Lene Juel Rasmussen
Professor
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Mitochondrial dysfunction induced by variation in the non-coding genome – A proposed workflow to improve diagnostics
du Mee, D. J. M., Bak, M., Østergaard, Elsebet & Rasmussen, Lene Juel, 2020, In: Mitochondrion. 53, p. 255-259Research output: Contribution to journal › Journal article › Research › peer-review
Novel DNA mismatch-repair activity involving YB-1 in human mitochondria
de Souza-Pinto, N. C., Mason, P. A., Hashiguchi, K., Weissman, L., Tian, J., Guay, D., Lebel, M., Stevnsner, T. V., Rasmussen, Lene Juel & Bohr, V. A., 2009, In: DNA Repair. 8, 6, p. 704-19 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Salidroside promotes healthy longevity by interfering with HSP90 activity
Zhang, J., Li, Zhiquan, Song, J., Zhou, L., Chen, X., Ge, W., Dong, T., Luo, Y., Mao, T., Li, Z., Tan, D., Rasmussen, Lene Juel, Bohr, Vilhelm, Tong, X. & Dai, F., 2024, In: GeroScience. 46, p. 1641–1655 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study
The International Mismatch Repair Consortium, T. I. M. R. C., Jul 2021, In: The Lancet Oncology. 22, 7, p. 1014-1022 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Meeting Summary of The NYO3 5th NO-Age/AD Meeting and the 1st Norway-UK Joint Meeting on Aging and Dementia: Recent Progress on the Mechanisms and Interventional Strategies
Wang, H. L., Siow, R., Schmauck-Medina, T., Zhang, J., Sandset, P. M., Filshie, C., Lund, Ø., Partridge, L., Bergersen, L. H., Juel Rasmussen, L., Palikaras, K., Sotiropoulos, I., Storm-Mathisen, J., Rubinsztein, D. C., Spillantini, M. G., De Zeeuw, C. I., Watne, L. O., Vyhnalek, M., Veverova, K., Liang, K. X. & 18 others, , 2024, In: The journals of gerontology. Series A, Biological sciences and medical sciences. 79, 4, 10 p., glae029.Research output: Contribution to journal › Journal article › Research › peer-review
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Disturbed mitochondrial function restricts glutamate uptake in the human Müller glia cell line, MIO-M1
Vohra, Rupali, Gurubaran, I. S., Henriksen, U., Bergersen, L. H., Rasmussen, Lene Juel, Desler, C., Jensen, Dorte Skytt & Kolko, Miriam, 2017, In: Mitochondrion. 36, p. 52-59Research output: Contribution to journal › Journal article › Research › peer-review
The LipB protein is a negative regulator of dam gene expression in Escherichia coli
Vaisvila, R., Rasmussen, Lene Juel, Løbner-Olesen, Anders, von Freiesleben, U. & Marinus, M. G., 2000, In: Biochimica et Biophysica Acta, Gene Structure and Expression. 1494, 1-2, p. 43-53 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Oxidative Stress-Induced Dysfunction of Muller Cells During Starvation
Toft-Kehler, A. K., Gurubaran, I. S., Desler, Claus, Rasmussen, Lene Juel, Jensen, Dorte Skytt & Kolko, Miriam, May 2016, In: Investigative Ophthalmology & Visual Science. 57, 6, p. 2721-2728Research output: Contribution to journal › Journal article › Research › peer-review
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Initial brain aging: heterogeneity of mitochondrial size is associated with decline in complex I-linked respiration in cortex and hippocampus
Thomsen, Kirsten Joan, Yokota, T., Hasan-Olive, M. M., Sherazi, N., Fakouri, N. B., Desler, Claus, Regnell, C. E., Larsen, S., Rasmussen, Lene Juel, Dela, Flemming, Bergersen, L. H. & Lauritzen, Martin, 2018, In: Neurobiology of Aging. 61, p. 215-224 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database
Thompson, B. A., Spurdle, A. B., Plazzer, J-P., Greenblatt, M. S., Akagi, K., Al-Mulla, F., Bapat, B., Bernstein, I., Capellá, G., den Dunnen, J. T., du Sart, D., Fabre, A., Farrell, M. P., Farrington, S. M., Frayling, I. M., Frebourg, T., Goldgar, D. E., Heinen, C. D., Holinski-Feder, E., Kohonen-Corish, M. & 31 others, , Feb 2014, In: Nature Genetics. 46, 2, p. 107-115 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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A Novel Rrm3 Function in Restricting DNA Replication via an Orc5-Binding Domain Is Genetically Separable from Rrm3 Function as an ATPase/Helicase in Facilitating Fork Progression
