Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    Influence of Nodal signalling on pluripotency factor expression, tumour cell proliferation and cisplatin-sensitivity in testicular germ cell tumours

    Harpelunde Poulsen, K., Nielsen, J. E., Grønkær Toft, B., Joensen, Ulla Nordström, Rasmussen, Lene Juel, Blomberg Jensen, M., Mitchell, R. T., Juul, Anders, Rajpert-De Meyts, E. & Jørgensen, Anders, 2020, In : BMC Cancer. 20, 1, 14 p., 349.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus

    Thomsen, Kirsten Joan, Yokota, T., Hasan-Olive, M. M., Sherazi, N., Fakouri, N. B., Madsen, Claus Desler, Regnell, C. E., Larsen, S., Rasmussen, Lene Juel, Dela, Flemming, Bergersen, Linda Hildegard & Lauritzen, Martin, 2018, In : Neurobiology of Aging. 61, p. 215-224 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 20 May 2020, In : Nucleic Acids Research. 45, 12, p. 6530–6546

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Interventions for age-related diseases: Shifting the paradigm

    Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, Andres, Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, Lene Juel, Xapelli, S., Ellam, T. & Bellantuono, I., Dec 2016, In : Mechanisms of Ageing and Development. 160, p. 69-92 24 p.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Introducing the hypothome: a way to integrate predicted proteins in interactomes

    Madsen, Claus Desler, Zambach, S., Suravajhala, P. & Rasmussen, Lene Juel, 2014, In : International Journal of Bioinformatics Research and Applications. 10, 6, p. 647-52 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours

    Rudolph, C., Melau, C., Nielsen, J. E., Jensen, K. V., Liu, D., Pena-Diaz, J., Meyts, E. R., Rasmussen, Lene Juel & Jorgensen, A., 2017, In : Cellular Oncology. 40, 4, p. 341-355

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

    Hansen, T. L., Rasmussen, Lene Juel, Madsen, Claus Desler, Frederiksen, J. B., Espersen, M. L. M. & Singh, K. K., 2012, In : Journal of Aging Research. 2012, p. 192503 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Is hEXO1 a cancer predisposing gene?

    Liberti, S. E. & Rasmussen, Lene Juel, Aug 2004, In : Molecular Cancer Research. 2, 8, p. 427-32 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published
  10. Published

    MERTK Acts as a costimulatory receptor on human cd8 t cells

    Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, Mads Hald, Olofsson, G. H., Svane, Inge Marie, Rasmussen, Lene Juel, Met, Özcan, Becker, J. C., dqp123, dqp123, Madsen, Claus Desler & thor Straten, Per, 2019, In : Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Mitochondria as determinant of nucleotide pools and chromosomal stability

    Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S., Kulawiec, M., Singh, K. K. & Rasmussen, Lene Juel, 1 Dec 2007, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Mitochondria in biology and medicine

    Madsen, Claus Desler & Rasmussen, Lene Juel, Jul 2012, In : Mitochondrion. 12, 4, p. 472-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Mitochondria in biology and medicine--2012

    Madsen, Claus Desler & Rasmussen, Lene Juel, May 2014, In : Mitochondrion. 16, p. 2-6 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  14. Published

    Mitochondria in health and disease: 3rd annual conference of society for mitochondrial research and medicine - 19-20 december 2013 - bengaluru, India

    Durhuus, J. A., Madsen, Claus Desler & Rasmussen, Lene Juel, Jan 2015, In : Mitochondrion. 20, p. 7-12 6 p.

    Research output: Contribution to journalConference articleResearchpeer-review

  15. Published

    Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

    Bjerregaard, V. A., Schönewolf-Greulich, B., Rasmussen, Lene Juel, Madsen, Claus Desler & Tümer, Asuman Zeynep, 2020, In : Frontiers in Neurology. 11, 9 p., 163.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Accepted/In press

    Mitochondrial dysfunction induced by variation in the non-coding genome – A proposed workflow to improve diagnostics

    du Mee, D. J. M., Bak, Mads, Østergaard, Elsebet & Rasmussen, Lene Juel, 2020, (Accepted/In press) In : Mitochondrion.

    Research output: Contribution to journalLetterResearchpeer-review

  17. Published

    Mitochondrial oxidative phosphorylation capacity of cryopreserved cells

    Lauridsen, P. E., Rasmussen, Lene Juel & Madsen, Claus Desler, 2019, In : Mitochondrion. 47, p. 47-53 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis

    Kermanizadeh, A., Jantzen, K., Ward, M. B., Durhuus, J. A., Rasmussen, Lene Juel, Loft, Steffen & Møller, Peter, Mar 2017, In : Nanotoxicology. 11, 2, p. 184-200 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Natural selection of mitochondria during somatic lifetime promotes healthy aging

    Rodell, A., Rasmussen, Lene Juel, Bergersen, Linda Hildegard, Singh, K. K. & Gjedde, Albert, 2013, In : Frontiers in Neuroenergetics. 5, p. 1-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

    de Souza-Pinto, N. C., Mason, P. A., Hashiguchi, K., Weissman, L., Tian, J., Guay, D., Lebel, M., Stevnsner, T. V., Rasmussen, Lene Juel & Bohr, V. A., 2009, In : DNA Repair. 8, 6, p. 704-19 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Novel growth rate control of dam gene expression in Escherichia coli

