Kristian Strømgaard

Professor

Biopharmaceuticals
Jagtvej 162
2100 København Ø
- kristian.stromgaard@sund.ku.dk
- https://drug.ku.dk
Phone: +4535336114

ORCID: 0000-0003-2206-4737

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Published
In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury
Sommer, J. B., Bach, Anders, Rytter, Hana Malá, Strømgaard, Kristian, Mogensen, J. & Pickering, Darryl S, 20 Jan 2017, In: European Journal of Neuroscience. 45, 2, p. 238-248 11 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma
Haugaard-Kedstrom, L. M., Clemmensen, L. S., Sereikaite, V., Jin, Z., Fernandes, E. F. A., Wind, B., Abalde-Gil, F., Daberger, J., Vistrup-Parry, M., Aguilar-Morante, D., Leblanc, R., Egea-Jimenez, A. L., Albrigtsen, M., Jensen, K. E., Jensen, T. M. T., Ivarsson, Y., Vincentelli, R., Hamerlik, P., Andersen, J. H., Zimmermann, P. & 2 others, Lee, W. & Strømgaard, Kristian, 2021, In: Journal of Medicinal Chemistry. 64, 3, p. 1423-1434 12 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition
Langlhofer, G., Schaefer, N., Maric, H. M., Keramidas, A., Zhang, Y., Baumann, P., Blum, R., Breitinger, U., Strømgaard, Kristian, Schlosser, A., Kessels, M. M., Koch, D., Qualmann, B., Breitinger, H. G., Lynch, J. W. & Villmann, C., 2020, In: Journal of Neuroscience. 40, 25, p. 4954-4969 16 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses
Lindqvist, R., Benz, C., Sereikaité, Vita, Maassen, L., Laursen, L., Jemth, P., Strømgaard, Kristian, Ivarsson, Y. & Overby, A. K., 2022, In: Viruses. 14, 10, 12 p., 2202.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain
Thorsen, T. S., Madsen, Kenneth Lindegaard, Dyhring, T., Bach, Anders, Peters, D., Strømgaard, Kristian, Rønn, L. C. B. & Gether, Ulrik, 1 Aug 2011, In: Combinatorial Chemistry & High Throughput Screening. 14, 7, p. 590-600 11 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A heteromeric snake toxin and the molecular details of pain perception
Strømgaard, Kristian & Kristensen, Anders Skov, 23 Apr 2012, In: Angewandte Chemie International Edition. 51, 17, p. 4009-4011
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain
Christensen, N. R., De Luca, M., Lever, M. B., Richner, M., Hansen, A. B., Noes-Holt, G., Jensen, K. L., Rathje, M., Jensen, D. B., Erlendsson, S., Bartling, C. R. O., Ammendrup-Johnsen, I., Pedersen, S. E., Schönauer, M., Nissen, K. B., Midtgaard, S. R., Teilum, K., Arleth, L., Sørensen, A. T., Bach, A. & 5 others, Strømgaard, Kristian, Meehan, Claire Francesca, Vægter, C. B., Gether, Ulrik & Madsen, Kenneth Lindegaard, 2020, In: EMBO Molecular Medicine. 12, 6, 25 p., e11248.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage
Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A parallel semisynthetic approach for structure-activity relationship studies of peptide YY
Albertsen, L., Østergaard, S., Paulsson, J. F., Norrild, J. C. & Strømgaard, Kristian, Sep 2013, In: ChemMedChem. 8, 9, p. 1505-13
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers
Pirhaghi, M., Frank, S. A., Alam, P., Nielsen, J., Sereikaité, Vita, Gupta, A., Strømgaard, Kristian, Andreasen, M., Sharma, D., Saboury, A. A. & Otzen, D. E., 2022, In: Journal of Biological Chemistry. 298, 12, 14 p., 102688.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A sequential binding mechanism in a PDZ domain
Chi, C. N., Bach, Anders, Engström, Å., Wang, H., Strømgaard, Kristian, Gianni, S. & Jemth, P., 2009, In: Biochemistry. 48, 30, p. 7089-7097
Research output: Contribution to journal › Journal article › Research › peer-review
Published
A versatile method for solid phase synthesis of polyamines: neuroactive polyamine toxins as example
Strømgaard, Kristian, Andersen, K., Ruhland, T., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 2001, In: Synthesis. 6, p. 877-884 8 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins
Strømgaard, Kristian & Mellor, I., Sep 2004, In: Medicinal Research Reviews. 24, 5, p. 589-620 32 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
An expanded view of the protein folding landscape of PDZ domains
Hultqvist, G., Pedersen, S. W., Chi, C. N., Strømgaard, Kristian, Gianni, S. & Jemth, P., 11 May 2012, In: Biochemical and Biophysical Research Communications. 421, 3, p. 550-553 4 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor
Strømgaard, Kristian, Brierley, M. J., Andersen, K., Sløk, F. A., Mellor, I. R., Usherwood, P. N., Krogsgaard-Larsen, Povl & Jaroszewski, J. W., 16 Dec 1999, In: Journal of Medicinal Chemistry. 42, 25, p. 5224-5234 11 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Antidepressive lægemidler: nu i 3D
Andersen, J., Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, Dec 2010, In: Lægemiddelforskning. 2010, p. 25-27
Research output: Contribution to journal › Journal article › Communication
Published
Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase**
Bolding, J. E., Martín-Gago, P., Rajabi, N., Gamon, Luke Francis, Hansen, T. N., Bartling, Christian Reinhard Otto, Strømgaard, Kristian, Davies, Michael J. & Olsen, Christian Adam, 2022, In: Angewandte Chemie - International Edition. 61, 47, 11 p., e202204565.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: Discovery of nanomolar, nonselective, and use-dependent antagonists
Frølund, S., Bella, A., Kristensen, Anders Skov, Ziegler, H. L., Witt, M., Olsen, C. A., Strømgaard, Kristian, Franzyk, Henrik & Jaroszewski, J. W., 2010, In: Journal of Medicinal Chemistry. 53, 20, p. 7441-7451
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners
Christensen, N. R., Pedersen, Christian Parsbæk, Sereikaité, Vita, Pedersen, J. N., Vistrup-Parry, M., Sørensen, Andreas Toft, Otzen, D., Teilum, Kaare, Madsen, Kenneth Lindegaard & Strømgaard, Kristian, 2022, In: iScience. 25, 2, 26 p., 103808.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Binding of ArgTX-636 in the NMDA receptor ion channel
Poulsen, M. H., Andersen, J., Christensen, R., Hansen, K. B., Traynelis, S. F., Strømgaard, Kristian & Kristensen, Anders Skov, 16 Jan 2015, In: Journal of Molecular Biology. 427, 1, p. 176-89 14 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter
Andersen, J., Ladefoged, L. K., Wang, D., Kristensen, T. N. B., Bang-Andersen, B., Kristensen, Anders Skov, Schiøtt, B. & Strømgaard, Kristian, 18 Nov 2015, In: A C S Chemical Neuroscience. 6, 11, p. 1892-900 9 p.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter
Andersen, J., Ringsted, K. B., Bang-Andersen, B., Strømgaard, Kristian & Kristensen, Anders Skov, 2015, In: Scientific Reports. 5, p. 1-12 12 p., 15650.
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97
Chi, C. N., Bach, Anders, Engström, Å., Strømgaard, Kristian, Lundström, P., Ferguson, N. & Jemth, P., 4 Feb 2011, In: Journal of Biological Chemistry. 286, 5, p. 3597-3606
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction
Bach, Anders, Eildal, J. N. N., Stuhr-Hansen, N., Deeskamp, R., Gottschalk, M., Pedersen, S. W., Kristensen, Anders Skov & Strømgaard, Kristian, 10 Mar 2011, In: Journal of Medicinal Chemistry. 54, 5, p. 1333-1346
Research output: Contribution to journal › Journal article › Research › peer-review
Published
Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites
Sørensen, L., Strømgaard, Kristian & Kristensen, Anders Skov, 18 Apr 2014, In: ACS chemical biology. 9, 4, p. 935-44 10 p.
Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1302559