Syed, S., Desler, Claus, Rasmussen, Lene Juel & Schmidt, K. H., Dec 2016, In: P L o S Genetics. 12, 12, 28 p., e1006451.Research output: Contribution to journal › Journal article › Research › peer-review
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Bloom syndrome DNA helicase deficiency is associated with oxidative stress and mitochondrial network changes
Subramanian, V., Rodemoyer, B., Shastri, V., Rasmussen, Lene Juel, Desler, Claus & Schmidt, K. H., 2021, In: Scientific Reports. 11, 2157.Research output: Contribution to journal › Journal article › Research › peer-review
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Bacterial infection increases risk of carcinogenesis by targeting mitochondria
Strickertsson, J. A. B., Desler, Claus & Rasmussen, Lene Juel, Dec 2017, In: Seminars in Cancer Biology. 47, p. 95-100 6 p.Research output: Contribution to journal › Review › Research › peer-review
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Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells
Strickertsson, J. A. B., Desler, Claus, Martin-Bertelsen, T., Machado, A. M. D., Wadstrøm, T., Winther, Ole, Rasmussen, Lene Juel & Friis-Hansen, Lennart Jan, 2013, In: PLOS ONE. 8, 4, p. 1-13 13 p., e63147.Research output: Contribution to journal › Journal article › Research › peer-review
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Enterococcus faecalis Infection and Reactive Oxygen Species Down-Regulates the miR-17-92 Cluster in Gastric Adenocarcinoma Cell Culture
Strickertsson, J. A. B., Rasmussen, Lene Juel & Friis-Hansen, Lennart Jan, 28 Aug 2014, In: Genes. 5, 3, p. 726-38 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Impact of bacterial infections on aging and cancer: Impairment of DNA repair and mitochondrial function of host cells
Strickertsson, J. A. B., Desler, Claus & Rasmussen, Lene Juel, Aug 2014, In: Experimental Gerontology. 56, p. 164-174 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CNOT6: A Novel Regulator of DNA Mismatch Repair
Song, P., Liu, S., Liu, D., Keijzers, G., Bakula, Daniela Janina, Duan, S., de Wind, N., Ye, Z., Vakhrushev, Sergey, Scheibye-Knudsen, Morten & Rasmussen, Lene Juel, 2022, In: Cells. 11, 3, 521.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of reactive oxygen species and mitochondrial dysfunction on reproductive aging
Song, J., Xiao, L., Zhang, Z., Wang, Y., Kouis, P., Rasmussen, Lene Juel & Dai, F., 2024, In: Frontiers in Cell and Developmental Biology. 12, 12 p., 1347286.Research output: Contribution to journal › Review › Research › peer-review
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Thymidine kinase 1 deficient cells show increased survival rate after UV-induced DNA damage
Skovgaard, T., Rasmussen, Lene Juel & Munch-Petersen, B., 2010, In: Nucleosides, Nucleotides and Nucleic Acids. 29, 4-6, p. 347-51 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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New hallmarks of ageing: a 2022 Copenhagen ageing meeting summary
Schmauck-Medina, T., Molière, A., Lautrup, S., Zhang, J., Chlopicki, S., Madsen, H. B., Cao, S., Soendenbroe, C., Mansell, E., Vestergaard, M. B., Li, Z., Shiloh, Y., Opresko, P. L., Egly, J. M., Kirkwood, T., Verdin, E., Bohr, V. A., Cox, L. S., Stevnsner, T., Rasmussen, L. J. & 1 others, , 2022, In: Aging. 14, 16, p. 6829-6839 11 p.Research output: Contribution to journal › Review › Research › peer-review
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The challenges of human population ageing
