Konstantin Khodosevich

Konstantin Khodosevich

Group leader, Professor

Member of:


    1. 2024
    2. Published

      Drug targeting in psychiatric disorders — how to overcome the loss in translation?

      Khodosevich, Konstantin, Dragicevic, K. & Howes, O., 2024, In: Nature Reviews Drug Discovery. 23, p. 218-231

      Research output: Contribution to journalJournal articlepeer-review

    3. 2023
    4. Published

      A maturational shift in the frontal cortex synaptic transcriptional landscape underlies schizophrenia-relevant behavioural traits: A congenital rat model

      Sønderstrup, M., Batiuk, M. Y., Mantas, P., Tapias-Espinosa, C., Oliveras, I., Cañete, T., Sampedro-Viana, D., Brudek, T., Rydbirk, Rasmus, Khodosevich, Konstantin, Fernandez-Teruel, A., Elfving, B. & Aznar, S., 2023, In: European Neuropsychopharmacology. 74, p. 32-46 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    5. Published

      Loss of maturity and homeostatic functions in Tuberous Sclerosis Complex-derived astrocytes

      Luinenburg, M. J., Scheper, M., Sørensen, Frederik Nørby Friis, Anink, J. J., Van Hecke, W., Korshunova, Irina, Jansen, F. E., Riney, K., van Eijsden, P., Gosselaar, P., Mills, J. D., Kalf, R. S., Zimmer, T. S., Broekaart, D. W. M., Khodosevich, Konstantin, Aronica, E. & Mühlebner, A., 2023, In: Frontiers in Cellular Neuroscience. 17, 15 p., 1284394.

      Research output: Contribution to journalJournal articlepeer-review

    6. Published

      Neurodevelopmental disorders - high-resolution rethinking of disease modeling

      Khodosevich, Konstantin & Sellgren, C. M., 2023, In: Molecular Psychiatry. 28, p. 34-43 10 p.

      Research output: Contribution to journalJournal articlepeer-review

    7. 2022
    8. Published
    9. Published

      Cell segmentation in imaging-based spatial transcriptomics

      Petukhov, V., Xu, R. J., Soldatov, R. A., Cadinu, P., Khodosevich, Konstantin, Moffitt, J. R. & Kharchenko, P. V., 2022, In: Nature Biotechnology. 40, p. 345-354

      Research output: Contribution to journalJournal articlepeer-review

    10. Published

      Ductal keratin 15+ luminal progenitors in normal breast exhibit a basal-like breast cancer transcriptomic signature

      Kohler, Katharina Theresa, Goldhammer, N., Demharter, S., Pfisterer, U., Khodosevich, Konstantin, Rønnov-Jessen, Lone, Petersen, Ole William, Villadsen, René & Kim, Jiyoung, 2022, In: npj Breast Cancer. 8, 1, 12 p., 81.

      Research output: Contribution to journalJournal articlepeer-review

    11. Published

      Expression profile of synaptic vesicle glycoprotein 2A, B, and C paralogues in temporal neocortex tissue from patients with temporal lobe epilepsy (TLE)

      Pazarlar, B. A., trj450, trj450, Petukhov, V., Pinborg, Lars Hageman, Khodosevich, Konstantin & Mikkelsen, Jens D., 2022, In: Molecular Brain. 15, 1, 45.

      Research output: Contribution to journalJournal articlepeer-review

    12. Published

      Identification of Vulnerable Interneuron Subtypes in 15q13.3 Microdeletion Syndrome Using Single-Cell Transcriptomics

      Malwade, S., Gasthaus, J., Bellardita, Carmelo, Andelic, M., Moric, Borna, Korshunova, Irina, Kiehn, Ole, Vasistha, Navneet A & Khodosevich, Konstantin, 2022, In: Biological Psychiatry. 91, 8, p. 727-739

      Research output: Contribution to journalJournal articlepeer-review

    13. Published

      Production of human entorhinal stellate cell-like cells by forward programming shows an important role of Foxp1 in reprogramming

      Bergmann, T., Liu, Y., Skov, J., Mogus, L., Lee, J., Pfisterer, U., Handfield, L. F., Asenjo-Martinez, A., Lisa-Vargas, I., Seemann, S. E., Lee, J. T. H., Patikas, N., Kornum, B. R., Denham, M., Hyttel, P., Witter, M. P., Gorodkin, J., Pers, T. H., Hemberg, M., Khodosevich, K. & 1 others, Hall, Vanessa Jane, 2022, In: Frontiers in Cell and Developmental Biology. 10, 976549.

