Jan Stenvang

Jan Stenvang

Associate Professor

  • Molecular and Cellular Pharmacology

    Jagtvej 160

    2100 København Ø


  1. 2021
  2. Published
  3. Published

    New use for old drugs: Epirubicin in colorectal cancer

    Tarpgaard, L. S., Qvortrup, C., Nielsen, S. L., Stenvang, Jan, Detlefsen, S., Brünner, Nils & Pfeiffer, P., 2021, In: Acta Oncologica. 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  4. Published

    Synthesis of thiazole linked chalcones and their pyrimidine analogues as anticancer agents

    Kesari, C., Rama, K. R., Sedighi, K., Stenvang, Jan, Björkling, Fredrik, Kankala, S. & Thota, N., 2021, In: Synthetic Communications. 51, 9, p. 1406-1416 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2020
  6. Published

    Targeting anti-cancer drug resistance in gastro-intestinal cancer: Inhibition of the SRPK1 kinase and degradation of the ABCG2 drug efflux pump

    Ladekarl, Monica, Schou, J. H. V., Roest, N. L., Stenvang, Jan, Brünner, Nils & Vestlev, P. M., Sep 2020, p. S503-S504. 2 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  7. Published

    The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

    Ambjørner, Sophie Emilie Blomgren, Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, L., Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, Nils & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    ABCG2 Protein Levels and Association to Response to First-Line Irinotecan-Based Therapy for Patients with Metastatic Colorectal Cancer

    Palshof, J. A., Cederbye, C. N., Hgdall, E. V. S., Poulsen, T. S., Linnemann, D., Nygaard, S. B., Stenvang, Jan, Christensen, I. J., Jensen, B. V., Pfeiffer, P., Brünner, Nils, Yilmaz, M., Viuff, B. M. & Nielsen, Dorte Lisbet, 2020, In: International Journal of Molecular Sciences. 21, 14, 13 p., 5027.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    An Explorative Analysis of ABCG2/TOP-1 mRNA Expression as a Biomarker Test for FOLFIRI Treatment in Stage III Colon Cancer Patients: Results from Retrospective Analyses of the PETACC-3 Trial

    Stenvang, Jan, Budinská, E., van Cutsem, E., Bosman, F., Popovici, V. & Brünner, Nils, 2020, In: Cancers. 12, 4, 12 p., 977.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Characterization of resistance to a recombinant hexameric Fas-ligand (APO010) in human cancer cell lines

    Jandu, H., Nielsen, A., Brünner, Nils, Hansen, A., Knudsen, S., Stenvang, Jan & Jensen, P. B., 2020, In: Experimental Hematology. 87, p. 33-41

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Four phase 1 trials to evaluate the safety and pharmacokinetic profile of single and repeated dosing of SCO-101 in adult male and female volunteers

    Bergmann, T. K., Stage, T. B., Stenvang, Jan, Christophersen, P., Jacobsen, T. A., Roest, N. L., Vestlev, P. M. & Brünner, Nils, 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 4, p. 329-337

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Pharmacodynamic modelling reveals synergistic interaction between docetaxel and SCO-101 in a docetaxel-resistant triple negative breast cancer cell line

    Nøhr-Nielsen, A., Bagger, Sofie Otzen, Brünner, Nils, Stenvang, Jan & Lund, Trine Meldgaard, 2020, In: European Journal of Pharmaceutical Sciences. 148, 10 p., 105315.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. 2019
  14. Published

    Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

    Thorsen, S. F., Gromova, I., Christensen, I. J., Fredriksson, S., Andersen, C. L., Nielsen, Hans J., Stenvang, Jan & Moreira, José, Dec 2019, In: International Journal of Molecular Sciences (Online). 20, 19 p., 6082.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase i gene

    Kümler, I., Balslev, E., Stenvang, Jan, Brünner, Nils, Ejlertsen, Bent Laursen, Jakobsen, E. H. & Nielsen, D. L., Jun 2019, In: BMC Cancer. 19, 5 p., 573.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

    Nordgaard, Cathrine, Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. 2018
  18. Published

    lncRNA profile study reveals the mRNAs and lncRNAs associated with docetaxel resistance in breast cancer cells

    Huang, P., Li, F., Li, L., You, Y., Luo, S., Dong, Z., Gao, Q., Wu, S., Brünner, Nils & Stenvang, Jan, 1 Dec 2018, In: Scientific Reports. 8, 1, 17970.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    State of the art in microRNA as diagnostic and therapeutic biomarkers in chronic lymphocytic leukemia

    Mirzaei, H., Fathullahzadeh, S., Khanmohammadi, R., Darijani, M., Momeni, F., Masoudifar, A., Goodarzi, M., Mardanshah, O., Stenvang, Jan, Jaafari, M. R. & Mirzaei, H. R., Feb 2018, In: Journal of Cellular Physiology. 233, 2, p. 888-900 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published