Sander, M., Oxlund, Bjarke, Jespersen, Astrid Pernille, Krasnik, Allan, Mortensen, Erik Lykke, Westendorp, Rudi GJ & Rasmussen, Lene Juel, Mar 2015, In: Age and Ageing. 44, 2, p. 185-7 3 p.Research output: Contribution to journal › Journal article › Communication
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Involvement of the DNA mismatch repair system in cisplatin sensitivity of testicular germ cell tumours
Rudolph, C., Melau, C., Nielsen, J. E., Jensen, K. V., Liu, D., Pena-Diaz, J., Meyts, E. R., Rasmussen, Lene Juel & Jorgensen, A., 2017, In: Cellular Oncology. 40, 4, p. 341-355Research output: Contribution to journal › Journal article › Research › peer-review
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Natural selection of mitochondria during somatic lifetime promotes healthy aging
Rodell, A., Rasmussen, Lene Juel, Bergersen, L. H., Singh, K. K. & Gjedde, Albert, 2013, In: Frontiers in Neuroenergetics. 5, p. 1-6 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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DNA damage response, bioenergetics, and neurological disease: the challenge of maintaining brain health in an aging human population
Rasmussen, Lene Juel, Shiloh, Y., Bergersen, L. H., Sander, M., Bohr, Vilhelm & Tønjum, T., Oct 2013, In: Mechanisms of Ageing and Development. 134, 10, p. 427-33 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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EXO1 (Exonuclease 1)
Rasmussen, Lene Juel & Keijzers, G., 5 Jan 2017, Encyclopedia of Signaling Molecules . Choi, S. (ed.). New York: Springer, 7 p.Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research
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Pathological assessment of mismatch repair gene variants in Lynch syndrome: Past, present, and future
Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Dec 2012, In: Human Mutation. 33, 12, p. 1617-25 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance
Rasmussen, Lene Juel, Heinen, C. D., Royer-Pokora, B., Drost, M., Tavtigian, S., Hofstra, R. M. W. & de Wind, N., Jun 2013, In: Human Mutation. 34, 6, p. 923-4 2 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Assessing Genetic Variants of Uncertain Significance: The Example of Lynch Syndrome
Rasmussen, Lene Juel & Heinen, C. D., 15 Apr 2014Research output: Other contribution › Net publication - Internet publication › Communication
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Aging, longevity and health
Rasmussen, Lene Juel, Sander, M., Wewer, Ulla M. & Bohr, Vilhelm, 23 Jul 2011, In: Mechanisms of Ageing and Development. p. 522-32 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Growth-rate-dependent transcription initiation from the dam P2 promoter
Rasmussen, Lene Juel, Løbner-Olesen, Anders & Marinus, M. G., 1995, In: Gene. 157, 1-2, p. 213-215 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Novel growth rate control of dam gene expression in Escherichia coli
Rasmussen, Lene Juel, Marinus, M. G. & Løbner-Olesen, Anders, 1994, In: Molecular Microbiology. 12, 4, p. 631-638 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Galectin-7 reprograms skin carcinogenesis by fostering innate immune evasive programs
Pinto, N. A., Abba, M. C., Laporte, L., Pérez Sáez, J. M., Blidner, A. G., Torres, N. I., Morales, R. M., Gatto, S. G., Bach, C. A., Veigas, F., García Rivello, H. J., Song, P., Frederiksen, J. H., Rasmussen, Lene Juel, Poirier, F., Croci, D. O., Sundblad, V., Rabinovich, G. A. & Cerliani, J. P., 2023, In: Cell Death and Differentiation. 30, p. pages906–921Research output: Contribution to journal › Journal article › Research › peer-review
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Approaches to diagnose DNA mismatch repair gene defects in cancer
Peña-Diaz, J. & Rasmussen, Lene Juel, Feb 2016, In: DNA Repair. 38, p. 147-154 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Functional examination of MLH1, MSH2, and MSH6 intronic mutations identified in Danish colorectal cancer patients
