Lene Juel Rasmussen

Lene Juel Rasmussen

Managing director of centre, professor

Member of:

  • Web: Center for Healthy Aging

  • Web Track 1: Modifiable pathways of damage and repair in aging


  1. Published

    The NAD+-mitophagy axis in healthy longevity and in artificial intelligence-based clinical applications

    Aman, Y., Frank, J., Lautrup, S. H., Matysek, A., Niu, Z., Yang, G., Shi, L., Bergersen, Linda Hildegard, Storm-Mathisen, J., Rasmussen, Lene Juel, Bohr, Vilhelm, Nilsen, H. & Fang, E. F., 2020, In : Mechanisms of Ageing and Development. 185, 111194.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    14-3-3 checkpoint regulatory proteins interact specifically with DNA repair protein human exonuclease 1 (hEXO1) via a semi-conserved motif

    Andersen, S. D., Keijzers, Guido, Rampakakis, E., Engels, K., Luhn, P., El-Shemerly, M., Nielsen, Finn Cilius, Du, Y., May, A., Bohr, Vilhelm, Ferrari, S., Zannis-Hadjopoulos, M., Fu, H. & Rasmussen, Lene Juel, Mar 2012, In : D N A Repair. 11, 3, p. 267-77 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Functional characterization of MLH1 missense variants identified in Lynch Syndrome patients

    Andersen, S. D., Liberti, S. E., Lützen, A., Drost, M., Bernstein, I., Nilbert, Mef Christina, Dominguez, M., Nyström, M., Hansen, T. V. O., Christoffersen, J. W., Jäger, A. C., de Wind, N., Nielsen, Finn Cilius, Tørring, P. M. & Rasmussen, Lene Juel, Dec 2012, In : Human Mutation. 33, 12, p. 1647-1655 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli

    Bendtsen, K. M., Jensen, M. B., May, A., Rasmussen, Lene Juel, Trusina, Ala, Bohr, Vilhelm & Jensen, Mogens Høgh, 14 Nov 2014, In : European Biophysics Journal. 43, 10-11, p. 509-516

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Mitochondrial Function in Gilles de la Tourette Syndrome Patients With and Without Intragenic IMMP2L Deletions

    Bjerregaard, V. A., Schönewolf-Greulich, B., Rasmussen, Lene Juel, Madsen, Claus Desler & Tümer, Asuman Zeynep, 2020, In : Frontiers in Neurology. 11, 9 p., 163.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Analysis of the antimicrobial susceptibility of the ionizing radiation-resistant bacterium Deinococcus radiodurans: implications for bioremediation of radioactive waste

    Bouchami, O., Sghaier, H., Madsen, Claus Desler, Lazim, H., Saidi, M., Rasmussen, Lene Juel & Ben Hassan, A., 2011, In : Annals of Microbiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia

    Bundgaard, A., Qvortrup, Klaus, Rasmussen, Lene Juel & Fago, A., 2019, In : Journal of Experimental Biology. 222, 11, 9 p., jeb200410.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Alterations of monocarboxylate transporter densities during hypoxia in brain and breast tumour cells

    Cheng, C., Edin, N. F. J., Lauritzen, K. H., Aspmodal, I., Christoffersen, S., Jian, L., Rasmussen, Lene Juel, Pettersen, E. O., Xiaoqun, G. & Bergersen, Linda Hildegard, Jun 2012, In : Cellular oncology (Dordrecht). 35, 3, p. 217-27 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published
  10. The role of mitochondrial dNTP levels in cells with reduced TK2 activity

    Desler, C., Munch-Petersen, B. & Rasmussen, Lene Juel, 2006, In : Nucleosides, nucleotides & nucleic acids. 25, 9-11, p. 1171-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The role of mitochondrial dysfunction in the progression of Alzheimer’s disease

    Madsen, Claus Desler, Lillenes, M. S., Tønjum, T. & Rasmussen, Lene Juel, 2018, In : Current Medicinal Chemistry. 25, 40, p. 5578 - 5587

    Research output: Contribution to journalReviewResearchpeer-review

  12. Mitochondria as determinant of nucleotide pools and chromosomal stability

    Desler, C., Munch-Petersen, B., Stevnsner, T., Matsui, S., Kulawiec, M., Singh, K. K. & Rasmussen, Lene Juel, 1 Dec 2007, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 625, 1-2, p. 112-24 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    In Silico screening for functional candidates amongst hypothetical proteins

    Madsen, Claus Desler, Suravajhala, P., Sanderhoff, M., Rasmussen, M. & Rasmussen, Lene Juel, 2009, In : BMC Bioinformatics. 10, p. 289

