John Robert Couchman

John Robert Couchman

Professor emeritus


  1. 2020
  2. Published

    Calcium in Cell-Extracellular Matrix Interactions

    Gopal, S., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 2020, In : Advances in Experimental Medicine and Biology. 1131, p. 1079-1102 24 p.

    Research output: Contribution to journalReview

  3. 2019
  4. Published

    Transforming growth factor-β activation in cell-free extracellular matrix preparations: Commentary

    Couchman, John Robert, 2019, In : Folia Histochemica et Cytobiologica. 57, 4, p. 157-158

    Research output: Contribution to journalJournal article

  5. 2018
  6. Published

    Keratinocytes negatively regulate the N-cadherin levels of melanoma cells via contact-mediated calcium regulation

    Chung, H., Jung, H., Jho, E., Multhaupt, Hinke Arnolda B V H, Couchman, John Robert & Oh, E., 2018, In : Biochemical and Biophysical Research Communications. 503, 2, p. 615-620 6 p.

    Research output: Contribution to journalJournal article

  7. Published

    Proteoglycan Isolation and Analysis

    Woods, A. & Couchman, John Robert, 2018, In : Current Protocols in Cell Biology. 80, 1, 21 p., e59.

    Research output: Contribution to journalJournal article

  8. 2017
  9. Published

    Syndecan-1 limits the progression of liver injury and promotes liver repair in acetaminophen-induced liver injury in mice

    Nam, E. J., Hayashida, K., Aquino, R. S., Couchman, John Robert, Kozar, R. A., Liu, J. & Park, P. W., 1 Nov 2017, In : Hepatology. 66, 5, p. 1601-1615 15 p.

    Research output: Contribution to journalJournal article

  10. Published

    Cell-extracellular matrix and cell-cell adhesion are linked by syndecan-4

    Pakideeri Karat, S. G., Multhaupt, Hinke Arnolda B V H, Pocock, R. & Couchman, John Robert, Jul 2017, In : Matrix Biology. 60-61, p. 57-69 13 p.

    Research output: Contribution to journalJournal article

  11. Published

    Proteoglycans, ion channels and cell-matrix adhesion

    Mitsou, I., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 15 Jun 2017, In : Biochemical Journal. 474, 12, p. 1965-1979 15 p.

    Research output: Contribution to journalReview

  12. Published

    Syndecans – key regulators of cell signaling and biological functions

    Afratis, N. A., Nikitovic, D., Multhaupt, Hinke Arnolda B V H, Theocharis, A. D., Couchman, John Robert & Karamanos, N. K., 1 Jan 2017, In : FEBS Journal. 284, 1, p. 27-41 15 p.

    Research output: Contribution to journalReview

  13. Published

    IGF-IR cooperates with ERα to inhibit breast cancer cell aggressiveness by regulating the expression and localisation of ECM molecules

    Afratis, N. A., Bouris, P., Skandalis, S. S., Multhaupt, Hinke Arnolda B V H, Couchman, John Robert, Theocharis, A. D. & Karamanos, N. K., 2017, In : Scientific Reports. 7, 12 p., 40138.

    Research output: Contribution to journalJournal article

  14. 2016
  15. Published

    New structural insight of C-terminal region of Syntenin-1, enhancing the molecular dimerization and inhibitory function related on Syndecan-4 signaling

    Choi, Y., Yun, J., Yoo, J., Lee, I., Kim, H., Son, H., Kim, I., Yoon, H. S., Zimmermann, P., Couchman, John Robert, Cho, H., Oh, E. & Lee, W., 10 Nov 2016, In : Scientific Reports. 6, 16 p., 36818.

    Research output: Contribution to journalJournal article

  16. Published

    Minireview: Syndecans and their crucial roles during tissue regeneration

    Chung, H., Multhaupt, Hinke Arnolda B V H, Oh, E. & Couchman, John Robert, Aug 2016, In : FEBS letters. 590, 15, p. 2408-2417 10 p.

    Research output: Contribution to journalReview

  17. Published

    Redefining the role of syndecans in C. elegans biology

    Gopal, S., Couchman, John Robert & Pocock, R., 14 Apr 2016, In : Worm. 5, 1, 7 p., e1142042.

    Research output: Contribution to journalJournal article

  18. Published

    Extracellular matrix component signaling in cancer

    Multhaupt, Hinke Arnolda B V H, Leitinger, B., Gullberg, D. & Couchman, John Robert, 1 Feb 2016, In : Advanced Drug Delivery Reviews. 97, p. 28–40

    Research output: Contribution to journalReview

  19. Published

    Recent Insights into Cell Surface Heparan Sulphate Proteoglycans and Cancer

    Couchman, John Robert, Multhaupt, Hinke Arnolda B V H & Sanderson, R. D., 2016, In : F1000Research. 5, 9 p., 1541.

