Leila Lo Leggio
Professor
Department of Chemistry
Universitetsparken 5
2100 København Ø
- 2024
- Published
A frontier-orbital view of the initial steps of lytic polysaccharide monooxygenase reactions
Wieduwilt, E. K., Lo Leggio, Leila & Hedegård, E. D., 2024, In: Dalton Transactions (Online). 53, 13, p. 5796-5807 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CI:Mor interactions in the lysogeny switches of Lactococcus lactis TP901-1 and Staphylococcus aureus φ13 bacteriophages
Varming, A. K., Huang, Zhiyu, Hamad, G. M., Rasmussen, K. K., Ingmer, Hanne, Kilstrup, M. & Lo Leggio, Leila, 2024, In: Microbiome Research Reports. 3, 2, 16 p., 15.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemoenzymatic indican for light-driven denim dyeing
Bidart, G. N., Teze, D., Jansen, C. U., Pasutto, E., Putkaradze, N., Sesay, A. M., Fredslund, F., Lo Leggio, Leila, Ögmundarson, O., Sukumara, S., Qvortrup, K. & Welner, D. H., 2024, In: Nature Communications. 15, 1, 11 p., 1489.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polysaccharide utilization loci from Bacteroidota encode CE15 enzymes with possible roles in cleaving pectin-lignin bonds
Seveso, A., Mazurkewich, S., Banerjee, S., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila & Larsbrink, J., 2024, In: Applied and Environmental Microbiology. 90, 1, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila
Sun, P., Huang, Zhiyu, Banerjee, S., Kadowaki, M. A. S., Veersma, R. J., Magri, S., Hilgers, R., Muderspach, Sebastian Jannick, Laurent, C. V. F. P., Ludwig, R., Cannella, D., Lo Leggio, Leila, van Berkel, W. J. H. & Kabel, M. A., 2023, In: ACS Catalysis. 13, 7, p. 4454-4467 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucuronoyl esterases – enzymes to decouple lignin and carbohydrates and enable better utilization of renewable plant biomass
Larsbrink, J. & Lo Leggio, Leila, 2023, In: Essays in Biochemistry. 67, 3, p. 493-503 11 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Joint X-ray/neutron structure of Lentinus similis AA9_A at room temperature
Tandrup, T., Lo Leggio, Leila & Meilleur, F., 2023, In: Acta crystallographica. Section F, Structural biology communications. 79, 1, p. 1-7 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and functional investigation of a fungal member of carbohydrate esterase family 15 with potential specificity for rare xylans
Mazurkewich, S., Scholzen, K. C., Brusch, R. H., Poulsen, Jens-Christian Navarro, Theibich, Yusuf, Hüttner, S., Olsson, L., Larsbrink, J. & Lo Leggio, Leila, 2023, In: Acta crystallographica. Section D, Structural biology. 79, 6, p. 545-555 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure, function, and protein engineering of GH53 β-1,4-galactanases
Muderspach, Sebastian Jannick, Jensen, K., Krogh, K. B. R. M. & Lo Leggio, Leila, 2023, Glycoside Hydrolases: Biochemistry, Biophysics, and Biotechnology. Elsevier, p. 295-322 28 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 2022
- Published
Mechanism and biomass association of glucuronoyl esterase: an α/β hydrolase with potential in biomass conversion
Zong, Z., Mazurkewich, S., Pereira, C. S., Fu, H., Cai, W., Shao, X., Skaf, M. S., Larsbrink, J. & Lo Leggio, Leila, Dec 2022, In: Nature Communications. 13, 1, 10 p., 1449.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Changes in active-site geometry on X-ray photo-reduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding
Tandrup, T., Muderspach, Sebastian Jannick, Banerjee, S., Santoni, G., Ipsen, J. O., Hernandez Rollan, Cristina, Norholm, M. H. H., Johansen, Katja Salomon, Meilleur, F. & Lo Leggio, Leila, Sep 2022, In: IUCrJ. 9, 5, p. 666-681 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Flexible linker modulates the binding affinity of the TP901-1 CI phage repressor to DNA