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair

    Dherin, C., Gueneau, E., Francin, M., Nunez, M., Miron, S., Liberti, S. E., Rasmussen, Lene Juel, Zinn-Justin, S., Gilquin, B., Charbonnier, J. & Boiteux, S., 2009, In : Molecular and Cellular Biology. 29, 3, p. 907-18 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Functional implications of the p.Cys680Arg mutation in the MLH1 mismatch repair protein

    Dominguez-Valentin, M., Drost, M., Therkildsen, C., Rambech, E., Ehrencrona, H., Angleys, M., Lau Hansen, T., de Wind, N., Nilbert, Mef Christina & Rasmussen, Lene Juel, Jul 2014, In : Molecular Genetics & Genomic Medicine. 2, 4, p. 352-355 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    A functional assay–based procedure to classify mismatch repair gene variants in Lynch syndrome

    Drost, M., Tiersma, Y., Thompson, B. A., Frederiksen, J. H., Keijzers, Guido, Glubb, D., Kathe, S., Osinga, J., Westers, H., Pappas, L., Boucher, K. M., Molenkamp, S., Zonneveld, J. B., van Asperen, C. J., Goldgar, D. E., Wallace, S. S., Sijmons, R. H., Spurdle, A. B., Rasmussen, Lene Juel, Greenblatt, M. S., de Wind, N. & Tavtigian, S. V., 2019, In : Genetics in Medicine. 21, p. 1486–1496

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 4 Jun 2013, In : Proceedings of the National Academy of Science of the United States of America. 110, 23, p. 9403-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    A rapid and cell-free assay to test the activity of lynch syndrome-associated MSH2 and MSH6 missense variants

    Drost, M., Zonneveld, J. B. M., van Hees, S., Rasmussen, Lene Juel, Hofstra, R. M. W. & de Wind, N., 2012, In : Human Mutation. 33, 3, p. 488-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Accepted/In press

    Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome

    Drost, M., Tiersma, Y., Glubb, D., Kathe, S., van Hees, S., Calléja, F., Zonneveld, J. B. M., Boucher, K. M., Ramlal, R. P. E., Thompson, B. A., Rasmussen, Lene Juel, Greenblatt, M. S., Lee, A., Spurdle, A. B., Tavtigian, S. V. & de Wind, N., 2020, (Accepted/In press) In : Genetics in Medicine.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Genetic screens to identify pathogenic gene variants in the common cancer predisposition Lynch syndrome

    Drost, M., Lützen, A., van Hees, S., Ferreira, D., Calléja, F., Zonneveld, J. B. M., Nielsen, Finn Cilius, Rasmussen, Lene Juel & de Wind, N., 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 23, p. 9403-9408 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase

    Duan, Shunlei, Han, Xuerui, Akbari, Mansour, Croteau, D. L., Rasmussen, Lene Juel & Bohr, Vilhelm, 2020, In : Nucleic Acids Research. 48, 12, p. 6530–6546

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Mitochondria in health and disease: 3rd annual conference of society for mitochondrial research and medicine - 19-20 december 2013 - bengaluru, India

    Durhuus, J. A., Madsen, Claus Desler & Rasmussen, Lene Juel, Jan 2015, In : Mitochondrion. 20, p. 7-12 6 p.

    Research output: Contribution to journalConference articleResearchpeer-review

  23. Published

    From powerhouse to perpetrator—mitochondria in health and disease

    Fakouri, N. B., Hansen, T. L., Madsen, Claus Desler, Anugula, Sharath & Rasmussen, Lene Juel, 2019, In : Biology. 8, 2, 15 p., 35.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

    Fakouri, N. B., Durhuus, J. A., Regnell, C. E., Angleys, M., Madsen, Claus Desler, Hasan-Olive, M., Martin-Pardillos, A., Tsaalbi-Shtylik, A., Thomsen, Kirsten Joan, Lauritzen, Martin, Bohr, Vilhelm, de Wind, N., Bergersen, Linda Hildegard & Rasmussen, Lene Juel, 2017, In : Scientific Reports. 7, 14 p., 12480.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Interventions for age-related diseases: Shifting the paradigm

    Figueira, I., Fernandes, A., Mladenovic Djordjevic, A., Lopez-Contreras, Andres, Henriques, C. M., Selman, C., Ferreiro, E., Gonos, E. S., Trejo, J. L., Misra, J., Rasmussen, Lene Juel, Xapelli, S., Ellam, T. & Bellantuono, I., Dec 2016, In : Mechanisms of Ageing and Development. 160, p. 69-92 24 p.

    Research output: Contribution to journalReviewResearchpeer-review

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