Knud Jørgen Jensen

Knud Jørgen Jensen

Professor


  1. 2020
  2. Published

    Self‐Assembly of DNA–Peptide Supermolecules: Coiled‐Coil Peptide Structures Templated by d‐DNA and l-DNA Triplexes Exhibit Chirality‐Independent but Orientation‐Dependent Stabilizing Cooperativity

    Lou, C., Boesen, Josephine Tuborg, Christensen, Niels Johan, Sørensen, K. K., Thulstrup, Peter Waaben, Pedersen, Martin Nors, Giralt, E., Jensen, Knud Jørgen & Wengel, J., 2020, In : Chemistry: A European Journal. 26, 25, p. 5676-5684 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Synthesis and Characterization of Adamantane-Containing Heteropeptides with a Chirality Switch

    Aloisi, A., Christensen, Niels Johan, Sorensen, K. K., Guilbaud-Chereau, C., Jensen, Knud Jørgen & Bianco, A., 2020, In : European Journal of Organic Chemistry. 2020, 7, p. 815-820

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    The ABC of Insulin: The Organic Chemistry of a Small Protein

    Østergaard, M., Mishra, N. K. & Jensen, Knud Jørgen, 2020, In : Chemistry: A European Journal. 26, 38, p. 8341-8357 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

    Wan, Feng, Bohr, Søren Schmidt-Rasmussen, Klodzinska, Sylvia Natalie, Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In : ACS Applied Materials and Interfaces. 12, p. 380-389

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. 2019
  7. Published

    Half-Life Extending Modifications of Peptide YY3-36 Direct Receptor-Mediated Internalization

    Bech, E. M., Kaiser, A., Bellmann-Sickert, K., Bohr, Søren Schmidt-Rasmussen, Sørensen, K. K., Elster, L., Hatzakis, Nikos, Pedersen, S. L., Beck-Sickinger, A. G. & Jensen, Knud Jørgen, 2019, In : Molecular Pharmaceutics. 16, 8, p. 3665-3677

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. 2018
  9. Published

    A plant chitinase controls cortical infection thread progression and nitrogen-fixing symbiosis

    Malolepszy, A., Kelly, S., Sørensen, K. K., James, E. K., Kalisch, C., Bozsoki, Z., Panting, M., Andersen, S. U., Sato, S., Tao, K., Jensen, D. B., Vinther, M., Jong, N. D., Madsen, L. H., Umehara, Y., Gysel, K., Berentsen, M. U., Blaise, M., Jensen, Knud Jørgen, Thygesen, Mikkel Boas, Sandal, N., Andersen, K. R. & Radutoiu, S., 2018, In : eLife. 7, p. 1-17 17 p., e38874.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration

    Yang, M., Zhang, Q., Wang, Q., Sørensen, K. K., Boesen, Josephine Tuborg, Ma, S. Y., Jensen, Knud Jørgen, Kwan, K. M., Ngo, J. C. K., Chan, H. Y. E. & Zuo, Z., 2018, In : Molecular Pharmaceutics. 15, 12, p. 5781-5792 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Chemical Strategies for Half-Life Extension of Biopharmaceuticals: Lipidation and Its Alternatives

    Bech, E. M., Pedersen, Søren Lhjungmann & Jensen, Knud Jørgen, 2018, In : ACS Medicinal Chemistry Letters. 9, 7, p. 577-580 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Epidermal LysM receptor ensures robust symbiotic signalling in Lotus japonicus

    Murakami, E., Cheng, J., Gysel, K., Bozsoki, Z., Kawaharada, Y., Hjuler, C. T., Sørensen, K. K., Tao, K., Kelly, S., Venice, F., Genre, A., Thygesen, Mikkel Boas, de Jong, N., Vinther, M., Jensen, D. B., Jensen, Knud Jørgen, Blaise, M., Madsen, L. H., Andersen, K. R., Stougaard, J. & Radutoiu, S., 2018, In : eLife. 7, 21 p., e33506.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Glycoconjugate Oxime Formation Catalyzed at Neutral pH: Mechanistic Insights and Applications of 1,4-Diaminobenzene as a Superior Catalyst for Complex Carbohydrates

    Østergaard, M., Christensen, Niels Johan, Hjuler, C. T., Jensen, Knud Jørgen & Thygesen, Mikkel Boas, 2018, In : Bioconjugate Chemistry. 29, 4, p. 1219-1230 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Selective N-terminal acylation of peptides and proteins with a Gly-His tag sequence

    Martos Maldonado, M. C., Hjuler, C. T., Sørensen, K. K., Thygesen, Mikkel Boas, Rasmussen, J. E., Villadsen, K., Midtgaard, S. R., Kol, S., Schoffelen, S. & Jensen, Knud Jørgen, 2018, In : Nature Communications. 9, 13 p., 3307 .

