Knud Jørgen Jensen

Knud Jørgen Jensen

Professor

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    ORCID: 0000-0003-3525-5452

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    1. Published

      The ABC of Insulin: The Organic Chemistry of a Small Protein

      Østergaard, M., Mishra, N. K. & Jensen, Knud Jørgen, 2020, In: Chemistry: A European Journal. 26, 38, p. 8341-8357 17 p.

      Research output: Contribution to journal › Review › Research › peer-review

    2. Published

      Glycoconjugate Oxime Formation Catalyzed at Neutral pH: Mechanistic Insights and Applications of 1,4-Diaminobenzene as a Superior Catalyst for Complex Carbohydrates

      Østergaard, M., Christensen, Niels Johan, Hjuler, C. T., Jensen, Knud Jørgen & Thygesen, Mikkel Boas, 2018, In: Bioconjugate Chemistry. 29, 4, p. 1219-1230 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      Half-life extension of biopharmaceuticals using chemical methods: alternatives to PEGylation

      van Witteloostuijn, S. B., Pedersen, S. L. & Jensen, Knud Jørgen, 2016, In: ChemMedChem. 11, 22, p. 2474-2495 22 p.

      Research output: Contribution to journal › Review › Research › peer-review

    4. Published

      Neoglycolipids for Prolonging the Effects of Peptides: Self-Assembling Glucagon-like Peptide 1 Analogues with Albumin Binding Properties and Potent in Vivo Efficacy

      van Witteloostuijn, S. B., Mannerstedt, K. M. S., Wismann, P., Bech, E. M., Thygesen, Mikkel Boas, Vrang, N., Jelsing, J., Jensen, Knud Jørgen & Pedersen, S. L., 2017, In: Molecular Pharmaceutics. 14, 1, p. 193-205 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      GUB06-046, a novel secretin/glucagon-like peptide 1 co-agonist, decreases food intake, improves glycemic control, and preserves beta cell mass in diabetic mice

      van Witteloostuijn, S. B., Dalboge, L. S., Hansen, G., Midtgaard, S. R., Jensen, G. V., Jensen, Knud Jørgen, Vrang, N., Jelsing, J. & Pedersen, S. L., 2017, In: Journal of Peptide Science. 23, 12, p. 845-854 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility

      Zhao, B., Xu, P., Jiang, L., Jensen, B. P., Kromann-Hansen, T., Jensen, J. K., Sorensen, H. P., Liu, Z., Nielsen, J. T., Christensen, A., Hosseini, M., Sørensen, K. K., Nielsen, N. C., Jensen, Knud Jørgen, Huang, M. & Andreasen, P., 2014, In: PLOS ONE. 9, 12, 27 p., e115872.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      A brain-targeting lipidated peptide for neutralizing RNA-mediated toxicity in Polyglutamine Diseases

      Zhang, Q., Yang, M., Sørensen, K. K., Madsen, C. S., Boesen, J. T., An, Y., Peng, S. H., Wei, Y., Wang, Q., Jensen, Knud Jørgen, Zuo, Z., Chan, H. Y. E. & Ngo, J. C. K., 2017, In: Scientific Reports. 7, 1, 13 p., 12077.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Brain-Targeting Delivery of Two Peptidylic Inhibitors for Their Combination Therapy in Transgenic Polyglutamine Disease Mice via Intranasal Administration

      Yang, M., Zhang, Q., Wang, Q., Sørensen, K. K., Boesen, J. T., Ma, S. Y., Jensen, Knud Jørgen, Kwan, K. M., Ngo, J. C. K., Chan, H. Y. E. & Zuo, Z., 2018, In: Molecular Pharmaceutics. 15, 12, p. 5781-5792 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Ca2+-Responsive Glyco-insulin

      Wu, S., Østergaard, M., Fredholt, Freja, Christensen, Niels Johan, Sørensen, K. K., Mishra, N. K., Nielsen, Hanne Mørck & Jensen, Knud Jørgen, 2023, In: Bioconjugate Chemistry. 34, 3, p. 518–528

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      4,6-O-benzylidene directed ß-mannosylation without intermediate triflate formation? Comparison of trichloroacetimidate and DISAL donors in microwave-promoted glycosylations under neutral conditions

