Lars Hansen
Lars Hansen

senior adviser


  1. 2020
  2. Accepted/In press

    Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3

    de las Rivas, M., Paul Daniel, E. J., Narimatsu, Yoshiki, Compañón, I., Kato, K., Hermosilla, P., Thureau, A., Ceballos-Laita, L., Coelho, H., Bernadó, P., Marcelo, F., Hansen, Lars, Maeda, R., Lostao, A., Corzana, F., Clausen, Henrik, Gerken, T. A. & Hurtado-Guerrero, R., 2020, (Accepted/In press) In : Nature Chemical Biology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2019
  4. Published

    A splice-site variant in the lncRNA gene RP1-140A9.1 cosegregates in the large Volkmann cataract family

    Eiberg, Hans Rudolf Lytchoff, Mikkelsen, Annemette Friis, Bak, Mads, Tommerup, Niels, Lund, A. M., Wenzel, Anne, Radhakrishnan, Sabarinathan, Gorodkin, Jan, Bang-Berthelsen, C. H. & Hansen, Lars, 2019, In : Molecular Vision. 25, p. 1-11 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation.

    Steentoft, Catharina, Yang, Zhang, Wang, S., Ju, T., Vester-Christensen, M. B., Festari, M. F., King-Smith, S. L., Moremen, K., Larsen, Ida Signe Bohse, Goth, Christoffer Knak, Schjoldager, Katrine Ter-Borch Gram, Hansen, Lars, Bennett, Eric Paul, Mandel, Ulla & Narimatsu, Yoshiki, 2019, In : Glycobiology. 29, 9, p. 645–656 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells

    Narimatsu, Yoshiki, Joshi, Hiren Jitendra, pxs190, pxs190, Van Coillie, Julie, Karlsson, R., Sun, Lingbo, Ye, Zilu, Chen, Y., Schjoldager, Katrine Ter-Borch Gram, Steentoft, Catharina, Furukawa, S., Bensing, B. A., Sullam, P. M., Thompson, A. J., Paulson, J. C., Büll, Christian, Adema, G. J., Mandel, Ulla, Hansen, Lars, Bennett, Eric Paul, Varki, A., Vakhrushev, Sergey, Yang, Zhang & Clausen, Henrik, 2019, In : Molecular Cell. 75, 2, p. 394-407, e1-e5

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells

    Tian, Weihua, Ye, Zilu, Wang, S., Schulz, M. A., Van Coillie, Julie, Sun, Lingbo, Chen, Y., Narimatsu, Yoshiki, Hansen, Lars, Kristensen, Claus, Mandel, Ulla, Bennett, Eric Paul, Jabbarzadeh-Tabrizi, S., Schiffmann, R., Shen, J., Vakhrushev, Sergey, Clausen, Henrik & Yang, Zhang, 2019, In : Nature Communications. 10, 13 p., 1785.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2018
  9. Published

    A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome

    Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Zhang, Y., Gomes, C., Chen, Y., Lorenzetti, F., Furukawa, S., Schjoldager, Katrine Ter-Borch Gram, Hansen, Lars, Clausen, Henrik, Bennett, Eric Paul & Wandall, Hans H., 2018, In : Glycobiology. 28, 5, p. 295–305

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published
  11. Published
  12. Published

    Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions

    Wang, S., Mao, Y., Narimatsu, Yoshiki, Ye, Zilu, Tian, Weihua, Goth, Christoffer Knak, Lira-Navarrete, E., Pedersen, N. B., Benito-Vicente, A., Martin, C., Uribe, K. B., Hurtado-Guerrero, R., Christoffersen, Christina, Seidah, N. G., Nielsen, R., Christensen, E. I., Hansen, Lars, Bennett, Eric Paul, Vakhrushev, Sergey, Schjoldager, Katrine Ter-Borch Gram & Clausen, Henrik, 2018, In : The Journal of Biological Chemistry. 293, 19, p. 7408 –7422