    Research output: Contribution to journalReview

  20. Published

    Syndecan heparan sulfate proteoglycans: Regulation, signaling and impact on tumor biology

    Gomes, A. M., Sinkeviciute, D., Multhaupt, Hinke Arnolda B V H, Yoneda, A. & Couchman, John Robert, 2016, In : Trends in Glycoscience and Glycotechnology. 28, 163, p. E79-E90

    Research output: Contribution to journalReview

  21. Published

    The Phosphorylation and Distribution of Cortactin Downstream of Integrin α9β1 Affects Cancer Cell Behaviour

    Høye, A. M., Couchman, John Robert, Wewer, Ulla M. & Yoneda, A., 2016, In : Scientific Reports. 6, 14 p., 28529.

    Research output: Contribution to journalJournal article

  22. 2015
  23. Published

    Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels

    Gopal, S., Søgaard, P., Multhaupt, Hinke Arnolda B V H, Pataki, C., Okina, E., Xian, X., Pedersen, M. E., Stevens, T., Griesbeck, O., Park, P. W., Pocock, R. D. J. & Couchman, John Robert, 28 Sep 2015, In : Journal of Cell Biology. 210, 7, p. 1199-211 13 p.

    Research output: Contribution to journalJournal article

  24. Published

    Wnt Signaling Cascades and the Roles of Syndecan Proteoglycans

    Pataki, C. A., Couchman, John Robert & Brábek, J., 24 Apr 2015, In : Journal of Histochemistry and Cytochemistry. 63, 7, p. 465-80 16 p.

    Research output: Contribution to journalReview

  25. Published

    Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

    Theocharis, A. D., Skandalis, S. S., Neill, T., Multhaupt, Hinke Arnolda B V H, Hubo, M., Frey, H., Gopal, S., Gomes, A., Afratis, N., Lim, H. C., Couchman, John Robert, Filmus, J., Sanderson, R. D., Schaefer, L., Iozzo, R. V. & Karamanos, N. K., Apr 2015, In : BBA Reviews on Cancer. 1855, 2, p. 276–300 25 p.

    Research output: Contribution to journalReview

  26. Published

    Fell-Muir Lecture: Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour

    Couchman, John Robert, Gopal, S., Lim, H. C., Nørgaard, Steffen & Multhaupt, Hinke Arnolda B V H, Feb 2015, In : International Journal of Experimental Pathology. 96, 1, p. 1-10 10 p.

    Research output: Contribution to journalReview

  27. Published

    Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells

    Lim, H. C., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 27 Jan 2015, In : Molecular Cancer. 14, 15, p. 1-18 18 p.

    Research output: Contribution to journalJournal article

  28. Published

    Constants in an era of change

    Couchman, John Robert, Jan 2015, In : Journal of Histochemistry and Cytochemistry. 63, 1, p. 7 1 p.

    Research output: Contribution to journalEditorial

  29. 2014
  30. Published

    Protein kinase C, focal adhesions and the regulation of cell migration

    Fogh, B. S., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, Mar 2014, In : Journal of Histochemistry and Cytochemistry. 62, 3, p. 172-84 13 p.

    Research output: Contribution to journalReview

  31. Published

    Syndecan-2 regulation of morphology in breast carcinoma cells is dependent on RhoGTPases

    Lim, H. C. & Couchman, John Robert, 18 Jan 2014, In : BBA General Subjects. 1840, 8, p. 2482–2490 9 p.

    Research output: Contribution to journalJournal article

  32. Published

    Peer review and reproducibility. Crisis or time for course correction?

    Couchman, John Robert, Jan 2014, In : Journal of Histochemistry and Cytochemistry. 62, 1, p. 9-10 2 p.

    Research output: Contribution to journalEditorial

  33. Published

    Attenuation of hedgehog acyltransferase-catalyzed sonic Hedgehog palmitoylation causes reduced signaling, proliferation and invasiveness of human carcinoma cells

    Konitsiotis, A. D., Chang, S., Jovanović, B., Ciepla, P., Masumoto, N., Palmer, C. P., Tate, E. W., Couchman, John Robert & Magee, A. I., 2014, In : PloS one. 9, 3, p. 1-13 13 p., e89899.