      Research output: Contribution to journalJournal articlepeer-review

    14. Published

      Single-nucleus transcriptomics of IDH1- and TP53-mutant glioma stem cells displays diversified commitment on invasive cancer progenitors

      Gulaia, V., Shmelev, M., Romanishin, A., Shved, N., Farniev, V., Goncharov, N., Biktimirov, A., Lisa Vargas, Irene, Khodosevich, Konstantin, Kagansky, A. & Kumeiko, V., 2022, In: Scientific Reports. 12, 18 p., 18975.

      Research output: Contribution to journalJournal articlepeer-review

    15. Published

      Upper cortical layer-driven network impairment in schizophrenia

      Batiuk, M. Y., Tyler, T., Dragicevic, K., Mei, S., Rydbirk, Rasmus, Petukhov, V., Deviatiiarov, R., Sedmak, D., Frank, E., Feher, V., Habek, N., Hu, Q., Igolkina, A., Roszik, L., Pfisterer, U., Garcia-Gonzalez, D., Petanjek, Z., Adorjan, I., Kharchenko, P. V. & Khodosevich, Konstantin, 2022, In: Science Advances. 8, 41, 24 p., eabn8367.

      Research output: Contribution to journalJournal articlepeer-review

    16. 2021
    17. Published

      Coordinated maintenance of H3K36/K27 methylation by histone demethylases preserves germ cell identity and immortality

      Zaghet, Nico, Madsen, Katrine, Rossi, F., Perez, D. F., Amendola, P. G., Demharter, S., Pfisterer, U., Khodosevich, Konstantin, Pasini, D. & Salcini, Anna Elisabetta, 2021, In: Cell Reports. 37, 8, p. 110050

      Research output: Contribution to journalJournal articlepeer-review

    18. Published

      Development of the entorhinal cortex occurs via parallel lamination during neurogenesis

      Liu, Y., Bergmann, T., Mori, Yuki, Peralvo Vidal, Juan Miguel, Pihl, M., Vasistha, Navneet A, Thomsen, Preben Dybdahl, Seemann, Ernst Stefan, Gorodkin, Jan, Hyttel, P., Khodosevich, Konstantin, Witter, M. P. & Hall, Vanessa Jane, 2021, In: Frontiers in Neuroanatomy. 15, 19 p., 663667.

      Research output: Contribution to journalJournal articlepeer-review

    19. Published

      PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia

      Magalhaes, J., Tresse, E., Ejlerskov, P., Hu, E., Liu, Y., Marin, A., Montalant, A., Satriano, L., Rundsten, C. F., Carlsen, E. M. M., Rydbirk, R., Sharifi-Zarchi, A., Andersen, J. B., Aznar, S., Brudek, T., Khodosevich, K., Prinz, M., Perrier, J. F. M., Sharma, M., Gasser, T. & 1 others, Issazadeh-Navikas, Shohreh, 2021, In: Molecular Psychiatry. 26, p. 6083–6099 17 p.

      Research output: Contribution to journalJournal articlepeer-review

    20. Published

      Selective vulnerability of supragranular layer neurons in schizophrenia

      Batiuk, M. Y., Tyler, T., Mei, S., Rydbirk, Rasmus, Petukhov, V., Sedmak, D., Frank, E., Feher, V., Habek, N., Hu, Q., Igolkina, A., Roszik, L., Pfisterer, U., Petanjek, Z., Adorjan, I., Kharchenko, P. V. & Khodosevich, Konstantin, 2021, (bioRxiv).

