Lars Hansen
Guest Researcher
Glycomics Program
Blegdamsvej 3
2200 København N.
Member of:
- 2024
- E-pub ahead of print
A family of di-glutamate mucin-degrading enzymes that bridges glycan hydrolases and peptidases
Narimatsu, Yoshiki, Büll, Christian, Taleb, V., Liao, Q., Compañón, I., Sánchez-Navarro, D., Durbesson, F., Vincentelli, R., Hansen, Lars, Corzana, F., Rovira, C., Henrissat, B., Clausen, Henrik, Joshi, Hiren Jitendra & Hurtado-Guerrero, R., 2024, (E-pub ahead of print) In: Nature Catalysis.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
A family with ulcerative colitis maps to 7p21.1 and comprises a region with regulatory activity for the aryl hydrocarbon receptor gene
Eiberg, Hans Rudolf Lytchoff, Olsson, J. B., Bak, M., Bang-Berthelsen, C. H., Troelsen, J. T. & Hansen, Lars, 2023, In: European Journal of Human Genetics. 31, p. 1440-1446 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase
Larsen, I. S. B., Povolo, Lorenzo, Zhou, L., Tian, W., Mygind, Kasper Johansen, Hintze, John, Jiang, C., Hartill, V., Prescott, K., Johnson, C. A., Mullegama, S. V., McConkie-Rosell, A., McDonald, M., Hansen, Lars, Vakhrushev, Sergey, Schjoldager, Katrine Ter-Borch Gram, Clausen, Henrik, Worzfeld, T., Joshi, Hiren Jitendra & Halim, Adnan, 2023, In: Proceedings of the National Academy of Sciences of the United States of America. 120, 21, p. e2302584120Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Installation of O-glycan sulfation capacities in human HEK293 cells for display of sulfated mucins
Sun, L., Konstantinidi, Andriana, Ye, Z., Nason, R., Zhang, Y., Büll, Christian, Kahl-Knutson, B., Hansen, Lars, Leffler, H., Vakhrushev, Sergey, Yang, Zhang, Clausen, Henrik & Narimatsu, Yoshiki, 2022, In: Journal of Biological Chemistry. 298, 2, 101382.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
Karlsson, R., Chopra, P., Joshi, A., Yang, Zhang, Vakhrushev, Sergey, Clausen, Thomas Mandel, Painter, C. D., Szekeres, G. P., Chen, Yen-Hsi, Sandoval, D. R., Hansen, Lars, Esko, J. D., Pagel, K., Dyer, D. P., Turnbull, Jeremy Ewan, Clausen, Henrik, Boons, G. J. & Miller, Rebecca Louise, 2021, In: Science Advances. 7, 52, eabl6026.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polypeptide n-acetylgalactosaminyltransferase-associated phenotypes in mammals
Kato, K., Hansen, Lars & Clausen, Henrik, 2021, In: Molecules. 26, 18, 5504.Research output: Contribution to journal › Review › Research › peer-review
- Published
Display of the human mucinome with defined O-glycans by gene engineered cells
Nason, R., Büll, C., Konstantinidi, A., Sun, L., Ye, Z., Halim, A., Du, W., Sørensen, D. M., Durbesson, F., Furukawa, S., Mandel, U., Joshi, H. J., Dworkin, L. A., Hansen, L., David, L., Iverson, T. M., Bensing, B. A., Sullam, P. M., Varki, A., Vries, E. D. & 6 others, , 2021, In: Nature Communications. 12, 1, 16 p., 4070.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
Lessons learned from 40 novel PIGA patients and a review of the literature
