Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, Guido, Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In : D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

    Andersen, S. D., Liberti, S. E., Lützen, A., Drost, M., Bernstein, I., Nilbert, Mef Christina, Dominguez, M., Nyström, M., Hansen, T. V. O., Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, Finn Cilius, Tørring, P. M. & Rasmussen, Lene Juel, Dec 2012, In : Human Mutation. 33, 12, p. 1647-1655 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In : European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

    Bjerregaard, V. A., Schönewolf-Greulich, B., Rasmussen, Lene Juel, Madsen, Claus Desler & Tümer, Asuman Zeynep, 2020, In : Frontiers in Neurology. 11, 9 p., 163.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste

    Bouchami, O., Sghaier, H., Madsen, Claus Desler, Lazim, H., Saidi, M., Rasmussen, Lene Juel & Ben Hassan, A., 2011, In : Annals of Microbiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia

    Bundgaard, A., Qvortrup, Klaus, Rasmussen, Lene Juel & Fago, A., 2019, In : Journal of Experimental Biology. 222, 11, 9 p., jeb200410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells

    Cheng, C., Edin, N. F. J., Lauritzen, K. H., Aspmodal, I., Christoffersen, S., Jian, L., Rasmussen, Lene Juel, Pettersen, E. O., Xiaoqun, G. & Bergersen, Linda Hildegard, Jun 2012, In : Cellular oncology (Dordrecht). 35, 3, p. 217-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published
  10. The role of mitochondrial dNTP levels in cells with reduced TK2 activity

    Desler, C., Munch-Petersen, B. & Rasmussen, Lene Juel, 2006, In : Nucleosides, nucleotides & nucleic acids. 25, 9-11, p. 1171-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease

    Madsen, Claus Desler, Lillenes, M. S., Tønjum, T. & Rasmussen, Lene Juel, 2018, In : Current Medicinal Chemistry. 25, 40, p. 5578 - 5587

    Research output: Contribution to journalReviewResearchpeer-review

  12. Mitochondria as determinant of nucleotide pools and chromosomal stability

    Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S., Kulawiec, M., Singh, K. K. & Rasmussen, Lene Juel, 1 Dec 2007, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    In Silico screening for functional candidates amongst hypothetical proteins

    Madsen, Claus Desler, Suravajhala, P., Sanderhoff, M., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In : BMC Bioinformatics. 10, p. 289

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair

    Dherin, C., Gueneau, E., Francin, M., Nunez, M., Miron, S., Liberti, S. E., Rasmussen, Lene Juel, Zinn-Justin, S., Gilquin, B., Charbonnier, J. & Boiteux, S., 2009, In : Molecular and Cellular Biology. 29, 3, p. 907-18 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein

    Dominguez-Valentin, M., Drost, M., Therkildsen, C., Rambech, E., Ehrencrona, H., Angleys, M., Lau Hansen, T., de Wind, N., Nilbert, Mef Christina & Rasmussen, Lene Juel, Jul 2014, In : Molecular Genetics & Genomic Medicine. 2, 4, p. 352-355 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome

    Drost, M., Tiersma, Y., Thompson, B. A., Frederiksen, J. H., Keijzers, Guido, Glubb, D., Kathe, S., Osinga, J., Westers, H., Pappas, L., Boucher, K. M., Molenkamp, S., Zonneveld, J. B., van Asperen, C. J., Goldgar, D. E., Wallace, S. S., Sijmons, R. H., Spurdle, A. B., Rasmussen, Lene Juel, Greenblatt, M. S., de Wind, N. & Tavtigian, S. V., 2019, In : Genetics in Medicine. 21, p. 1486–1496

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 4 Jun 2013, In : Proceedings of the National Academy of Science of the United States of America. 110, 23, p. 9403-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants

    Drost, M., Zonneveld, J. B. M., van Hees, S., Rasmussen, Lene Juel, Hofstra, R. M. W. & de Wind, N., 2012, In : Human Mutation. 33, 3, p. 488-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 23, p. 9403-9408 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Accepted/In press

    Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

    Drost, M., Tiersma, Y., Glubb, D., Kathe, S., van Hees, S., Calléja, F., Zonneveld, J. B. M., Boucher, K. M., Ramlal, R. P. E., Thompson, B. A., Rasmussen, Lene Juel, Greenblatt, M. S., Lee, A., Spurdle, A. B., Tavtigian, S. V. & de Wind, N., 2020, (Accepted/In press) In : Genetics in Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Mitochondria in health and disease: 3rd annual conference of society for mitochondrial research and medicine - 19-20 december 2013 - bengaluru, India

    Durhuus, J. A., Madsen, Claus Desler & Rasmussen, Lene Juel, Jan 2015, In : Mitochondrion. 20, p. 7-12 6 p.

