Knud Jørgen Jensen
Professor
Department of Chemistry
Universitetsparken 5, 2100 København Ø, 71 Højhus 71, Building: 71-4-T425
Member of:
- 2016
- Published
Peptide–oligonucleotide conjugates as nanoscale building blocks for assembly of an artificial three-helix protein mimic
Lou, C., Martos Maldonado, M. C., Madsen, C. S., Thomsen, R. P., Midtgaard, S. R., Christensen, Niels Johan, Kjems, J., Thulstrup, Peter Waaben, Wengel, J. & Jensen, Knud Jørgen, 2016, In: Nature Communications. 7, 9 p., 12294.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Construction of insulin 18-mer nanoassemblies driven by coordination to Iron(II) and Zinc(II) ions at distinct sites
Munch, H. K., Nygård, Jesper, Christensen, Niels Johan, Engelbrekt, C., Østergaard, M., Porsgaard, T., Hoeg-Jensen, T., Zhang, J., Arleth, Lise, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2016, In: Angewandte Chemie International Edition. 55, 7, p. 2378-2381 4 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Carbohydrate-modified gold nanoparticles
Thygesen, Mikkel Boas & Jensen, Knud Jørgen, 2016, Carbohydrate nanotechnology. J. Stine, K. (ed.). Wiley, p. 79-98Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Large-scale biophysical evaluation of protein PEGylation effects: in vitro properties of 61 protein entities
Vernet, E., Popa, G., Pozdnyakova, I., Rasmussen, J. E., Grohganz, Holger, Giehm, L., Jensen, M. H., Wang, H., Plesner, B., Nielsen, Hanne Mørck, Jensen, Knud Jørgen, Berthelsen, J., Sundström, M. & van de Weert, Marco, 2016, In: Molecular Pharmaceutics. 13, 5, p. 1587-1598 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Half-life extension of biopharmaceuticals using chemical methods: alternatives to PEGylation
van Witteloostuijn, S. B., Pedersen, S. L. & Jensen, Knud Jørgen, 2016, In: ChemMedChem. 11, 22, p. 2474-2495 22 p.Research output: Contribution to journal › Review › Research › peer-review
- 2015
- Published
Synthesis and evaluation of novel lipidated neuromedin U analogs with increased stability and effects on food intake
Dalbøge, L. S., Pedersen, S. L., van Witteloostuijn, S. B., Rasmussen, J. E., Rigbolt, K. T. G., Jensen, Knud Jørgen, Holst, B., Vrang, N. & Jelsing, J., 2015, In: Journal of Peptide Science. 21, 2, p. 85-94 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression, receptor binding, and biophysical characterization of guinea pig insulin desB30: a monomeric insulin variant
Engholm, E., Hansen, Thomas Hesselhøj, Johansson, E., Strauss, H. M., Vinther, T. N., Jensen, Knud Jørgen, Hubálek, F. & Kjeldsen, T. B., 2015, In: ChemBioChem. 16, 6, p. 954-958 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues
Jiang, L., Zhao, B., Xu, P., Sørensen, H. P., Jensen, J. K., Christensen, A., Hosseini, M., Nielsen, N. C., Jensen, Knud Jørgen, Andreasen, P. & Huang, M., 2015, In: International Journal of Biochemistry & Cell Biology. 62, p. 88-92 5 p.Research output: Contribution to journal › Letter › Research › peer-review
- Published
Receptor-mediated exopolysaccharide perception controls bacterial infection
Kawaharada, Y., Kelly, S., Wibroe Nielsen, M., Hjuler, C. T., Gysel, K., Muszyński, A., Carlson, R. W., Thygesen, Mikkel Boas, Sandal, N., Asmussen, M. H., Vinther, M., Andersen, S. U., Krusell, L., Thirup, S., Jensen, Knud Jørgen, Ronson, C. W., Blaise, M., Radutoiu, S. & Stougaard, J., 2015, In: Nature. 523, 7560, p. 308-312 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases
Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Bjørnholm, T., Iversen, L., Uline, M., Szleifer, I., Jensen, Knud Jørgen, Hatzakis, Nikos & Stamou, Dimitrios, 2015, In: Nature Chemical Biology. 11, 3, p. 192-194 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A de novo designed monomeric, compact three helix bundle protein on a carbohydrate template
Malik, L., Nygård, Jesper, Christensen, Niels Johan, Madsen, C. S., Rösner, Heike Ilona, Kragelund, Birthe Brandt, Høiberg-Nielsen, R., Streicher, W., Arleth, Lise, Thulstrup, Peter Waaben & Jensen, Knud Jørgen, 2015, In: ChemBioChem. 16, 13, p. 1905-1918 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ultramild protein-mediated click chemistry creates efficient oligonucleotide probes for targeting and detecting nucleic acids
