Konstantin Khodosevich
Group leader, Professor
Khodosevich Group
Ole Maaløes Vej 5, 2200 København N.
Member of:
- 2024
- Published
Drug targeting in psychiatric disorders — how to overcome the loss in translation?
Khodosevich, Konstantin, Dragicevic, K. & Howes, O., 2024, In: Nature Reviews Drug Discovery. 23, p. 218-231Research output: Contribution to journal › Journal article › peer-review
- 2023
- Published
A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits: A congenital rat model
Sønderstrup, M., Batiuk, M. Y., Mantas, P., Tapias-Espinosa, C., Oliveras, I., Cañete, T., Sampedro-Viana, D., Brudek, T., Rydbirk, Rasmus, Khodosevich, Konstantin, Fernandez-Teruel, A., Elfving, B. & Aznar, S., 2023, In: European Neuropsychopharmacology. 74, p. 32-46 15 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Loss of maturity and homeostatic functions in Tuberous Sclerosis Complex-derived astrocytes
Luinenburg, M. J., Scheper, M., Sørensen, Frederik Nørby Friis, Anink, J. J., Van Hecke, W., Korshunova, Irina, Jansen, F. E., Riney, K., van Eijsden, P., Gosselaar, P., Mills, J. D., Kalf, R. S., Zimmer, T. S., Broekaart, D. W. M., Khodosevich, Konstantin, Aronica, E. & Mühlebner, A., 2023, In: Frontiers in Cellular Neuroscience. 17, 15 p., 1284394.Research output: Contribution to journal › Journal article › peer-review
- Published
Neurodevelopmental disorders - high-resolution rethinking of disease modeling
Khodosevich, Konstantin & Sellgren, C. M., 2023, In: Molecular Psychiatry. 28, p. 34-43 10 p.Research output: Contribution to journal › Journal article › peer-review
- 2022
- Published
Single cell mapping the evolution of the spatial processing centre within the brain
Ralbovszki, Dorottya Maria, Bertelsen, Mads Frost, Buchmann, Kurt, Mori, Yuki, Gorodkin, Jan, Hemberg, M., Seemann, Ernst Stefan, Khodosevich, Konstantin & Hall, Vanessa Jane, 1 May 2022.Research output: Contribution to conference › Poster › Communication
- Published
Cell segmentation in imaging-based spatial transcriptomics
Petukhov, V., Xu, R. J., Soldatov, R. A., Cadinu, P., Khodosevich, Konstantin, Moffitt, J. R. & Kharchenko, P. V., 2022, In: Nature Biotechnology. 40, p. 345-354Research output: Contribution to journal › Journal article › peer-review
- Published
Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature
Kohler, Katharina Theresa, Goldhammer, N., Demharter, S., Pfisterer, U., Khodosevich, Konstantin, Rønnov-Jessen, Lone, Petersen, Ole William, Villadsen, René & Kim, Jiyoung, 2022, In: npj Breast Cancer. 8, 1, 12 p., 81.Research output: Contribution to journal › Journal article › peer-review
- Published
Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)
Pazarlar, B. A., trj450, trj450, Petukhov, V., Pinborg, Lars Hageman, Khodosevich, Konstantin & Mikkelsen, Jens D., 2022, In: Molecular Brain. 15, 1, 45.Research output: Contribution to journal › Journal article › peer-review
- Published
Identification of Vulnerable Interneuron Subtypes in 15q13.3 Microdeletion Syndrome Using Single-Cell Transcriptomics
Malwade, S., Gasthaus, J., Bellardita, Carmelo, Andelic, M., Moric, Borna, Korshunova, Irina, Kiehn, Ole, Vasistha, Navneet A & Khodosevich, Konstantin, 2022, In: Biological Psychiatry. 91, 8, p. 727-739Research output: Contribution to journal › Journal article › peer-review
- Published
Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming
Bergmann, T., Liu, Y., Skov, J., Mogus, L., Lee, J., Pfisterer, U., Handfield, L. F., Asenjo-Martinez, A., Lisa-Vargas, I., Seemann, S. E., Lee, J. T. H., Patikas, N., Kornum, B. R., Denham, M., Hyttel, P., Witter, M. P., Gorodkin, J., Pers, T. H., Hemberg, M., Khodosevich, K. & 1 others, , 2022, In: Frontiers in Cell and Developmental Biology. 10, 976549.Research output: Contribution to journal › Journal article › peer-review
