Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. 1994
  2. Published

    Novel growth rate control of dam gene expression in Escherichia coli

    Rasmussen, Lene Juel, Marinus, M. G. & Løbner-Olesen, Anders, 1994, In : Molecular Microbiology. 12, 4, p. 631-638 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 1995
  4. Growth-rate-dependent transcription initiation from the dam P2 promoter

    Rasmussen, Lene Juel, Løbner-Olesen, Anders & Marinus, M. G., 1995, In : Gene. 157, 1-2, p. 213-215 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2000
  6. The LipB protein is a negative regulator of dam gene expression in Escherichia coli

    Vaisvila, R., Rasmussen, Lene Juel, Løbner-Olesen, Anders, von Freiesleben, U. & Marinus, M. G., 2000, In : Biochimica et Biophysica Acta, Gene Structure and Expression. 1494, 1-2, p. 43-53 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2004
  8. Is hEXO1 a cancer predisposing gene?

    Liberti, S. E. & Rasmussen, Lene Juel, Aug 2004, In : Molecular Cancer Research. 2, 8, p. 427-32 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Cadmium inhibits human DNA mismatch repair in vivo

    Lützen, A., Liberti, S. E. & Rasmussen, Lene Juel, 13 Aug 2004, In : Biochemical and Biophysical Research Communications. 321, 1, p. 21-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2006
  11. The role of mitochondrial dNTP levels in cells with reduced TK2 activity

    Desler, C., Munch-Petersen, B. & Rasmussen, Lene Juel, 2006, In : Nucleosides, nucleotides & nucleic acids. 25, 9-11, p. 1171-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. 2007
  13. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

    Knudsen, N. Ø., Nielsen, Finn Cilius, Vinther, L., Bertelsen, R., Holten-Andersen, S., Liberti, S. E., Hofstra, R., Kooi, K. & Rasmussen, Lene Juel, 2007, In : Nucleic Acids Research. 35, 8, p. 2609-19 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Mitochondria as determinant of nucleotide pools and chromosomal stability

    Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S., Kulawiec, M., Singh, K. K. & Rasmussen, Lene Juel, 1 Dec 2007, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2008
  16. Published

    Functional analysis of HNPCC-related missense mutations in MSH2

    Lützen, A., de Wind, N., Georgijevic, D., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 14 Oct 2008, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 645, 1-2, p. 44-55 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2009
  18. Published

    Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome

    Ou, J., Rasmussen, M., Westers, H., Andersen, S. D., Jager, P. O., Kooi, K. A., Niessen, R. C., Eggen, B. J. L., Nielsen, Finn Cilius, Kleibeuker, J. H., Sijmons, R. H., Rasmussen, Lene Juel & Hofstra, R. M. W., 2009, In : Genes, Chromosomes & Cancer. 48, 4, p. 340-50 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair

    Dherin, C., Gueneau, E., Francin, M., Nunez, M., Miron, S., Liberti, S. E., Rasmussen, Lene Juel, Zinn-Justin, S., Gilquin, B., Charbonnier, J. & Boiteux, S., 2009, In : Molecular and Cellular Biology. 29, 3, p. 907-18 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases

    Larsen, N. B., Heiberg Engel, P. J., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In : Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 11, p. 839-48 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells

    Machado, A. M. D., Figueiredo, C., Touati, E., Máximo, V., Sousa, S., Michel, V., Carneiro, F., Nielsen, Finn Cilius, Seruca, R. & Rasmussen, Lene Juel, 2009, In : Clinical Cancer Research. 15, 9, p. 2995-3002 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    In Silico screening for functional candidates amongst hypothetical proteins

    Madsen, Claus Desler, Suravajhala, P., Sanderhoff, M., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In : BMC Bioinformatics. 10, p. 289

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Novel DNA mismatch-repair activity involving YB-1 in human mitochondria

    de Souza-Pinto, N. C., Mason, P. A., Hashiguchi, K., Weissman, L., Tian, J., Guay, D., Lebel, M., Stevnsner, T. V., Rasmussen, Lene Juel & Bohr, V. A., 2009, In : DNA Repair. 8, 6, p. 704-19 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities

    Knudsen, N. Ø., Andersen, S. D., Lützen, A., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 2009, In : DNA Repair. 8, 6, p. 682-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Repair of DNA damage induced by anthanthrene, a polycyclic aromatic hydrocarbon (PAH) without bay or fjord regions