    Therapeutic application of multipotent stem cells

    Mirzaei, H., Sahebkar, A., Sichani, L. S., Moridikia, A., Nazari, S., Sadri Nahand, J., salehi, H., Stenvang, Jan, Masoudifar, A., Mirzaei, H. R. & Jaafari, M. R., 2018, In: Journal of Cellular Physiology. 233, 4, p. 2815–2823

    Research output: Contribution to journalReviewResearchpeer-review

  21. 2017
  22. Published

    Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance

    Du, P., Huang, P., Huang, X., Li, X., Feng, Z., Li, F., Liang, S., Song, Y., Stenvang, Jan, Brünner, Nils, Yang, H., Ou, Y., Gao, Q. & Li, L., Dec 2017, In: Scientific Reports. 7, 9 p., 15324.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Implications of ABCG2 Expression on Irinotecan Treatment of Colorectal Cancer Patients: A Review

    Nielsen, Dorte Lisbet, Palshof, J. A., Brünner, Nils, Stenvang, Jan & Viuff, B. M., Sep 2017, In: International Journal of Molecular Sciences (Online). 18, 9, 16 p., 1926.

    Research output: Contribution to journalReviewResearchpeer-review

  24. Published

    Topoisomerase I copy number alterations as biomarker for irinotecan efficacy in metastatic colorectal cancer

    Palshof, J. A., Hogdall, E. V. S., Poulsen, T. S., Linnemann, D., Jensen, B. V., Pfeiffer, P., Tarpgaard, L. S., Brünner, Nils, Stenvang, Jan, Yilmaz, M. & Nielsen, Dorte Lisbet, 11 Jan 2017, In: BMC Cancer. 17, 10 p., 48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    BMP-2 induces EMT and breast cancer stemness through Rb and CD44

    Huang, P., Chen, A., He, W., Li, Z., Zhang, G., Liu, Z., Liu, G., Liu, X., He, S., Xiao, G., Huang, F., Stenvang, Jan, Brünner, Nils, Hong, A. & Wang, J., 2017, In: Cell Death Discovery. 3, 12 p., 17039.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

    Yu, J., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, Jan, Li, Y., Wang, X., Xu, X., Chen, N., Wu, W. K. K., Al-Aama, J., Nielsen, H. J., Kiilerich, P., Jensen, Benjamin Anderschou Holbech, Yau, T. O., Lan, Z., Jia, H., Li, J., Xiao, L., Lam, T. Y. T., Ng, S. C., Cheng, A. S., Wong, V. W., Chan, F. K. L., Xu, X., Yang, H., Madsen, L., Datz, C., Tilg, H., Wang, J., Brünner, Nils, Kristiansen, Karsten, Arumugam, Mani, Sung, J. J. & Wang, J., 2017, In: Gut. 66, p. 70-78 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2016
  28. Published

    Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

    Ellegaard, A., Dehlendorff, C., Vind, Anna Constance, Anand, A., Cederkvist, L., Petersen, N. H. T., Nylandsted, J., Stenvang, Jan, Mellemgaard, A., Osterlind, K., Friis, S. & Jaattela, Marja, Jul 2016, In: EBioMedicine. 9, p. 130-139 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells

    Hansen, S. N., Ehlers, N. S., Zhu, S., Thomsen, M. B. H., Nielsen, R. L., Liu, D., Wang, G., Hou, Y., Zhang, X., Xu, X., Bolund, L., Yang, H., Wang, J., Moreira, José, Ditzel, H. J., Brünner, Nils, Rasmussen, A. S., Stenvang, Jan & Gupta, R., 9 Jun 2016, In: B M C Genomics. 17, 15 p., 442.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue

    Karlsson, Camilla Cederbye, Palshof, J. A., Kuhlmann, Tine Plato, Duun-Henriksen, A. K., Linnemann, D., Stenvang, Jan, Nielsen, Dorte Lisbet, Brünner, Nils & Viuff, B. M., 3 Jun 2016, In: Scientific Reports. 6, 16 p., 26997.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines

    Jandu, H., Aluzaité, K., Fogh, L., Thrane, S. W., Noer, Julie Boertmann, Proszek, J., Nguyen Do, K., Hansen, S. N., Damsgaard-Hansen, B., Nielsen, Signe Lykke, Stougaard, M., Knudsen, B. R., Moreira, José, Hamerlik, P., Gajjar, M., Smid, M., Martens, J., Foekens, J., Pommier, Y., Brünner, Nils, Rasmussen, A. S. & Stenvang, Jan, 22 Jan 2016, In: B M C Cancer. 16, 13 p., 34.

    Research output: Contribution to journalJournal articleResearchpeer-review

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