Bayat, A., Knaus, A., Pendziwiat, M., Afenjar, A., Stefan Barakat, T., Bosch, F., Callewaert, B., Calvas, P., Ceulemans, B., Chassaing, N., Depienne, C., Endziniene, M., Ferreira, C. R., Moura de Souza, C. F., Freihuber, C., Ganesan, S., Gataullina, S., Guerrini, R., Guerrot, A. M., Hansen, L. & 34 others, , 2020, In: Epilepsia. 61, 6, p. 1142-1155Research output: Contribution to journal › Journal article › Research › peer-review
- Published
RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis
Farooq, M., Lindbæk, L., Krogh, N., Doganli, C., Keller, C., Mönnich, M., Gonçalves, A. B., Sakthivel, S., Mang, Y., Fatima, A., Andersen, V. S., Hussain, M. S., Eiberg, H., Hansen, L., Kjaer, K. W., Gopalakrishnan, J., Pedersen, L. B., Møllgård, K., Nielsen, H., Baig, S. M. & 3 others, , 2020, In: Nature Communications. 11, 16 p., 5816.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A mutation map for human glycoside hydrolase genes
Hansen, Lars, Husein, D. M., Gericke, B., Hansen, Torben, Pedersen, Oluf Borbye, Tambe, M. A., Freeze, H. H., Naim, H. Y., Henrissat, B., Wandall, Hans H., Clausen, Henrik & Bennett, Eric Paul, 2020, In: Glycobiology. 30, 8, p. 500-515 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Novel congenital disorder of O-linked glycosylation caused by GALNT2 loss of function
Zilmer, M., Edmondson, A. C., Khetarpal, S. A., Alesi, V., Zaki, M. S., Rostasy, K., Madsen, C. G., Lepri, F. R., Sinibaldi, L., Cusmai, R., Novelli, A., Issa, M. Y., Fenger, C. D., Jamra, R. A., Reutter, H., Briuglia, S., Agolini, E., Hansen, L., Petäjä-Repo, U. E., Hintze, J. & 12 others, , 2020, In: Brain. 143, 4, p. 1114-1126 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular basis for fibroblast growth factor 23 O-glycosylation by GalNAc-T3
de las Rivas, M., Paul Daniel, E. J., Narimatsu, Yoshiki, Compañón, I., Kato, K., Hermosilla, P., Thureau, A., Ceballos-Laita, L., Coelho, H., Bernadó, P., Marcelo, F., Hansen, Lars, Maeda, R., Lostao, A., Corzana, F., Clausen, Henrik, Gerken, T. A. & Hurtado-Guerrero, R., 2020, In: Nature Chemical Biology. 16, p. 351–360Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
A splice-site variant in the lncRNA gene RP1-140A9.1 cosegregates in the large Volkmann cataract family
Eiberg, Hans Rudolf Lytchoff, Mikkelsen, Annemette Friis, Bak, M., Tommerup, Niels, Lund, A. M., Wenzel, Anne, Sabarinathan, R., Gorodkin, Jan, Bang-Berthelsen, C. H. & Hansen, Lars, 2019, In: Molecular Vision. 25, p. 1-11 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
An Atlas of Human Glycosylation Pathways Enables Display of the Human Glycome by Gene Engineered Cells
Narimatsu, Y., Joshi, H. J., Nason, R., Van Coillie, J., Karlsson, R., Sun, L., Ye, Z., Chen, Y-H., Schjoldager, K. T., Steentoft, C., Furukawa, S., Bensing, B. A., Sullam, P. M., Thompson, A. J., Paulson, J. C., Büll, C., Adema, G. J., Mandel, U., Hansen, L., Bennett, E. P. & 4 others, , 2019, In: Molecular Cell. 75, 2, p. 394-407, e1-e5Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A validated collection of mouse monoclonal antibodies to human glycosyltransferases functioning in mucin-type O-glycosylation.