Varming, A. K., Rasmussen, K. K., Zong, Z., Thulstrup, Peter Waaben, Kilstrup, M. & Lo Leggio, Leila, 2022, In: FEBS Journal. 289, 4, p. 1135-1148 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Protonation State of an Important Histidine from High Resolution Structures of Lytic Polysaccharide Monooxygenases
Banerjee, S., Muderspach, Sebastian Jannick, Tandrup, T., Frandsen, Kristian Erik Høpfner, Singh, R. K., Ipsen, J. O., Hernandez Rollan, Cristina, Nørholm, M. H. H., Bjerrum, Morten Jannik, Johansen, Katja Salomon & Lo Leggio, Leila, 2022, In: Biomolecules. 12, 2, 15 p., 194.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Engineering the substrate binding site of the hyperthermostable archaeal endo-β-1,4-galactanase from Ignisphaera aggregans
Muderspach, Sebastian Jannick, Fredslund, F., Volf, V., Poulsen, Jens-Christian Navarro, Blicher, T. H., Clausen, M. H., Rasmussen, K. K., Krogh, K. B. R. M., Jensen, K. & Lo Leggio, Leila, 1 Dec 2021, In: Biotechnology for Biofuels. 14, 1, 16 p., 183.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the genetic switch from phage ɸ13 important for Staphylococcus aureus colonization in humans
Kristensen, C. S., Varming, A. K., Leinweber, H. A. K., Hammer, K., Lo Leggio, Leila, Ingmer, Hanne & Kilstrup, M., 1 Oct 2021, In: MicrobiologyOpen. 10, 5, 22 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from Caldicellulosiruptor kristjansonii
Krska, D., Mazurkewich, S., Brown, H. A., Theibich, Yusuf, Poulsen, Jens-Christian Navarro, Morris, A. L., Koropatkin, N. M., Lo Leggio, Leila & Larsbrink, J., 13 Jul 2021, In: Biochemistry. 60, 27, p. 2206-2220 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Crystal structures of Val58Ile tryptophan repressor in a domain-swapped array in the presence and absence of L-tryptophan
Sprenger, J., Lawson, C. L., Von Wachenfeldt, C., Lo Leggio, Leila & Carey, J., 1 Jul 2021, In: Acta Crystallographica Section F: Structural Biology Communications. 77, 7, p. 215-225 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Probing the determinants of the transglycosylation/hydrolysis partition in a retaining α-L-arabinofuranosidase
Zhao, J., Tandrup, T., Bissaro, B., Barbe, S., Poulsen, Jens-Christian Navarro, André, I., Dumon, C., Lo Leggio, Leila, O'Donohue, M. J. & Fauré, R., 25 May 2021, In: New Biotechnology. 62, p. 68-78 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Estimating the accuracy of calculated electronparamagnetic resonance hyperfine couplings for alytic polysaccharide monooxygenase
Theibich, Y. A., Sauer, Stephan P. A., Lo Leggio, Leila & Hedegård, E. D., 12 Jan 2021, In: Computational and Structural Biotechnology Journal. 19, p. 555-567 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Identification of the molecular determinants driving the substrate specificity of fungal lytic polysaccharide monooxygenases (LPMOs)
Frandsen, Kristian Erik Høpfner, Haon, M., Grisel, S., Henrissat, B., Lo Leggio, Leila & Berrin, J., 1 Jan 2021, In: Journal of Biological Chemistry. 296, 11 p., 100086.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Calmodulin complexes with brain and muscle creatine kinase peptides
Sprenger, J., Trifan, A., Patel, N., Vanderbeck, A., Bredfelt, J., Tajkhorshid, E., Rowlett, R., Lo Leggio, Leila, Åkerfeldt, K. S. & Linse, S., 2021, In: Current Research in Structural Biology. 3, p. 121-132 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Controlling the fractal dimension in self-assembly of terpyridine modified insulin by Fe2+ and Eu3+ to direct in vivo effects