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2017
  14. Published

    Isoform-specific mucin type O-glycosylation maintain epithelial homeostasis

    Bagdonaite, Ieva , E.M.H., P., K., L., Vakhrushev, Sergey, Hansen, Lars, Joshi, Hiren Jitendra, Bennett, Eric Paul, Dabelsteen, Sally & Wandall, Hans H., 2017, In : Glycoconjugate Journal. 34, Suppl. 1, p. S42 1 p., Abstract 78.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  15. Published

    Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression

    Pinto, R., Hansen, Lars, Hintze, John, Almeida, R., Larsen, S., Coskun, M., Davidsen, J., Mitchelmore, C., David, L., Troelsen, J. T. & Bennett, Eric Paul, 2017, In : Nucleic Acids Research. 45, 13, 15 p., e123.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. 2016
  17. Published

    Regulation of protein O-glycosylation in epithelial cells - the polypeptide GalNAc-transferases direct cellular differentiation and maintenance of tissue homeostasis

    Pallesen, E. M., Bagdonaite, Ieva , Vakhrushev, Sergey, Hansen, Lars, Joshi, Hiren Jitendra, Dabelsteen, Sally & Wandall, Hans H., Dec 2016, In : Glycobiology. 26, 12, p. 1391-1391

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  18. Published

    Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents

    Khetarpal, S. A., Schjoldager, Katrine Ter-Borch Gram, Christoffersen, Christina, Raghavan, A., Edmondson, A. C., Reutter, H. M., Ahmed, B., Ouazzani, R., Peloso, G. M., Vitali, C., Zhao, W., Somasundara, A. V. H., Millar, J. S., Park, Y., Fernando, G., Livanov, V., Choi, S., Noé, E., Patel, P., Ho, S. P., Kirchgessner, T. G., Wandall, Hans H., Hansen, Lars, Bennett, Eric Paul, Vakhrushev, Sergey, Saleheen, D., Kathiresan, S., Brown, C. D., Abou Jamra, R., LeGuern, E., Clausen, Henrik & Rader, D. J., 9 Aug 2016, In : Cell Metabolism. 24, 2, p. 234-245 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    A novel splice site mutation in CEP135 is associated with primary microcephaly in a Pakistani family

    Farooq, Muhammad, Fatima, A., Mang, Yuan, Hansen, Lars, Kjær, Klaus Wilbrandt, Baig, S. M., Larsen, Lars Allan & Tommerup, Niels, Mar 2016, In : Journal of Human Genetics. 61, 3, p. 271-273 3 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  20. 2015
  21. Published

    Fast and sensitive detection of indels induced by precise gene targeting

    Yang, Zhang, Steentoft, Catharina, Hauge, C., Hansen, Lars, Thomsen, A. L., Niola, Francesco, Vester-Christensen, M. B., Frödin, Morten, Clausen, Henrik, Wandall, Hans H. & Bennett, Eric Paul, 19 May 2015, In : Nucleic Acids Research. 43, 9, p. 1-8 8 p., e59.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    A glycogene mutation map for discovery of diseases of glycosylation

    Hansen, Lars, Lind-Thomsen, A., Joshi, Hiren Jitendra, Pedersen, N. B., Have, C. T., Kong, Y., Wang, S., Sparso, T., Grarup, Niels, Vester-Christensen, M. B., Schjoldager, Katrine Ter-Borch Gram, Freeze, H. H., Hansen, Torben, Pedersen, Oluf Borbye, Henrissat, B., Mandel, Ulla, Clausen, Henrik, Wandall, Hans H. & Bennett, Eric Paul, 2015, In : Glycobiology. 25, 2, p. 211-224 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2014
  24. Published

    The myosin chaperone UNC45B is involved in lens development and autosomal dominant juvenile cataract

    Hansen, Lars, Comyn, S., Mang, Yuan, Lind-Thomsen, A., Myhre, L., Jean, F., Eiberg, Hans Rudolf Lytchoff, Tommerup, Niels, Rosenberg, T. & Pilgrim, D., Nov 2014, In : European Journal of Human Genetics. 22, 11, p. 1290-1297 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Immature truncated O-glycophenotype of cancer directly induces oncogenic features