      Research output: Working paperPreprintResearch

    21. Published

      The impact of (ab)normal maternal environment on cortical development

      Vasistha, Navneet A & Khodosevich, Konstantin, 2021, In: Progress in Neurobiology. 202, 22 p., 102054.

      Research output: Contribution to journalReviewpeer-review

    22. 2020
    23. Published

      A community-based transcriptomics classification and nomenclature of neocortical cell types

      Yuste, R., Hawrylycz, M., Aalling, N., Aguilar-valles, A., Arendt, D., Arnedillo, R. A., Ascoli, G. A., Bielza, C., Bokharaie, V., Bergmann, T. B., Bystron, I., Capogna, M., Chang, Y., Clemens, A., De Kock, C. P. J., Defelipe, J., Dos Santos, S. E., Dunville, K., Feldmeyer, D., Fiáth, R. & 53 others, Fishell, G. J., Foggetti, A., Gao, X., Ghaderi, P., Goriounova, N. A., Güntürkün, O., Hagihara, K., Hall, Vanessa Jane, Helmstaedter, M., Herculano, S., Hilscher, M. M., Hirase, Hajime, Hjerling-leffler, J., Hodge, R., Huang, J., Huda, R., Khodosevich, Konstantin, Kiehn, Ole, Koch, H., Kuebler, E. S., Kühnemund, M., Larrañaga, P., Lelieveldt, B., Louth, E. L., Lui, J. H., Mansvelder, H. D., Marin, O., Martinez-trujillo, J., Moradi Chameh, H., Nath, A., Nedergaard, M., Němec, P., Ofer, N., Pfisterer, U. G., Pontes, S., Redmond, W., Rossier, J., Sanes, J. R., Scheuermann, R., Serrano-saiz, E., Steiger, J. F., Somogyi, P., Tamás, G., Tolias, A. S., Tosches, M. A., García, M. T., Vieira, H. M., Wozny, C., Wuttke, T. V., Yong, L., Yuan, J., Zeng, H. & Lein, E., 2020, In: Nature Neuroscience. 23, p. 1456-1468 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    24. Published

      Bayesian segmentation of spatially resolved transcriptomics data

      Petukhov, V., Soldatov, R. A., Khodosevich, Konstantin & Kharchenko, P. V., 2020, Cold Spring Harbor Laboratory, (bioRxiv).

      Research output: Working paperPreprintResearch

    25. Published

      Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function

      Sanz-Morello, B., Pfisterer, U., Hansen, Nikolaj Winther, Demharter, S., Thakur, A., Fujii, K., Levitskii, S. A., Montalant, Alexia, Korshunova, Irina, Mammen, P. P., Kamenski, P., Noguchi, S., Aldana, Blanca, Hougaard, K. S., Perrier, Jean-Francois Marie & Khodosevich, Konstantin, 2020, In: The EMBO Journal. 39, 18, p. 1-21 e105759.

      Research output: Contribution to journalJournal articlepeer-review

    26. Published

      Genetic modification increases the survival and the neuroregenerative properties of transplanted neural stem cells

      Korshunova, Irina, Rhein, S., vsz834, vsz834, Stölting, I., Pfisterer, U., Barta, A., Dmytriyeva, O., Kirkeby, Agnete, Schwaninger, M. & Khodosevich, Konstantin, 2020, In: JCI insight. 5, 4, p. 1-19 e126268.

      Research output: Contribution to journalJournal articlepeer-review

    27. Published

      Maternal inflammation has a profound effect on cortical interneuron development in a stage and subtype-specific manner

      Vasistha, Navneet A, Pardo-Navarro, M., Gasthaus, J., Weijers, D., Müller, M. K., vsz834, vsz834, Malwade, S., Korshunova, Irina, Pfisterer, U., von Engelhardt, J., Hougaard, K. S. & Khodosevich, Konstantin, 2020, In: Molecular Psychiatry. 25, p. 2313-2329

      Research output: Contribution to journalJournal articlepeer-review

    28. 2019
    29. Published

      The developing Entorhinal cortex - a cellular map

      Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Handfield, L., Asenjo Martinez, A., Seemann, Ernst Stefan, Witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Hemberg, M., Pers, Tune H & Hall, Vanessa Jane, 25 Nov 2019. 1 p.

