Kei Sakamoto
Professor
Sakamoto Group
Blegdamsvej 3B, Mærsk Tårnet, 6. sal, 2200 København N.
Member of:
- 2024
- Published
The AMPK-related kinase NUAK1 controls cortical axons branching by locally modulating mitochondrial metabolic functions
Lanfranchi, M., Yandiev, S., Meyer-Dilhet, G., Ellouze, S., Kerkhofs, M., Dos Reis, R., Garcia, A., Blondet, C., Amar, A., Kneppers, A., Polvèche, H., Plassard, D., Foretz, M., Viollet, B., Sakamoto, Kei, Mounier, R., Bourgeois, C. F., Raineteau, O., Goillot, E. & Courchet, J., 2024, In: Nature Communications. 15, 17 p., 2487.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b
Uehara, K., Lee, W. D., Stefkovich, M., Biswas, Dipsikha, Santoleri, D., Whitlock, A. G., Quinn, W., Coopersmith, T., Creasy, K. T., Rader, D. J., Sakamoto, Kei, Rabinowitz, J. D. & Titchenell, P. M., 2024, In: Journal of Clinical Investigation. 134, 7, 13 p., e173782.Research output: Contribution to journal › Journal article › Research › peer-review
- 2023
- Published
AMPKα2 is a skeletal muscle stem cell intrinsic regulator of myonuclear accretion
Kneppers, A., Ben Larbi, S., Theret, M., Saugues, A., Dabadie, C., Gsaier, L., Ferry, A., Rhein, P., Gondin, J., Sakamoto, Kei & Mounier, R., 2023, In: iScience. 26, 12, 17 p., 108343.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Amino acid homeostasis is a target of metformin therapy
Forteath, C., Mordi, I., Nisr, R., Gutierrez-Lara, E. J., Alqurashi, N., Phair, I. R., Cameron, A. R., Beall, C., Bahr, I., Mohan, M., Wong, A. K. F., Dihoum, A., Mohammad, A., Palmer, C. N. A., Lamont, D., Sakamoto, Kei, Viollet, B., Foretz, M., Lang, C. C. & Rena, G., 2023, In: Molecular Metabolism. 74, 16 p., 101750.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle
Negoita, F., Addinsall, A. B., Hellberg, K., Bringas, C. F., Hafen, P. S., Sermersheim, T. J., Agerholm, M., Lewis, C. T. A., Ahwazi, D., Ling, N. X. Y., Larsen, J. K., Deshmukh, A. S., Hossain, M. A., Oakhill, J. S., Ochala, J., Brault, J. J., Sankar, U., Drewry, D. H., Scott, J. W., Witczak, C. A. & 1 others, , 2023, In: Molecular Metabolism. 75, 14 p., 101761.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
In Vitro Screening for Probiotic Properties of Lactobacillus and Bifidobacterium Strains in Assays Relevant for Non-Alcoholic Fatty Liver Disease Prevention
Lopez-Escalera, S., Lund, M. L., Hermes, G. D. A., Choi, Beatrice So-Yun, Sakamoto, Kei & Wellejus, A., 2023, In: Nutrients. 15, 10, 23 p., 2361.Research output: Contribution to journal › Journal article › Research › peer-review
- 2022
- Published
Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis
Neopane, K., Kozlov, N., Negoita, F., Murray-Segal, L., Brink, R., Hoque, A., Ovens, A. J., Tjin, G., McAloon, L. M., Yu, D., Ling, N. X. Y., Sanders, M. J., Oakhill, J. S., Scott, J. W., Steinberg, G. R., Loh, K., Kemp, B. E., Sakamoto, Kei & Galic, S., 2022, In: Cell Reports. 41, 12, 26 p., 111862.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Glucose-Dependent miR-125b Is a Negative Regulator of β-Cell Function
Cheung, R., Pizza, G., Chabosseau, P., Rolando, D., Tomas, A., Burgoyne, T., Wu, Z., Salowka, A., Thapa, A., Macklin, A., Cao, Y., Nguyen-Tu, M. S., Dickerson, M. T., Jacobson, D. A., Marchetti, P., Shapiro, J., Piemonti, L., de Koning, E., Leclerc, I., Bouzakri, K. & 4 others, , 2022, In: Diabetes. 71, 7, p. 1525-1545 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Mechanism of glycogen synthase inactivation and interaction with glycogenin
Marr, L., Biswas, Dipsikha, Daly, L. A., Browning, C., Vial, S. C. M., Maskell, D. P., Hudson, C., Bertrand, J. A., Pollard, J., Ranson, N. A., Khatter, H., Eyers, C. E., Sakamoto, Kei & Zeqiraj, E., 2022, In: Nature Communications. 13, 1, 14 p., 3372.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Natural (dihydro)phenanthrene plant compounds are direct activators of AMPK through its allosteric drug and metabolite–binding site
Sanders, M. J., Ratinaud, Y., Neopane, K., Bonhoure, N., Day, E. A., Ciclet, O., Lassueur, S., Pinta, M. N., Deak, M., Brinon, B., Christen, S., Steinberg, G. R., Barron, D. & Sakamoto, Kei, 2022, In: Journal of Biological Chemistry. 298, 5, 15 p., 101852.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Opposing effects on regulated insulin secretion of acute vs chronic stimulation of AMP-activated protein kinase