Mishra, N. K., Østergaard, M., Midtgaard, S. R., Strindberg, S. S., Winkler, S., Wu, S., Sørensen, Thomas Just, Hassenkam, Tue, Poulsen, Jens-Christian Navarro, Lo Leggio, Leila, Nielsen, Hanne Mørck, Arleth, Lise, Christensen, Niels Johan, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2021, In: Nanoscale. 13, 18, p. 8467–8473 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Copper binding and reactivity at the histidine brace motif: insights from mutational analysis of the Pseudomonas fluorescens copper chaperone CopC
Ipsen, J. Ø., Hernández‐Rollán, C., Muderspach, Sebastian Jannick, Brander, Søren, Bertelsen, A. B., Jensen, Poul Erik, Nørholm, M. H. H., Lo Leggio, Leila, Johansen, Katja Salomon & Ferguson, S. (ed.), 2021, In: FEBS Letters. 595, 12, p. 1708-1720 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Guest-protein incorporation into solvent channels of a protein host crystal (hostal)
Sprenger, J., Carey, J., Schulz, Alexander, Drouard, F., Lawson, C. L., Von Wachenfeldt, C., Linse, S. & Lo Leggio, Leila, 2021, In: Acta crystallographica Section D: Structural biology . 77, p. 471-485 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Inhibition of lytic polysaccharide monooxygenase by natural plant extracts
Tokin, Radina, Frandsen, Kristian Erik Høpfner, Ipsen, J. Ø., Lo Leggio, Leila, Poojary, Mahesha Manjunatha, Berrin, J., Grisel, S., Brander, Søren, Jensen, Poul Erik & Johansen, Katja Salomon, 2021, In: New Phytologist. 232, 3, p. 1337–1349 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications
Ipsen, J., Hallas-Møller, Magnus, Brander, Søren, Lo Leggio, Leila & Johansen, Katja Salomon, 2021, In: Biochemical Society Transactions. 49, 1, p. 531-540 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Scission of Glucosidic Bonds by a Lentinus similis Lytic Polysaccharide Monooxygenases Is Strictly Dependent on H2O2while the Oxidation of Saccharide Products Depends on O2
Brander, Søren, Tokin, Radina, Ipsen, J., Jensen, Poul Erik, Hernández-Rollán, C., Nørholm, M. H. H., Lo Leggio, Leila, Dupree, P. & Johansen, Katja Salomon, 2021, In: ACS Catalysis. 11, 22, p. 13848-13859Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Biochemical evidence of both copper chelation and oxygenase activity at the histidine brace
Brander, Søren, Horvath, I., Ipsen, J. Ø., Peciulyte, A., Olsson, L., Hernández-rollán, C., Nørholm, M. H. H., Mossin, S., Lo Leggio, Leila, Probst, C., Thiele, D. J. & Johansen, Katja Salomon, 1 Dec 2020, In: Scientific Reports. 10, 1, 11 p., 16369.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Revealing the mechanism of repressor inactivation during switching of a temperate bacteriophage
Rasmussen, K. K., Palencia, A., Varming, A. K., El-Wali, H., Erba, E. B., Blackledge, M., Hammer, K., Herrmann, T., Kilstrup, M., Lo Leggio, Leila & Jensen, M. R., 25 Aug 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 34, p. 20576-20585 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Repression of the lysogenic PR promoter in bacteriophage TP901-1 through binding of a CI-MOR complex to a composite OM-OR operator
Pedersen, M., Neergaard, J. T., Cassias, J., Rasmussen, K. K., Lo Leggio, Leila, Sneppen, Kim, Hammer, K. & Kilstrup, M., 26 May 2020, In: Scientific Reports. 10, 1, 13 p., 8659.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An 1,4-α-Glucosyltransferase Defines a New Maltodextrin Catabolism Scheme in Lactobacillus acidophilus
Andersen, S., Møller, M. S., Poulsen, Jens-Christian Navarro, Pichler, M. J., Svensson, B., Lo Leggio, Leila, Goh, Y. J. & Abou Hachem, M., 22 May 2020, In: Applied and Environmental Microbiology. 86, 15, 14 p., e00661-20.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A fungal family of lytic polysaccharide monooxygenase-like copper proteins
Labourel, A., Frandsen, Kristian Erik Høpfner, Zhang, F., Brouilly, N., Grisel, S., Haon, M., Ciano, L., Ropartz, D., Fanuel, M., Martin, F., Navarro, D., Rosso, M., Tandrup, T., Bissaro, B., Johansen, Katja Salomon, Zerva, A., Walton, P. H., Henrissat, B., Lo Leggio, Leila & Berrin, J., 2020, In: Nature Chemical Biology. 16, p. 345-350 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis
Garcia-Santamarina, S., Probst, C., Festa, R. A., Ding, C., Smith, A. D., Conklin, S. E., Brander, Søren, Kinch, L. N., Grishin, N. V., Franz, K. J., Riggs-Gelasco, P., Lo Leggio, Leila, Johansen, Katja Salomon & Thiele, D. J., 2020, In: Nature Chemical Biology. 16, p. 337-344 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oligosaccharide Binding and Thermostability of Two Related AA9 Lytic Polysaccharide Monooxygenases
Tandrup, T., Tryfona, T., Frandsen, Kristian Erik Høpfner, Johansen, Katja Salomon, Dupree, P. & Lo Leggio, Leila, 2020, In: Biochemistry. 59, 36, p. 3347-3358 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Structural studies of temperate phage genetic switches
Varming, A., Rasmussen, K. K., Kilstrup, M., Hammer, K., Ringkjøbing Jensen, M., Ingmer, Hanne & Lo Leggio, Leila, 18 Aug 2019, p. e105-e105. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis
Sakanaka, M., Hansen, M. E., Gotoh, A., Katoh, T., Yoshida, K., Odamaki, T., Yachi, H., Sugiyama, Y., Kurihara, S., Hirose, J., Urashima, T., Xiao, J., Kitaoka, M., Fukiya, S., Yokota, A., Lo Leggio, Leila, Abou Hachem, M. & Katayama, T., 2019, In: Science Advances. 5, 8, p. 1-15 15 p., eaaw7696.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Further structural studies of the lytic polysaccharide monooxygenase AoAA13 belonging to the starch-active AA13 family
Muderspach, Sebastian Jannick, Tandrup, T., Frandsen, Kristian Erik Høpfner, Santoni, G., Poulsen, Jens-Christian Navarro & Lo Leggio, Leila, 2019, In: Amylase. 3, 1, p. 41-54 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases
Frandsen, Kristian Erik Høpfner, Tovborg, M., Jørgensen, C. I., Spodsberg, N., Rosso, M., Hemsworth, G. R., Garman, E. F., Grime, G. W., Poulsen, Jens-Christian Navarro, Batth, T. S., Miyauchi, S., Lipzen, A., Daum, C., Grigoriev, I. V., Johansen, Katja Salomon, Henrissat, B., Berrin, J. & Lo Leggio, Leila, 2019, In: The Journal of Biological Chemistry. 294, p. 17117-17130 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structural and biochemical studies of the glucuronoyl esterase OtCE15A illuminate its interaction with lignocellulosic components
Mazurkewich, S., Poulsen, Jens-Christian Navarro, Lo Leggio, Leila & Larsbrink, J., 2019, In: Journal of Biological Chemistry. 294, 52, p. 19978-19987Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure and Dynamics of a Promiscuous Xanthan Lyase from Paenibacillus nanensis and the Design of Variants with Increased Stability and Activity
Jensen, P. F., Kadziola, Anders, Comamala, G., Segura, D. R., Anderson, L., Poulsen, Jens-Christian Navarro, Rasmussen, K. K., Agarwal, S., Sainathan, R. K., Monrad, R. N., Svendsen, A., Nielsen, J. E., Lo Leggio, Leila & Rand, Kasper Dyrberg, 2019, In: Cell Chemical Biology. 26, 2, p. 191-202.e1-e6 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of Aspergillus aculeatus β-1,4-galactanase in complex with galactobiose
Torpenholt, S., Poulsen, Jens-Christian Navarro, Muderspach, Sebastian Jannick, De Maria, L. & Lo Leggio, Leila, 2019, In: Acta Crystallographica Section F: Structural Biology Communications. 75, 6, p. 399-404 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure–function analyses reveal that a glucuronoyl esterase from Teredinibacter turnerae interacts with carbohydrates and aromatic compounds
Arnling Bååth, J., Mazurkewich, S., Poulsen, Jens-Christian Navarro, Olsson, L., Lo Leggio, Leila & Larsbrink, J., 2019, In: Journal of Biological Chemistry. 294, 16, p. 6635-6644 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Substrate preference of an ABC importer corresponds to selective growth on β-(1,6)-galactosides in Bifidobacterium animalis subsp. lactis