      Research output: Contribution to conferenceConference abstract for conferenceCommunication

    30. Published

      Joint analysis of heterogeneous single-cell RNA-seq dataset collections

      Barkas, N., Petukhov, V., Nikolaeva, D., Lozinsky, Y., Demharter, S., Khodosevich, Konstantin & Kharchenko, P. V., Aug 2019, In: Nature Methods. 16, 8, p. 695-698

      Research output: Contribution to journalJournal articlepeer-review

    31. Published

      Dynamic Changes in Ultrastructure of the Primary Cilium in Migrating Neuroblasts in the Postnatal Brain

      Matsumoto, M., Sawada, M., vsz834, vsz834, Herranz-pérez, V., Ogino, T., Bang Nguyen, H., Quynh Thai, T., Narita, K., Kumamoto, N., Ugawa, S., Saito, Y., Takeda, S., Kaneko, N., Khodosevich, Konstantin, Monyer, H., García-verdugo, J. M., Ohno, N. & Sawamoto, K., 2019, In: The Journal of Neuroscience. 39, 50, p. 9967-9988

      Research output: Contribution to journalJournal articlepeer-review

    32. Published

      GluA4-Targeted AAV Vectors Deliver Genes Selectively to Interneurons while Relying on the AAV Receptor for Entry

      Hartmann, J., Thalheimer, F. B., Höpfner, F., Kerzel, T., Khodosevich, Konstantin, vsz834, vsz834, Monyer, H., Diester, I., Büning, H., Carette, J. E., Fries, P. & Buchholz, C. J., 2019, In: Molecular Therapy - Methods & Clinical Development. 14, p. 252-260 9 p.

      Research output: Contribution to journalJournal articlepeer-review

    33. Published

      Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing

      Adorjan, I., Tyler, T., Bhaduri, A., Demharter, S., Finszter, C. K., Bako, M., Sebok, O. M., Nowakowski, T. J., Khodosevich, Konstantin, Møllgård, Kjeld, Kriegstein, A. R., Shi, L., Hoerder-Suabedissen, A., Ansorge, O. & Molnár, Z., 2019, In: Journal of Anatomy. 235, 3, p. 543-554 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    34. Published

      Production of stellate cells from induced pluripotent stem cells to study Alzheimer's disease pathology

      Mogus, L., Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Handfield, L., Asenjo Martinez, A., Seemann, Ernst Stefan, Witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Hemberg, M., Pers, Tune H & Hall, Vanessa Jane, 2019. 1 p.

      Research output: Contribution to conferenceConference abstract for conferenceCommunication

    35. Published

      Sandwich cortial lamination and single-cell analysis decodes the developing spatial processing system

      Liu, Y., Bergmann, T. B., Lee, J., Pfisterer, U. G., Handfield, L-F., Mori, Y., Asenjo Martinez, A., Lisa Vargas, I., Seemann, E. S., Lee, J. T. H., Patikis, N., Peralvo Vidal, J. M., Pihl, M., Kornum, B. R., Thomsen, P. D., Hyttel, P., Witter, M., Khodosevich, K., Gorodkin, J., Hemberg, M. & 2 others, Pers, Tune H & Hall, Vanessa Jane, 2019. 45 p.

      Research output: Contribution to conferencePaperCommunication

    36. Published

      The developing Entorhinal Cortex – a cellular map

      Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Asenjo Martinez, A., Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Hyttel, P., witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Pers, Tune H & Hall, Vanessa Jane, 2019.

