Jan Stenvang

Jan Stenvang

Associate Professor

  • Molecular and Cellular Pharmacology

    Jagtvej 160

    2100 København Ø


  1. Published

    miRNA profiling of circulating EpCAM(+) extracellular vesicles: promising biomarkers of colorectal cancer

    Ostenfeld, M. S., Jensen, S. G., Jeppesen, D. K., Christensen, L., Thorsen, S. B., Stenvang, Jan, Hvam, M. L., Thomsen, A., Mouritzen, P., Rasmussen, M. H., Nielsen, H. J., Ørntoft, T. F. & Andersen, C. L., 2016, In: Journal of Extracellular Vesicles. 5, 14 p., 31488.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    lncRNA profile study reveals the mRNAs and lncRNAs associated with docetaxel resistance in breast cancer cells

    Huang, P., Li, F., Li, L., You, Y., Luo, S., Dong, Z., Gao, Q., Wu, S., Brünner, Nils & Stenvang, Jan, 1 Dec 2018, In: Scientific Reports. 8, 1, 17970.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase i gene

    Kümler, I., Balslev, E., Stenvang, Jan, Brünner, Nils, Ejlertsen, Bent Laursen, Jakobsen, E. H. & Nielsen, D. L., Jun 2019, In: BMC Cancer. 19, 5 p., 573.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Topoisomerase-1 gene copy aberrations are frequent in patients with breast cancer

    Kümler, I., Balslev, E., Poulsen, T. S., Nielsen, Signe Lykke, Nygård, S. B., Rømer, M. U., Christensen, I. J., Høgdall, E., Moreira, José, Nielsen, Dorte Lisbet, Brünner, Nils & Stenvang, Jan, 8 Apr 2015, In: International Journal of Cancer. 137, 8, p. 2000-2006 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Topoisomerase-1 and -2A gene copy numbers are elevated in mismatch repair-proficient colorectal cancers

    Sønderstrup, I. M. H., Nygård, S. B., Poulsen, T. S., Linnemann, D., Stenvang, Jan, Nielsen, H. J., Bartek, J., Brünner, Nils, Nørgaard, P. & Riis, Lene Buhl, 4 Mar 2015, In: Molecular Oncology. 9, 6, p. 1207-1217 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Topoisomerase I copy number alterations as biomarker for irinotecan efficacy in metastatic colorectal cancer

    Palshof, J. A., Hogdall, E. V. S., Poulsen, T. S., Linnemann, D., Jensen, B. V., Pfeiffer, P., Tarpgaard, L. S., Brünner, Nils, Stenvang, Jan, Yilmaz, M. & Nielsen, Dorte Lisbet, 11 Jan 2017, In: BMC Cancer. 17, 10 p., 48.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Therapeutic application of multipotent stem cells

    Mirzaei, H., Sahebkar, A., Sichani, L. S., Moridikia, A., Nazari, S., Sadri Nahand, J., salehi, H., Stenvang, Jan, Masoudifar, A., Mirzaei, H. R. & Jaafari, M. R., 2018, In: Journal of Cellular Physiology. 233, 4, p. 2815–2823

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    The utility of LNA in microRNA-based cancer diagnostics and therapeutics

    Stenvang, Jan, Silahtaroglu, Asli, Lindow, M., Elmen, J. & Kauppinen, S., 2008, In: Seminars in Cancer Biology. 18, 2, p. 89-102 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    The therapeutic potential of MicroRNAs in cancer

    Thorsen, S. B., Obad, S., Jensen, N. F., Stenvang, Jan & Kauppinen, S., 2012, In: Cancer Journal. 18, 3, p. 275-284 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    The stepwise evolution of the exome during acquisition of docetaxel resistance in breast cancer cells

