Laura Mikél Mc Nair

Laura Mikél Mc Nair

Postdoc

  • Peptides and Proteins

    Jagtvej 162, 2100 København Ø, FARMA, bygn. 30, Building: 040

    Phone: +45 35 32 61 32Mobile: +45 29 72 56 47

Introductory remarks on publicationslist

My latest results include identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures (McNair et al. 2018 FEMS Yeast). A project conducted in tight collaboration with a food company. I am currently continuing this line of work and expect to present new exciting findings in the near future.

The work from my PhD include thorough characterisation of cellular energy metabolism in acutely isolated hippocampal and cerebral cortical mouse brain slices using 13C-mapping, GC-MS and HPLC (McNair et al. 2017 Neurochem Res) and provides evidence of metabolic similarity of these two brain regions. Moreover, I propose new interesting approaches for interpreting 13C-mapping data. This work was followed-up by evaluating the specificity of 13C-substrates for assessing astrocytic and neuronal metabolism individually in acute brain slices (Andersen, McNair et al. 2017 J Neurosci Res). Other parts of my work in acute brain slices have contributed to a recent review discussing the role of glutamate dehydrogenase and amino transferases in connection to glutamate oxidation in astrocytes (McKenna, Stridt, McNair et al. 2016 J Neurosci Res).

As part of my PhD I also completed two large rodent ex vivo studies combining 13C-mapping with GC-MS and 13C/1H NMR, in collaboration with excellent researchers at Yale University and Harvard Medical School (USA), respectively. I reveal significant brain regional differences in the rate of pyruvate carboxylase, an astrocytic enzyme essential for de novo synthesis of the excitatory neurotransmitter glutamate (manuscript in progress). Furthermore, I provide data suggesting that the glutamate transporter GLT-1 expressed in neurons is important for glutamate homeostasis and synaptoc energy metabolism (submitted to J Neurosci).

Results from my undergraduate research (2011-2012) at Bath University (UK) provide indications of differential changes in neural plasticity induced by addictive drug exposure with and without the context of a place-preference learning task, measured as long-term potentiation in hippocampal slices. This work was presented on scientific poster at the British Pharmacology Society meeting in 2012 and my data formed the basis for further work within Prof. C. Bailey's group.

Finally, my Master’s thesis elucidates the significant impact of pre-natal exposure to nicotine on brain function, measured as calcium responses to glutamatergic stimulation in brain slice from pubs born of nicotine treated mice (McNair & Kohlmeier 2015 J Dev Orig Health Dis).


Publication year:
  1. 2020
  2. Published

    Evaluation of the antidiabetic potential of Psidium guajava L. (Myrtaceae) using assays for α-glucosidase, α-amylase, muscle glucose uptake, liver glucose production and triglyceride accumulation in adipocytes

    Beidokhti, M. N., Eid, H. M., Villavicencio, M. L. S., Jäger, A. K., Lobbens, E. S., Rasoanaivo, P. R., McNair, Laura M., Haddad, P. S. & Stærk, Dan, 17 Apr 2020, In : Journal of Ethnopharmacology. 257, 8 p., 112877.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. E-pub ahead of print

    Conditional Knockout of GLT-1 in Neurons Leads to Alterations in Aspartate Homeostasis and Synaptic Mitochondrial Metabolism in Striatum and Hippocampus

    McNair, Laura M., Andersen, Jens Velde, Nissen, J. D., Sun, Y., Fischer, K. D., Hodgson, N. W., Du, M., Aoki, C. J., Waagepetersen, Helle S., Rosenberg, P. A. & Aldana Garcia, Blanca Irene, 6 Mar 2020, In : Neurochemical Research. 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

    Malik, A., Ardalani, H., Anam, S., McNair, Laura M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, Henrik, Stærk, Dan & Kongstad, Kenneth Thermann, 2020, In : Fitoterapia. 142, 104522.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Competitive Exclusion Is a Major Bioprotective Mechanism of Lactobacilli against Fungal Spoilage in Fermented Milk Products

    Siedler, S., Rau, M. H., Bidstrup, S., Vento, J. M., Aunsbjerg, S. D., Bosma, E. F., McNair, Laura M., Beisel, C. L. & Neves, A. R., 2020, In : Applied and Environmental Microbiology. 86, 7, 14 p., ARTN e02312-19.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2019
  7. Published

    Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function

    McNair, Laura M., Andersen, Jens Velde, Aldana Garcia, Blanca Irene, Hohnholt, M. C., Nissen, J. D., Sun, Y., Fischer, K. D., Sonnewald, U., Nyberg, N., Webster, S. C., Kapur, K., Rimmele, T. S., Barone, I., Hawks-Mayer, H., Lipton, J. O., Hodgson, N. W., Aoki, C. J., Rosenberg, P. A. & Waagepetersen, Helle S., 2019, In : The Journal of neuroscience : the official journal of the Society for Neuroscience. 39, 25, p. 4847-4863

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Glutamate homeostasis revisited - neuronal transport and metabolism

    Waagepetersen, Helle S., McNair, Laura M., Christensen, Sofie Kjellerup, Andersen, Jens Velde & Aldana Garcia, Blanca Irene, 2019, p. 19-19.

    Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

  9. 2018
  10. Published

    Identification and characterization of a new antifungal peptide in fermented milk product containing bioprotective Lactobacillus cultures

    McNair, Laura M., Siedler, S., Vinther, J. M., Hansen, A. M., Neves, A. R., Jäger, A. K., Franzyk, Henrik & Stærk, Dan, 2018, In : F E M S Yeast Research. 18, 9 p., foy094.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. 2017
  12. Published

    Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-(13)C]Glucose and [1,2-(13)C]Acetate as Substrates

    McNair, Laura M., Kornfelt, R., Walls, Anne Byriel, Andersen, Jens Velde, Aldana, B. I., Nissen, J. D., Schousboe, Arne & Waagepetersen, Helle S., 2017, In : Neurochemical Research. 42, 3, p. 810-826 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published
  14. 2016
  15. Published

    Glutamate oxidation in astrocytes: Roles of glutamate dehydrogenase and aminotransferases

    McKenna, M. C., Stridh, M. H., McNair, Laura M., Sonnewald, U., Waagepetersen, Helle S. & Schousboe, Arne, 15 Sep 2016, In : Journal of Neuroscience Research. 94, 12, p. 1561-1571 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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