    Radhakrishnan, P., Dabelsteen, Sally, Madsen, F. B., Francavilla, C., Kopp, K. L., Steentoft, Catharina, Vakhrushev, Sergey, Olsen, Jesper Velgaard, Hansen, Lars, Bennett, Eric Paul, Woetmann, A., Yin, G., Chen, L., Song, H., Bak, Mads, Hlady, R. A., Peters, S. L., Opavsky, R., Thode, C., Qvortrup, Klaus, Schjoldager, Katrine Ter-Borch Gram, Clausen, Henrik, Hollingsworth, M. A. & Wandall, Hans H., 12 Aug 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 39, p. e4066-e4077 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    UDP-gal: BetaGlcNAc Beta 1,3-galactosyltransferase, polypeptide 1,2 (B3GALT1,2)

    Vester-Christensen, M. B., Hansen, Lars & Clausen, Henrik, 1 Jan 2014, Handbook of Glycosyltransferases and Related Genes, Second Edition. Springer Japan, Vol. 1. p. 73-80 8 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  27. Published

    UDP-gal: BetaGal beta 1,3-galactosyltransferase polypeptide 6 (B3GALT6)

    Vester-Christensen, M. B., Hansen, Lars & Clausen, Henrik, 1 Jan 2014, Handbook of Glycosyltransferases and Related Genes, Second Edition. Springer Japan, Vol. 1. p. 101-108 8 p.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  28. 2013
  29. Published

    Genetic heterogeneity in Pakistani microcephaly families

    Sajid Hussain, M., Bakhtiar, S. M., Farooq, Muhammad, Anjum, I., Janzen, E., Reza Toliat, M., Eiberg, Hans Rudolf Lytchoff, Kjær, Klaus Wilbrandt, Tommerup, Niels, Noegel, A. A., Nürnberg, P., Baig, S. M. & Hansen, Lars, May 2013, In : Clinical Genetics. 83, 5, p. 446-51 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Hypomorphic mutations in PGAP2, encoding a GPI-anchor-remodeling protein, cause autosomal-recessive intellectual disability

    Hansen, Lars, Tawamie, H., Murakami, Y., Mang, Yuan, ur Rehman, S., Buchert, R., Schaffer, S., Muhammad, S., Bak, Mads, Nöthen, M. M., Bennett, Eric Paul, Maeda, Y., Aigner, M., Reis, A., Kinoshita, T., Tommerup, Niels, Baig, S. M. & Abou Jamra, R., 4 Apr 2013, In : American Journal of Human Genetics. 92, 4, p. 575-83 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Mutations in c10orf11, a melanocyte-differentiation gene, cause autosomal-recessive albinism

    Grønskov, K., Dooley, C. M., Østergaard, Elsebet, Kelsh, R. N., Hansen, Lars, Levesque, M. P., Vilhelmsen, K., Møllgård, Kjeld, Stemple, D. L. & Rosenberg, T., 7 Mar 2013, In : American Journal of Human Genetics. 92, 3, p. 415-21 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. 2012
  33. Published

    Novel mutation in ATP13A2 widens the spectrum of Kufor-Rakeb syndrome (PARK9)

    Eiberg, Hans Rudolf Lytchoff, Hansen, Lars, Korbo, L., Nielsen, Inge-Merete, Svenstrup, K., Bech, S., Pinborg, L., Friberg, L., Hjermind, Lena Elisabeth, Olsen, O. & Nielsen, Jørgen Erik, Nov 2012, In : Clinical Genetics. 82, 3, p. 256-63 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Author response: Nonspecific PCR amplification of CRYBB2-pseudogene leads to misconception of natural variation as mutation

    Hansen, Lars & Rosenberg, T., 1 Sep 2012, In : Investigative Ophthalmology and Visual Science. 53, 10, 1 p.

    Research output: Contribution to journalLetterResearchpeer-review

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