Jette Sandholm Jensen Kastrup

Jette Sandholm Jensen Kastrup

Professor


  1. Published

    (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: Further Exploration of Bioisosteric Replacements, Structural and Biological Investigation.

    Brogi, S., Brindisi, M., Butini, S., Kshirsagar, G., Maramai, S., Chemi, G., Gemma, S., Campiani, G., Novellino, E., Fiorenzani, P., Pinassi, J., Aloisi, A. M., Gynther, M., Venskutonyte, R., Han, L., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, 8 Mar 2018, In: Journal of Medicinal Chemistry. 61, 5, p. 2124-2130 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  2. Published

    7-Phenoxy-Substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

    Goffin, E., Drapier, T., Larsen, A. P., Geubelle, P., Ptak, C. P., Laulumaa, S., Rovinskaja, K., Gilissen, J., Tullio, P. D., Olsen, L., Frydenvang, Karla Andrea, Pirotte, B., Hanson, J., Oswald, R. E., Kastrup, Jette Sandholm Jensen & Francotte, P., Jan 2018, In: Journal of Medicinal Chemistry. 61, 1, p. 251–264

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    N-(7-(1H-imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide - a new kainate receptor selective antagonist and analgesic: Synthesis, X-ray crystallography, structure-affinity relationships, in vitro and in vivo pharmacology

    Møllerud, S., Hansen, R. B., Pallesen, J. S., Temperini, Piero, Pasini, D., Bornholdt, J., Nielsen, Birgitte, Mamedova, Esmira, Chalupnik, P., Paternain, A. V., Lerma, J., Del Castillo, M. D., Andreasen T., Jesper, Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov & Pickering, Darryl S, 2019, In: ACS Chemical Neuroscience. 10, p. 4685-4695 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. Published

    A helical structural nucleus is the primary elongating unit of insulin amyloid fibrils

    Vestergaard, Bente, Jensen, M. G., Roessle, M., Kastrup, Jette Sandholm Jensen, van de Weert, Marco, Flink, J. M., Frøkjær, Sven, Gajhede, Michael & Svergun, D. I., 2007, In: PLoS - Biology. 5, 5, p. 1089-1097

    Research output: Contribution to journalJournal articlepeer-review

  5. Published

    A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage

    Bach, Anders, Clausen, B. H., Møller, M., Vestergaard, Bente, Chi, C. N., Round, A., Sørensen, P. L., Nissen, K. B., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Jemth, P., Kristensen, Anders Skov, Lundström, P., Lambertsen, K. L. & Strømgaard, Kristian, 28 Feb 2012, In: Proceedings of the National Academy of Sciences of the United States of America. 109, 9, p. 3317-3322

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: Synthesis, resolution, pharmacology, and crystal structure

    Szymanska, E., Frydenvang, Karla Andrea, Contreras-Sanz, A., Pickering, Darryl S, Frola, E., Serafimoska, Z., Nielsen, Birgitte, Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 4 Oct 2011, In: Journal of Medicinal Chemistry. 54, 20, p. 7289-7298

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures

    Christiansen, G. B., Harbak, B., Hede, S. E., Gouliaev, A. H., Olsen, L., Frydenvang, Karla Andrea, Egebjerg, J., Kastrup, Jette Sandholm Jensen & Holm, M. M., 3 Dec 2015, In: Neuroscience. 310, p. 709-22 14 p.

    Research output: Contribution to journalJournal articlepeer-review

  8. Published

    A parallel panning scheme used for selection of a GluA4-specific Fab targeting the ligand-binding domain

    Clausen, Rasmus Prætorius, Mohr, A. Ø., Riise, E., Jensen, Anders A., Gill, A., Madden, D. R., Kastrup, Jette Sandholm Jensen & Skottrup, P. D., 8 Jul 2016, In: International Journal of Biological Macromolecules. 92, p. 779-787 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  9. Published

    A pharmacological profile of the high-affinity GluK5 kainate receptor

    Møllerud, S., Kastrup, Jette Sandholm Jensen & Pickering, Darryl S, 2016, In: European Journal of Pharmacology. 788, p. 315-320 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  10. Published

    A tetrazolyl-substituted subtype-selective AMPA receptor agonist

    Vogensen, S. B., Frydenvang, Karla Andrea, Greenwood, J. R., Postorino, G., Nielsen, Birgitte, Pickering, Darryl S, Ebert, B., Bølcho, U., Egebjerg, J., Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Johansen, Tommy Nørskov, Clausen, Rasmus Prætorius & Krogsgaard-Larsen, Povl, 2007, In: Journal of Medicinal Chemistry. 50, 10, p. 2408-2414

    Research output: Contribution to journalJournal articlepeer-review

  11. Published

    A unique set of SH3-SH3 interactions controls IB1 homodimerization

    Kristensen, O., Guenat, S., Dar, I., Allaman-Pillet, N., Abderrahmani, A., Ferdaoussi, M., Roduit, R., Maurer, F., Beckmann, J. S., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Bonny, C., 2006, In: E M B O Journal. 25, 4, p. 785-97 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  12. Published