Nguyen-Tu, M., Harris, J., Martinez-Sanchez, A., Chabosseau, P., Hu, M., Georgiadou, E., Pollard, A., Otero, P., Lopez-Noriega, L., Leclerc, I., Sakamoto, Kei, Schmoll, D., Smith, D. M., Carling, D. & Rutter, G. A., 2022, In: Diabetologia. 65, p. 997-1011 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
PEN2: Metformin’s new partner at lysosome
Sakamoto, Kei & Jessen, N., 2022, In: Cell Research. 32, p. 507-508Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids
Desjardins, E. M., Smith, B. K., Day, E. A., Ducommun, S., Sanders, M. J., Nederveen, J. P., Ford, R. J., Pinkosky, S. L., Townsend, L. K., Gutgesell, R. M., Lu, R., Sakamoto, Kei & Steinberg, G. R., 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 48, 8 p., e2119824119.Research output: Contribution to journal › Journal article › Research › peer-review
- 2021
- Published
Skeletal muscle
Markby, G. R. & Sakamoto, Kei, 1 Jan 2021, Autophagy in Health and Disease. Elsevier, p. 213-225 13 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner
Kopietz, F., Alshuweishi, Y., Bijland, S., Alghamdi, F., Degerman, E., Sakamoto, Kei, Salt, I. P. & Göransson, O., 2021, In: Biochemical Journal. 478, 3, p. 633-646 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
Rhein, P., Desjardins, E. M., Rong, P., Ahwazi, D., Bonhoure, N., Stolte, J., Santos, M. D., Ovens, A. J., Ehrlich, A. M., Sanchez Garcia, J. L., Ouyang, Q., Yabut, J. M., Kjolby, M., Membrez, M., Jessen, N., Oakhill, J. S., Treebak, J. T., Maire, P., Scott, J. W., Sanders, M. J. & 4 others, , 2021, In: Molecular Metabolism. 51, 18 p., 101228.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965
Ahwazi, Danial, Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, Anna Skab, Gräsle, P., Alshuweishi, Y., Treebak, Jonas Thue, Salt, I. P., Göransson, O., Zeqiraj, E., Scott, J. W. & Sakamoto, Kei, 2021, In: Biochemical Journal. 478, 15, p. 2977-2997 21 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2020
- Published
AMPK-dependent activation of the Cyclin Y/CDK16 complex controls autophagy
Dohmen, M., Krieg, S., Agalaridis, G., Zhu, X., Shehata, S. N., Pfeiffenberger, E., Amelang, J., Bütepage, M., Buerova, E., Pfaff, C. M., Chanda, D., Geley, S., Preisinger, C., Sakamoto, Kei, Lüscher, B., Neumann, D. & Vervoorts, J., 2020, In: Nature Communications. 11, 1, 18 p., 1032.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transcription factor EB and TFE3: new metabolic coordinators mediating adaptive responses to exercise in skeletal muscle?
Markby, G. R. & Sakamoto, Kei, 2020, In: American Journal of Physiology: Endocrinology and Metabolism. 319, 4, p. E763-E768 6 p.Research output: Contribution to journal › Review › Research › peer-review
- 2019
AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
Collodet, C., Foretz, M., Deak, M., Bultot, L., Metairon, S., Viollet, B., Lefebvre, G., Raymond, F., Parisi, A., Civiletto, G., Gut, P., Descombes, P. & Sakamoto, Kei, Nov 2019, In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 11, p. 12374-12391 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen
Shehata, S. N., Deak, M., Collodet, C., Spiegl, S., Geley, S., Sumpton, D. & Sakamoto, Kei, Jul 2019, In: Cellular Signalling. 59, p. 53-61 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates
Ducommun, S., Deak, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, Thomas Elbenhardt, Viollet, B., Foretz, M., Gut, P., Sumpton, D. & Sakamoto, Kei, 2019, In: Cellular Signalling. 57, p. 45-57 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2018
AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation
Gélinas, R., Mailleux, F., Dontaine, J., Bultot, L., Demeulder, B., Ginion, A., Daskalopoulos, E. P., Esfahani, H., Dubois-Deruy, E., Lauzier, B., Gauthier, C., Olson, A. K., Bouchard, B., Des Rosiers, C., Viollet, B., Sakamoto, K., Balligand, J. L., Vanoverschelde, J. L., Beauloye, C., Horman, S. & 1 others, , 1 Dec 2018, In: Nature Communications. 9, 1, 374.Research output: Contribution to journal › Journal article › Research › peer-review
The Salt-Inducible Kinases: Emerging Metabolic Regulators
Sakamoto, Kei, Bultot, L. & Göransson, O., Dec 2018, In: Trends in Endocrinology and Metabolism. 29, 12, p. 827-840 14 p.Research output: Contribution to journal › Review › Research › peer-review
Ampk activation by a-769662 and 991 does not affect catecholamine-induced lipolysis in human adipocytes
