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• Presentation
• CV
• Research outputs
• Activities
• Keywords

Primary fields of research

Computational chemistry and molecular modeling in drug design - especially within the target areas of GPCRs, G proteins and ligand-gated ion channels.

Selected publications

1. Published

   5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology

   Peng, Y., McCorvy, J. D., Harpsøe, Kasper, Lansu, K., Yuan, S., Popov, P., Qu, L., Pu, M., Che, T., Nikolajsen, L. F., Huang, X., Wu, Y., Shen, L., Bjørn-Yoshimoto, Walden, Ding, K., Wacker, D., Han, G. W., Cheng, J., Katritch, V., Jensen, Anders A., Hanson, M. A., Zhao, S., Gloriam, David E., Roth, B. L., Stevens, R. C. & Liu, Z., 2018, In : Cell. 172, 4, p. 719-730 P719-730.E14.

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Published

   Total synthesis and structure–activity relationship studies of a series of selective G protein inhibitors

   Xiong, X., Zhang, H., Underwood, C. R., Harpsøe, Kasper, Gardella, T. J., Wöldike, M. F., Mannstadt, M., Gloriam, David E., Bräuner-Osborne, Hans & Strømgaard, Kristian, 2016, In : Nature Chemistry. 8, 11, p. 1035-1041 7 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity

   Malfacini, D., Patt, J., Annala, S., Harpsøe, Kasper, Eryilmaz, F., Reher, R., Crüsemann, M., Hanke, W., Zhang, H., Tietze, D., Gloriam, David E., Bräuner-Osborne, Hans, Strømgaard, Kristian, König, G. M., Inoue, A., Gomeza, J. & Kostenis, E., 12 Apr 2019, In : The Journal of Biological Chemistry. 294, 15, p. 5747-5758

   Research output: Contribution to journal › Journal article › Research › peer-review

4. Published

   GPCRdb in 2018: adding GPCR structure models and ligands

   Pándy-Szekeres, G., Munk, Christian, Tsonkov, T. M., Mordalski, Stefan Mateusz, Harpsøe, Kasper, Hauser, Alexander Sebastian, Bojarski, A. J. & Gloriam, David E., 2018, In : Nucleic Acids Research. 46, D1, 7 p., gkx1109.

   Research output: Contribution to journal › Journal article › Research › peer-review

5. Published

   Structural insight to mutation effects uncover a common allosteric site in class C GPCRs

   Harpsøe, Kasper, Boesgaard, Michael Worch, Munk, Christian, Bräuner-Osborne, Hans & Gloriam, David E., 2017, In : Bioinformatics (Oxford, England). 33, 8, p. 1116-1120 5 p., btw784.

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   Integrating structural and mutagenesis data to elucidate GPCR ligand binding

   Munk, Christian, Harpsøe, Kasper, Hauser, Alexander Sebastian, Isberg, V. & Gloriam, David E., Oct 2016, In : Current Opinion in Pharmacology. 30, p. 51-58 8 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

7. Published

   GPCRdb: an information system for G protein-coupled receptors

   Isberg, V., Mordalski, S., Munk, Christian, Rataj, K., Harpsøe, Kasper, Hauser, Alexander Sebastian, Vroling, B., Bojarski, A. J., Vriend, G. & Gloriam, David E., 4 Jan 2016, In : Nucleic Acids Research. 44, D1, p. D356-64

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors - A Structural Perspective of Ligands and Mutants

   Harpsøe, Kasper, Isberg, V., Tehan, B. G., Weiss, D., Arsova, A., Marshall, F. H., Bräuner-Osborne, Hans & Gloriam, David E., 11 Sep 2015, In : Scientific Reports. 5, p. 1-11 11 p., 13869.

   Research output: Contribution to journal › Journal article › Research › peer-review

9. Published

   A robust force field based method for calculating conformational energies of charged drug-like molecules

   Pøhlsgaard, J., Harpsøe, Kasper, Jørgensen, Flemming Steen & Olsen, L., 2012, In : Journal of Chemical Information and Modeling. 52, 2, p. 409-419

   Research output: Contribution to journal › Journal article › Research › peer-review

10. Published

    Unraveling the high- and low-sensitivity agonist responses of nicotinic acetylcholine receptors

    Harpsøe, Kasper, Ahring, P. K., Christensen, J. K., Jensen, M. L., Peters, D. & Balle, T., 27 Jul 2011, In : Journal of Neuroscience. 31, 30, p. 10759-10766

    Research output: Contribution to journal › Journal article › Research › peer-review