      Research output: Contribution to conferenceConference abstract for conferenceResearch

    37. Published

      Tracing the origin of adult intestinal stem cells

      Guiu, J., Hannezo, E., Yui, S., Demharter, S., Ulyanchenko, Svetlana, Maimets, Martti, Jørgensen, A., Perlman, S., Lundvall, L., Mamsen, L. S., Larsen, A., Olesen, R. H., Andersen, C. Y., Thuesen, L. L., Hare, Kristine Juul, Pers, Tune H, Khodosevich, Konstantin, Simons, B. D. & Jensen, Kim Bak, 2019, In: Nature. 570, 7759, p. 107-111

      Research output: Contribution to journalLetterpeer-review

    38. Published

      Uncovering the anatomical and molecular landscape of the starting point of Alzheimer’s disease in the brain

      Bergmann, T. B., Liu, Y., Lee, J., Pfisterer, U. G., Asenjo Martinez, A., Seemann, Ernst Stefan, Pihl, M., Thomsen, Preben Dybdahl, Hyttel, P., witter, M., Khodosevich, Konstantin, Gorodkin, Jan, Pers, Tune H & Hall, Vanessa Jane, 2019.

      Research output: Contribution to conferenceConference abstract for conferenceResearch

    39. 2018
    40. Published

      An advanced enrichment method for rare somatic retroelement insertions sequencing

      Komkov, A. Y., Minervina, A. A., Nugmanov, G. A., Saliutina, M. V., Khodosevich, Konstantin, Lebedev, Y. B. & Mamedov, I. Z., 2018, In: Mobile DNA. 9, 1, p. 1-11 11 p., 31.

      Research output: Contribution to journalJournal articlepeer-review

    41. Published

      MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke

      Tseng, K., Anttila, J. E., Khodosevich, Konstantin, Tuominen, R. K., Lindahl, M., Domanskyi, A. & Airavaara, M., 2018, In: Molecular therapy : the journal of the American Society of Gene Therapy. 26, 1, p. 238-255 18 p.

      Research output: Contribution to journalJournal articlepeer-review

    42. Published

      Maternal inflammation significantly impacts cortical interneuron development in a subtype-specific manner

      Vasistha, Navneet A, Pardo-Navarro, M., Gasthaus, J., Weijers, D., Müller, M. K., Pfisterer, U. G., Hougaard, K. S. & Khodosevich, Konstantin, 2018, Cold Spring Harbor Laboratory Press, 39 p. (bioRxiv).

      Research output: Working paperResearch

    43. Published

      Maternal inhalation of carbon black nanoparticles induces neurodevelopmental changes in mouse offspring

      Umezawa, M., Onoda, A., Korshunova, Irina, Jensen, A. C. Ø., Koponen, I. K., Jensen, K. A., Khodosevich, Konstantin, Vogel, U. & Hougaard, K. S., 2018, In: Particle and Fibre Toxicology. 15, p. 1-18 18 p., 36.

      Research output: Contribution to journalJournal articlepeer-review

    44. Published

      Wiring together large single-cell RNA-seq sample collections

      Barkas, N., Petukhov, V., Nikolaeva, D., Lozinsky, Y., Demharter, S., Khodosevich, Konstantin & Kharchenko, P. V., 2018, Biorxiv: Cold Spring Harbor Laboratory, 14 p.

      Research output: Working paperResearch

    45. 2017
    46. Published

      Serotonergic Projections Govern Postnatal Neuroblast Migration

      García-González, D., Khodosevich, Konstantin, Watanabe, Y., Rollenhagen, A., Lübke, J. H. R. & Monyer, H., 3 May 2017, In: Neuron. 94, 3, p. 534-549.e9 26 p.

      Research output: Contribution to journalJournal articlepeer-review

    47. Published

      Neuronal survival in the brain: neuron type-specific mechanisms: neuron type-specific mechanisms

      Pfisterer, U. G. & Khodosevich, Konstantin, 2 Mar 2017, In: Cell Death & Disease. 8, 3, 14 p., e2643.