Petersen, S. M., Dandanell, M., Rasmussen, Lene Juel, Gerdes, Anne-Marie Axø, Krogh, L. N., Bernstein, I., Okkels, H., Wikman, F., Nielsen, Finn Cilius & Hansen, Thomas van Overeem, 2013, In: BMC Medical Genetics. 14, p. 103Research output: Contribution to journal › Journal article › Research › peer-review
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Mitochondrial-Linked De Novo Pyrimidine Biosynthesis Dictates Human T-Cell Proliferation but Not Expression of Effector Molecules
Peeters, M. J. W., Aehnlich, P., Pizzella, A., Mølgaard, K., Seremet, T., Met, Özcan, Rasmussen, Lene Juel, thor Straten, P. & Desler, Claus, 2021, In: Frontiers in Immunology. 12, 718863.Research output: Contribution to journal › Journal article › Research › peer-review
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MERTK Acts as a costimulatory receptor on human cd8 t cells
Peeters, M. J. W., Dulkeviciute, D., Draghi, A., Ritter, C., Rahbech, A., Skadborg, S. K., Seremet, T., Simoes, A. M. C., Martinenaite, E., Halldorsdottir, H. R., Andersen, Mads Hald, Olofsson, G. H., Svane, Inge Marie, Rasmussen, Lene Juel, Met, Özcan, Becker, J. C., dqp123, dqp123, Desler, Claus & Straten, P. T., 2019, In: Cancer Immunology Research. 7, 9, p. 1472-1484 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Biochemical characterization of MLH3 missense mutations does not reveal an apparent role of MLH3 in Lynch syndrome
Ou, J., Rasmussen, M., Westers, H., Andersen, S. D., Jager, P. O., Kooi, K. A., Niessen, R. C., Eggen, B. J. L., Nielsen, Finn Cilius, Kleibeuker, J. H., Sijmons, R. H., Rasmussen, Lene Juel & Hofstra, R. M. W., 2009, In: Genes, Chromosomes & Cancer. 48, 4, p. 340-50 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Acquired Localized Cutis Laxa due to Increased Elastin Turnover
Nygaard, R. H., Maynard, S., Schjerling, P., Kjær, M., Qvortrup, Klaus, Bohr, Vilhelm, Rasmussen, Lene Juel, Jemec, Gregor & Heidenheim, M., 14 Jun 2016, In: Case Reports in Dermatology. 8, 1, p. 42-51 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Predicting the impact of Lynch syndrome-causing missense mutations from structural calculations
Nielsen, S. V., Stein, Amelie, Dinitzen, A. B., Papaleo, E., Tatham, M. H., Poulsen, E. G., Kassem, M. M., Rasmussen, Lene Juel, Lindorff-Larsen, Kresten & Hartmann-Petersen, Rasmus, 19 Apr 2017, In: PLoS Genetics. 13, 4, 26 p., e1006739.Research output: Contribution to journal › Journal article › Research › peer-review
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Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
Navarro, J. F., Croteau, D. L., Jurek, A., Andrusivova, Z., Yang, B., Wang, Y., Ogedegbe, B., Riaz, T., Støen, M., Desler, Claus, Rasmussen, Lene Juel, Tønjum, T., Galas, M. C., Lundeberg, J. & Bohr, Vilhelm, 2020, In: iScience. 23, 10, 42 p., 101556.Research output: Contribution to journal › Journal article › Research › peer-review
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Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells
Møller, S. H., Mellergaard, M., Madsen, M., Bermejo, A. V., Jepsen, Stine Dam, Hansen, M. H., Høgh, R. I., Aldana, Blanca, Desler, Claus, Rasmussen, Lene Juel, Sustarsic, E. G., Gerhart-Hines, Zach, Daskalaki, E., Wheelock, C. E., Hiron, T. K., Lin, D., O'Callaghan, C. A., Wandall, Hans H., Andresen, Lars & Skov, Søren, 2020, In: Frontiers in Immunology. 11, 22 p., 1968.Research output: Contribution to journal › Journal article › Research › peer-review
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Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium
The European Hereditary Tumour Group (EHTG) and the International Mismatch Repair Consortium (IMRC), T. E. H. T. G. (. A. T. I. M. R. C. (., 2022, In: Hereditary Cancer in Clinical Practice. 20, 36.Research output: Contribution to journal › Journal article › Research › peer-review