Kopietz, F., Berggreen, C., Larsson, S., Säll, J., Ekelund, M., Sakamoto, Kei, Degerman, E., Holm, C. & Göransson, O., Nov 2018, In: American Journal of Physiology - Endocrinology and Metabolism. 315, 5, p. E1075-E1085Research output: Contribution to journal › Journal article › Research › peer-review
Metformin reduces liver glucose production by inhibition of fructose-1-6-bisphosphatase
Hunter, R. W., Hughey, C. C., Lantier, L., Sundelin, E. I., Peggie, M., Zeqiraj, E., Sicheri, F., Jessen, N., Wasserman, D. H. & Sakamoto, Kei, 1 Sep 2018, In: Nature Medicine. 24, 9, p. 1395-1406 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism
Patra, K. C., Kato, Y., Mizukami, Y., Widholz, S., Boukhali, M., Revenco, I., Grossman, E. A., Ji, F., Sadreyev, R. I., Liss, A. S., Screaton, R. A., Sakamoto, Kei, Ryan, D. P., Mino-Kenudson, M., Castillo, C. F. D., Nomura, D. K., Haas, W. & Bardeesy, N., 1 Jul 2018, In: Nature Cell Biology. 20, 7, p. 811-822 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
MiR-184 expression is regulated by AMPK in pancreatic islets
Martinez-Sanchez, A., Nguyen-Tu, M. S., Cebola, I., Yavari, A., Marchetti, P., Piemonti, L., De Koning, E., Shapiro, A. M. J., Johnson, P., Sakamoto, Kei, Smith, D. M., Leclerc, I., Ashrafian, H., Ferrer, J. & Rutter, G. A., May 2018, In: FASEB Journal. 32, 5, p. 2587-2600 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Metformin selectively targets redox control of complex I energy transduction
Cameron, A. R., Logie, L., Patel, K., Erhardt, S., Bacon, S., Middleton, P., Harthill, J., Forteath, C., Coats, J. T., Kerr, C., Curry, H., Stewart, D., Sakamoto, Kei, Repiščák, P., Paterson, M. J., Hassinen, I., McDougall, G. & Rena, G., Apr 2018, In: Redox Biology. 14, p. 187-197 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
AMPK promotes survival of c-Myc-positive melanoma cells by suppressing oxidative stress
Kfoury, A., Armaro, M., Collodet, C., Sordet-Dessimoz, J., Giner, M. P., Christen, S., Moco, S., Leleu, M., de Leval, L., Koch, U., Trumpp, A., Sakamoto, Kei, Beermann, F. & Radtke, F., 1 Mar 2018, In: EMBO Journal. 37, 5, e97673.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle
Hingst, J. R., Bruhn, L., Hansen, M. B., Rosschou, M. F., Birk, Jesper Bratz, Fentz, J., Foretz, M., Viollet, B., Sakamoto, Kei, Færgeman, N. J., Havelund, J. F., Parker, B. L., James, D. E., Kiens, Bente, Richter, Erik A., Jensen, J. & Wojtaszewski, Jørgen F P, 2018, In: Molecular Metabolism. 16, p. 24-34 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2017
The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs
Dite, T. A., Ling, N. X. Y., Scott, J. W., Hoque, A., Galic, S., Parker, B. L., Ngoei, K. R. W., Langendorf, C. G., O'Brien, M. T., Kundu, M., Viollet, B., Steinberg, G. R., Sakamoto, Kei, Kemp, B. E. & Oakhill, J. S., 1 Dec 2017, In: Nature Communications. 8, 1, 571.Research output: Contribution to journal › Journal article › Research › peer-review
AMPKα1-LDH pathway regulates muscle stem cell self-renewal by controlling metabolic homeostasis
Theret, M., Gsaier, L., Schaffer, B., Juban, G., Ben Larbi, S., Weiss-Gayet, M., Bultot, L., Collodet, C., Foretz, M., Desplanches, D., Sanz, P., Zang, Z., Yang, Lin, Vial, G., Viollet, B., Sakamoto, Kei, Brunet, A., Chazaud, B. & Mounier, R., 3 Jul 2017, In: EMBO Journal. 36, 13, p. 1946-1962 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis
Zibrova, D., Vandermoere, F., Göransson, O., Peggie, M., Mariño, K. V., Knierim, A., Spengler, K., Weigert, C., Viollet, B., Morrice, N. A., Sakamoto, Kei & Heller, R., 15 Mar 2017, In: Biochemical Journal. 474, 6, p. 983-1001 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
Structure and inhibitor specificity of the PCTAIRE-family kinase CDK16
Dixon-Clarke, S. E., Shehata, S. N., Krojer, T., Sharpe, T. D., Von Delft, F., Sakamoto, Kei & Bullock, A. N., 1 Mar 2017, In: Biochemical Journal. 474, 5, p. 699-713 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Corrigendum: SIKs control osteocyte responses to parathyroid hormone
Wein, M. N., Liang, Y., Goransson, O., Sundberg, T. B., Wang, J., Williams, E. A., O'Meara, M. J., Govea, N., Beqo, B., Nishimori, S., Nagano, K., Brooks, D. J., Martins, J. S., Corbin, B., Anselmo, A., Sadreyev, R., Wu, J. Y., Sakamoto, K., Foretz, M., Xavier, R. J. & 6 others, , 22 Feb 2017, In: Nature Communications. 8, 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice
Chen, Q., Xie, B., Zhu, S., Rong, P., Sheng, Y., Ducommun, S., Chen, L., Quan, C., Li, M., Sakamoto, Kei, MacKintosh, C., Chen, S. & Wang, H. Y., 2017, In: Diabetologia. 60, 2, p. 336-345 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2016
Standardized LC×LC-ELSD Fractionation Procedure for the Identification of Minor Bioactives via the Enzymatic Screening of Natural Extracts
Coulerie, P., Ratinaud, Y., Moco, S., Merminod, L., Naranjo Pinta, M., Boccard, J., Bultot, L., Deak, M., Sakamoto, Kei, Queiroz, E. F., Wolfender, J. L. & Barron, D., 23 Nov 2016, In: Journal of Natural Products. 79, 11, p. 2856-2864 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
SIKs control osteocyte responses to parathyroid hormone
Wein, M. N., Liang, Y., Goransson, O., Sundberg, T. B., Wang, J., Williams, E. A., O'Meara, M. J., Govea, N., Beqo, B., Nishimori, S., Nagano, K., Brooks, D. J., Martins, J. S., Corbin, B., Anselmo, A., Sadreyev, R., Wu, J. Y., Sakamoto, K., Foretz, M., Xavier, R. J. & 6 others, , 19 Oct 2016, In: Nature Communications. 7, 13176.Research output: Contribution to journal › Journal article › Research › peer-review
Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle
Sakakibara, I., Wurmser, M., Dos Santos, M., Santolini, M., Ducommun, S., Davaze, R., Guernec, A., Sakamoto, Kei & Maire, P., 5 Sep 2016, In: Skeletal Muscle. 6, 1, 30.Research output: Contribution to journal › Journal article › Research › peer-review
Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status
Cameron, A. R., Morrison, V. L., Levin, D., Mohan, M., Forteath, C., Beall, C., McNeilly, A. D., Balfour, D. J. K., Savinko, T., Wong, A. K. F., Viollet, B., Sakamoto, Kei, Fagerholm, S. C., Foretz, M., Lang, C. C. & Rena, G., 19 Aug 2016, In: Circulation Research. 119, 5, p. 652-665 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug
Cameron, A. R., Logie, L., Patel, K., Bacon, S., Forteath, C., Harthill, J., Roberts, A., Sutherland, C., Stewart, D., Viollet, B., Sakamoto, Kei, McDougall, G., Foretz, M. & Rena, G., 1 Aug 2016, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1862, 8, p. 1412-1422 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function
Mottillo, E. P., Desjardins, E. M., Crane, J. D., Smith, B. K., Green, A. E., Ducommun, S., Henriksen, T. I., Rebalka, I. A., Razi, A., Sakamoto, Kei, Schéele, Camilla Charlotte Nielsen, Kemp, B. E., Hawke, T. J., Ortega, J., Granneman, J. G. & Steinberg, G. R., 12 Jul 2016, In: Cell Metabolism. 24, 1, p. 118-129 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Medium-chain fatty acids inhibit mitochondrial metabolism in astrocytes promoting astrocyte-neuron lactate and ketone body shuttle systems
Thevenet, J., De Marchi, U., Domingo, J. S., Christinat, N., Bultot, L., Lefebvre, G., Sakamoto, Kei, Descombes, P., Masoodi, M. & Wiederkehr, A., May 2016, In: FASEB Journal. 30, 5, p. 1913-1926 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding
Langendorf, C. G., Ngoei, K. R. W., Scott, J. W., Ling, N. X. Y., Issa, S. M. A., Gorman, M. A., Parker, M. W., Sakamoto, Kei, Oakhill, J. S. & Kemp, B. E., 8 Mar 2016, In: Nature Communications. 7, 10912.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle
Bultot, L., Jensen, Thomas Elbenhardt, Lai, Y., Madsen, A. L. B., Collodet, C., Kviklyte, S., Deak, M., Yavari, A., Foretz, M., Ghaffari, S., Bellahcene, M., Ashrafian, H., Rider, M. H., Richter, Erik A. & Sakamoto, Kei, 2016, In: American Journal of Physiology: Endocrinology and Metabolism. 311, 4, p. E706-E719 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion
Chen, L., Chen, Q., Xie, B., Quan, C., Sheng, Y., Zhu, S., Rong, P., Zhou, S., Sakamoto, Kei, MacKintosh, C., Wang, H. Y. & Chen, S., 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 26, p. 7219-7224 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2015
Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16
Shehata, S. N., Deak, M., Morrice, N. A., Ohta, E., Hunter, R. W., Kalscheuer, V. M. & Sakamoto, Kei, 1 Aug 2015, In: Biochemical Journal. 469, 3, p. 409-420 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Motif affinity and mass spectrometry proteomic approach for the discovery of cellular AMPK targets: Identification of mitochondrial fission factor as a new AMPK substrate