Nåbo, L. J., Madsen, C. S., Jensen, Knud Jørgen, Kongsted, J. & Astakhova, K., 2015, In: ChemBioChem. 16, 8, p. 1163-1167 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antimicrobial peptide shows enhanced activity and reduced toxicity upon grafting to chitosan polymers
Sahariah, P., Sørensen, K. K., Hjálmarsdóttir, M. Á., Sigurjónsson, Ó. E., Jensen, Knud Jørgen, Másson, M. & Thygesen, Mikkel Boas, 2015, In: Chemical Communications. 51, 58, p. 11611-11614 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Impact of chain length on antibacterial activity and hemocompatibility of quaternary N-alkyl and N,N-dialkyl chitosan derivatives
Sahariah, P., Benediktssdóttir, B. E., Hjálmarsdóttir, M. Á., Sigurjonsson, O. E., Sørensen, K. K., Thygesen, Mikkel Boas, Jensen, Knud Jørgen & Másson, M., 2015, In: Biomacromolecules. 16, 5, p. 1449-1460 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Selection of high-affinity peptidic serine protease inhibitors with increased binding entropy from a back-flip library of peptide-protease fusions
Sørensen, H. P., Xu, P., Jiang, L., Kromann-Hansen, T., Jensen, Knud Jørgen, Huang, M. & Andreasen, P. A., 2015, In: Journal of Molecular Biology. 427, 19, p. 3110-3122 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Additional disulfide bonds in insulin: prediction, recombinant expression, receptor binding affinity, and stability
Vinther, T. N., Pettersson, I., Huus, K., Schlein, M., Steensgaard, D. B., Sørensen, A., Jensen, Knud Jørgen, Kjeldsen, T. & Hubalek, F., 2015, In: Protein Science. 24, 5, p. 779-788 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The road to the first, fully active and more stable human insulin variant with an additional disulfide bond
Vinther, T. N., Kjeldsen, T. B., Jensen, Knud Jørgen & Hubálek, F., 2015, In: Journal of Peptide Science. 21, 11, p. 797-806 10 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase
Wong, M. M. J. E., Midtgaard, S. R., Gysel, K., Thygesen, Mikkel Boas, Sørensen, K. K., Jensen, Knud Jørgen, Stougaard, J., Thirup, S. S. & Blaise, M., 2015, In: Acta Crystallographica. Section D: Biological Crystallography. 71, p. 592-605 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
- Published
How membrane curvature drives the up-concentration of N-Ras proteins to ordered lipid domains: correlation of in vivo and in vitro experiments with mean field theory calculations and coarse grain simulations
Hatzakis, Nikos, Larsen, J. B., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Koldsoe, H., Fowler, P., Uline, M. J., Szleifer, I. G., Bjørnholm, T., Sansom, M., Jensen, Knud Jørgen & Stamou, Dimitrios, 2014, In: Biophysical Society. Annual Meeting. Abstracts. 106, 2, p. 713a 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Lipochitin oligosaccharides immobilized through oximes in glycan microarrays bind LysM proteins
Maolanon, N. N., Blaise, M., Sørensen, K. K., Thygesen, Mikkel Boas, Clo, E., Sullivan, J. T., Ronson, C. W., Stougaard, J., Blixt, K. O. & Jensen, Knud Jørgen, 2014, In: ChemBioChem. 15, 3, p. 425-434 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Self-assembling peptides form nanodiscs that stabilize membrane proteins
Midtgaard, S. R., Pedersen, Martin Cramer, Kirkensgaard, Jacob Judas Kain, Sørensen, K. K., Mortensen, Kell, Jensen, Knud Jørgen & Arleth, Lise, 1 Jan 2014, In: Soft Matter. 10, 5, p. 738-752 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemically synthesized 58-mer LysM domain binds lipochitin oligosaccharide
Sørensen, K. K., Simonsen, J. B., Maolanon, N. N., Stougaard, J. & Jensen, Knud Jørgen, 2014, In: ChemBioChem. 15, 14, p. 2097-2105 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility
Zhao, B., Xu, P., Jiang, L., Jensen, B. P., Kromann-Hansen, T., Jensen, J. K., Sorensen, H. P., Liu, Z., Nielsen, J. T., Christensen, A., Hosseini, M., Sørensen, K. K., Nielsen, N. C., Jensen, Knud Jørgen, Huang, M. & Andreasen, P., 2014, In: PLOS ONE. 9, 12, 27 p., e115872.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
- Published
Solid-phase synthesis of phosphopeptides
Højlys-Larsen, K. B. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 191-199 9 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Leonidas Zervas award lecture: Abiotic ligands for new quaternary architectures of peptides and proteins
