control of dam gene expression in Escherichia coli

    Rasmussen, Lene Juel, Marinus, M. G. & Løbner-Olesen, Anders, 1994, In: Molecular Microbiology. 12, 4, p. 631-638 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

    Knudsen, N. Ø., Nielsen, Finn Cilius, Vinther, L., Bertelsen, R., Holten-Andersen, S., Liberti, S. E., Hofstra, R., Kooi, K. & Rasmussen, Lene Juel, 2007, In: Nucleic Acids Research. 35, 8, p. 2609-19 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities

    Knudsen, N. Ø., Andersen, S. D., Lützen, A., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 2009, In: DNA Repair. 8, 6, p. 682-9 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation

    Toft-Kehler, A. K., Gurubaran, I. S., Desler, Claus, Rasmussen, Lene Juel, Jensen, Dorte Skytt & Kolko, Miriam, May 2016, In: Investigative Ophthalmology & Visual Science. 57, 6, p. 2721-2728

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

    Jantzen, K., Roursgaard, Martin, Desler, Claus, Loft, Steffen, Rasmussen, Lene Juel & Møller, Peter, Nov 2012, In: Mutagenesis. 27, 6, p. 693-701 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Partial inhibition of mitochondrial-linked pyrimidine synthesis increases tumorigenic potential and lysosome accumulation

    Desler, Claus, Durhuus, J. A., Hansen, T. L. L., Anugula, Sharath, Zelander, N. T., Bøggild, S. & Rasmussen, Lene Juel, 2022, In: Mitochondrion. 64, p. 73-81 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future

    Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Dec 2012, In: Human Mutation. 33, 12, p. 1617-25 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Pooled analysis of frontal lobe transcriptomic data identifies key mitophagy gene changes in Alzheimer's disease brain

    Mei, T., Li, Yuan, Orduña Dolado, A., Li, Zhiquan, Andersson, Robin, Berliocchi, Laura & Rasmussen, Lene Juel, 2023, In: Frontiers in Aging Neuroscience. 15, 14 p., 1101216.

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 13558388