Ducommun, S., Deak, M., Sumpton, D., Ford, R. J., Núñez Galindo, A., Kussmann, M., Viollet, B., Steinberg, G. R., Foretz, M., Dayon, L., Morrice, N. A. & Sakamoto, Kei, 1 May 2015, In: Cellular Signalling. 27, 5, p. 978-988 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Expression and purification of functional human glycogen synthase-1:glycogenin-1 complex in insect cells
Hunter, R. W., Zeqiraj, E., Morrice, N., Sicheri, F. & Sakamoto, Kei, Apr 2015, In: Protein Expression and Purification. 108, p. 23-29 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes
Henriksson, E., Säll, J., Gormand, A., Wasserstrom, S., Morrice, N. A., Fritzen, Andreas Mæchel, Foretz, M., Campbell, D. G., Sakamoto, Kei, Ekelund, M., Degerman, E., Stenkula, K. G. & Göransson, O., 2015, In: Journal of Cell Science. 128, 3, p. 472-486 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2014
The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver
Patel, K., Foretz, M., Marion, A., Campbell, D. G., Gourlay, R., Boudaba, N., Tournier, E., Titchenell, P., Peggie, M., Deak, M., Wan, M., Kaestner, K. H., Göransson, O., Viollet, B., Gray, N. S., Birnbaum, M. J., Sutherland, C. & Sakamoto, Kei, 4 Aug 2014, In: Nature Communications. 5, 4535.Research output: Contribution to journal › Journal article › Research › peer-review
Mechanism of action of compound-13: An α1-selective small molecule activator of AMPK
Hunter, R. W., Foretz, M., Bultot, L., Fullerton, M. D., Deak, M., Ross, F. A., Hawley, S. A., Shpiro, N., Viollet, B., Barron, D., Kemp, B. E., Steinberg, G. R., Hardie, D. G. & Sakamoto, Kei, 17 Jul 2014, In: Chemistry and Biology. 21, 7, p. 866-879 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Structural basis for the recruitment of glycogen synthase by glycogenin
Zeqiraj, E., Tang, X., Hunter, R. W., García-Rocha, M., Judd, A., Deak, M., Von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, Kei & Sicheri, F., 15 Jul 2014, In: Proceedings of the National Academy of Sciences of the United States of America. 111, 28, p. E2831-E2840Research output: Contribution to journal › Journal article › Research › peer-review
A-769662 potentiates the effect of other AMP-activated protein kinase activators on cardiac glucose uptake
Timmermans, A. D., Balteau, M., Gélinas, R., Renguet, E., Ginion, A., de Meester, C., Sakamoto, Kei, Balligand, J. L., Bontemps, F., Vanoverschelde, J. L., Horman, S., Beauloye, C. & Bertrand, L., 15 Jun 2014, In: American Journal of Physiology - Heart and Circulatory Physiology. 306, 12, p. H1619-H1630Research output: Contribution to journal › Journal article › Research › peer-review
The Ca2+/calmodulin-dependent kinase kinase β-AMP-activated protein kinase-α1 pathway regulates phosphorylation of cytoskeletal targets in thrombin-stimulated human platelets
Onselaer, M. B., Oury, C., Hunter, R. W., Eeckhoudt, S., Barile, N., Lecut, C., Morel, N., Viollet, B., Jacquet, L. M., Bertrand, L., Sakamoto, Kei, Vanoverschelde, J. L., Beauloye, C. & Horman, S., Jun 2014, In: Journal of Thrombosis and Haemostasis. 12, 6, p. 973-986 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Enhanced activation of cellular AMPK by dual-small molecule treatment: AICAR and A769662
Ducommun, S., Ford, R. J., Bultot, L., Deak, M., Bertrand, L., Kemp, B. E., Steinberg, G. R. & Sakamoto, Kei, 15 Mar 2014, In: American Journal of Physiology - Endocrinology and Metabolism. 306, 6, p. E688-E696Research output: Contribution to journal › Journal article › Research › peer-review
Mutation in the γ2-Subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage
Kim, M., Hunter, R. W., Garcia-Menendez, L., Gong, G., Yang, Y. Y., Kolwicz, S. C., Xu, J., Sakamoto, Kei, Wang, W. & Tian, R., 14 Mar 2014, In: Circulation Research. 114, 6, p. 966-975 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Investigation of LKB1 Ser431 phosphorylation and Cys 433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity
Houde, V. P., Ritorto, M. S., Gourlay, R., Varghese, J., Davies, P., Shpiro, N., Sakamoto, Kei & Alessi, D. R., 15 Jan 2014, In: Biochemical Journal. 458, 1, p. 41-56 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells
De Meester, C., Timmermans, A. D., Balteau, M., Ginion, A., Roelants, V., Noppe, G., Porporato, P. E., Sonveaux, P., Viollet, B., Sakamoto, Kei, Feron, O., Horman, S., Vanoverschelde, J. L., Beauloye, C. & Bertrand, L., 1 Jan 2014, In: Cardiovascular Research. 101, 1, p. 20-29 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Salicylic acid: old and new implications for the treatment of type 2 diabetes?