Jensen, Knud Jørgen, 2013, In: Journal of Peptide Science. 19, 9, p. 537-544 8 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Solid-phase peptide synthesis: an introduction
Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 1-21 21 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Lipid-Anchored Ras is Sorted by Membrane Curvature Both In Vitro and in Living Cells
Larsen, J., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Bjornholm, T., Jensen, Knud Jørgen, Kohnke, M., Abankwa, D., Alexandrov, K., Hatzakis, Nikos & Stamou, Dimitrios, 2013, In: Biophysical Journal. 104, 2, 1 p., 500-Pos.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Microwave-assisted solid-phase peptide synthesis using the biotage syro Wave™
Malik, L. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 225-234 10 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Self-assembly of designed coiled coil peptides studied by small-angle X-ray scattering and analytical ultracentrifugation
Malik, L., Nygaard, J., Christensen, Niels Johan, Thulstrup, Peter Waaben, Arleth, Lise, Jensen, Knud Jørgen & Streicher, W., 2013, In: Journal of Peptide Science. 19, 5, p. 283-292 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Gold-ferrocene glyco-nanoparticles for high-sensitivity electrochemical detection of carbohydrate-lectin interactions
Martos Maldonado, M. C., Thygesen, Mikkel Boas, Jensen, Knud Jørgen & Vargas-Berenguel, A., 2013, In: European Journal of Organic Chemistry. 2013, 14, p. 2793-2801 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Site-selective three-component reaction for dual-functionalization of peptides
Munch, H. K., Rasmussen, J. E., Popa, G., Christensen, Jørn Bolstad & Jensen, Knud Jørgen, 2013, In: Chemical Communications. 49, 19, p. 1936-1938 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Instruments for automated peptide synthesis
Pedersen, S. L. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 215-224 10 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Peptide release, side-chain deprotection, work-up, and isolation
Pedersen, S. L. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 43-63 21 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Improved PET Imaging of uPAR expression using new Cu-64-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies
Persson, M., Hosseini, M., Madsen, J., Jørgensen, T. J. D., Jensen, Knud Jørgen, Kjær, Andreas & Ploug, Michael, 2013, In: Theranostics. 3, 9, p. 618-632 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Bicyclic peptide inhibitor of urokinase-type plasminogen activator: mode of action
Roodbeen, R., Jensen, B. P., Jiang, L., Jensen, J. K., Christensen, A., Nielsen, J. T., Huang, M., Mulder, F., Nielsen, N. C., Andreasen, P. & Jensen, Knud Jørgen, 2013, In: ChemBioChem. 14, 16, p. 2179-2188 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synthesis of N-methylated peptides: on-resin methylation and microwave-assisted couplings
Roodbeen, R. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 141-149 9 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Sorting of tN-Ras by Membrane Curvature in Lipid Vesicles and Tubes
Rosholm, K. R., Larsen, J., Pedersen, S. L., Munch, H. K., Jensen, Knud Jørgen, Hatzakis, Nikos & Stamou, Dimitrios, 2013, In: Biophysical Journal. 104, Supplement 1, p. 549A 1 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Kinetic analysis of inhibition of glucoamylase and active site mutants via chemoselective oxime immobilization of acarbose on SPR chip surfaces
Sauer, J., Abou Hachem, M., Svensson, B., Jensen, Knud Jørgen & Thygesen, Mikkel Boas, 2013, In: Carbohydrate Research. 375, p. 21-28 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Backbone amide linker strategy: protocols for the synthesis of C-terminal peptide aldehydes
Shelton, A. P. T. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 131-139 9 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Linkers, resins, and general procedures for solid-phase peptide synthesis
Shelton, A. P. T. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 23-41 19 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Synthesis of C-terminal peptide thioesters using Fmoc-based solid-phase peptide chemistry