    Research output: Contribution to journalConference articleResearchpeer-review

  22. Published

    From powerhouse to perpetrator—mitochondria in health and disease

    Fakouri, N. B., Hansen, T. L., Madsen, Claus Desler, Anugula, Sharath & Rasmussen, Lene Juel, 2019, In : Biology. 8, 2, 15 p., 35.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Interventions for age-related diseases: Shifting the paradigm

    Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, Andres, Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, Lene Juel, Xapelli, S., Ellam, T. & Bellantuono, I., Dec 2016, In : Mechanisms of Ageing and Development. 160, p. 69-92 24 p.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Published

    Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?

    Hansen, T. L., Rasmussen, Lene Juel, Madsen, Claus Desler, Frederiksen, J. B., Espersen, M. L. M. & Singh, K. K., 2012, In : Journal of Aging Research. 2012, p. 192503 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    A Ketogenic Diet Improves Mitochondrial Biogenesis and Bioenergetics via the PGC1α-SIRT3-UCP2 Axis

    Hasan-Olive, M. M., Lauritzen, K. H., Ali, M., Rasmussen, Lene Juel, Storm-Mathisen, J. & Bergersen, Linda Hildegard, 2019, In : Neurochemical Research. 44, 1, p. 22-37 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays

    Heinen, C. D. & Rasmussen, Lene Juel, Jul 2012, In : Hereditary Cancer in Clinical Practice. 10, 1, p. 9

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Bioenergetic Changes during Differentiation of Human Embryonic Stem Cells along the Hepatic Lineage

    Hopkinson, B. M., Madsen, Claus Desler, Kalisz, M., Vestentoft, P. S., Rasmussen, Lene Juel & Bisgaard, Hanne Cathrine, 2017, In : Oxidative Medicine and Cellular Longevity. 2017, 11 p., 5080128.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The inhibitors of soluble adenylate cyclase 2-OHE, KH7, and bithionol compromise mitochondrial ATP production by distinct mechanisms

    Jakobsen, Emil, Lange, S. C., Andersen, Jens Velde, Madsen, Claus Desler, Kihl, H. F., Hohnholt, M., Stridh, M. H., Rasmussen, Lene Juel, Waagepetersen, Helle S. & Bak, Lasse Kristoffer, 2018, In : Biochemical Pharmacology. 155, p. 92-101 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

    Jantzen, K., Roursgaard, Martin, Madsen, Claus Desler, Loft, Steffen, Rasmussen, Lene Juel & Møller, Peter, Nov 2012, In : Mutagenesis. 27, 6, p. 693-701 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients

    Jensen, M. B., Dunn, C. A., Keijzers, Guido, Kulikowicz, T., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2012, In : Aging. 4, 11, p. 790-802 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    The role of RecQ helicases in non-homologous end-joining

    Keijzers, Guido, Maynard, S., Shamanna, R. A., Rasmussen, Lene Juel, Croteau, D. L. & Bohr, Vilhelm, Nov 2014, In : Critical Reviews in Biochemistry and Molecular Biology. 49, 6, p. 463-472 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  33. Published

    Human exonuclease 1 (EXO1) activity characterization and its function on FLAP structures

    Keijzers, Guido, Bohr, Vilhelm & Rasmussen, Lene Juel, 25 Apr 2015, In : Bioscience Reports. 35, 3, 23 p., e00206.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Exonuclease 1 and its versatile roles in DNA repair

    Keijzers, Guido, Liu, D. & Rasmussen, Lene Juel, 5 Aug 2016, In : Critical Reviews in Biochemistry and Molecular Biology. 51, 6, p. 440–451 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Published

    Nanomaterial-induced cell death in pulmonary and hepatic cells following exposure to three different metallic materials: The role of autophagy and apoptosis

    Kermanizadeh, A., Jantzen, K., Ward, M. B., Durhuus, J. A., Rasmussen, Lene Juel, Loft, Steffen & Møller, Peter, Mar 2017, In : Nanotoxicology. 11, 2, p. 184-200 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Nuclear translocation contributes to regulation of DNA excision repair activities