Rena, G. & Sakamoto, Kei, 1 Jan 2014, In: Diabetology International. 5, 4, p. 212-218 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2013
Glucose-6-phosphate-mediated activation of liver glycogen synthase plays a key role in hepatic glycogen synthesis
Von Wilamowitz-Moellendorff, A., Hunter, R. W., García-Rocha, M., Kang, L., López-Soldado, I., Lantier, L., Patel, K., Peggie, M. W., Martínez-Pons, C., Voss, M., Calbó, J., Cohen, P. T. W., Wasserman, D. H., Guinovart, J. J. & Sakamoto, Kei, 1 Dec 2013, In: Diabetes. 62, 12, p. 4070-4082 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Molecular mechanism of action of metformin: Old or new insights?
Rena, G., Pearson, E. R. & Sakamoto, Kei, 1 Sep 2013, In: Diabetologia. 56, 9, p. 1898-1906 9 p.Research output: Contribution to journal › Review › Research › peer-review
AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration
Mounier, R., Théret, M., Arnold, L., Cuvellier, S., Bultot, L., Göransson, O., Sanz, N., Ferry, A., Sakamoto, Kei, Foretz, M., Viollet, B. & Chazaud, B., 6 Aug 2013, In: Cell Metabolism. 18, 2, p. 251-264 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition
Wan, M., Leavens, K. F., Hunter, R. W., Koren, S., Von Wilamowitz-Moellendorff, A., Lu, M., Satapati, S., Chu, Q., Sakamoto, Kei, Burgess, S. C. & Birnbaum, M. J., 2 Jul 2013, In: Cell Metabolism. 18, 1, p. 99-105 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
Dual regulation of glycogen synthase kinase 3 (GSK3)α/β by protein kinase C (PKC)α and Akt promotes thrombin-mediated integrin α∥bβ3 activation and granule secretion in platelets
Moore, S. F., Van Den Bosch, M. T. J., Hunter, R. W., Sakamoto, Kei, Poole, A. W. & Hers, I., 8 Feb 2013, In: Journal of Biological Chemistry. 288, 6, p. 3918-3928 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues
Wang, H. Y., Ducommun, S., Quan, C., Xie, B., Li, M., Wasserman, D. H., Sakamoto, Kei, Mackintosh, C. & Chen, S., 15 Jan 2013, In: Biochemical Journal. 449, 2, p. 479-489 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
LKB1 regulates lipid oxidation during exercise independently of AMPK
Jeppesen, J. F., Maarbjerg, S. J., Jordy, A. B., Fritzen, Andreas Mæchel, Pehmøller, C., Sylow, Lykke, Serup, A. K. L., Jessen, N., Thorsen, K., Prats Gavalda, Clara, Qvortrup, Klaus, Dyck, J. R. B., Hunter, R. W., Sakamoto, Kei, Thomson, D. M., Schjerling, Peter, Wojtaszewski, Jørgen F P, Richter, Erik A. & Kiens, Bente, 2013, In: Diabetes. 62, 5, p. 1490-1499 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2012
- Published
Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase
Shehata, S. N., Hunter, R. W., Ohta, E., Peggie, M. W., Lou, H. J., Sicheri, F., Zeqiraj, E., Turk, B. E. & Sakamoto, Kei, 1 Nov 2012, In: Cellular Signalling. 24, 11, p. 2085-2094 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise
Li, M., Verdijk, L. B., Sakamoto, Kei, Ely, B., van Loon, L. J. C. & Musi, N., 1 Nov 2012, In: Mechanisms of Ageing and Development. 133, 11-12, p. 655-664 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects
Jensen, J., Tantiwong, P., Stuenæs, J. T., Molina-Carrion, M., de Fronzo, R. A., Sakamoto, Kei & Musi, N., 1 Jul 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 303, 1, p. E82-E89Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser 358 in adipocytes
Henriksson, E., Jones, H. A., Patel, K., Peggie, M., Morrice, N., Sakamoto, Kei & Göransson, O., 15 Jun 2012, In: Biochemical Journal. 444, 3, p. 503-514 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cellular responses to the metal-binding properties of metformin
Logie, L., Harthill, J., Patel, K., Bacon, S., Hamilton, D. L., Macrae, K., McDougall, G., Wang, H. H., Xue, L., Jiang, H., Sakamoto, Kei, Prescott, A. R. & Rena, G., 1 Jun 2012, In: Diabetes. 61, 6, p. 1423-1433 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells
Din, F. V. N., Valanciute, A., Houde, V. P., Zibrova, D., Green, K. A., Sakamoto, Kei, Alessi, D. R. & Dunlop, M. G., Jun 2012, In: Gastroenterology. 142, 7, p. 1504-1515.e3Research output: Contribution to journal › Journal article › Research › peer-review
The ancient drug salicylate directly activates AMP-activated protein kinase