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Synergy of Two Highly Specific Biomolecular Recognition Events: Aligning an AT-Hook Peptide in DNA Minor Grooves via Covalent Conjugation to 2′-Amino-LNA

    Ejlersen, M., Christensen, Niels Johan, Sørensen, K. K., Jensen, Knud Jørgen, Wengel, J. & Lou, C., 2018, In : Bioconjugate Chemistry. 29, p. 1025-1029 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Videnskabelig usikkerhed i kemi: Hvad er farligt?

    Green, Sara, Emmeche, Claus & Jensen, Knud Jørgen, 2018, In : Aktuel Naturvidenskab. 6, p. 38-41 4 p.

    Research output: Contribution to journalJournal articleCommunication

  17. 2017
  18. Published

    Membrane curvature regulates ligand-specific membrane sorting of GPCRs in living cells

    Rosholm, K. R., Leijnse, Natascha, Mantsiou, A., Tkach, V., Pedersen, S. L., Wirth, V. F., Oddershede, Lene Broeng, Jensen, Knud Jørgen, Martinez, Karen Laurence, Hatzakis, Nikos, Bendix, Poul Martin, Callan-Jones, A. & Stamou, Dimitrios, 8 May 2017, In : Nature Chemical Biology. 13, 7, p. 724-729

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases

    Zhang, Q., Yang, M., Sørensen, K. K., Madsen, C. S., Boesen, J. T., An, Y., Peng, S. H., Wei, Y., Wang, Q., Jensen, Knud Jørgen, Zuo, Z., Chan, H. Y. E. & Ngo, J. C. K., 2017, In : Scientific Reports. 7, 1, 13 p., 12077.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Antisense Oligonucleotides Internally Labeled with Peptides Show Improved Target Recognition and Stability to Enzymatic Degradation

    Taskova, M., Madsen, C. S., Jensen, Knud Jørgen, Hansen, L. H., Vester, B. & Astakhova, K., 2017, In : Bioconjugate Chemistry. 28, 3, p. 768-774 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates

    Villadsen, K., Martos Maldonado, M. C., Jensen, Knud Jørgen & Thygesen, Mikkel Boas, 2017, In : ChemBioChem. 18, 7, p. 574-612 39 p.

    Research output: Contribution to journalReviewResearchpeer-review

  22. Published

    Folding Topology of a Short Coiled-Coil Peptide Structure Templated by an Oligonucleotide Triplex

    Lou, C., Christensen, Niels Johan, Martos Maldonado, M. C., Midtgaard, S. R., Ejlersen, M., Thulstrup, Peter Waaben, Sørensen, K. K., Jensen, Knud Jørgen & Wengel, J., 2017, In : Chemistry - A European Journal. 23, 39, p. 9297-9305 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

    van Witteloostuijn, S. B., Dalboge, L. S., Hansen, G., Midtgaard, S. R., Jensen, G. V., Jensen, Knud Jørgen, Vrang, N., Jelsing, J. & Pedersen, S. L., 2017, In : Journal of Peptide Science. 23, 12, p. 845-854 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Inside Cover: Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates

    Villadsen, K., Martos Maldonado, M. C., Jensen, Knud Jørgen & Thygesen, Mikkel Boas, 2017, In : ChemBioChem. 18, 7, p. 573 1 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Integrin targeting and toxicological assessment of peptide-conjugated liposome delivery systems to activated endothelial cells

    Kermanizadeh, A., Villadsen, K., Østrem, R. G., Jensen, Knud Jørgen, Møller, Peter & Loft, Steffen, 2017, In : Basic & Clinical Pharmacology & Toxicology. 120, 4, p. 380-389 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Linear Multiepitope (Glyco)peptides for Type-Specific Serology of Herpes Simplex Virus (HSV) Infections

    Risinger, C. W., Sørensen, K. K., Jensen, Knud Jørgen, Olofsson, S., Bergström, T. & Blixt, Klas Ola, 2017, In : ACS Infectious Diseases. 3, 5, p. 360-367 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Membrane Curvature and Lipid Composition Synergize To Regulate N-Ras Anchor Recruitment

    Larsen, J. B., Kennard, C., Pedersen, S. L., Jensen, Knud Jørgen, Uline, M. J., Hatzakis, Nikos & Stamou, Dimitrios, 2017, In : Biophysical Journal. 113, 6, p. 1269-1279 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Neoglycolipids for Prolonging the Effects of Peptides: Self-Assembling Glucagon-like Peptide 1 Analogues with Albumin Binding Properties and Potent in Vivo Efficacy

    van Witteloostuijn, S. B., Mannerstedt, K. M. S., Wismann, P., Bech, E. M., Thygesen, Mikkel Boas, Vrang, N., Jelsing, J., Jensen, Knud Jørgen & Pedersen, S. L., 2017, In : Molecular Pharmaceutics. 14, 1, p. 193-205 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Peptide Half-Life Extension: Divalent, Small-Molecule Albumin Interactions Direct the Systemic Properties of Glucagon-Like Peptide 1 (GLP-1) Analogues