      Worm-Leonhard, K., Larsen, K. & Jensen, Knud Jørgen, 2007, In: Journal of Carbohydrate Chemistry. 26, 7, p. 349-368 20 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase

      Wong, M. M. J. E., Midtgaard, S. R., Gysel, K., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Stougaard, J., Thirup, S. S. & Blaise, M., 2015, In: Acta Crystallographica. Section D: Biological Crystallography. 71, p. 592-605 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      Ultrasmall TPGS-PLGA Hybrid Nanoparticles for Site-Specific Delivery of Antibiotics into Pseudomonas aeruginosa Biofilms in Lungs

      Wan, F., Bohr, S. S. R., Kłodzińska, S. N., Jumaa, H., Huang, Z., Nylander, T., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Sternberg, C., Hatzakis, Nikos & Nielsen, Hanne Mørck, 2020, In: ACS Applied Materials and Interfaces. 12, p. 380-389

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Hierarchical self-assembly of designed 2 x 2-a-helix bundle proteins on Au(111) surfaces

      Wackerbarth, H., Tofteng, A. P., Jensen, Knud Jørgen, Chorkendorff, I. & Ulstrup, J., 2006, In: Langmuir. 22, p. 6661-6667 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Y2 receptor agonists

      Vrang, N., Jensen, Knud Jørgen, Pedersen, S. L., Chelur, S. S., Sasikumar, P. G. N., Dhakshinamoorthy, S. & Ramachandra, M., 2009, Patent No. WO2009/080608 A1, 2 Jul 2009

      Research output: Patent

    15. Published

      Insulin analog with additional disulfide bond has increased stability and preserved activity

      Vinther, T. N., Norrman, M., Ribel, U., Huus, K., Schlein, M., Steensgaard, D. B., Pedersen, T. Å., Pettersson, I., Ludvigsen, S., Kjeldsen, T., Jensen, Knud Jørgen & Hubálek, F., 2013, In: Protein Science. 22, 3, p. 296-305 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization

      Vinther, T. N., Norrman, M., Strauss, H. M., Huus, K., Schlein, M., Pedersen, T. Å., Kjeldsen, T., Jensen, Knud Jørgen & Hubálek, F., 2012, In: P L o S One. 7, 2, 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      The road to the first, fully active and more stable human insulin variant with an additional disulfide bond

      Vinther, T. N., Kjeldsen, T. B., Jensen, Knud Jørgen & Hubálek, F., 2015, In: Journal of Peptide Science. 21, 11, p. 797-806 10 p.

      Research output: Contribution to journal › Review › Research › peer-review

    18. Published

      Identification of anchor points for chemical modification of a small cysteine-rich protein by using a cysteine scan

      Vinther, T. N., Ribel, U., Pedersen, T. Å., Kjeldsen, T. B., Jensen, Knud Jørgen & Hubálek, F., 2011, In: ChemBioChem. 12, 16, p. 2448–2455 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      Additional disulfide bonds in insulin: prediction, recombinant expression, receptor binding affinity, and stability

      Vinther, T. N., Pettersson, I., Huus, K., Schlein, M., Steensgaard, D. B., Sørensen, A., Jensen, Knud Jørgen, Kjeldsen, T. & Hubalek, F., 2015, In: Protein Science. 24, 5, p. 779-788 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Inside Cover: Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates

      Villadsen, K., Martos Maldonado, M. C., Jensen, Knud Jørgen & Thygesen, Mikkel Boas, 2017, In: ChemBioChem. 18, 7, p. 573 1 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Chemoselective Reactions for the Synthesis of Glycoconjugates from Unprotected Carbohydrates

      Villadsen, K., Martos Maldonado, M. C., Jensen, Knud Jørgen & Thygesen, Mikkel Boas, 2017, In: ChemBioChem. 18, 7, p. 574-612 39 p.

      Research output: Contribution to journal › Review › Research › peer-review

    22. Published

      Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities

      Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In: Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Predictive mutagenesis of ligation-independent cloning (LIC) vectors for protein expression and site-specific chemical conjugation

      Vernet, E., Sauer, J., Andersen, P. A., Jensen, Knud Jørgen & Voldborg, B. G. R., 2011, In: Analytical Biochemistry. 414, 2, p. 312-314 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Total chemical synthesis of insulin via biomimetic disulfide pairing and folding

      Tofteng, A. P., Jensen, Knud Jørgen & Hoeg-Jensen, T., 2007, Ikke angivet. Rolka, K., Rekowski, P. & Silberring, J. (eds.). Kenes International, Vol. 29. p. 566-567 2 p.

      Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research

    25. Published

      Synthesis of functionalized de novo designed 8-16 kDa model proteins towards metal ion-binding and esterase activity

      Tofteng, A. P., Hansen, Thomas Hesselhøj, Brask, J., Nielsen, J., Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2007, In: Organic & Biomolecular Chemistry. 5, 14, p. 2225-2233 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      Peptide dithiodiethanol esters for in situ generation of thioesters for use in native ligation

      Tofteng, A. P., Jensen, Knud Jørgen & Hoeg-Jensen, T., 2007, In: Tetrahedron Letters. 48, 12, p. 2105-2107 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      Peptides on nanoparticles: linkers for chemoselective, biocompatible immobilization

      Thygesen, Mikkel Boas & Jensen, Knud Jørgen, 2007, In: Journal of Peptide Science. 88, 4, p. 616 1 p.

      Research output: Contribution to journal › Conference abstract in journal › Research

    28. Published

      Peptides on nanoparticles: linkers for chemoselective, biocompatible immobilization

      Thygesen, Mikkel Boas & Jensen, Knud Jørgen, 2007. 1 p.

      Research output: Contribution to conference › Poster › Research

    29. Published

      Chemoselectivity and Glyconanoparticles

      Thygesen, Mikkel Boas & Jensen, Knud Jørgen, 2011, Petite and sweet: Glyco-nanotechnology as a bridge to new medicines. American Chemical Society, p. 37-48 12 p. (A C S Symposium Series, Vol. 1091).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    30. Published

      Nucleophilic catalysis of carbohydrate oxime formation by anilines

      Thygesen, Mikkel Boas, Munch, H. K., Sauer, J., Cló, E., Jørgensen, M. R., Hindsgaul, O. & Jensen, Knud Jørgen, 2010, In: Journal of Organic Chemistry. 75, 5, p. 1752-1755 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      Chemoselective capture of glycans for analysis on gold nanoparticles: carbohydrate oxime tautomers provide functional recognition by proteins

      Thygesen, Mikkel Boas, Sauer, J. & Jensen, Knud Jørgen, 2009, In: Chemistry: A European Journal. 15, 7, p. 1949-1960 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      Direct chemoselective synthesis of glyconanoparticles from unprotected reducing glycans and glycopeptide aldehydes

      Thygesen, Mikkel Boas, Sørensen, K. K., Cló, E. & Jensen, Knud Jørgen, Nov 2009, In: Chemical Communications. 42, p. 6367-9 3 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Carbohydrate-modified gold nanoparticles

      Thygesen, Mikkel Boas & Jensen, Knud Jørgen, 2016, Carbohydrate nanotechnology. J. Stine, K. (ed.). Wiley, p. 79-98

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    34. Published

      Synchrotron radiation circular dichroism spectroscopy applied to metmyoglobin and a 4-a-helix bundle carboprotein

      Thulstrup, Peter Waaben, Brask, J., Jensen, Knud Jørgen & Larsen, Erik, 2005, In: Biopolymers. 78, p. 46-52 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Antisense Oligonucleotides Internally Labeled with Peptides Show Improved Target Recognition and Stability to Enzymatic Degradation

      Taskova, M., Madsen, C. S., Jensen, Knud Jørgen, Hansen, L. H., Vester, B. & Astakhova, K., 2017, In: Bioconjugate Chemistry. 28, 3, p. 768-774 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Chemically synthesized 58-mer LysM domain binds lipochitin oligosaccharide

      Sørensen, K. K., Simonsen, J. B., Maolanon, N. N., Stougaard, J. & Jensen, Knud Jørgen, 2014, In: ChemBioChem. 15, 14, p. 2097-2105 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      High‐Performance Reversed‐Phase Flash Chromatography Purification of Peptides and Chemically Modified Insulins