    Hansen, S. N., Ehlers, N. S., Zhu, S., Thomsen, M. B. H., Nielsen, R. L., Liu, D., Wang, G., Hou, Y., Zhang, X., Xu, X., Bolund, L., Yang, H., Wang, J., Moreira, José, Ditzel, H. J., Brünner, Nils, Rasmussen, A. S., Stenvang, Jan & Gupta, R., 9 Jun 2016, In: B M C Genomics. 17, 15 p., 442.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The potential role of Alu Y in the development of resistance to SN38 (Irinotecan) or oxaliplatin in colorectal cancer

    Lin, X., Stenvang, Jan, Rasmussen, M. H., Zhu, S., Jensen, N. F., Tarpgaard, L. S., Yang, G., Belling, Kirstine G, Andersen, C. L., Li, J., Bolund, L. & Brünner, Nils, 2015, In: BMC Genomics. 16, 17 p., 404.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    The glutamate transport inhibitor DL-Threo-β-Benzyloxyaspartic acid (DL-TBOA) differentially affects SN38- and oxaliplatin-induced death of drug-resistant colorectal cancer cells

    Cuesta, E. P., Christensen, S., Jensen, Anders A., Jensen, N. F., Bunch, Lennart, Rømer, M. U. K., Brünner, Nils, Stenvang, Jan & Pedersen, Stine Helene Falsig, 2015, In: B M C Cancer. 15, 1, 17 p., 411.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    The Pyrazolo[3,4-d]pyrimidine Derivative, SCO-201, Reverses Multidrug Resistance Mediated by ABCG2/BCRP

    Ambjørner, Sophie Emilie Blomgren, Wiese, M., Köhler, S. C., Svindt, J., Lund, X. L., Gajhede, Michael, Saaby, L., Larsen, Birger Brodin, Rump, S., Weigt, H., Brünner, Nils & Stenvang, Jan, 4 Mar 2020, In: Cells. 9, 3, 22 p., 613.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Targeting of microRNAs for therapeutics

    Stenvang, Jan, Lindow, M. & Kauppinen, S., 2008, In: Biochemical Society Transactions. 36, Pt 6, p. 1197-200 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Targeting anti-cancer drug resistance in gastro-intestinal cancer: Inhibition of the SRPK1 kinase and degradation of the ABCG2 drug efflux pump

    Ladekarl, Monica, Schou, J. H. V., Roest, N. L., Stenvang, Jan, Brünner, Nils & Vestlev, P. M., Sep 2020, p. S503-S504. 2 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  16. Published

    TOP1 gene copy numbers are increased in cancers of the bile duct and pancreas

    Grunnet, M., Calatayud, D., Schultz, N. A., Hasselby, Jane Preuss, Mau-Sørensen, M., Brünner, Nils & Stenvang, Jan, 2015, In: Scandinavian Journal of Gastroenterology. 50, 4, p. 485-494 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    TIMP1 overexpression mediates resistance of MCF-7 human breast cancer cells to fulvestrant and down-regulates progesterone receptor expression

    Bjerre, C. A., Jensen, L. V., Belling, Kirstine G, Würtz, S. Ø., Yadav, R., Lademann, U. A., Rigina, O., Do, K. N., Ditzel, H. J., Lykkesfeldt, A. E., Wang, J., Nielsen, H. B., Brünner, Nils, Gupta, R., Rasmussen, A. S. & Stenvang, Jan, 2013, In: Tumor Biology. 34, 6, p. 3839-3851 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    TIMP-1 overexpression does not affect sensitivity to HER2-targeting drugs in the HER2-gene-amplified SK-BR-3 human breast cancer cell line

    Deng, X., Fogh, L., Lademann, U. A., Jensen, V., Stenvang, Jan, Yang, H., Brünner, Nils & Rasmussen, A. S., 2013, In: Tumor Biology. 34, 2, p. 1161-1170 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    TIMP-1 increases expression and phosphorylation of proteins associated with drug resistance in breast cancer cells