- Published
Single-nucleus transcriptomics of IDH1- and TP53-mutant glioma stem cells displays diversified commitment on invasive cancer progenitors
Gulaia, V., Shmelev, M., Romanishin, A., Shved, N., Farniev, V., Goncharov, N., Biktimirov, A., Lisa Vargas, Irene, Khodosevich, Konstantin, Kagansky, A. & Kumeiko, V., 2022, In: Scientific Reports. 12, 18 p., 18975.Research output: Contribution to journal › Journal article › peer-review
- Published
Upper cortical layer-driven network impairment in schizophrenia
Batiuk, M. Y., Tyler, T., Dragicevic, K., Mei, S., Rydbirk, Rasmus, Petukhov, V., Deviatiiarov, R., Sedmak, D., Frank, E., Feher, V., Habek, N., Hu, Q., Igolkina, A., Roszik, L., Pfisterer, U., Garcia-Gonzalez, D., Petanjek, Z., Adorjan, I., Kharchenko, P. V. & Khodosevich, Konstantin, 2022, In: Science Advances. 8, 41, 24 p., eabn8367.Research output: Contribution to journal › Journal article › peer-review
- 2021
- Published
Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality
Zaghet, Nico, Madsen, Katrine, Rossi, F., Perez, D. F., Amendola, P. G., Demharter, S., Pfisterer, U., Khodosevich, Konstantin, Pasini, D. & Salcini, Anna Elisabetta, 2021, In: Cell Reports. 37, 8, p. 110050Research output: Contribution to journal › Journal article › peer-review
- Published
Development of the entorhinal cortex occurs via parallel lamination during neurogenesis
Liu, Y., Bergmann, T., Mori, Yuki, Peralvo Vidal, Juan Miguel, Pihl, M., Vasistha, Navneet A, Thomsen, Preben Dybdahl, Seemann, Ernst Stefan, Gorodkin, Jan, Hyttel, P., Khodosevich, Konstantin, Witter, M. P. & Hall, Vanessa Jane, 2021, In: Frontiers in Neuroanatomy. 15, 19 p., 663667.Research output: Contribution to journal › Journal article › peer-review
- Published
PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia
Magalhaes, J., Tresse, E., Ejlerskov, P., Hu, E., Liu, Y., Marin, A., Montalant, A., Satriano, L., Rundsten, C. F., Carlsen, E. M. M., Rydbirk, R., Sharifi-Zarchi, A., Andersen, J. B., Aznar, S., Brudek, T., Khodosevich, K., Prinz, M., Perrier, J. F. M., Sharma, M., Gasser, T. & 1 others, , 2021, In: Molecular Psychiatry. 26, p. 6083–6099 17 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Selective vulnerability of supragranular layer neurons in schizophrenia
Batiuk, M. Y., Tyler, T., Mei, S., Rydbirk, Rasmus, Petukhov, V., Sedmak, D., Frank, E., Feher, V., Habek, N., Hu, Q., Igolkina, A., Roszik, L., Pfisterer, U., Petanjek, Z., Adorjan, I., Kharchenko, P. V. & Khodosevich, Konstantin, 2021, (bioRxiv).Research output: Working paper › Preprint › Research
- Published
The impact of (ab)normal maternal environment on cortical development
Vasistha, Navneet A & Khodosevich, Konstantin, 2021, In: Progress in Neurobiology. 202, 22 p., 102054.Research output: Contribution to journal › Review › peer-review
- 2020
- Published
A community-based transcriptomics classification and nomenclature of neocortical cell types
Yuste, R., Hawrylycz, M., Aalling, N., Aguilar-valles, A., Arendt, D., Arnedillo, R. A., Ascoli, G. A., Bielza, C., Bokharaie, V., Bergmann, T. B., Bystron, I., Capogna, M., Chang, Y., Clemens, A., De Kock, C. P. J., Defelipe, J., Dos Santos, S. E., Dunville, K., Feldmeyer, D., Fiáth, R. & 53 others, , 2020, In: Nature Neuroscience. 23, p. 1456-1468 13 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Bayesian segmentation of spatially resolved transcriptomics data
Petukhov, V., Soldatov, R. A., Khodosevich, Konstantin & Kharchenko, P. V., 2020, Cold Spring Harbor Laboratory, (bioRxiv).Research output: Working paper › Preprint › Research
- Published
Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function