Shelton, A. P. T. & Jensen, Knud Jørgen, 2013, Peptide synthesis and applications. Jensen, K. J., Shelton, P. T. & Pedersen, S. L. (eds.). Humana Press, p. 119-129 11 p. (Methods in Molecular Biology, Vol. 1047).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
COMU: scope and limitations of the latest innovation in peptide acyl transfer reagents
Subirós-Funosas, R., Nieto-Rodriguez, L., Jensen, Knud Jørgen & Albericio, F., 2013, In: Journal of Peptide Science. 19, 7, p. 408-414 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Insulin analog with additional disulfide bond has increased stability and preserved activity
Vinther, T. N., Norrman, M., Ribel, U., Huus, K., Schlein, M., Steensgaard, D. B., Pedersen, T. Å., Pettersson, I., Ludvigsen, S., Kjeldsen, T., Jensen, Knud Jørgen & Hubálek, F., 2013, In: Protein Science. 22, 3, p. 296-305 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Regioselective fluorescent labeling of N,N,N-trimethyl chitosan via oxime formation
Benediktsdóttir, B. E., Sørensen, K. K., Thygesen, Mikkel Boas, Jensen, Knud Jørgen, Gudjónsson, T., Baldursson, Ó. & Másson, M., 2012, In: Carbohydrate Polymers. 90, 3, p. 1273-1280 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Legume receptors perceive the rhizobial lipochitin oligosaccharide signal molecules by direct binding
Broghammer, A., Krusell, L., Blaise, M., Sauer, J., Sullivan, J. T., Maolanon, N. N., Vinther, M., Lorentzen, A. M., Madsen, E. B., Jensen, Knud Jørgen, Roepstorff, P., Thirup, S. S., Ronson, C. W., Thygesen, Mikkel Boas & Stougaard, J., 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 34, p. 13859-13864 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Characterization of the viral O-glycopeptidome: a novel tool of relevance for vaccine design and serodiagnosis
Cló, E., Kracun, S. K., Nudelman, A. S., Jensen, Knud Jørgen, Liljeqvist, J., Olofsson, S., Bergström, T. & Blixt, K. O., Jun 2012, In: Journal of Virology. 86, 11, p. 6268-78 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Multivalent display of the antimicrobial peptides BP100 and BP143
Güell, I., Ferre, R., Sørensen, K. K., Badosa, E., Ng-Choi, I., Montesinos, E., Bardají, E., Feliu, L., Jensen, Knud Jørgen & Planas, M., 2012, In: Beilstein Journal of Organic Chemistry. 8, p. 2106-2117 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Synergy of Liquid Ordered "Raft Like" Domains and Membrane Curvature in Promoting Sorting of Lipidated Proteins Such As NRas
Hatzakis, Nikos, Larsen, J. K., Jensen, M. B., Bhatia, V. K., Pedersen, S. L., Jensen, Knud Jørgen & Stamou, Dimitrios, 2012, In: Biophysical Journal. 102, 3 Supplement 1, p. 18a-19a 2 p.Research output: Contribution to journal › Conference abstract in journal › Research
- Published
Probing protein phosphatase substrate binding: affinity pull-down of ILKAP phosphatase 2C with phosphopeptides
Højlys-Larsen, K. B., Sørensen, K. K., Jensen, Knud Jørgen & Gammeltoft, S., 2012, In: Molecular BioSystems. 8, 5, p. 1452-1460 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
End-to-end assembly of gold nanorods via oligopeptide linking and surfactant control: [and] Corrigendum to “End-to-end assembly of gold nanorods via oligopeptide linking and surfactant control”
Jain, T., Roodbeen, R., Reeler, N. E. A., Vosch, Tom, Jensen, Knud Jørgen, Bjørnholm, T. & Nørgaard, K., 2012, In: Journal of Colloid and Interface Science. 376, 1, p. 83-90 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4238020
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Novel covalently linked insulin dimer engineered to investigate the function of insulin dimerization
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1295
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An intermolecular binding mechanism involving multiple LysM domains mediates carbohydrate recognition by an endopeptidase
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
1157
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A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility
Research output: Contribution to journal › Journal article › Research › peer-review
Published