    Hekmat, O., Munk, S., Fogh, L., Yadav, R., Francavilla, C., Horn, H., Würtz, S. Ø., Schrohl, A., Damsgaard, B., Romer, M. U., Belling, Kirstine G, Jensen, N. F., Gromova, I., Bekker-Jensen, D. B., Moreira, José, Jensen, Lars Juhl, Gupta, R., Lademann, U. A., Brünner, Nils, Olsen, Jesper Velgaard & Stenvang, Jan, 5 Aug 2013, In: Journal of Proteome Research. 12, 9, p. 4136-4151 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Synthesis of thiazole linked chalcones and their pyrimidine analogues as anticancer agents

    Kesari, C., Rama, K. R., Sedighi, K., Stenvang, Jan, Björkling, Fredrik, Kankala, S. & Thota, N., 2021, In: Synthetic Communications. 51, 9, p. 1406-1416 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Synthesis and biological evaluation of nucleobase-modified analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd)

    Hrdlicka, P. J., Jepsen, J. S., Nielsen, C., Wengel, J. & Stenvang, Jan, 15 Feb 2005, In: Bioorganic & Medicinal Chemistry. 13, 4, p. 1249-60 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)

    Hrdlicka, P. J., Stenvang, Jan & Wengel, J., 2005, In: Nucleosides, nucleotides & nucleic acids. 24, 5-7, p. 397-400 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Synthesis and biological evaluation of branched and conformationally restricted analogs of the anticancer compounds 3'-C-ethynyluridine (EUrd) and 3'-C-ethynylcytidine (ECyd)

    Hrdlicka, P. J., Andersen, N. K., Stenvang, Jan, Hansen, F. G., Haselmann, K. F., Nielsen, C. & Wengel, J., 1 Apr 2005, In: Bioorganic & Medicinal Chemistry. 13, 7, p. 2597-621 25 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    State of the art in microRNA as diagnostic and therapeutic biomarkers in chronic lymphocytic leukemia

    Mirzaei, H., Fathullahzadeh, S., Khanmohammadi, R., Darijani, M., Momeni, F., Masoudifar, A., Goodarzi, M., Mardanshah, O., Stenvang, Jan, Jaafari, M. R. & Mirzaei, H. R., Feb 2018, In: Journal of Cellular Physiology. 233, 2, p. 888-900 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  25. Silencing of microRNA families by seed-targeting tiny LNAs

    Obad, S., dos Santos, C. O., Petri, A., Heidenblad, M., Broom, O., Ruse, C., Fu, C., Lindow, M., Stenvang, Jan, Straarup, E. M., Hansen, H. F., Koch, T., Pappin, D., Hannon, G. J. & Kauppinen, S., 2011, In: Nature Genetics. 43, 4, p. 371-8 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Sequential versus combined treatment of human breast cancer cells with antiestrogens and the vitamin D analogue EB1089 and evaluation of predictive markers for vitamin D treatment.

    Christensen, G. L., Stenvang, Jan, Fog, C. K., Christensen, I. J. & Lykkesfeldt, A. E., 2004, In: Breast Cancer Research and Treatment. p. 53–63

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Repurposing Cationic Amphiphilic Antihistamines for Cancer Treatment

    Ellegaard, A., Dehlendorff, C., Vind, Anna Constance, Anand, A., Cederkvist, L., Petersen, N. H. T., Nylandsted, J., Stenvang, Jan, Mellemgaard, A., Osterlind, K., Friis, S. & Jaattela, Marja, Jul 2016, In: EBioMedicine. 9, p. 130-139 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Purification and characterization of bioactive his6-tagged recombinant human tissue inhibitor of metalloproteinases-1 (TIMP-1) protein expressed at high yields in mammalian cells

    Jensen, L. V., Lademann, U. A., Andersen, E. V., Højrup, P., Thaysen-Andersen, M., Krogh, B. O., Viuff, B. M., Brünner, Nils, Stenvang, Jan & Moreira, José, 2014, In: Protein Expression and Purification. 101, p. 157-164 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Proximity probing assays for simultaneous visualization of protein complexes in situ