    Acetylcholine-Binding Protein Engineered to Mimic the α4-α4 Binding Pocket in α4β2 Nicotinic Acetylcholine Receptors Reveals Interface Specific Interactions Important for Binding and Activity

    Shahsavar, A., Ahring, P. K., Olsen, J. A., Krintel, C., Kastrup, Jette Sandholm Jensen, Balle, T. & Gajhede, Michael, Oct 2015, In: Molecular Pharmacology. 88, 4, p. 697-707 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  13. Published

    At være eller ikke være en antagonist

    Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In: Lægemiddelforskning. p. 43-45

    Research output: Contribution to journalJournal article

  14. Published

    Atomic resolution structure of human HBP/CAP37/Azurocidin

    Karlsen, S., Iversen, L. F., Larsen, I. K., Flodgaard, H. J. & Kastrup, Jette Sandholm Jensen, 1998, In: Acta Crystallographica. Section D: Biological Crystallography. 54, p. 598-609 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  15. Published

    Binding Mode of an α-Amino Acid-Linked Quinoxaline-2,3-dione Analogue at Glutamate Receptor Subtype GluK1

    Demmer, C. S., Møller, C., Brown, P. M. G. E., Han, L., Pickering, Darryl S, Nielsen, Birgitte, Bowie, D., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen & Bunch, Lennart, 9 Apr 2015, In: A C S Chemical Neuroscience. 6, p. 845-854 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    Binding of a negative allosteric modulator and competitive antagonist can occur simultaneously at the ionotropic glutamate receptor GluA2

    Krintel, C., Dorosz, J., Larsen, A. H., Thorsen, T. S., Venskutonytė, R., Mirza, Osman Asghar, Gajhede, Michael, Boesen, T. & Kastrup, Jette Sandholm Jensen, 2021, In: The FEBS Journal. 288, p. 995-1007 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  17. Published
  18. Published

    Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid

    Frydenvang, Karla Andrea, Pickering, Darryl S, Greenwood, J. R., Krogsgaard-Larsen, N., Brehm, L., Nielsen, Birgitte, Vogensen, S. B., Hald, H., Kastrup, Jette Sandholm Jensen, Krogsgaard-Larsen, Povl & Clausen, Rasmus Prætorius, 10 Nov 2010, In: Journal of Medicinal Chemistry. 53, 23, p. 8354-8361

    Research output: Contribution to journalJournal articlepeer-review

  19. Published

    Biostructure-based drug design

    Jørgensen, Flemming Steen & Kastrup, Jette Sandholm Jensen, 2010, Textbook of drug design and discovery. Krogsgaard-Larsen, P., Strømgaard, K. & Madsen, U. (eds.). 4 ed. Boca Raton: CRC Press, p. 29-42

    Research output: Chapter in Book/Report/Conference proceedingBook chapterEducation

  20. Published

    Characterization of the allosteric binding pocket of human liver fructose-1,6-bisphosphatase by protein crystallography and inhibitor activity studies

    Iversen, L. F., Brzozowski, M., Hastrup, S., Larsen, I. K., Kastrup, Jette Sandholm Jensen, Nærum, L., Nørskov-Lauridsen, L., Rasmussen, P. B., Thim, L., Wiberg, F. C. & Lundgren, K., 1997, In: Protein Sci.. 6, p. 971-982 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  21. Published

    Chemo-enzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters

    Assaf, Z., Larsen, A. P., Venskutonyte, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, Anders A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 2013, In: Journal of Medicinal Chemistry. 56, 4, p. 1614-1628

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 ligand-binding core, in comparison with DNQX

    Hogner, A., Greenwood, J. R., Liljefors, T., Lunn, M., Egebjerg, J., Larsen, I. K., Gouaux, E. & Kastrup, Jette Sandholm Jensen, 16 Jan 2003, In: Journal of Medicinal Chemistry. 46, 2, p. 214-21 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  23. Published

    Computeren viser vejen til et nyt potentielt lægemiddel

    Harpsøe, Kasper, Kaae, B. H., Balle, T., Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: Lægemiddelforskning. p. 28-30

    Research output: Contribution to journalJournal article

  24. Published

    Conformational analysis of the fungicide fenpropimorph by molecular mechanics calculations and NMR spectroscopy

    Kastrup, Jette Sandholm Jensen, Jørgensen, Flemming Steen, Klemmensen, P. D., Hacksell, U. & Petersson, I., 1992, In: Journal of Pesticide Science. 36, p. 309-318 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. Published
  26. Published

    Crystal Structure of Lymnaea stagnalis AChBP Complexed with the Potent nAChR Antagonist DHßE Suggests a Unique Mode of Antagonism

    Shahsavar, Azadeh, Kastrup, Jette Sandholm Jensen, Nielsen, E. Ø., Kristensen, Jesper Langgaard, Gajhede, Michael & Balle, T., 2012, In: P L o S One. 7, 8, p. e40757