Hawley, S. A., Fullerton, M. D., Ross, F. A., Schertzer, J. D., Chevtzoff, C., Walker, K. J., Peggie, M. W., Zibrova, D., Green, K. A., Mustard, K. J., Kemp, B. E., Sakamoto, Kei, Steinberg, G. R. & Hardie, D. G., 18 May 2012, In: Science. 336, 6083, p. 918-922 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
Thr 649 Ala-AS160 knock-in mutation does not impair contraction/ AICAR-induced glucose transport in mouse muscle
Ducommun, S., Wang, H. Y., Sakamoto, Kei, MacKintosh, C. & Chen, S., 1 May 2012, In: American Journal of Physiology - Endocrinology and Metabolism. 302, 9, p. E1036-E1043Research output: Contribution to journal › Journal article › Research › peer-review
AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase
Bultot, L., Guigas, B., Von Wilamowitz-Moellendorff, A., Maisin, L., Vertommen, D., Hussain, N., Beullens, M., Guinovart, J. J., Foretz, M., Viollet, B., Sakamoto, Kei, Hue, L. & Rider, M. H., 1 Apr 2012, In: Biochemical Journal. 443, 1, p. 193-203 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Impaired adaptive response to mechanical overloading in dystrophic skeletal muscle
Joanne, P., Hourdé, C., Ochala, J., Caudéran, Y., Medja, F., Vignaud, A., Mouisel, E., Hadj-Said, W., Arandel, L., Garcia, L., Goyenvalle, A., Mounier, R., Zibroba, D., Sakamoto, Kei, Sakamato, K., Butler-Browne, G., Agbulut, O. & Ferry, A., 2012, In: PLoS ONE. 7, 4, p. e35346Research output: Contribution to journal › Journal article › Research › peer-review
- 2011
Chemical Genetic Screen for AMPKα2 Substrates Uncovers a Network of Proteins Involved in Mitosis
Banko, M. R., Allen, J. J., Schaffer, B. E., Wilker, E. W., Tsou, P. P., White, J. L., Villén, J., Wang, B., Kim, S. R., Sakamoto, Kei, Gygi, S. P., Cantley, L. C., Yaffe, M. B., Shokat, K. M. & Brunet, A., 23 Dec 2011, In: Molecular Cell. 44, 6, p. 878-892 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
A small molecule AMPK activator protects the heart against ischemia-reperfusion injury
Kim, A. S., Miller, E. J., Wright, T. M., Li, J., Qi, D., Atsina, K., Zaha, V., Sakamoto, Kei & Young, L. H., 1 Jul 2011, In: Journal of Molecular and Cellular Cardiology. 51, 1, p. 24-32 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
Protor-1 is required for efticient mT0RC2-mediated activation of SGK1 in the kidney
Pearce, L. R., Sommer, E. M., Sakamoto, Kei, Wullschleger, S. & Alessi, D. R., 15 May 2011, In: Biochemical Journal. 436, 1, p. 169-179 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Counter-modulation of fatty acid-induced pro-inflammatory nuclear factor κB signalling in rat skeletal muscle cells by AMP-activated protein kinase
Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, Kei & Hundal, H. S., 15 Apr 2011, In: Biochemical Journal. 435, 2, p. 463-474 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways
Richardson, C., Sakamoto, Kei, De Los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. & Alessi, D. R., 1 Mar 2011, In: Journal of Cell Science. 124, 5, p. 789-800 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4) P2 in regulating insulin sensitivity defined by knock-in analysis
Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, Kei & Alessi, D. R., 1 Mar 2011, In: Biochemical Journal. 434, 2, p. 265-274 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking
Chen, S., Wasserman, D. H., MacKintosh, C. & Sakamoto, Kei, 5 Jan 2011, In: Cell Metabolism. 13, 1, p. 68-79 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance
Wullschleger, S., Sakamoto, Kei, Johnstone, L., Duce, S., Fleming, S. & Alessi, D. R., 1 Jan 2011, In: DMM Disease Models and Mechanisms. 4, 1, p. 95-103 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Molecular mechanism by which AMP-activated protein kinase activation promotes glycogen accumulation in muscle
Hunter, R. W., Treebak, Jonas Thue, Wojtaszewski, Jørgen F P & Sakamoto, Kei, 2011, In: Diabetes. 60, 3, p. 766-774 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes
Gormand, A., Henriksson, E., Ström, K., Jensen, Thomas Elbenhardt, Sakamoto, Kei & Göransson, O., 2011, In: Journal of Cellular Biochemistry. 112, 5, p. 1364-1375 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2010