    Bech, E. M., Martos-Maldonado, M. C., Wismann, P., Sorensen, K. K., van Witteloostuijn, S. B., Thygesen, Mikkel Boas, Vrang, N., Jelsing, J., Pedersen, S. L. & Jensen, Knud Jørgen, 2017, In : Journal of Medicinal Chemistry. 60, 17, p. 7434-7446 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Preparation of glycoconjugates from unprotected carbohydrates for protein-binding studies

    Hjuler, C. T., Maolanon, N. N., Sauer, J., Stougaard, J., Thygesen, Mikkel Boas & Jensen, Knud Jørgen, 2017, In : Nature Protocols (Print). 12, 11, p. 2411-2422 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. 2016
  32. Published

    Carbohydrate-modified gold nanoparticles

    Thygesen, Mikkel Boas & Jensen, Knud Jørgen, 2016, Carbohydrate nanotechnology. J. Stine, K. (ed.). Wiley, p. 79-98

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  33. Published

    Construction of insulin 18-mer nanoassemblies driven by coordination to Iron(II) and Zinc(II) ions at distinct sites

    Munch, H. K., Nygård, Jesper, Christensen, Niels Johan, Engelbrekt, C., Østergaard, M., Porsgaard, T., Hoeg-Jensen, T., Zhang, J., Arleth, Lise, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2016, In : Angewandte Chemie International Edition. 55, 7, p. 2378-2381 4 p.

    Research output: Contribution to journalLetterResearchpeer-review

  34. Published

    Dimeric peptides with three different linkers self-assemble with phospholipids to form peptide nanodiscs that stabilize membrane proteins

    Larsen, A. N., Sørensen, K. K., Johansen, Nicolai Tidemand, Martel, A., Kirkensgaard, Jacob Judas Kain, Jensen, Knud Jørgen, Arleth, Lise & Midtgaard, S. R., 2016, In : Soft Matter. 12, 27, p. 5937-5949 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Half-life extension of biopharmaceuticals using chemical methods: alternatives to PEGylation

    van Witteloostuijn, S. B., Pedersen, S. L. & Jensen, Knud Jørgen, 2016, In : ChemMedChem. 11, 22, p. 2474-2495 22 p.

    Research output: Contribution to journalReviewResearchpeer-review

  36. Published

    Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities

    Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In : Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    N-RAS lipid anchor adsorption to membranes as a function of lipid composition and curvature

    Larsen, J. B., Kennard, C., Pedersen, S. L., Jensen, Knud Jørgen, Hatzakis, Nikos, Uline, M. J. & Stamou, Dimitrios, 2016, In : Biophysical Society. Annual Meeting. Abstracts. 110, 3, p. 579A 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  38. Published

    Peptide-stabilized, fluorescent silver nanoclusters: solid-phase synthesis and screening

    Gregersen, S., Vosch, Tom & Jensen, Knud Jørgen, 2016, In : Chemistry: A European Journal. 22, 51, p. 18492-18500 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic

    Lou, C., Martos Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, Niels Johan, Kjems, J., Thulstrup, Peter Waaben, Wengel, J. & Jensen, Knud Jørgen, 2016, In : Nature Communications. 7, 9 p., 12294.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. 2015
  41. Published

    A de novo designed monomeric, compact three helix bundle protein on a carbohydrate template

    Malik, L., Nygård, Jesper, Christensen, Niels Johan, Madsen, C. S., Rösner, Heike Ilona, Kragelund, Birthe Brandt, Høiberg-Nielsen, R., Streicher, W., Arleth, Lise, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2015, In : ChemBioChem. 16, 13, p. 1905-1918 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Additional disulfide bonds in insulin: prediction, recombinant expression, receptor binding affinity, and stability

    Vinther, T. N., Pettersson, I., Huus, K., Schlein, M., Steensgaard, D. B., Sørensen, A., Jensen, Knud Jørgen, Kjeldsen, T. & Hubalek, F., 2015, In : Protein Science. 24, 5, p. 779-788 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase

    Wong, M. M. J. E., Midtgaard, S. R., Gysel, K., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Stougaard, J., Thirup, S. S. & Blaise, M., 2015, In : Acta Crystallographica. Section D: Biological Crystallography. 71, p. 592-605 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers

    Sahariah, P., Sørensen, K. K., Hjálmarsdóttir, M. Á., Sigurjónsson, Ó. E., Jensen, Knud Jørgen, Másson, M. & Thygesen, Mikkel Boas, 2015, In : Chemical Communications. 51, 58, p. 11611-11614 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues

    Jiang, L., Zhao, B., Xu, P., Sørensen, H. P., Jensen, J. K., Christensen, A., Hosseini, M., Nielsen, N. C., Jensen, Knud Jørgen, Andreasen, P. & Huang, M., 2015, In : International Journal of Biochemistry & Cell Biology. 62, p. 88-92 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  46. Published

    Expression, receptor binding, and biophysical characterization of guinea pig insulin desB30: a monomeric insulin variant

    Engholm, Ebbe, Hansen, Thomas Hesselhøj, Johansson, E., Strauss, H. M., Vinther, T. N., Jensen, Knud Jørgen, Hubálek, F. & Kjeldsen, T. B., 2015, In : ChemBioChem. 16, 6, p. 954-958 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Impact of chain length on antibacterial activity and hemocompatibility of quaternary N-alkyl and N,N-dialkyl chitosan derivatives

    Sahariah, P., Benediktssdóttir, B. E., Hjálmarsdóttir, M. Á., Sigurjonsson, O. E., Sørensen, K. K., Thygesen, Mikkel Boas, Jensen, Knud Jørgen & Másson, M., 2015, In : Biomacromolecules. 16, 5, p. 1449-1460 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

    Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Bjørnholm, T., Iversen, L., Uline, M., Szleifer, I., Jensen, Knud Jørgen, Hatzakis, Nikos & Stamou, Dimitrios, 2015, In : Nature Chemical Biology. 11, 3, p. 192-194 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Receptor-mediated exopolysaccharide perception controls bacterial infection

    Kawaharada, Y., Kelly, S., Wibroe Nielsen, M., Hjuler, C. T., Gysel, K., Muszyński, A., Carlson, R. W., Thygesen, Mikkel Boas, Sandal, N., Asmussen, M. H., Vinther, M., Andersen, S. U., Krusell, L., Thirup, S., Jensen, Knud Jørgen, Ronson, C. W., Blaise, M., Radutoiu, S. & Stougaard, J., 2015, In : Nature. 523, 7560, p. 308-312 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Selection of high-affinity peptidic serine protease inhibitors with increased binding entropy from a back-flip library of peptide-protease fusions

    Sørensen, H. P., Xu, P., Jiang, L., Kromann-Hansen, T., Jensen, Knud Jørgen, Huang, M. & Andreasen, P. A., 2015, In : Journal of Molecular Biology. 427, 19, p. 3110-3122 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake

    Dalbøge, L. S., Pedersen, S. L., van Witteloostuijn, S. B., Rasmussen, J. E., Rigbolt, K. T. G., Jensen, Knud Jørgen, Holst, B., Vrang, N. & Jelsing, J., 2015, In : Journal of Peptide Science. 21, 2, p. 85-94 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The road to the first, fully active and more stable human insulin variant with an additional disulfide bond

    Vinther, T. N., Kjeldsen, T. B., Jensen, Knud Jørgen & Hubálek, F., 2015, In : Journal of Peptide Science. 21, 11, p. 797-806 10 p.

    Research output: Contribution to journalReviewResearchpeer-review

  53. Published

    Ultramild protein-mediated click chemistry creates efficient oligonucleotide probes for targeting and detecting nucleic acids

    Nåbo, L. J., Madsen, C. S., Jensen, Knud Jørgen, Kongsted, J. & Astakhova, K., 2015, In : ChemBioChem. 16, 8, p. 1163-1167 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2014
  55. Published

    Self-assembling peptides form nanodiscs that stabilize membrane proteins

    Midtgaard, S. R., Pedersen, Martin Cramer, Kirkensgaard, Jacob Judas Kain, Sørensen, K. K., Mortensen, Kell, Jensen, Knud Jørgen & Arleth, Lise, 1 Jan 2014, In : Soft Matter. 10, 5, p. 738-752 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility

    Zhao, B., Xu, P., Jiang, L., Jensen, B. P., Kromann-Hansen, T., Jensen, J. K., Sorensen, H. P., Liu, Z., Nielsen, J. T., Christensen, A., Hosseini, M., Sørensen, K. K., Nielsen, N. C., Jensen, Knud Jørgen, Huang, M. & Andreasen, P., 2014, In : PLOS ONE. 9, 12, 27 p., e115872.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Chemically synthesized 58-mer LysM domain binds lipochitin oligosaccharide

    Sørensen, K. K., Simonsen, J. B., Maolanon, N. N., Stougaard, J. & Jensen, Knud Jørgen, 2014, In : ChemBioChem. 15, 14, p. 2097-2105 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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