    Research output: Contribution to journalJournal articlepeer-review

  27. Published

    Crystal Structure of NCAM2 Ig1 (I4122 Cell Unit)

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Poulsen, Jens-Christian Navarro, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2008

    Research output: Non-textual formDatasetResearch

  28. Published

    Crystal Structures of Potent Dimeric Positive Allosteric Modulators at the Ligand-Binding Domain of the GluA2 Receptor

    Laulumaa, S., Hansen, K. V., Masternak, M., Drapier, T., Francotte, P., Pirotte, B., Frydenvang, Karla Andrea & Kastrup, Jette Sandholm Jensen, 14 Mar 2019, In: ACS Medicinal Chemistry Letters. 10, 3, p. 243-247 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. Published

    Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site

    Kvist, T., Steffensen, T. B., Greenwood, J. R., Mehrzad Tabrizi, F., Hansen, K. B., Gajhede, Michael, Pickering, Darryl S, Traynelis, S. F., Kastrup, Jette Sandholm Jensen & Bräuner, Hans, 2013, In: The Journal of Biological Chemistry. 288, p. 33124-35 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  30. Published

    Crystal structure of NCAM2 IgIV-Fn3I

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual formDatasetResearch

  31. Published

    Crystal structure of NCAM2 IgIV-Fn3II

    Kulahin, N., Rasmussen, K. K., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M., Walmod, P. S. & Gajhede, Michael, 2009

    Research output: Non-textual formDatasetResearch

  32. Published

    Crystal structure of a partly self-complementary peptide nucleic acid (PNA) oligomer showing a duplex-triplex network

    Petersson, B., Nielsen, B. B., Rasmussen, H., Larsen, I. K., Gajhede, Michael, Nielsen, Peter E. & Kastrup, Jette Sandholm Jensen, 9 Feb 2005, In: Journal of the American Chemical Society. 127, 5, p. 1424-30 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. Published

    Crystal structure of a peptide nucleic acid (PNA) duplex at 1.7 Å resolution

    Rasmussen, H. B., Kastrup, Jette Sandholm Jensen, Nielsen, J. N., Nielsen, J. M. & Nielsen, Peter E., 1997, In: Nature Structural and Molecular Biology. 4, p. 98-101 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  34. Published

    Crystal structure of sucrose phosphorylase from Bifidobacterium adolescentis

    Sprogøe, D., van den Broek, L. A. M., Mirza, Osman Asghar, Kastrup, Jette Sandholm Jensen, Voragen, A. G. J., Gajhede, Michael & Skov, L., 10 Feb 2004, In: Biochemistry. 43, 5, p. 1156-62 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. Published

    Crystal structure of tetranectin, a trimeric plasminogen binding protein with an alpha-helical coiled coil

    Nielsen, B. B., Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Las Holtet, T., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., 1997, In: FEBS Letters. 412, p. 388-396 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  36. Published

    Crystal structure of the Ig1 domain of the neural cell adhesion molecule NCAM2 displays domain swapping.

    Rasmussen, K. K., Kulahin, N., Kristensen, O., Poulsen, Jens-Christian Navarro, Sigurskjold, B. W., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E., Walmod, P. S. & Gajhede, Michael, 2008, In: Journal of Molecular Biology. 382, 5, p. 1113-20 7 p.

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Crystal structure of the acetylcholine binding protein (AChBP) from Lymnaea stagnalis in complex with NS3950 (1-(6-bromo-5-ethoxypyridin-3-yl)-1,4-diazepane)

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. O., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 14 Dec 2011

    Research output: Other contributionResearch

  38. Published

    Crystal structure of the kainate receptor GluR5 ligand-binding core in complex with (S)-glutamate

    Naur, P., Vestergaard, Bente, Skov, L., Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Letters. 579, p. 1154-60

    Research output: Contribution to journalJournal articlepeer-review

  39. Published

    Crystal structures of two peptide-HLA-B*1501 complexes; structural characterization of the HLA-B62 supertype

    Røder, G., Blicher, T., Justesen, S., Johannesen, B., Kristensen, O., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2006, In: Acta Crystallographica. Section D: Biological Crystallography. 62, Pt 11, p. 1300-10 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. Published

    Crystallization and molecular replacement solution of human heparin binding protein

    Iversen, L. F., Kastrup, Jette Sandholm Jensen, Larsen, I. K., Bjørn, S. E., Rasmussen, P. B., Wiberg, F. C. & Flodgaard, H. J., 1996, In: Acta Crystallographica. Section D: Biological Crystallography. 52, p. 1222-1223 2 p.