      Research output: Contribution to journalReviewpeer-review

    48. 2015
    49. Auxiliary subunits of the CKAMP family differentially modulate AMPA receptor properties

      Farrow, P., Khodosevich, Konstantin, Sapir, Y., Schulmann, A., Aslam, M., Stern-Bach, Y., Monyer, H. & von Engelhardt, J., 1 Dec 2015, In: eLife. 4, p. e09693

      Research output: Contribution to journalJournal articlepeer-review

    50. The evidence for increased L1 activity in the site of human adult brain neurogenesis

      Kurnosov, A. A., Ustyugova, S. V., Nazarov, V. I., Minervina, A. A., Komkov, A. Y., Shugay, M., Pogorelyy, M. V., Khodosevich, Konstantin, Mamedov, I. Z. & Lebedev, Y. B., 2015, In: PLOS ONE. 10, 2, p. e0117854

      Research output: Contribution to journalJournal articlepeer-review

    51. 2014
    52. Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function

      Khodosevich, Konstantin, Jacobi, E., Farrow, P., Schulmann, A., Rusu, A., Zhang, L., Sprengel, R., Monyer, H. & von Engelhardt, J., 6 Aug 2014, In: Neuron. 83, 3, p. 601-15 15 p.

      Research output: Contribution to journalJournal articlepeer-review

    53. Dendrite development regulated by the schizophrenia-associated gene FEZ1 involves the ubiquitin proteasome system

      Watanabe, Y., Khodosevich, Konstantin & Monyer, H., 24 Apr 2014, In: Cell Reports. 7, 2, p. 552-64 13 p.

      Research output: Contribution to journalJournal articlepeer-review

    54. A novel approach to identification of somatic retroelements' insertions in human genome

      Kurnosov, A. A., Ustiugova, S. V., Pogorelyĭ, M. V., Komkov, A. I., Bolotin, D. A., Khodosevich, Konstantin, Mamedov, I. Z. & Lebedev, I. B., 9 Apr 2014, In: Bioorganicheskaya Khimiya. 39, 4, p. 466-76 11 p.

      Research output: Contribution to journalJournal articlepeer-review

    55. 2013
    56. Connective tissue growth factor regulates interneuron survival and information processing in the olfactory bulb

      Khodosevich, Konstantin, Lazarini, F., von Engelhardt, J., Kaneko, H., Lledo, P. & Monyer, H., 18 Sep 2013, In: Neuron. 79, 6, p. 1136-51 16 p.

      Research output: Contribution to journalJournal articlepeer-review

    57. 2012
    58. Dynamic changes in the transcriptional profile of subventricular zone-derived postnatally born neuroblasts

      Khodosevich, Konstantin, Alfonso, J. & Monyer, H., 12 Dec 2012, In: Mechanisms of Development. 130, 6-8, p. 424-32 9 p.

      Research output: Contribution to journalReviewpeer-review

    59. Connexin45 modulates the proliferation of transit-amplifying precursor cells in the mouse subventricular zone

      Khodosevich, Konstantin, Zuccotti, A., Kreuzberg, M. M., Le Magueresse, C., Frank, M., Willecke, K. & Monyer, H., 4 Dec 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 49, p. 20107-12 6 p.

      Research output: Contribution to journalJournal articlepeer-review

    60. Diazepam binding inhibitor promotes progenitor proliferation in the postnatal SVZ by reducing GABA signaling

      Alfonso, J., Le Magueresse, C., Zuccotti, A., Khodosevich, Konstantin & Monyer, H., 6 Jan 2012, In: Cell Stem Cell. 10, 1, p. 76-87 12 p.

      Research output: Contribution to journalJournal articlepeer-review

    61. 2011
    62. "Small axonless neurons": postnatally generated neocortical interneurons with delayed functional maturation

      Le Magueresse, C., Alfonso, J., Khodosevich, Konstantin, Arroyo Martín, A. A., Bark, C. & Monyer, H., 16 Nov 2011, In: The Journal of neuroscience : the official journal of the Society for Neuroscience. 31, 46, p. 16731-47 17 p.

      Research output: Contribution to journalJournal articlepeer-review

    63. EphA4 preserves postnatal and adult neural stem cells in an undifferentiated state in vivo

      Khodosevich, Konstantin, Watanabe, Y. & Monyer, H., 15 Apr 2011, In: Journal of Cell Science. 124, Pt 8, p. 1268-79 12 p.

      Research output: Contribution to journalJournal articlepeer-review

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