Research

Kristian Strømgaard

Biopharmaceuticals

In vitro and in vivo effects of a novel dimeric inhibitor of PSD‐95 on excitotoxicity and functional recovery after experimental traumatic brain injury

A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma

A Novel Glycine Receptor Variant with Startle Disease Affects Syndapin I and Glycinergic Inhibition

A Syntenin Inhibitor Blocks Endosomal Entry of SARS-CoV-2 and a Panel of RNA Viruses

A fluorescence polarization based screening assay for identification of small molecule inhibitors of the PICK1 PDZ domain

A heteromeric snake toxin and the molecular details of pain perception

A high-affinity, bivalent PDZ domain inhibitor complexes PICK1 to alleviate neuropathic pain

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

A parallel semisynthetic approach for structure-activity relationship studies of peptide YY

A penetratin-derived peptide reduces the membrane permeabilization and cell toxicity of α-synuclein oligomers

A sequential binding mechanism in a PDZ domain

A versatile method for solid phase synthesis of polyamines: neuroactive polyamine toxins as example

AMPA receptor ligands: synthetic and pharmacological studies of polyamines and polyamine toxins

An expanded view of the protein folding landscape of PDZ domains

Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor

Antidepressive lægemidler: nu i 3D

Aryl Fluorosulfate Based Inhibitors That Covalently Target the SIRT5 Lysine Deacylase**

Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: Discovery of nanomolar, nonselective, and use-dependent antagonists

Bidirectional protein–protein interactions control liquid–liquid phase separation of PSD-95 and its interaction partners

Binding of ArgTX-636 in the NMDA receptor ion channel

Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter

Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter

Biophysical characterization of the complex between human papillomavirus E6 protein and synapse-associated protein 97

Cell-permeable and plasma-stable peptidomimetic inhibitors of the postsynaptic density-95/N-methyl-D-aspartate receptor interaction

Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites

Most downloads

PDZ domain-mediated interactions of G protein-coupled receptors with postsynaptic density protein 95: quantitative characterization of interactions