    Research output: Contribution to journalJournal articlepeer-review

  41. Published

    Crystallization and molecular-replacement solution of a truncated form of human recombinant tetranectin

    Nielsen, B. B., Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Graversen, J. H., Etzerodt, M., Thøgersen, H. C. & Larsen, I. K., May 2000, In: Acta Crystallographica. Section D: Biological Crystallography. 56, Pt 5, p. 637-9 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  42. Published

    Crystallization and preliminary X-ray analysis of a PNA-DNA complex

    Kastrup, Jette Sandholm Jensen, Pilgaard, M., Jørgensen, Flemming Steen, Nielsen, Peter E. & Rasmussen, H. B., 1995, In: FEBS Letters. 363, 1-2, p. 115-117 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  43. Published
  44. Published

    Design and characterization of dimeric ligands cross-linking two identical modulatory AMPA receptor sites

    Kaae, B. H., Harpsøe, Kasper, Sanz, A. C., Pickering, Darryl S, Sauerberg, P., Clausen, Rasmus Prætorius, Kastrup, Jette Sandholm Jensen, Liljefors, T. & Madsen, Ulf, 19 Aug 2007, In: American Chemical Society. Abstracts of Papers (at the National Meeting). 234

    Research output: Contribution to journalConference abstract in journal

  45. Published

    Development of Thiochroman Dioxide Analogues of Benzothiadiazine Dioxides as New Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors

    Etsè, K. S., Dorosz, J., McLain Christensen, K., Thomas, J. Y., Botez Pop, I., Goffin, E., Colson, T., Lestage, P., Danober, L., Pirotte, B., Kastrup, Jette Sandholm Jensen & Francotte, P., 2021, In: ACS Chemical Neuroscience. 12, 14, p. 2679-2692

    Research output: Contribution to journalJournal articlepeer-review

  46. Published

    Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics

    Masternak, Magdalena, Koch, A., Laulumaa, S., Tapken, D., Hollmann, M., Jørgensen, Flemming Steen & Kastrup, Jette Sandholm Jensen, 2023, In: F E B S Journal. 290, 15, p. 3781-3801

    Research output: Contribution to journalJournal articlepeer-review

  47. Published

    Dimerization effect of sucrose octasulfate on rat FGF1.

    Kulahin, N., Kiselyov, V., Kochoyan, A., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. M. & Gajhede, Michael, 2008, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 64, Pt6, p. 448-452 5 p.

    Research output: Contribution to journalJournal articlepeer-review

  48. Published

    Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2

    Hald, H., Ahring, P. K., Timmermann, D. B., Liljefors, T., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Molecular Biology. 391, 5, p. 906-917

    Research output: Contribution to journalJournal articlepeer-review

  49. Published

    Engineered α4β2 nicotinic acetylcholine receptors as models for measuring agonist binding and effect at the orthosteric low-affinity α4-α4 interface

    Ahring, P. K., Olsen, J. A., Nielsen, E. Ø., Peters, D., Pedersen, M. H. F., Rohde, L. A., Kastrup, Jette Sandholm Jensen, Shahsavar, A., Indurthi, D. C., Chebib, M., Gajhede, Michael & Balle, T., 2015, In: Neuropharmacology. 92, p. 135-45 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. Published

    Enhancing Action of Positive Allosteric Modulators through the Design of Dimeric Compounds

    Drapier, T., Geubelle, P., Bouckaert, C., Nielsen, L., Laulumaa, S., Goffin, E., Dilly, S., Francotte, P., Hanson, J., Pochet, L., Kastrup, Jette Sandholm Jensen & Pirotte, B., 28 Jun 2018, In: Journal of Medicinal Chemistry. 61, 12, p. 5279-5291 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  51. Published

    Enthalpy-Entropy Compensation in the Binding of Modulators at Ionotropic Glutamate Receptor GluA2

    Krintel, C., Francotte, P., Pickering, Darryl S, Juknaite, L., Pøhlsgaaard, J., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Pirotte, B. & Kastrup, Jette Sandholm Jensen, 2016, In: Biophysical Journal. 110, 11, p. 2397-2406 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  52. Published

    Enzyme kinetic studies of histone demethylases KDM4C and KDM6A: Towards understanding selectivity of inhibitors targeting oncogenic histone demethylases

    Kristensen, J. B. L., Nielsen, A. L., Jørgensen, L., Kristensen, L. H., Helgstrand, C., Juknaite, L., Kristensen, Jesper Langgaard, Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius, Olsen, L. & Gajhede, Michael, 23 Jun 2011, In: F E B S Letters. 585, 12, p. 1951-1956

    Research output: Contribution to journalJournal articlepeer-review

  53. Published

    Erratum: Chemoenzymatic synthesis of new 2,4- syn -functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters (Journal of Medicinal Chemistry (2013) 56 (1614-1628))

    Assaf, Z., Larsen, A. P., Venskutonyteì, R., Han, L., Abrahamsen, B., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Jensen, A. A., Pickering, Darryl S, Frydenvang, Karla Andrea, Gefflaut, T. & Bunch, Lennart, 25 Jul 2013, In: Journal of Medicinal Chemistry. 56, 14, p. 5985 1 p.

    Research output: Contribution to journalComment/debatepeer-review

  54. Published

    Establishment of an immunized murine Fab library for selection of iGluR6 binders by phage display

    Mohr, A. Ø., Skottrup, P. D., Jensen, A. A., Kastrup, Jette Sandholm Jensen, Clausen, Rasmus Prætorius & Riise, E. S., 28 May 2009.