    Moreira, José, Thorsen, S. B., Brünner, Nils & Stenvang, Jan, 2013, In: Expert Review of Proteomics. 10, 3, p. 219-221 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Protein kinase C alpha is a marker for antiestrogen resistance and is involved in the growth of tamoxifen resistant human breast cancer cells

    Frankel, Lisa, Lykkesfeldt, A. E., Hansen, J. B. H. & Stenvang, Jan, 2007, In: Breast Cancer Research and Treatment. 104, 2, p. 165-179 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Progesterone receptor isoform analysis by quantitative real-time polymerase chain reaction in formalin-fixed, paraffin-embedded canine mammary dysplasias and tumors

    Guil-Luna, S., Stenvang, Jan, Brünner, Nils, Sánchez-Céspedes, R., Millán, Y., Gómez-Laguna, J. & Mulas, J. M. D. L., 2014, In: Veterinary Pathology. 51, 5, p. 895-902 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma

    Guil-Luna, S., Stenvang, Jan, Brünner, Nils, De Andrés, F. J., Rollón, E., Domingo, V., Sánchez-Céspedes, R., Millán, Y. & Mulas, J. M. D. L., 2014, In: B M C Veterinary Research. 10, 8 p., 296.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

    Thorsen, S. B., Christensen, S. L. T., Würtz, S. Ø., Lundberg, M., Nielsen, B. E. S., Jensen, L. V., Knowles, M., Gee, N., Fredriksson, S., Møller, S., Brünner, Nils, Rasmussen, A. S. & Stenvang, Jan, 2013, In: B M C Cancer. 13, 12 p., 598.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Pharmacodynamic modelling reveals synergistic interaction between docetaxel and SCO-101 in a docetaxel-resistant triple negative breast cancer cell line

    Nøhr-Nielsen, A., Bagger, Sofie Otzen, Brünner, Nils, Stenvang, Jan & Lund, Trine Meldgaard, 2020, In: European Journal of Pharmaceutical Sciences. 148, 10 p., 105315.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    No effect of ablation of surfactant protein-D on acute cerebral infarction in mice

    Lambertsen, K. L., Østergaard, K., Clausen, B. H., Hansen, S., Stenvang, Jan, Thorsen, S. B., Meldgaard, M., Kristensen, B. W., Hansen, P. B. L., Sørensen, G. L. & Finsen, B., 2014, In: Journal of Neuroinflammation. 11, 13 p., 123.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    New use for old drugs: Epirubicin in colorectal cancer

    Tarpgaard, L. S., Qvortrup, C., Nielsen, S. L., Stenvang, Jan, Detlefsen, S., Brünner, Nils & Pfeiffer, P., 2021, In: Acta Oncologica. 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  37. Published

    Multiplexed homogeneous proximity ligation assays for high throughput protein biomarker research in serological material

    Lundberg, M., Thorsen, S. B., Assarsson, E., Villablanca, A., Tran, B., Gee, N., Knowles, M., Nielsen, B. E. S., Couto, E. G., Martin, R., Nilsson, O., Fermer, C., Schlingemann, J., Christensen, I. J., Nielsen, Hans J., Ekstrom, B., Andersson, C., Gustafsson, M., Brünner, Nils, Stenvang, Jan & Fredriksson, S., Apr 2011, In: Molecular and Cellular Proteomics. 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines

    Jandu, H., Aluzaité, K., Fogh, L., Thrane, S. W., Noer, Julie Boertmann, Proszek, J., Nguyen Do, K., Hansen, S. N., Damsgaard-Hansen, B., Nielsen, Signe Lykke, Stougaard, M., Knudsen, B. R., Moreira, José, Hamerlik, P., Gajjar, M., Smid, M., Martens, J., Foekens, J., Pommier, Y., Brünner, Nils, Rasmussen, A. S. & Stenvang, Jan, 22 Jan 2016, In: B M C Cancer. 16, 13 p., 34.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Molecular Profiling of Docetaxel-Resistant Prostate Cancer Cells Identifies Multiple Mechanisms of Therapeutic Resistance