    Madsen, Claus Desler, Johannessen, C. & Rasmussen, Lene Juel, 2009, In : Chemico-Biological Interactions. 177, 3, p. 212-7 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2010
  27. Published

    Helicobacter pylori infection generates genetic instability in gastric cells

    Machado, A. M. D., Figueiredo, C., Seruca, R. & Rasmussen, Lene Juel, 2010, In : BBA General Subjects. 1806, 1, p. 58-65 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage

    Skovgaard, T., Rasmussen, Lene Juel & Munch-Petersen, B., 2010, In : Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 347-51 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The effect of mitochondrial dysfunction on cytosolic nucleotide metabolism

    Madsen, Claus Desler, Lykke, A. & Rasmussen, Lene Juel, 1 Jan 2010, In : Journal of Nucleic Acids. 2010

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. 2011
  31. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste

    Bouchami, O., Sghaier, H., Madsen, Claus Desler, Lazim, H., Saidi, M., Rasmussen, Lene Juel & Ben Hassan, A., 2011, In : Annals of Microbiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

    Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, Guido, Nielsen, Finn Cilius, Charbonnier, J., Bohr, Vilhelm & Rasmussen, Lene Juel, 2 Jan 2011, In : DNA Repair. 10, 1, p. 73-86 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    The importance of mitochondrial DNA in aging and cancer

    Madsen, Claus Desler, Espersen, M. L. M., Singh, K. K. & Rasmussen, Lene Juel, 30 Mar 2011, In : Journal of Aging Research. 2011, p. 407536

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Aging, longevity and health

    Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In : Mechanisms of Ageing and Development. p. 522-32 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. 2012
  36. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants

    Drost, M., Zonneveld, J. B. M., van Hees, S., Rasmussen, Lene Juel, Hofstra, R. M. W. & de Wind, N., 2012, In : Human Mutation. 33, 3, p. 488-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Genome-wide screens for expressed hypothetical proteins

    Madsen, Claus Desler, Durhuus, J. A. & Rasmussen, Lene Juel, 2012, In : Methods in molecular biology (Clifton, N.J.). 815, p. 25-38 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

    Hansen, T. L., Rasmussen, Lene Juel, Madsen, Claus Desler, Frederiksen, J. B., Espersen, M. L. M. & Singh, K. K., 2012, In : Journal of Aging Research. 2012, p. 192503 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, Guido, Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In : D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells

    Cheng, C., Edin, N. F. J., Lauritzen, K. H., Aspmodal, I., Christoffersen, S., Jian, L., Rasmussen, Lene Juel, Pettersen, E. O., Xiaoqun, G. & Bergersen, Linda Hildegard, Jun 2012, In : Cellular oncology (Dordrecht). 35, 3, p. 217-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

    Heinen, C. D. & Rasmussen, Lene Juel, Jul 2012, In : Hereditary Cancer in Clinical Practice. 10, 1, p. 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Mitochondria in biology and medicine

    Madsen, Claus Desler & Rasmussen, Lene Juel, Jul 2012, In : Mitochondrion. 12, 4, p. 472-6 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

    Jantzen, K., Roursgaard, Martin, Madsen, Claus Desler, Loft, Steffen, Rasmussen, Lene Juel & Møller, Peter, Nov 2012, In : Mutagenesis. 27, 6, p. 693-701 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, Guido, Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In : Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

    Andersen, S. D., Liberti, S. E., Lützen, A., Drost, M., Bernstein, I., Nilbert, Mef Christina, Dominguez, M., Nyström, M., Hansen, T. V. O., Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, Finn Cilius, Tørring, P. M. & Rasmussen, Lene Juel, Dec 2012, In : Human Mutation. 33, 12, p. 1647-1655 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future

    Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Dec 2012, In : Human Mutation. 33, 12, p. 1617-25 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. 2013
  48. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells

    Machado, A. M. D., Desler, C., Boggild, S., Strickertsson, J. A. B., Friis-Hansen, L., Figueiredo, C., Seruca, R. & Rasmussen, Lene Juel, 2013, In : Mechanisms of Ageing and Development. 134, 10, p. 460-466 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells

    Strickertsson, J. A. B., Madsen, Claus Desler, Martin-Bertelsen, T., Machado, A. M. D., Wadstrøm, T., Winther, Ole, Rasmussen, Lene Juel & Friis-Hansen, L., 2013, In : PLOS ONE. 8, 4, p. 1-13 13 p., e63147.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients

    Petersen, S. M., Dandanell, M., Rasmussen, Lene Juel, Gerdes, Anne-Marie Axø, Krogh, L. N., Bernstein, I., Okkels, H., Wikman, F., Nielsen, Finn Cilius & Hansen, T. V. O., 2013, In : BMC Medical Genetics. 14, p. 103

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 23, p. 9403-9408 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Natural selection of mitochondria during somatic lifetime promotes healthy aging

    Rodell, A., Rasmussen, Lene Juel, Bergersen, Linda Hildegard, Singh, K. K. & Gjedde, Albert, 2013, In : Frontiers in Neuroenergetics. 5, p. 1-6 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance

    Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Jun 2013, In : Human Mutation. 34, 6, p. 923-4 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 4 Jun 2013, In : Proceedings of the National Academy of Science of the United States of America. 110, 23, p. 9403-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population

    Rasmussen, Lene Juel, Shiloh, Y., Bergersen, Linda Hildegard, Sander, M., Bohr, Vilhelm & Tønjum, T., Oct 2013, In : Mechanisms of Ageing and Development. 134, 10, p. 427-33 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells

    Maynard, S., Keijzers, Guido, Gram, M., Madsen, Claus Desler, Bendix, L., Budtz-Joergensen, Esben, Molbo, Drude, Croteau, D. L., Osler, Merete, Stevnsner, T. V., Rasmussen, Lene Juel, Dela, Flemming, Avlund, K. & Bohr, Vilhelm, 30 Nov 2013, In : Aging. p. 850-864 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. 2014
  58. Published

    Introducing the hypothome: a way to integrate predicted proteins in interactomes

    Madsen, Claus Desler, Zambach, S., Suravajhala, P. & Rasmussen, Lene Juel, 2014, In : International Journal of Bioinformatics Research and Applications. 10, 6, p. 647-52 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database

    Thompson, B. A., Spurdle, A. B., Plazzer, J., Greenblatt, M. S., Akagi, K., Al-Mulla, F., Bapat, B., Bernstein, I., Capellá, G., den Dunnen, J. T., du Sart, D., Fabre, A., Farrell, M. P., Farrington, S. M., Frayling, I. M., Frebourg, T., Goldgar, D. E., Heinen, C. D., Holinski-Feder, E., Kohonen-Corish, M., Robinson, K. L., Leung, S. Y., Martins, A., Moller, P., Morak, M., Nystrom, M., Peltomaki, P., Pineda, M., Qi, M., Ramesar, R., Rasmussen, Lene Juel, Royer-Pokora, B., Scott, R. J., Sijmons, R., Tavtigian, S. V., Tops, C. M., Weber, T., Wijnen, J., Woods, M. O., Macrae, F., Genuardi, M., Castillejo, A., Sexton, A., Chan, A. K. W., Viel, A., Blanco, A., French, A., Laner, A., Wagner, A., van den Ouweland, A. & on behalf of InSiGHT, O. B. O. I., Feb 2014, In : Nature Genetics. 46, 2, p. 107-115 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome

    Rasmussen, Lene Juel & Heinen, C. D., 15 Apr 2014

    Research output: Other contributionNet publication - Internet publicationCommunication

  61. Published

    Mitochondria in biology and medicine--2012

    Madsen, Claus Desler & Rasmussen, Lene Juel, May 2014, In : Mitochondrion. 16, p. 2-6 5 p.

    Research output: Contribution to journalReviewResearchpeer-review

  62. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein

    Dominguez-Valentin, M., Drost, M., Therkildsen, C., Rambech, E., Ehrencrona, H., Angleys, M., Lau Hansen, T., de Wind, N., Nilbert, Mef Christina & Rasmussen, Lene Juel, Jul 2014, In : Molecular Genetics & Genomic Medicine. 2, 4, p. 352-355 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Impact of bacterial infections on aging and cancer: Impairment of DNA repair and mitochondrial function of host cells

    Strickertsson, J. A. B., Madsen, Claus Desler & Rasmussen, Lene Juel, Aug 2014, In : Experimental Gerontology. 56, p. 164-174 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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