    Research output: Contribution to conferencePosterResearch

  55. Published

    Exploring the GluR2 ligand-binding core in complex with the bicyclical AMPA analogue (S)-4-AHCP

    Nielsen, B. B., Pickering, Darryl S, Greenwood, J. R., Brehm, L., Gajhede, Michael, Schousboe, Arne & Kastrup, Jette Sandholm Jensen, 2005, In: FEBS Journal. 272, 7, p. 1639-48 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  56. Published

    Exploring thienothiadiazine dioxides as isosteric analogues of benzo- and pyridothiadiazine dioxides in the search of new AMPA and kainate receptor positive allosteric modulators

    Francotte, P., Bay, Yasmin, Goffin, E., Colson, T., Lesenfants, C., Dorosz, J., Laulumaa, S., Fraikin, P., de Tullio, P., Beaufour, C., Botez, I., Pickering, Darryl S, Frydenvang, Karla Andrea, Danober, L., Kristensen, A. S., Kastrup, Jette Sandholm Jensen & Pirotte, B., 2024, In: European Journal of Medicinal Chemistry. 264, 15 p., 116036.

    Research output: Contribution to journalJournal articlepeer-review

  57. Published

    Expression, crystallization and preliminary X-ray analysis of extracellular modules of the neural cell-adhesion molecules NCAM and L1

    Kulahin, N., Kasper, C., Gajhede, Michael, Berezin, V., Bock, E. & Kastrup, Jette Sandholm Jensen, Mar 2004, In: Acta Crystallographica. Section D: Biological Crystallography. 60, Pt 3, p. 591-3 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  58. Published

    Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I-IV and F3 modules I-III of the neural cell-adhesion molecule L1

    Kulahin, N., Kasper, C., Kristensen, O., Kastrup, Jette Sandholm Jensen, Berezin, V., Bock, E. & Gajhede, Michael, 2005, In: Acta Crystallographica. Section F : Structural Biology and Crystallization Communications. 61, Pt 9, p. 858-60 2 p.

    Research output: Contribution to journalJournal articlepeer-review

  59. Published

    Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine

    Frydenvang, Karla Andrea, Lash, L. L., Naur, P., Postila, P. A., Pickering, Darryl S, Smith, C. M., Gajhede, Michael, Sasaki, M., Sakai, R., Pentikäinen, O. T., Swanson, G. T. & Kastrup, Jette Sandholm Jensen, 2009, In: Journal of Biological Chemistry. 284, 21, p. 14219-14229

    Research output: Contribution to journalJournal articlepeer-review

  60. Published

    Gennembrud i forståelsen af insulinfibrillering

    Jensen, M. G., Vestergaard, Bente, Frøkjær, Sven, Gajhede, Michael, Flink, J. M., van de Weert, Marco, Kastrup, Jette Sandholm Jensen & Svergun, D. I., 2007, In: Lægemiddelforskning. p. 10-11

    Research output: Contribution to journalJournal article

  61. Published

    GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists

    Kasper, C., Lunn, M., Liljefors, T., Gouaux, E., Egebjerg, J. & Kastrup, Jette Sandholm Jensen, 6 Nov 2002, In: F E B S Letters. 531, 2, p. 173-8 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  62. Published

    High resolution crystal structures of the p120 RasGAP SH3 domain

    Ross, B., Kristensen, O., Favre, D., Walicki, J., Kastrup, Jette Sandholm Jensen, Widmann, C. & Gajhede, Michael, 2007, In: Biochemical and Biophysical Research Communications. 353, 2, p. 463-468

    Research output: Contribution to journalJournal articlepeer-review

  63. Published

    High-resolution structure of HLA-A*1101 in complex with SARS nucleocapsid peptide

    Blicher, T., Kastrup, Jette Sandholm Jensen, Buus, Søren & Gajhede, Michael, 2005, In: Acta Crystallographica. Section D: Biological Crystallography. 61, Pt 8, p. 1031-40 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  64. Published

    Human plasminogen binding protein tetranectin: crystallization and preliminary X-ray analysis of the C-type lectin CRD and the full-length protein

    Kastrup, Jette Sandholm Jensen, Rasmussen, H. B., Nielsen, B. B., Larsen, I. K., Las Holtet, T., Graversen, J. H., Etzerodt, M. & Thøgersen, H. C., 1997, In: Acta Crystallographica. Section D: Biological Crystallography. 53, p. 108-111 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  65. Published

    Hvad har varme at gøre med lægemidler?

    Olsen, L., Kasper, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Jørgensen, Flemming Steen, 2006, In: Lægemiddelforskning. p. 31-33

    Research output: Contribution to journalJournal article

  66. Published

    Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

    Larsen, A. P., Fièvre, S., Frydenvang, Karla Andrea, Francotte, P., Pirotte, B., Kastrup, Jette Sandholm Jensen & Mulle, C., Jun 2017, In: Molecular Pharmacology. 91, 6, p. 576-585 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  67. Published

    Interaction partners of PSD-93 studied by X-ray crystallography and fluorescence polarization spectroscopy

    Fiorentini, M., Bach, Anders, Strømgaard, Kristian, Kastrup, Jette Sandholm Jensen & Gajhede, Michael, Apr 2013, In: Acta Crystallographica. Section D: Biological Crystallography. 69, Pt 4, p. 587-94 8 p.