- Published
Allosteric regulation of glycogen synthase controls glycogen synthesis in muscle
Bouskila, M., Hunter, R. W., Ibrahim, A. F. M., Delattre, L., Peggie, M., Van Diepen, J. A., Voshol, P. J., Jensen, J. & Sakamoto, Kei, 3 Nov 2010, In: Cell Metabolism. 12, 5, p. 456-466 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, Kei, Andreelli, F. & Viollet, B., 1 Jul 2010, In: Journal of Clinical Investigation. 120, 7, p. 2355-2369 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2009
- Published
Beyond AICA riboside: In search of new specific AMP-activated protein kinase activators
Guigas, B., Sakamoto, Kei, Taleux, N., Reyna, S. M., Musi, N., Viollet, B. & Hue, L., 1 Dec 2009, In: IUBMB Life. 61, 1, p. 18-26 9 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Important role for AMPKα1 in limiting skeletal muscle cell hypertrophy
Mounier, R., Lantier, L., Leclerc, J., Sotiropoulos, A., Pende, M., Daegelen, D., Sakamoto, Kei, Foretz, M. & Viollet, B., Jul 2009, In: FASEB Journal. 23, 7, p. 2264-2273 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2008
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
Towler, M. C., Fogarty, S., Hawley, S. A., Pan, D. A., Martin, D. M. A., Morrice, N. A., McCarthy, A., Galardo, M. N., Meroni, S. B., Cigorraga, S. B., Ashworth, A., Sakamoto, Kei & Hardie, D. G., 15 Nov 2008, In: Biochemical Journal. 416, 1, p. 1-14 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Regulating the Motor for GLUT4 Vesicle Traffic
Holman, G. D. & Sakamoto, Kei, 5 Nov 2008, In: Cell Metabolism. 8, 5, p. 344-346 3 p.Research output: Contribution to journal › Comment/debate › Research › peer-review
- Published
Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake
Green, C. J., Göransson, O., Kular, G. S., Leslie, N. R., Gray, A., Alessi, D. R., Sakamoto, Kei & Hundal, H. S., 10 Oct 2008, In: Journal of Biological Chemistry. 283, 41, p. 27653-27667 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic
Sakamoto, Kei & Holman, G. D., 1 Jul 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 295, 1, p. E29-E37Research output: Contribution to journal › Review › Research › peer-review
Effect of high-intensity intermittent swimming on postexercise insulin sensitivity in rat epitrochlearis muscle
Koshinaka, K., Sano, A., Howlett, K. F., Yamazaki, T., Sasaki, M., Sakamoto, Kei & Kawanaka, K., 1 Jun 2008, In: Metabolism: Clinical and Experimental. 57, 6, p. 749-756 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
Huang, X., Wullschleger, S., Shpiro, M., McGuire, V. A., Sakamoto, Kei, Woods, Y. L., McBurnie, W., Fleming, S. & Alessi, D. R., 1 Jun 2008, In: Biochemical Journal. 412, 2, p. 211-221 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mutation of the PDK1 PH domain inhibits protein kinase B/Akt, leading to small size and insulin resistance
Bayascas, J. R., Wullschleger, S., Sakamoto, Kei, García-Martínez, J. M., Clacher, C., Komander, D., Van Aalten, D. M. F., Boini, K. M., Lang, F., Lipina, C., Logie, L., Sutherland, C., Chudek, J. A., Van Diepen, J. A., Voshol, P. J., Lucocq, J. M. & Alessi, D. R., May 2008, In: Molecular and Cellular Biology. 28, 10, p. 3258-3272 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
The effect of exercise and insulin on AS160 phosphorylation and 14-3-3 binding capacity in human skeletal muscle
Howlett, K. F., Mathews, A., Garnham, A. & Sakamoto, Kei, 1 Feb 2008, In: American Journal of Physiology - Endocrinology and Metabolism. 294, 2, p. E401-E407Research output: Contribution to journal › Journal article › Research › peer-review
ID: 227976158
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Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle
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Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates
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Compound- and fiber type-selective requirement of AMPKγ3 for insulin-independent glucose uptake in skeletal muscle
Research output: Contribution to journal › Journal article › Research › peer-review
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