    Knudsen, N. Ø., Andersen, S. D., Lützen, A., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 2009, In : DNA Repair. 8, 6, p. 682-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)

    Knudsen, N. Ø., Nielsen, Finn Cilius, Vinther, L., Bertelsen, R., Holten-Andersen, S., Liberti, S. E., Hofstra, R., Kooi, K. & Rasmussen, Lene Juel, 2007, In : Nucleic Acids Research. 35, 8, p. 2609-19 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Differential expression of hMLH1 in sporadic human colorectal cancer tumors and distant metastases

    Larsen, N. B., Heiberg Engel, P. J., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In : Acta Pathologica Microbiologica et Immunologica Scandinavica. 117, 11, p. 839-48 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Mitochondrial oxidative phosphorylation capacity of cryopreserved cells

    Lauridsen, P. E., Rasmussen, Lene Juel & Madsen, Claus Desler, 2019, In : Mitochondrion. 47, p. 47-53 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Impaired dynamics and function of mitochondria caused by mtDNA toxicity leads to heart failure

    Lauritzen, K. H., Kleppa, L., Aronsen, J. M., Eide, L., Carlsen, H., Haugen, O. P., Sjaastad, I., Klungland, A., Rasmussen, Lene Juel, Attramadal, H., Storm-Mathisen, J. & Bergersen, Linda Hildegard, 1 Aug 2015, In : American Journal of Physiology: Heart and Circulatory Physiology. 309, 3, p. H434-H449 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks

    Liberti, S. E., Andersen, S. D., Wang, J., May, A., Miron, S., Perderiset, M., Keijzers, Guido, Nielsen, Finn Cilius, Charbonnier, J., Bohr, Vilhelm & Rasmussen, Lene Juel, 2 Jan 2011, In : DNA Repair. 10, 1, p. 73-86 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Is hEXO1 a cancer predisposing gene?

    Liberti, S. E. & Rasmussen, Lene Juel, Aug 2004, In : Molecular Cancer Research. 2, 8, p. 427-32 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    DNA mismatch repair and its many roles in eukaryotic cells

    Liu, D., Keijzers, Guido & Rasmussen, Lene Juel, Jul 2017, In : Mutation Research - Reviews in Mutation Research. 773, p. 174-187 14 p.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro

    Liu, D., Frederiksen, J. H., Liberti, S. E., Lützen, A., Keijzers, Guido, Pena-Diaz, J. & Rasmussen, Lene Juel, 19 Sep 2017, In : Nucleic Acids Research. 45, 16, p. 9427-9440 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

    Lopez-Contreras, Andres, Specks, J., Barlow, J. H., Ambrogio, C., Madsen, Claus Desler, Vikingsson, S., Rodrigo-Perez, S., Green, H., Rasmussen, Lene Juel, Murga, M., Nussenzweig, A. & Fernandez-Capetillo, O., 1 Apr 2015, In : Genes & Development. 29, 7, p. 690-5 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

    Lu, H., Shamanna, R. A., Keijzers, Guido, Anand, R., Rasmussen, Lene Juel, Cejka, P., Croteau, D. L. & Bohr, Vilhelm, 28 Jun 2016, In : Cell Reports. 16, 1, p. 161-173 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Functional analysis of HNPCC-related missense mutations in MSH2

    Lützen, A., de Wind, N., Georgijevic, D., Nielsen, Finn Cilius & Rasmussen, Lene Juel, 14 Oct 2008, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 645, 1-2, p. 44-55 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Cadmium inhibits human DNA mismatch repair in vivo

    Lützen, A., Liberti, S. E. & Rasmussen, Lene Juel, 13 Aug 2004, In : Biochemical and Biophysical Research Communications. 321, 1, p. 21-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Helicobacter pylori infection generates genetic instability in gastric cells

    Machado, A. M. D., Figueiredo, C., Seruca, R. & Rasmussen, Lene Juel, 2010, In : BBA General Subjects. 1806, 1, p. 58-65 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Helicobacter pylori infection affects mitochondrial function and DNA repair, thus, mediating genetic instability in gastric cells

    Machado, A. M. D., Desler, C., Boggild, S., Strickertsson, J. A. B., Friis-Hansen, L., Figueiredo, C., Seruca, R. & Rasmussen, Lene Juel, 2013, In : Mechanisms of Ageing and Development. 134, 10, p. 460-466 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

Previous 1 2 Next

ID: 13558388