    Research output: Contribution to journalJournal article

  68. Published

    Intersubunit bridge formation governs agonist efficacy at nicotinic acetylcholine alpha4beta2 receptors: Unique role of halogen bonding revealed

    Rohde, L. A. H., Ahring, P. K., Jensen, M. L., Nielsen, E. Ø., Peters, D., Helgstrand, C., Krintel, C., Harpsøe, Kasper, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Balle, T., 3 Feb 2012, In: The Journal of Biological Chemistry. 287, 6, p. 4248-4259

    Research output: Contribution to journalJournal articlepeer-review

  69. Published

    Invisible detergents for structure determination of membrane proteins by small-angle neutron scattering

    Midtgaard, S. R., Darwish, T. A., Pedersen, M. C., Huda, P., Larsen, A. H., Jensen, G. V., Kynde, S. A. R., Skar-Gislinge, N., Nielsen, A. J. Z., Olesen, C., Blaise, M., Dorosz, J. J., Thorsen, T. S., Venskutonytė, R., Krintel, C., Møller, J. V., Frielinghaus, H., Gilbert, E. P., Martel, A., Kastrup, J. S. J. & 3 others, Jensen, P. E., Nissen, P. & Arleth, Lise, Jan 2018, In: F E B S Journal. 285, 2, p. 357-371 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  70. Published

    Ionotropic glutamate receptor GluA2 in complex with bicyclic pyrimidinedione-based compounds: when small compound modifications have distinct effects on binding interactions

    Frydenvang, Karla Andrea, Pickering, Darryl S, Kshirsagar, G. U., Chemi, G., Gemma, S., Sprogøe, D., Kærn, A. M., Brogi, S., Campiani, G., Butini, S. & Kastrup, Jette Sandholm Jensen, 2020, In: ACS Chemical Neuroscience. 11, 12, p. 1791-1800

    Research output: Contribution to journalJournal articlepeer-review

  71. Published

    Ionotropic glutamate-like receptor d2 binds D-serine and glycine.

    Naur, P., Hansen, K. B., Kristensen, Anders Skov, Dravid, S. M., Pickering, Darryl S, Olsen, L., Vestergaard, Bente, Egebjerg, J., Gajhede, Michael, Traynelis, S. F. & Kastrup, Jette Sandholm Jensen, 2007, In: Proceedings of the National Academy of Science of the United States of America. 104, 35, p. 14116-14121

    Research output: Contribution to journalJournal articlepeer-review

  72. Published

    Jagten på et signalstof til hjernens delta2-receptor

    Naur, P., Olsen, L., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Lægemiddelforskning. p. 32-33

    Research output: Contribution to journalJournal article

  73. Published

    Kainate induces various domain closures in AMPA and kainate receptors

    Venskutonyte, R., Frydenvang, Karla Andrea, Hald, H., Rabassa, A. C. D., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, Sep 2012, In: Neurochemistry International. 61, 4, p. 536-545

    Research output: Contribution to journalJournal articlepeer-review

  74. Published

    L-Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand-binding domain

    Krintel, C., Frydenvang, Karla Andrea, Ceravalls de Rabassa, A., Kaern, A. M., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 27 Mar 2014, In: F E B S Journal. p. 2422–2430 9 p.

    Research output: Contribution to journalJournal articlepeer-review

  75. Published

    Lessons from crystal structures of kainate receptors

    Møllerud, S., Frydenvang, Karla Andrea, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 1 Jan 2017, In: Neuropharmacology. 112, Part A, p. 16-28 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  76. Published

    Lessons from more than 80 structures of the GluA2 ligand-binding domain in complex with agonists, antagonists and allosteric modulators

    Pøhlsgaard, J., Frydenvang, Karla Andrea, Madsen, Ulf & Kastrup, Jette Sandholm Jensen, 1 Jan 2011, In: Neuropharmacology. 60, 1, p. 135-150

    Research output: Contribution to journalReviewpeer-review

  77. Published

    Ligand binding analyses of the putative peptide transporter YjdL from E. coli display a significant selectivity towards dipeptides

    Ernst, H. A., Pham, A., Hald, H., Kastrup, Jette Sandholm Jensen, Rahman, M. & Mirza, Osman Asghar, 2009, In: Biochemical and Biophysical Research Communications. 389, 1, p. 112-116

    Research output: Contribution to journalJournal articlepeer-review

  78. Published

    Lipopolysaccharide affinity measurement by scintillation proximity assay: application to human heparin binding protein

    Linde, V., Bjørn, S., Kastrup, Jette Sandholm Jensen & Flodgaard, H., Feb 2000, In: BioTechniques. 28, 2, p. 218-20, 222

    Research output: Contribution to journalJournal articlepeer-review

  79. Published

    Measurement of apoptosis by the TUNEL method using scintillating microplates

    Linde, V., Flodgaard, H., Kastrup, Jette Sandholm Jensen & Bjørn, S., 10 Apr 2000, In: Analytical Biochemistry. 280, 1, p. 186-8 3 p.