    Rasmussen, Lene Juel, Marinus, M. G. & Løbner-Olesen, Anders, May 1994, In : Molecular Microbiology. 12, 4, p. 631-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

    Knudsen, N. Ø., Nielsen, Finn Cilius, Vinther, L., Bertelsen, R., Holten-Andersen, S., Liberti, S. E., Hofstra, R., Kooi, K. & Rasmussen, Lene Juel, 2007, In : Nucleic Acids Research. 35, 8, p. 2609-19 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities

    Knudsen, N. Ø., Andersen, S. D., Lützen, A., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 2009, In : DNA Repair. 8, 6, p. 682-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation

    Toft-Kehler, A. K., Gurubaran, I. S., Madsen, Claus Desler, Rasmussen, Lene Juel, Jensen, Dorte Skytt & Kolko, Miriam, May 2016, In : Investigative Ophthalmology & Visual Science. 57, 6, p. 2721-2728

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

    Jantzen, K., Roursgaard, Martin, Madsen, Claus Desler, Loft, Steffen, Rasmussen, Lene Juel & Møller, Peter, Nov 2012, In : Mutagenesis. 27, 6, p. 693-701 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future

    Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Dec 2012, In : Human Mutation. 33, 12, p. 1617-25 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations

    Nielsen, S. V., Stein, Amelie, Dinitzen, A. B., Papaleo, E., Tatham, M. H., Poulsen, E. G., Kassem, M. M., Rasmussen, Lene Juel, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 19 Apr 2017, In : PLoS Genetics. 13, 4, 26 p., e1006739.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, Guido, Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In : Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells

    Maynard, S., Keijzers, Guido, Gram, M., Madsen, Claus Desler, Bendix, L., Budtz-Joergensen, Esben, Molbo, Drude, Croteau, D. L., Osler, Merete, Stevnsner, T. V., Rasmussen, Lene Juel, Dela, Flemming, Avlund, K. & Bohr, Vilhelm, 30 Nov 2013, In : Aging. p. 850-864 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions

    Madsen, Claus Desler, Johannessen, C. & Rasmussen, Lene Juel, 2009, In : Chemico-Biological Interactions. 177, 3, p. 212-7 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance

    Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Jun 2013, In : Human Mutation. 34, 6, p. 923-4 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The LipB protein is a negative regulator of dam gene expression in Escherichia coli

    Vaisvila, R., Rasmussen, Lene Juel, Løbner-Olesen, Anders, von Freiesleben, U. & Marinus, M. G., 15 Nov 2000, In : B B A - Reviews on Cancer. 1494, 1-2, p. 43-53 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    The challenges of human population ageing

    Sander, M., Oxlund, Bjarke, Jespersen, Astrid Pernille, Krasnik, Allan, Mortensen, Erik Lykke, Westendorp, Rudi GJ & Rasmussen, Lene Juel, Mar 2015, In : Age and Ageing. 44, 2, p. 185-7 3 p.

    Research output: Contribution to journalJournal articleCommunication

  36. Published

    The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism

    Madsen, Claus Desler, Lykke, A. & Rasmussen, Lene Juel, 1 Jan 2010, In : Journal of Nucleic Acids. 2010

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, Guido, Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In : Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    The importance of mitochondrial DNA in aging and cancer

    Madsen, Claus Desler, Espersen, M. L. M., Singh, K. K. & Rasmussen, Lene Juel, 30 Mar 2011, In : Journal of Aging Research. 2011, p. 407536

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

    Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Madsen, Claus Desler, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In : Biochemical Pharmacology. 155, p. 92-101 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, Guido, Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. The role of mitochondrial dNTP levels in cells with reduced TK2 activity

    Desler, C., Munch-Petersen, B. & Rasmussen, Lene Juel, 2006, In : Nucleosides, nucleotides & nucleic acids. 25, 9-11, p. 1171-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease

    Madsen, Claus Desler, Lillenes, M. S., Tønjum, T. & Rasmussen, Lene Juel, 2018, In : Current Medicinal Chemistry. 25, 40, p. 5578 - 5587

    Research output: Contribution to journalReviewResearchpeer-review

  43. Published

    Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage

    Skovgaard, T., Rasmussen, Lene Juel & Munch-Petersen, B., 2010, In : Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 347-51 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia

    Bundgaard, A., Qvortrup, Klaus, Rasmussen, Lene Juel & Fago, A., 2019, In : Journal of Experimental Biology. 222, 11, 9 p., jeb200410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Accepted/In press

    Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

    Drost, M., Tiersma, Y., Glubb, D., Kathe, S., van Hees, S., Calléja, F., Zonneveld, J. B. M., Boucher, K. M., Ramlal, R. P. E., Thompson, B. A., Rasmussen, Lene Juel, Greenblatt, M. S., Lee, A., Spurdle, A. B., Tavtigian, S. V. & de Wind, N., 2020, (Accepted/In press) In : Genetics in Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

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