      Sørensen, K. K., Mishra, N. K., Paprocki, M. P., Mehrotra, A. & Jensen, Knud Jørgen, 2021, In: ChemBioChem. 22, 10, p. 1818–1822

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Selection of high-affinity peptidic serine protease inhibitors with increased binding entropy from a back-flip library of peptide-protease fusions

      Sørensen, H. P., Xu, P., Jiang, L., Kromann-Hansen, T., Jensen, Knud Jørgen, Huang, M. & Andreasen, P. A., 2015, In: Journal of Molecular Biology. 427, 19, p. 3110-3122 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Synthesis of two D-glucosamine derived 3,4-epoxides as potential scaffolds for combinatorial chemistry

      Svejgaard, L., Fuglsang, H., Jensen, P. B., Kelly, N. M., Pedersen, H., Andersen, K., Ruhland, T. & Jensen, Knud Jørgen, 2003, In: Journal of Carbohydrate Chemistry. 22, 3/4, p. 179-184 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents

      Subirós-Funosas, R., Nieto-Rodriguez, L., Jensen, Knud Jørgen & Albericio, F., 2013, In: Journal of Peptide Science. 19, 7, p. 408-414 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Characterization of an immunodominant cancer-specific O-glycopeptide epitope in murine podoplanin (OTS8)

      Steentoft, C., Schjoldager, Katrine Ter-Borch Gram, Cló, E., Mandel, Ulla, Levery, S. B., Pedersen, J. W., Jensen, Knud Jørgen, Blixt, O. & Clausen, Henrik, 2010, In: Glycoconjugate Journal. 27, 6, p. 571-82 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Effect of residual water and microwave heating on half-lifes of reagents and reactive intermediates in peptide synthesis

      Shelton, A. P. T., Pedersen, S. L., Stærk, Dan & Jensen, Knud Jørgen, 2012, In: Chemistry: A European Journal. 18, 29, p. 9024-9031 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Fmoc solid-phase synthesis of C-terminal peptide thioesters by formation of a backbone pyroglutamyl imide moiety

      Shelton, A. P. T., Sørensen, K. K., Conde-Frieboes, K. W., Hoeg-Jensen, T. & Jensen, Knud Jørgen, 2009, In: Angewandte Chemie - International Edition. 48, 40, p. 7411-7414 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Total synthesis of desB30 insulin analogues by biomimetic folding of single-chain precursors

      Shelton, A. P. T., Jensen, Knud Jørgen, Schäffer, L. & Hoeg-Jensen, T., 2008, In: ChemBioChem. 9, 18, p. 2989-2996 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Linkers, resins, and general procedures for solid-phase peptide synthesis

      Shelton, A. P. T. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 23-41 19 p. (Methods in Molecular Biology, Vol. 1047).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    46. Published

      Synthesis of C-terminal peptide thioesters using Fmoc-based solid-phase peptide chemistry

      Shelton, A. P. T. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 119-129 11 p. (Methods in Molecular Biology, Vol. 1047).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    47. Published

      Backbone amide linker strategy: protocols for the synthesis of C-terminal peptide aldehydes

      Shelton, A. P. T. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 131-139 9 p. (Methods in Molecular Biology, Vol. 1047).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    48. Published

      Kinetic analysis of inhibition of glucoamylase and active site mutants via chemoselective oxime immobilization of acarbose on SPR chip surfaces

      Sauer, J., Abou Hachem, M., Svensson, B., Jensen, Knud Jørgen & Thygesen, Mikkel Boas, 2013, In: Carbohydrate Research. 375, p. 21-28 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Impact of chain length on antibacterial activity and hemocompatibility of quaternary N-alkyl and N,N-dialkyl chitosan derivatives

      Sahariah, P., Benediktssdóttir, B. E., Hjálmarsdóttir, M. Á., Sigurjonsson, O. E., Sørensen, K. K., Thygesen, Mikkel Boas, Jensen, Knud Jørgen & Másson, M., 2015, In: Biomacromolecules. 16, 5, p. 1449-1460 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers

      Sahariah, P., Sørensen, K. K., Hjálmarsdóttir, M. Á., Sigurjónsson, Ó. E., Jensen, Knud Jørgen, Másson, M. & Thygesen, Mikkel Boas, 2015, In: Chemical Communications. 51, 58, p. 11611-11614 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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