Sanz-Morello, B., Pfisterer, U., Hansen, Nikolaj Winther, Demharter, S., Thakur, A., Fujii, K., Levitskii, S. A., Montalant, Alexia, Korshunova, Irina, Mammen, P. P., Kamenski, P., Noguchi, S., Aldana, Blanca, Hougaard, K. S., Perrier, Jean-Francois Marie & Khodosevich, Konstantin, 2020, In: The EMBO Journal. 39, 18, p. 1-21 e105759.Research output: Contribution to journal › Journal article › peer-review
- Published
Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells
Korshunova, Irina, Rhein, S., vsz834, vsz834, Stölting, I., Pfisterer, U., Barta, A., Dmytriyeva, O., Kirkeby, Agnete, Schwaninger, M. & Khodosevich, Konstantin, 2020, In: JCI insight. 5, 4, p. 1-19 e126268.Research output: Contribution to journal › Journal article › peer-review
- Published
Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner
Vasistha, Navneet A, Pardo-Navarro, M., Gasthaus, J., Weijers, D., Müller, M. K., vsz834, vsz834, Malwade, S., Korshunova, Irina, Pfisterer, U., von Engelhardt, J., Hougaard, K. S. & Khodosevich, Konstantin, 2020, In: Molecular Psychiatry. 25, p. 2313-2329Research output: Contribution to journal › Journal article › peer-review
- 2019
- Published
The developing Entorhinal cortex - a cellular map
Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Handfield, L., Asenjo Martinez, A., Seemann, Ernst Stefan, Witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Hemberg, M., Pers, Tune H & Hall, Vanessa Jane, 25 Nov 2019. 1 p.Research output: Contribution to conference › Conference abstract for conference › Communication
- Published
Joint analysis of heterogeneous single-cell RNA-seq dataset collections
Barkas, N., Petukhov, V., Nikolaeva, D., Lozinsky, Y., Demharter, S., Khodosevich, Konstantin & Kharchenko, P. V., Aug 2019, In: Nature Methods. 16, 8, p. 695-698Research output: Contribution to journal › Journal article › peer-review
- Published
Dynamic Changes in Ultrastructure of the Primary Cilium in Migrating Neuroblasts in the Postnatal Brain
Matsumoto, M., Sawada, M., vsz834, vsz834, Herranz-pérez, V., Ogino, T., Bang Nguyen, H., Quynh Thai, T., Narita, K., Kumamoto, N., Ugawa, S., Saito, Y., Takeda, S., Kaneko, N., Khodosevich, Konstantin, Monyer, H., García-verdugo, J. M., Ohno, N. & Sawamoto, K., 2019, In: The Journal of Neuroscience. 39, 50, p. 9967-9988Research output: Contribution to journal › Journal article › peer-review
- Published
GluA4-Targeted AAV Vectors Deliver Genes Selectively to Interneurons while Relying on the AAV Receptor for Entry
Hartmann, J., Thalheimer, F. B., Höpfner, F., Kerzel, T., Khodosevich, Konstantin, vsz834, vsz834, Monyer, H., Diester, I., Büning, H., Carette, J. E., Fries, P. & Buchholz, C. J., 2019, In: Molecular Therapy - Methods & Clinical Development. 14, p. 252-260 9 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing
Adorjan, I., Tyler, T., Bhaduri, A., Demharter, S., Finszter, C. K., Bako, M., Sebok, O. M., Nowakowski, T. J., Khodosevich, Konstantin, Møllgård, Kjeld, Kriegstein, A. R., Shi, L., Hoerder-Suabedissen, A., Ansorge, O. & Molnár, Z., 2019, In: Journal of Anatomy. 235, 3, p. 543-554 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Production of stellate cells from induced pluripotent stem cells to study Alzheimer's disease pathology
Mogus, L., Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Handfield, L., Asenjo Martinez, A., Seemann, Ernst Stefan, Witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Hemberg, M., Pers, Tune H & Hall, Vanessa Jane, 2019. 1 p.Research output: Contribution to conference › Conference abstract for conference › Communication
- Published
Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system
Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, , 2019. 45 p.Research output: Contribution to conference › Paper › Communication
- Published
The developing Entorhinal Cortex – a cellular map
Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Asenjo Martinez, A., Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Hyttel, P., witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Pers, Tune H & Hall, Vanessa Jane, 2019.Research output: Contribution to conference › Conference abstract for conference › Research
- Published
Tracing the origin of adult intestinal stem cells
Guiu, J., Hannezo, E., Yui, S., Demharter, S., Ulyanchenko, Svetlana, Maimets, Martti, Jørgensen, A., Perlman, S., Lundvall, L., Mamsen, L. S., Larsen, A., Olesen, R. H., Andersen, C. Y., Thuesen, L. L., Hare, Kristine Juul, Pers, Tune H, Khodosevich, Konstantin, Simons, B. D. & Jensen, Kim Bak, 2019, In: Nature. 570, 7759, p. 107-111Research output: Contribution to journal › Letter › peer-review
- Published
Uncovering the anatomical and molecular landscape of the starting point of Alzheimer’s disease in the brain
Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Asenjo Martinez, A., Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Hyttel, P., witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Pers, Tune H & Hall, Vanessa Jane, 2019.Research output: Contribution to conference › Conference abstract for conference › Research
- 2018
- Published
An advanced enrichment method for rare somatic retroelement insertions sequencing
Komkov, A. Y., Minervina, A. A., Nugmanov, G. A., Saliutina, M. V., Khodosevich, Konstantin, Lebedev, Y. B. & Mamedov, I. Z., 2018, In: Mobile DNA. 9, 1, p. 1-11 11 p., 31.Research output: Contribution to journal › Journal article › peer-review
- Published
MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke
Tseng, K., Anttila, J. E., Khodosevich, Konstantin, Tuominen, R. K., Lindahl, M., Domanskyi, A. & Airavaara, M., 2018, In: Molecular therapy : the journal of the American Society of Gene Therapy. 26, 1, p. 238-255 18 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Maternal inflammation significantly impacts cortical interneuron development in a subtype-specific manner
Vasistha, Navneet A, Pardo-Navarro, M., Gasthaus, J., Weijers, D., Müller, M. K., Pfisterer, U. G., Hougaard, K. S. & Khodosevich, Konstantin, 2018, Cold Spring Harbor Laboratory Press, 39 p. (bioRxiv).Research output: Working paper › Research
- Published
Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring
Umezawa, M., Onoda, A., Korshunova, Irina, Jensen, A. C. Ø., Koponen, I. K., Jensen, K. A., Khodosevich, Konstantin, Vogel, U. & Hougaard, K. S., 2018, In: Particle and Fibre Toxicology. 15, p. 1-18 18 p., 36.Research output: Contribution to journal › Journal article › peer-review
- Published
Wiring together large single-cell RNA-seq sample collections
Barkas, N., Petukhov, V., Nikolaeva, D., Lozinsky, Y., Demharter, S., Khodosevich, Konstantin & Kharchenko, P. V., 2018, Biorxiv: Cold Spring Harbor Laboratory, 14 p.Research output: Working paper › Research
- 2017
- Published
Serotonergic Projections Govern Postnatal Neuroblast Migration
García-González, D., Khodosevich, Konstantin, Watanabe, Y., Rollenhagen, A., Lübke, J. H. R. & Monyer, H., 3 May 2017, In: Neuron. 94, 3, p. 534-549.e9 26 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Neuronal survival in the brain: neuron type-specific mechanisms: neuron type-specific mechanisms
Pfisterer, U. G. & Khodosevich, Konstantin, 2 Mar 2017, In: Cell Death & Disease. 8, 3, 14 p., e2643.Research output: Contribution to journal › Review › peer-review
- 2015
Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties
Farrow, P., Khodosevich, Konstantin, Sapir, Y., Schulmann, A., Aslam, M., Stern-Bach, Y., Monyer, H. & von Engelhardt, J., 1 Dec 2015, In: eLife. 4, p. e09693Research output: Contribution to journal › Journal article › peer-review
The evidence for increased L1 activity in the site of human adult brain neurogenesis