    Research output: Contribution to journalJournal article

  34. 2013
  35. Published

    Phosphorylation and mRNA splicing of collapsin response mediator protein-2 determine inhibition of rho-associated protein kinase (ROCK) II function in carcinoma cell migration and invasion

    Morgan-Fisher, M., Couchman, John Robert & Yoneda, A., 25 Oct 2013, In : The Journal of Biological Chemistry. 288, 43, p. 31229-40 12 p.

    Research output: Contribution to journalJournal article

  36. Published

    An epidermal microRNA regulates neuronal migration through control of the cellular glycosylation state

    Pedersen, M. E., Snieckute, Goda, Kagias, K., Nehammer, C., Multhaupt, Hinke Arnolda B V H, Couchman, John Robert & Pocock, R., 20 Sep 2013, In : Science. 341, 6152, p. 1404-8 5 p.

    Research output: Contribution to journalJournal article

  37. Published

    Mapping of matrix metalloproteinase cleavage sites on syndecan-1 and syndecan-4 ectodomains

    Manon-Jensen, T., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, May 2013, In : F E B S Journal. 280, 10, p. 2320-31 12 p.

    Research output: Contribution to journalJournal article

  38. Published

    Celebrating 60 years

    Couchman, John Robert, Jan 2013, In : Journal of Histochemistry and Cytochemistry. 61, 1, p. 9-10 2 p.

    Research output: Contribution to journalEditorial

  39. 2012
  40. Published

    An introduction to proteoglycans and their localization

    Couchman, John Robert & Pataki, A. C., Dec 2012, In : Journal of Histochemistry and Cytochemistry. 60, 12, p. 885-97 13 p.

    Research output: Contribution to journalJournal article

  41. Published

    Heparan sulfate biosynthesis: methods for investigation of the heparanosome

    Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, Dec 2012, In : Journal of Histochemistry and Cytochemistry. 60, 12, p. 908-15 8 p.

    Research output: Contribution to journalJournal article

  42. Published

    Diacylglycerol kinase ζ regulates RhoA activation via a kinase-independent scaffolding mechanism

    Ard, R., Mulatz, K., Abramovici, H., Maillet, J., Fottinger, A., Foley, T., Byham, M., Iqbal, T. A., Yoneda, A., Couchman, John Robert, Parks, R. J. & Gee, S. H., Oct 2012, In : Molecular Biology of the Cell. 23, 20, p. 4008-19 12 p.

    Research output: Contribution to journalJournal article

  43. Published

    On the roles and regulation of chondroitin sulfate and heparan sulfate in zebrafish pharyngeal cartilage morphogenesis

    Holmborn, K., Habicher, J., Kasza, Z., Eriksson, A. S., Filipek-Gorniok, B., Gopal, S., Couchman, John Robert, Ahlberg, P. E., Wiweger, M., Spillmann, D., Kreuger, J. & Ledin, J., 28 Sep 2012, In : The Journal of Biological Chemistry. 287, 40, p. 33905-16 12 p.

    Research output: Contribution to journalJournal article

  44. Published

    The newcomer in the integrin family: Integrin α9 in biology and cancer.

    Høye, A. M., Couchman, John Robert, Wewer, Ulla M., Yoneda, A. & Fukami, K., May 2012, In : Advances in Biological Regulation. 52, 2, p. 326-339

    Research output: Contribution to journalReview

  45. Published

    A collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II

    Yoneda, A., Morgan-Fisher, M., Wait, R., Couchman, John Robert & Wewer, Ulla M., 2012, In : Molecular and Cellular Biology. 32, 10, p. 1788-804 17 p.

    Research output: Contribution to journalJournal article

  46. Published

    Alpha-actinin interactions with syndecan-4 are integral to fibroblast-matrix adhesion and regulate cytoskeletal architecture

    Okina, E., Grossi, A. B., Pakideeri Karat, S. G., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 2012, In : International Journal of Biochemistry & Cell Biology. 44, 12, p. 2161-2174 14 p.

    Research output: Contribution to journalJournal article

  47. Published

    Breast and ovarian cancers: a survey and possible roles for the cell surface heparan sulfate proteoglycans

    Yoneda, A., Lendorf, M. E., Couchman, John Robert & Multhaupt, Hinke Arnolda B V H, 2012, In : Journal of Histochemistry and Cytochemistry. 60, 1, p. 9-21 13 p.