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ARDD 2020: from aging mechanisms to interventions
Mkrtchyan, G. V., Abdelmohsen, K., Andreux, P., Bagdonaite, I., Barzilai, N., Brunak, S., Cabreiro, F., Cabo, R. D., Campisi, J., Cuervo, A. M., Demaria, M., Ewald, C. Y., Fang, E. F., Faragher, R., Ferrucci, L., Freund, A., Silva-García, C. G., Georgievskaya, A., Gladyshev, V. N., Glass, D. J. & 46 others, , 2020, In: Aging. 12, 24, p. 24486-24503 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pooled analysis of frontal lobe transcriptomic data identifies key mitophagy gene changes in Alzheimer's disease brain
Mei, T., Li, Yuan, Orduña Dolado, A., Li, Zhiquan, Andersson, Robin, Berliocchi, Laura & Rasmussen, Lene Juel, 2023, In: Frontiers in Aging Neuroscience. 15, 14 p., 1101216.Research output: Contribution to journal › Journal article › Research › peer-review
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Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients
Maynard, S., Hejl, Anne-Mette, Dinh, T. T. S., Keijzers, G., Hansen, Åse Marie, Desler, Claus, Moreno-Villanueva, M., Bürkle, A., Rasmussen, Lene Juel, Waldemar, Gunhild & Bohr, Vilhelm, Oct 2015, In: Aging. 7, 10, p. 793-815 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells
Maynard, S., Keijzers, G., Gram, M., Desler, Claus, Bendix, L., Budtz-Joergensen, Esben, Molbo, Drude, Croteau, D. L., Osler, Merete, Stevnsner, T. V., Rasmussen, Lene Juel, Dela, Flemming, Avlund, K. & Bohr, Vilhelm, 30 Nov 2013, In: Aging. p. 850-864 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Associations of subjective vitality with DNA damage, cardiovascular risk factors and physical performance
Maynard, S., Keijzers, G., Hansen, Åse Marie, Osler, Merete, Molbo, Drude, Bendix, L., Møller, Peter, Loft, Steffen, Moreno-Villanueva, M., Bürkle, A., Hvitby, C. P., Schurman, S. H., Stevnsner, T. V., Rasmussen, Lene Juel, Avlund, K. & Bohr, Vilhelm, Jan 2015, In: Acta Physiologica (Print). 213, 1, p. 156-170 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions
Martín-Pardillos, A., Tsaalbi-Shtylik, A., Chen, S., Lazare, S., Van Os, R. P., Dethmers-Ausema, A., Fakouri, N. B., Bosshard, M., Aprigliano, R., Van Loon, B., Salvatori, D. C. F., Hashimoto, K., Van Der Spek, C. D., Moriya, M., Rasmussen, Lene Juel, De Haan, G., Raaijmakers, M. H. G. P. & De Wind, N., 2017, In: Blood. 130, 13, p. 1523-1534 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The DNA repair enzyme, aprataxin, plays a role in innate immune signaling
Madsen, Helena Borland, Pease, L. I., Scanlan, R. L., Akbari, M., Rasmussen, Lene Juel, Shanley, D. P. & Bohr, Vilhelm, 2023, In: Frontiers in Aging Neuroscience. 15, 17 p., 1290681.Research output: Contribution to journal › Journal article › Research › peer-review
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The cGAS-STING signaling pathway is modulated by urolithin A
Madsen, Helena Borland, Park, J. H., Chu, X., Hou, Y., Li, Zhiquan, Rasmussen, Lene Juel, Croteau, D. L., Bohr, Vilhelm & Akbari, M., 2024, In: Mechanisms of Ageing and Development. 217, 11 p., 111897.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13558388
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Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
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Enterococcus faecalis infection causes inflammation, intracellular oxphos-independent ROS production, and DNA damage in human gastric cancer cells
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LIFESTAT – Living with statins: An interdisciplinary project on the use of statins as a cholesterol-lowering treatment and for cardiovascular risk reduction
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