Kurnosov, A. A., Ustyugova, S. V., Nazarov, V. I., Minervina, A. A., Komkov, A. Y., Shugay, M., Pogorelyy, M. V., Khodosevich, Konstantin, Mamedov, I. Z. & Lebedev, Y. B., 2015, In: PLOS ONE. 10, 2, p. e0117854Research output: Contribution to journal › Journal article › peer-review
- 2014
Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function
Khodosevich, Konstantin, Jacobi, E., Farrow, P., Schulmann, A., Rusu, A., Zhang, L., Sprengel, R., Monyer, H. & von Engelhardt, J., 6 Aug 2014, In: Neuron. 83, 3, p. 601-15 15 p.Research output: Contribution to journal › Journal article › peer-review
Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system
Watanabe, Y., Khodosevich, Konstantin & Monyer, H., 24 Apr 2014, In: Cell Reports. 7, 2, p. 552-64 13 p.Research output: Contribution to journal › Journal article › peer-review
A novel approach to identification of somatic retroelements' insertions in human genome
Kurnosov, A. A., Ustiugova, S. V., Pogorelyĭ, M. V., Komkov, A. I., Bolotin, D. A., Khodosevich, Konstantin, Mamedov, I. Z. & Lebedev, I. B., 9 Apr 2014, In: Bioorganicheskaya Khimiya. 39, 4, p. 466-76 11 p.Research output: Contribution to journal › Journal article › peer-review
- 2013
Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb
Khodosevich, Konstantin, Lazarini, F., von Engelhardt, J., Kaneko, H., Lledo, P. & Monyer, H., 18 Sep 2013, In: Neuron. 79, 6, p. 1136-51 16 p.Research output: Contribution to journal › Journal article › peer-review
- 2012
Dynamic changes in the transcriptional profile of subventricular zone-derived postnatally born neuroblasts
Khodosevich, Konstantin, Alfonso, J. & Monyer, H., 12 Dec 2012, In: Mechanisms of Development. 130, 6-8, p. 424-32 9 p.Research output: Contribution to journal › Review › peer-review
Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone
Khodosevich, Konstantin, Zuccotti, A., Kreuzberg, M. M., Le Magueresse, C., Frank, M., Willecke, K. & Monyer, H., 4 Dec 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 49, p. 20107-12 6 p.Research output: Contribution to journal › Journal article › peer-review
Diazepam binding inhibitor promotes progenitor proliferation in the postnatal SVZ by reducing GABA signaling
Alfonso, J., Le Magueresse, C., Zuccotti, A., Khodosevich, Konstantin & Monyer, H., 6 Jan 2012, In: Cell Stem Cell. 10, 1, p. 76-87 12 p.Research output: Contribution to journal › Journal article › peer-review
- 2011
"Small axonless neurons": postnatally generated neocortical interneurons with delayed functional maturation
Le Magueresse, C., Alfonso, J., Khodosevich, Konstantin, Arroyo Martín, A. A., Bark, C. & Monyer, H., 16 Nov 2011, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 31, 46, p. 16731-47 17 p.Research output: Contribution to journal › Journal article › peer-review
EphA4 preserves postnatal and adult neural stem cells in an undifferentiated state in vivo
Khodosevich, Konstantin, Watanabe, Y. & Monyer, H., 15 Apr 2011, In: Journal of Cell Science. 124, Pt 8, p. 1268-79 12 p.Research output: Contribution to journal › Journal article › peer-review
ID: 144897711
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Neuronal survival in the brain: neuron type-specific mechanisms: neuron type-specific mechanisms
Research output: Contribution to journal › Review › peer-review
Published -
203
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MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke
Research output: Contribution to journal › Journal article › peer-review
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132
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GluA4-Targeted AAV Vectors Deliver Genes Selectively to Interneurons while Relying on the AAV Receptor for Entry
Research output: Contribution to journal › Journal article › peer-review
Published