    Research output: Contribution to journalJournal article

  48. Published

    Prdm5 Regulates Collagen Gene Transcription by Association with RNA Polymerase II in Developing Bone

    Galli, G. G., Honnens de Lichtenberg, Kristian, Carrara, M., Hans, W., Wuelling, M., Mentz, B., Multhaupt, Hinke Arnolda B V H, Tonnesen, C. K. F., Jensen, K. T., Rappsilber, J., Vortkamp, A., Coulton, L., Fuchs, H., Gailus-Durner, V., Hrabe de Angelis, M., Calogero, R. A., Couchman, John Robert & Lund, Anders H., 2012, In : P L o S Genetics (Online). 8, 5, p. e1002711

    Research output: Contribution to journalJournal article

  49. 2011
  50. Published

    Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma

    Lendorf, M. E., Manon-Jensen, Tina, Kronqvist, P., Multhaupt, Hinke Arnolda B V H & Couchman, John Robert, 1 Jun 2011, In : Journal of Histochemistry and Cytochemistry. 59, 6, p. 615-29 15 p.

    Research output: Contribution to journalJournal article

  51. Published

    Syndecans as cell surface receptors: Unique structure equates with functional diversity

    Choi, Y., Chung, H., Jung, H., Couchman, John Robert & Oh, E., 1 Mar 2011, In : Matrix Biology. 30, 2, p. 93-9 7 p.

    Research output: Contribution to journalJournal article

  52. Published

    Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148

    Whiteford, J. R., Xian, X., Chaussade, C., Vanhaesebroeck, B., Nourshargh, S. & Couchman, John Robert, 2011, In : Molecular Biology of the Cell. 22, 19, p. 3609-24 16 p.

    Research output: Contribution to journalJournal article

  53. Published

    Two distinct sites in sonic Hedgehog combine for heparan sulfate interactions and cell signaling functions

    Chang, S., Mulloy, B., Magee, A. I. & Couchman, John Robert, 2011, In : Journal of Biological Chemistry. 286, 52, p. 44391-402 12 p.

    Research output: Contribution to journalJournal article

  54. 2010
  55. Published

    Transmembrane Signaling Proteoglycans

    Couchman, John Robert, 10 Nov 2010, In : Annual Review of Cell and Developmental Biology. 26, p. 89-114 26 p.

    Research output: Contribution to journalJournal article

  56. Published

    Serine34 phosphorylation of RHO guanine dissociation inhibitor (RHOGDI{alpha}) links signaling from conventional protein kinase C to RHO GTPase in cell adhesion

    Dovas, A., Choi, Y., Yoneda, A., Multhaupt, Hinke Arnolda B V H, Kwon, S., Kang, D., Oh, E. & Couchman, John Robert, 15 May 2010, In : Journal of Biological Chemistry. 285, 30, p. 23296-308 15 p.

    Research output: Contribution to journalJournal article

  57. Published

    Heparan sulfate chain valency controls syndecan-4 function in cell adhesion

    Gopal, S., Bober, A., Whiteford, J. R., Multhaupt, Hinke Arnolda B V H, Yoneda, A. & Couchman, John Robert, 12 Feb 2010, In : Journal of Biological Chemistry. 285, 19, p. 14247-58 12 p.

    Research output: Contribution to journalJournal article

  58. Published

    Characterisation of stromal-cellular mechanotransduction through syndecan-4

    Hollosi, P., Grossi, A. & Couchman, John Robert, 2010.

    Research output: Contribution to conferencePosterResearch

  59. Published

    Proteoglycans in health and disease: the multiple roles of syndecan shedding

    Manon-Jensen, Tina, Itoh, Y. & Couchman, John Robert, 2010, In : FEBS Journal. 277, 19, p. 3876-89 13 p.

    Research output: Contribution to journalJournal article

  60. 2009
  61. Published

    Alpha9beta1 integrin in melanoma cells can signal different adhesion states for migration and anchorage

    Lydolph, M. C., Morgan-Fisher, M., Høye, A. M., Couchman, John Robert, Wewer, Ulla M. & Yoneda, A., 2009, In : Experimental Cell Research. 315, 19, p. 3312-24 12 p.

    Research output: Contribution to journalJournal article

  62. Published

    Dynamics of extracellular matrix in ovarian follicles and corpora lutea of mice

    Irving-Rodgers, H. F., Hummitzsch, K., Murdiyarso, L. S., Bonner, W. M., Sado, Y., Ninomiya, Y., Couchman, John Robert, Sorokin, L. M. & Rodgers, R. J., 2009, In : Cell and Tissue Research. 339, 3, p. 613-24 11 p.

    Research output: Contribution to journalJournal article

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