Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, Guido, Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In : D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells

    Machado, A. M. D., Desler, C., Boggild, S., Strickertsson, J. A. B., Friis-Hansen, L., Figueiredo, C., Seruca, R. & Rasmussen, Lene Juel, 2013, In : Mechanisms of Ageing and Development. 134, 10, p. 460-466 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

    Hasan-Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, Lene Juel, Storm-Mathisen, J. & Bergersen, Linda Hildegard, 2019, In : Neurochemical Research. 44, 1, p. 22-37 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression

    Syed, S., Madsen, Claus Desler, Rasmussen, Lene Juel & Schmidt, K. H., Dec 2016, In : P L o S Genetics. 12, 12, 28 p., e1006451.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome

    Drost, M., Tiersma, Y., Thompson, B. A., Frederiksen, J. H., Keijzers, Guido, Glubb, D., Kathe, S., Osinga, J., Westers, H., Pappas, L., Boucher, K. M., Molenkamp, S., Zonneveld, J. B., van Asperen, C. J., Goldgar, D. E., Wallace, S. S., Sijmons, R. H., Spurdle, A. B., Rasmussen, Lene Juel, Greenblatt, M. S., de Wind, N. & Tavtigian, S. V., 2019, In : Genetics in Medicine. 21, p. 1486–1496

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants

    Drost, M., Zonneveld, J. B. M., van Hees, S., Rasmussen, Lene Juel, Hofstra, R. M. W. & de Wind, N., 2012, In : Human Mutation. 33, 3, p. 488-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Acquired Localized Cutis Laxa due to Increased Elastin Turnover

    Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, Michael, 14 Jun 2016, In : Case Reports in Dermatology. 8, 1, p. 42-51 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Aging, longevity and health

    Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In : Mechanisms of Ageing and Development. p. 522-32 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells

    Cheng, C., Edin, N. F. J., Lauritzen, K. H., Aspmodal, I., Christoffersen, S., Jian, L., Rasmussen, Lene Juel, Pettersen, E. O., Xiaoqun, G. & Bergersen, Linda Hildegard, Jun 2012, In : Cellular oncology (Dordrecht). 35, 3, p. 217-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste

    Bouchami, O., Sghaier, H., Madsen, Claus Desler, Lazim, H., Saidi, M., Rasmussen, Lene Juel & Ben Hassan, A., 2011, In : Annals of Microbiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Thompson, B. A., Spurdle, A. B., Plazzer, J., Greenblatt, M. S., Akagi, K., Al-Mulla, F., Bapat, B., Bernstein, I., Capellá, G., den Dunnen, J. T., du Sart, D., Fabre, A., Farrell, M. P., Farrington, S. M., Frayling, I. M., Frebourg, T., Goldgar, D. E., Heinen, C. D., Holinski-Feder, E., Kohonen-Corish, M., Robinson, K. L., Leung, S. Y., Martins, A., Moller, P., Morak, M., Nystrom, M., Peltomaki, P., Pineda, M., Qi, M., Ramesar, R., Rasmussen, Lene Juel, Royer-Pokora, B., Scott, R. J., Sijmons, R., Tavtigian, S. V., Tops, C. M., Weber, T., Wijnen, J., Woods, M. O., Macrae, F., Genuardi, M., Castillejo, A., Sexton, A., Chan, A. K. W., Viel, A., Blanco, A., French, A., Laner, A., Wagner, A., van den Ouweland, A. & on behalf of InSiGHT, O. B. O. I., Feb 2014, In : Nature Genetics. 46, 2, p. 107-115 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Approaches to diagnose DNA mismatch repair gene defects in cancer

    Peña-Diaz, J. & Rasmussen, Lene Juel, Feb 2016, In : DNA Repair. 38, p. 147-154 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome

    Rasmussen, Lene Juel & Heinen, C. D., 15 Apr 2014

    Research output: Other contributionNet publication - Internet publicationCommunication

  14. Published

    Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance

    Maynard, S., Keijzers, Guido, Hansen, Åse Marie, Osler, Merete, Molbo, Drude, Bendix, L., Møller, Peter, Loft, Steffen, Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T. V., Rasmussen, Lene Juel, Avlund, K. & Bohr, Vilhelm, Jan 2015, In : Acta Physiologica (Print). 213, 1, p. 156-170 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Bacterial infection increases risk of carcinogenesis by targeting mitochondria

    Strickertsson, J. A. B., Madsen, Claus Desler & Rasmussen, Lene Juel, Dec 2017, In : Seminars in Cancer Biology. 47, p. 95-100 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

    Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, Guido, Nielsen, Finn Cilius, Charbonnier, J., Bohr, Vilhelm & Rasmussen, Lene Juel, 2 Jan 2011, In : DNA Repair. 10, 1, p. 73-86 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome

    Ou, J., Rasmussen, M., Westers, H., Andersen, S. D., Jager, P. O., Kooi, K. A., Niessen, R. C., Eggen, B. J. L., Nielsen, Finn Cilius, Kleibeuker, J. H., Sijmons, R. H., Rasmussen, Lene Juel & Hofstra, R. M. W., 2009, In : Genes, Chromosomes & Cancer. 48, 4, p. 340-50 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage

    Hopkinson, B. M., Madsen, Claus Desler, Kalisz, M., Vestentoft, P. S., Rasmussen, Lene Juel & Bisgaard, Hanne Cathrine, 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 11 p., 5080128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Cadmium inhibits human DNA mismatch repair in vivo

    Lützen, A., Liberti, S. E. & Rasmussen, Lene Juel, 13 Aug 2004, In : Biochemical and Biophysical Research Communications. 321, 1, p. 21-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair

    Dherin, C., Gueneau, E., Francin, M., Nunez, M., Miron, S., Liberti, S. E., Rasmussen, Lene Juel, Zinn-Justin, S., Gilquin, B., Charbonnier, J. & Boiteux, S., 2009, In : Molecular and Cellular Biology. 29, 3, p. 907-18 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population

    Rasmussen, Lene Juel, Shiloh, Y., Bergersen, Linda Hildegard, Sander, M., Bohr, Vilhelm & Tønjum, T., Oct 2013, In : Mechanisms of Ageing and Development. 134, 10, p. 427-33 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    DNA mismatch repair and its many roles in eukaryotic cells

    Liu, D., Keijzers, Guido & Rasmussen, Lene Juel, Jul 2017, In : Mutation Research - Reviews in Mutation Research. 773, p. 174-187 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients

    Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, Guido, Hansen, Åse Marie, Madsen, Claus Desler, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In : Aging. 7, 10, p. 793-815 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

    Heinen, C. D. & Rasmussen, Lene Juel, Jul 2012, In : Hereditary Cancer in Clinical Practice. 10, 1, p. 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases

    Larsen, N. B., Heiberg Engel, P. J., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In : Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 11, p. 839-48 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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