Steentoft, C., Yang, Zhang, Wang, S., Ju, T., Vester-Christensen, M. B., Festari, M. F., King-Smith, S. L., Moremen, K., Larsen, I. S. B., Goth, C. K., Schjoldager, Katrine Ter-Borch Gram, Hansen, Lars, Bennett, Eric Paul, Mandel, Ulla & Narimatsu, Yoshiki, 2019, In: Glycobiology. 29, 9, p. 645–656 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Tian, W., Ye, Z., Wang, S., Schulz, M. A., Van Coillie, Julie, Sun, L., Chen, Yen-Hsi, Narimatsu, Yoshiki, Hansen, Lars, Kristensen, C., Mandel, Ulla, Bennett, Eric Paul, Jabbarzadeh-Tabrizi, S., Schiffmann, R., Shen, J., Vakhrushev, Sergey, Clausen, Henrik & Yang, Zhang, 2019, In: Nature Communications. 10, 13 p., 1785.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
- Published
Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases
Joshi, Hiren Jitendra, Hansen, Lars, Narimatsu, Yoshiki, Freeze, H. H., Henrissat, B., Bennett, Eric Paul, Wandall, Hans H., Clausen, Henrik & Schjoldager, Katrine Ter-Borch Gram, 2018, In: Glycobiology. 28, 5, p. 284-294Research output: Contribution to journal › Journal article › Research › peer-review
- Published
De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium
Lavrsen, K., Dabelsteen, Sally, Vakhrushev, Sergey, Levann, Asha Maria Rudjord, Haue, Amalie Dahl, Dylander, A., Mandel, Ulla, Hansen, Lars, Frödin, Morten, Bennett, Eric Paul & Wandall, Hans H., 2018, In: The Journal of Biological Chemistry. 293, p. 1298-1314Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome
Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Zhang, Y., Gomes, C., Chen, Yen-Hsi, Lorenzetti, F., Furukawa, S., Schjoldager, Katrine Ter-Borch Gram, Hansen, Lars, Clausen, Henrik, Bennett, Eric Paul & Wandall, Hans H., 2018, In: Glycobiology. 28, 5, p. 295–305Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-specific O-glycosylation of members of the low-density lipoprotein receptor superfamily enhances ligand interactions
Wang, S., Mao, Y., Narimatsu, Y., Ye, Z., Tian, W., Goth, C. K., Lira-Navarrete, E., Pedersen, N. B., Benito-Vicente, A., Martin, C., Uribe, K. B., Hurtado-Guerrero, R., Christoffersen, C., Seidah, N. G., Nielsen, R., Christensen, E. I., Hansen, L., Bennett, E. P., Vakhrushev, S. Y., Schjoldager, K. T. & 1 others, , 2018, In: The Journal of Biological Chemistry. 293, 19, p. 7408 –7422Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
- Published
Isoform-specific mucin type O-glycosylation maintain epithelial homeostasis
Bagdonaite, Ieva , E.M.H., P., K., L., Vakhrushev, Sergey, Hansen, Lars, Joshi, Hiren Jitendra, Bennett, Eric Paul, Dabelsteen, Sally & Wandall, Hans H., 2017, In: Glycoconjugate Journal. 34, Suppl. 1, p. S42 1 p., Abstract 78.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Discovery of an O-mannosylation pathway selectively serving cadherins and protocadherins
Larsen, I. S. B., Narimatsu, Yoshiki, Joshi, Hiren Jitendra, Siukstaite, L., Harrison, O. J., Brasch, J., Goodman, K. M., Hansen, Lars, Shapiro, L., Honig, B., Vakhrushev, Sergey, Clausen, Henrik & Halim, Adnan, 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 42, p. 11163-11168 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression
Pinto, R., Hansen, Lars, Hintze, John, Almeida, R., Larsen, S., Coskun, M., Davidsen, J., Mitchelmore, C., David, L., Troelsen, J. T. & Bennett, Eric Paul, 2017, In: Nucleic Acids Research. 45, 13, 15 p., e123.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
- Published
A novel splice site mutation in CEP135 is associated with primary microcephaly in a Pakistani family
Farooq, M., Fatima, A., Mang, Y., Hansen, Lars, Kjaer, K. W., Baig, S. M., Larsen, Lars Allan & Tommerup, Niels, Mar 2016, In: Journal of Human Genetics. 61, 3, p. 271-273 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents
Khetarpal, S. A., Schjoldager, K. T., Christoffersen, C., Raghavan, A., Edmondson, A. C., Reutter, H. M., Ahmed, B., Ouazzani, R., Peloso, G. M., Vitali, C., Zhao, W., Somasundara, A. V. H., Millar, J. S., Park, Y., Fernando, G., Livanov, V., Choi, S., Noé, E., Patel, P., Ho, S. P. & 12 others, , 9 Aug 2016, In: Cell Metabolism. 24, 2, p. 234-245 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 544414
Most downloads
-
244
downloads
Precise integration of inducible transcriptional elements (PrIITE) enables absolute control of gene expression
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
179
downloads
The glycosylation design space for recombinant lysosomal replacement enzymes produced in CHO cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
75
downloads
Display of the human mucinome with defined O-glycans by gene engineered cells
Research output: Contribution to journal › Journal article › Research › peer-review
Published