Theilmann, M. C., Fredslund, F., Svensson, B., Lo Leggio, Leila & Abou Hachem, M., 2019, In: Journal of Biological Chemistry. 294, 31, p. 11701-11711 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Biochemical and structural features of diverse bacterial glucuronoyl esterases facilitating recalcitrant biomass conversion
Baath, J. A., Mazurkewich, S., Knudsen, R. M., Poulsen, Jens-Christian Navarro, Olsson, L., Lo Leggio, Leila & Larsbrink, J., 2018, In: Biotechnology for Biofuels. 11, 14 p., 213.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
NCAM2 Fibronectin type-III domains form a rigid structure that binds and activates the Fibroblast Growth Factor Receptor
Rasmussen, K. K., Falkesgaard, M. H., Winther, M., Roed, N. K., Quistgaard, C. L. A., Teisen, M. N., Edslev, S. M., Petersen, D. L., Aljubouri, A., Christensen, C., Thulstrup, Peter Waaben, Lo Leggio, Leila, Teilum, Kaare & Walmod, P. S., 2018, In: Scientific Reports. 8, 13 p., 8957 .Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Recent insights into lytic polysaccharide monooxygenases (LPMOs)
Tandrup, T., Frandsen, Kristian Erik Høpfner, Johansen, Katja Salomon, Berrin, J. & Lo Leggio, Leila, 2018, In: Biochemical Society Transactions. 46, 6, p. 1431-1447 17 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Structural basis of the bacteriophage TP901‐1 CI repressor dimerization and interaction with DNA
Rasmussen, K. K., Varming, A. K., Schmidt, S. N., Frandsen, Kristian Erik Høpfner, Thulstrup, Peter Waaben, Jensen, M. R. & Lo Leggio, Leila, 2018, In: F E B S Letters. 592, 10, p. 1738-1750 13 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Structure of a hyperthermostable carbonic anhydrase identified from an active hydrothermal vent chimney
Fredslund, F., Borchert, M. S., Poulsen, Jens-Christian Navarro, Mortensen, S. B., Perner, M., Streit, W. R. & Lo Leggio, Leila, 2018, In: Enzyme and Microbial Technology. 114, p. 48-54 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Structure of a lytic polysaccharide monooxygenase from Aspergillus fumigatus and an engineered thermostable variant
Lo Leggio, Leila, Weihe, C. D., Poulsen, Jens-Christian Navarro, Sweeney, M., Rasmussen, F., Lin, J., De Maria, L. & Wogulis, M., 2018, In: Carbohydrate Research. 469, p. 55-59 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Target highlights from the first post-PSI CASP experiment (CASP12, May-August 2016)
Kryshtafovych, A., Albrecht, R., Basle, A., Bule, P., Caputo, A. T., Carvalho, A. L., Chao, K. L., Diskin, R., Fidelis, K., Fontes, C. M. G. A., Fredslund, F., Gilbert, H. J., Goulding, C. W., Hartmann, M. D., Hayes, C. S., Herzberg, O., Hill, J. C., Joachimiak, A., Kohring, G-W., Koning, R. I. & 19 others, , 2018, In: Proteins: Structure, Function, and Bioinformatics. 86, S1, p. 27-50 24 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 13810
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2031
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Purification, crystal structure determination and functional characterization of type III antifreeze proteins from the European eelpout Zoarces viviparus
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1597
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A structural overview of GH61proteins – fungal cellulose degrading polysaccharide monooxygenases
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500
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Learning from oligosaccharide soaks of crystals of an AA13 lytic polysaccharide monooxygenase: crystal packing, ligand binding and active-site disorder
Research output: Contribution to journal › Journal article › Research › peer-review
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