    Research output: Contribution to journalJournal articlepeer-review

  80. Published

    Modulation of the dimer interface at ionotropic glutamate-like receptor d2 by D-serine and extracellular calcium

    Hansen, K. B., Naur, P., Kurtkaya, N. L., Kristensen, Anders Skov, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., 2009, In: Journal of Neuroscience. 29, 4, p. 907-917

    Research output: Contribution to journalJournal articlepeer-review

  81. Published

    Molecular determinants of subtype-selective efficacies of cytisine and the novel compound NS3861 at heteromeric nicotinic acetylcholine receptors

    Harpsøe, Kasper, Hald, H., Timmermann, D. B., Jensen, M. L., Dyhring, T., Nielsen, E. Ø., Peters, D., Balle, T., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Ahring, P. K., 25 Jan 2013, In: Journal of Biological Chemistry. 288, 4, p. 2559-2570 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  82. Published

    Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4

    Kasper, C., Frydenvang, Karla Andrea, Naur, P., Gajhede, Michael, Pickering, Darryl S & Kastrup, Jette Sandholm Jensen, 2008, In: FEBS Letters. 582, 29, p. 4089-4094

    Research output: Contribution to journalJournal articlepeer-review

  83. Published

    Molecular recognition of the neurotransmitter acetylcholine by an acetylcholine binding protein reveals determinants of binding to nicotinic acetylcholine receptors

    Olsen, J. A., Balle, T., Gajhede, Michael, Ahring, P. K. & Kastrup, Jette Sandholm Jensen, 17 Mar 2014, In: PLOS ONE. 9, 3, p. e91232 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  84. Published

    Molecular recognition of two 2,4-syn-functionalized (S)-glutamate analogues by the kainate receptor GluK3 ligand-binding domain

    Venskutonyte, R., Larsen, A. P., Frydenvang, Karla Andrea, Gajhede, Michael, Gefflaut, T., Pickering, Darryl S, Bunch, Lennart & Kastrup, Jette Sandholm Jensen, 2014, In: ChemMedChem. 9, 10, p. 2254-2259 6 p.

    Research output: Contribution to journalJournal articlepeer-review

  85. Published

    N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships and in vitro Pharmacology

    Pallesen, J. S., Møllerud, S., Frydenvang, Karla Andrea, Pickering, Darryl S, Bornholt, J., Nielsen, Birgitte, Pasini, D., Han, L., Marconi, L., Kastrup, Jette Sandholm Jensen & Johansen, Tommy Nørskov, 20 Mar 2019, In: A C S Chemical Neuroscience. 10, p. 1841-1853 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  86. Published

    Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors

    Dawe, G. B., Kadir, M. F., Venskutonyte, R., Perozzo, A. M., Yan, Y., Alexander, R. P. D., Navarrete, C., Santander, E. A., Arsenault, M., Fuentes, C., Aurousseau, M. R. P., Frydenvang, Karla Andrea, Barrera, N. P., Kastrup, Jette Sandholm Jensen, Edwardson, J. M. & Bowie, D., 5 Jun 2019, In: Neuron. 102, 5, p. 976-+

    Research output: Contribution to journalJournal articlepeer-review

  87. Published

    Neuroplastin-55 binds to and signals through the fibroblast growth factor receptor

    Owczarek, S., Kiryushko, D., Hald Larsen, M., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sandi, C., Berezin, V., Bock, E. & Soroka, V., 2010, In: The FASEB Journal. 24, 4, p. 1139-1150 12 p.

    Research output: Contribution to journalJournal articlepeer-review

  88. Published

    Novel Guaiane Esters from Thapsia villosa

    Lemmich, E., Smitt, U. W., Kastrup, Jette Sandholm Jensen & Christensen, Søren Brøgger, 1991, In: Phytochemistry. 30, p. 2987-2990 4 p.

    Research output: Contribution to journalJournal articlepeer-review

  89. Published

    Over-expression, purification and characterization of an Asc-1 homologue from Gloeobacter violaceus

    Wang, X., Hald, H., Ernst, H. A., Egebjerg, J., Christensen, K. V., Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Mirza, Osman Asghar, 2010, In: Protein Expression and Purification. 71, 2, p. 179-183

    Research output: Contribution to journalJournal articlepeer-review

  90. Published

    Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-bining core in complex with domoic acid and 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid

    Hald, H., Naur, P., Pickering, Darryl S, Sprogøe, D., Madsen, Ulf, Timmermann, D. B., Ahring, P. K., Liljefors, T., Schousboe, Arne, Egebjerg, J., Gajhede, Michael & Kastrup, Jette Sandholm Jensen, 2007, In: Journal of Biological Chemistry. 282, 35, p. 25726-25736