    Lima, T. S., Iglesias Gato, Diego, De Oliveira Souza, Luciano, Stenvang, Jan, Lima, D. S., Røder, Martin Andreas, Brasso, K. & Moreira, José, 2021, In: Cancers. 13, 19 p.

    Research output: Contribution to journalJournal articleResearch

  40. Modulation of CpG oligodeoxynucleotide-mediated immune stimulation by locked nucleic acid (LNA)

    Vollmer, J., Uhlmann, E., Stenvang, Jan, Schetter, C., Jurk, M., Wader, T., Wüllner, M. & Krieg, A. M., 2004, In: Oligonucleotides. 14, 1, p. 23-31 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    MicroRNAs, epigenetics and disease

    Silahtaroglu, Asli & Stenvang, Jan, 2010, In: Essays in Biochemistry. 48, 1, p. 165-185 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    MicroRNAs as targets for antisense-based therapeutics

    Stenvang, Jan & Kauppinen, M. S., 2008, In: Expert Opinion on Biological Therapy. 8, 1, p. 59-81 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo

    Eskildsen, T., Taipaleenmäki, H., Stenvang, Jan, Abdallah, B., Ditzel, N., Nossent, A. Y., Bak, Mads, Kauppinen, S. & Kassem, M., 12 Apr 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6139-44 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Submitted

    MicroRNA profiling in generated oxaliplatin- and SN-38-resistant colorectal cancer cell lines

    Jensen, N. F., Søkilde, R., Stenvang, Jan, Litman, T., Brünner, Nils & Rømer, M. U. K., 2011, (Submitted). 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  45. MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4

    Sonkoly , E., Janson , P., Majuri , M., Savinko , T., Fyhrquist , N., Eidsmo , L., Xu , N., Meisgen , F., Wei , T., Bradley , M., Stenvang, Jan, Kauppinen , S., Alenius, H., Lauerma , A., Homey , B., Winqvist , O., Ståhle , M. & Pivarcsi , A., 2010, In: Journal of Allergy and Clinical Immunology. 126, 3, p. 581-589.e20 29 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

    Nordgaard, Cathrine, Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

    Yu, J., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, Jan, Li, Y., Wang, X., Xu, X., Chen, N., Wu, W. K. K., Al-Aama, J., Nielsen, H. J., Kiilerich, P., Jensen, Benjamin Anderschou Holbech, Yau, T. O., Lan, Z., Jia, H., Li, J., Xiao, L., Lam, T. Y. T., Ng, S. C., Cheng, A. S., Wong, V. W., Chan, F. K. L., Xu, X., Yang, H., Madsen, L., Datz, C., Tilg, H., Wang, J., Brünner, Nils, Kristiansen, Karsten, Arumugam, Mani, Sung, J. J. & Wang, J., 2017, In: Gut. 66, p. 70-78 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody

    Smith, D. H., Fiehn, A. K., Fogh, L., Christensen, I. J., Hansen, T. P., Stenvang, Jan, Nielsen, Hans J., Nielsen, K. V., Hasselby, J. P., Brünner, Nils & Jensen, S. S., 2014, In: Scientific Reports. 4, p. 1-8 8 p., 4313.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology

    Stenvang, Jan, Sørensen, M. D. & Wengel, J., 2004, In: Oligonucleotides. 14, 2, p. 130-46 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. LNA-antisense rivals siRNA for gene silencing

    Stenvang, Jan & Wengel, J., Mar 2004, In: Current Opinion in Drug Discovery & Development. 7, 2, p. 188-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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