    Research output: Contribution to journalJournal articlepeer-review

  91. Published

    Peptide nucleic acids (PNA) derived from N-(N-methylamino-ethyl)glycine. Synthesis, hybridization and structural roperties

    Haaima, G., Rasmussen, H. B., Schmidt, G., Jensen, D. K., Kastrup, Jette Sandholm Jensen, Stafshede, P. W., Nordén, B., Buchardt, O. & Nielsen, Peter E., 1999, In: New. J. Chem.. 23, p. 833-840 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  92. Published

    Pharmacological and structural characterization of conformationally restricted (S)-glutamate analogues at ionotropic glutamate receptors

    Juknaite, L., Venskutonyte, R., Assaf, Z., Faure, S., Gefflaut, T., Aitken, D. J., Nielsen, Birgitte, Gajhede, Michael, Kastrup, Jette Sandholm Jensen, Bunch, Lennart, Frydenvang, Karla Andrea & Pickering, Darryl S, 2012, In: Journal of Structural Biology. 180, 1, p. 39-46

    Research output: Contribution to journalJournal articlepeer-review

  93. Published

    Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors

    Kristensen, Anders Skov, Hansen, K. B., Naur, P., Olsen, L., Kurtkaya, N. L., Dravid, S. M., Kvist, T., Yi, F., Pøhlsgaard, J., Clausen, Rasmus Prætorius, Gajhede, Michael, Kastrup, Jette Sandholm Jensen & Traynelis, S. F., Feb 2016, In: Molecular Pharmacology. 89, 2, p. 253-262 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  94. Published

    Pharmacology and crystal structure of novel 2,3-quinoxalinediones at kainate receptors

    Møllerud, S., Pallesen, J. S., Pasini, D., Marconi, L., Han, L., Bornholt, J., Johansen, Tommy Nørskov, Kastrup, Jette Sandholm Jensen, Pickering, Darryl S & Frydenvang, Karla Andrea, Aug 2017, In: Journal of Neurochemistry. 142, S1, p. 124 1 p., MTU07-13.

    Research output: Contribution to journalConference abstract in journalpeer-review

  95. Published

    Positive Allosteric Modulators of 2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic Acid Receptors Belonging to 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-pyridothiadiazine Dioxides and Diversely Chloro-Substituted 4-Cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides

    Francotte, P., Nørholm, A., Deva, T., Olsen, L., Frydenvang, Karla Andrea, Goffin, E., Fraikin, P., de Tullio, P., Challal, S., Thomas, J., Iop, F., Louis, C., Botez-Pop, I., Lestage, P., Danober, L., Kastrup, Jette Sandholm Jensen & Pirotte, B., 26 Nov 2014, In: Journal of Medicinal Chemistry. 57, 22, p. 9539-53 15 p.

    Research output: Contribution to journalJournal articlepeer-review

  96. Published

    På jagt efter et virkningssted i hjernen

    Frydenvang, Karla Andrea, Juknaite, L. & Kastrup, Jette Sandholm Jensen, 2013, In: Lægemiddelforskning. p. 50-52 3 p.

    Research output: Contribution to journalJournal article

  97. Published

    Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface

    Nørgrd Larsen, Andreas, Perozzo, A. M., Biggin, P. C., Bowie, D. & Kastrup, Jette Sandholm Jensen, 2024, In: Journal of Biological Chemistry. 300, 3, 10 p., 105717.

    Research output: Contribution to journalJournal articlepeer-review

  98. Published

    Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis

    Pedersen, A. K., Guo, X., Møller, K. B., Peters, G. H., Andersen, H. S., Kastrup, Jette Sandholm Jensen, Mortensen, T. S., Iversen, L. F., Zhang, Z. & Møller, N. P. H., 1 Mar 2004, In: Biochemical Journal. 378, Pt 2, p. 421-33 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  99. Published

    Selective kainate receptor (GluK1) ligands structurally based upon1H-Cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization

    Venskutonyte, R., Butini, S., Coccone, S. S., Gemma, S., Brindisi, M., Kumar, V., Guarino, E., Maramai, S., Valenti, S., Amir, A., Valades, E. A., Frydenvang, Karla Andrea, Kastrup, Jette Sandholm Jensen, Novellino, E., Campiani, G. & Pickering, Darryl S, 14 Jul 2011, In: Journal of Medicinal Chemistry. 54, 13, p. 4793-4805

    Research output: Contribution to journalJournal articlepeer-review

  100. Published

    Small angle X-ray studies reveal that Aspergillus niger glucoamylase has a defined extended conformation and can form dimers in solution

    Jørgensen, A. D., Nøhr, J., Kastrup, Jette Sandholm Jensen, Gajhede, Michael, Sigurskjold, B. W., Sauer, J., Svergun, D. I., Svensson, B. & Vestergaard, Bente, 2008, In: Journal of Biological Chemistry. 283, 21, p. 14772-14780

    Research output: Contribution to journalJournal articlepeer-review

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