Jan Stenvang

Jan Stenvang

Associate Professor

  • Molecular and Cellular Pharmacology

    Jagtvej 160

    2100 København Ø


  1. Published

    A Comprehensive RNA Study to Identify circRNA and miRNA Biomarkers for Docetaxel Resistance in Breast Cancer

    Huang, P., Li, F., Mo, Z., Geng, C., Wen, F., Zhang, C., Guo, J., Wu, S., Li, L., Brünner, Nils & Stenvang, Jan, 2021, In: Frontiers in oncology. 11, 14 p., 669270.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A novel dual-target steroid sulfatase inhibitor and antiestrogen: SR 16157, a promising agent for the therapy of breast cancer

    Rasmussen, L. M., Zaveri, N. T., Stenvang, Jan, Peters, R. H. & Lykkesfeldt, A. E., 2007, In: Breast Cancer Research and Treatment. 106, 2, p. 191-203 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A phase II study of Epirubicin in oxaliplatin-resistant patients with metastatic colorectal cancer and TOP2A gene amplification

    Tarpgaard, L. S., Qvortrup, C., Nygård, S. B., Nielsen, Signe Lykke, Andersen, D. R., Jensen, N. F., Stenvang, Jan, Detlefsen, S., Brünner, Nils & Pfeiffer, P., 2016, In: B M C Cancer. 16, 5 p., 91.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A phase II study of weekly irinotecan in patients with locally advanced or metastatic HER2- negative breast cancer and increased copy numbers of the topoisomerase 1 (TOP1) gene: a study protocol

    Kümler, Iben, Balslev, E., Stenvang, Jan, Brünner, Nils & Nielsen, D., 2015, In: B M C Cancer. 15, 5 p., 78.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    A systematic review on topoisomerase 1 inhibition in the treatment of metastatic breast cancer

    Kümler, I., Brünner, Nils, Stenvang, Jan, Balslev, E. & Nielsen, D. L., 2013, In: Breast Cancer Research and Treatment. 138, 2, p. 347-358 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    ABCG2 Protein Levels and Association to Response to First-Line Irinotecan-Based Therapy for Patients with Metastatic Colorectal Cancer

    Palshof, J. A., Cederbye, C. N., Hgdall, E. V. S., Poulsen, T. S., Linnemann, D., Nygaard, S. B., Stenvang, Jan, Christensen, I. J., Jensen, B. V., Pfeiffer, P., Brünner, Nils, Yilmaz, M., Viuff, B. M. & Nielsen, Dorte Lisbet, 2020, In: International Journal of Molecular Sciences. 21, 14, 13 p., 5027.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Acquisition of docetaxel resistance in breast cancer cells reveals upregulation of ABCB1 expression as a key mediator of resistance accompanied by discrete upregulation of other specific genes and pathways

    Hansen, S. N., Westergaard, D., Thomsen, M. B. H., Vistesen, M. V., Do, K. N., Fogh, L., Belling, Kirstine G, Wang, J., Yang, H., Gupta, R., Ditzel, H. J., Moreira, José, Brünner, Nils, Stenvang, Jan & Rasmussen, A. S., 2015, In: Tumor Biology. 36, 6, p. 4327-4338 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    An Explorative Analysis of ABCG2/TOP-1 mRNA Expression as a Biomarker Test for FOLFIRI Treatment in Stage III Colon Cancer Patients: Results from Retrospective Analyses of the PETACC-3 Trial

    Stenvang, Jan, Budinská, E., van Cutsem, E., Bosman, F., Popovici, V. & Brünner, Nils, 2020, In: Cancers. 12, 4, 12 p., 977.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue

    Karlsson, Camilla Cederbye, Palshof, J. A., Kuhlmann, Tine Plato, Duun-Henriksen, A. K., Linnemann, D., Stenvang, Jan, Nielsen, Dorte Lisbet, Brünner, Nils & Viuff, B. M., 3 Jun 2016, In: Scientific Reports. 6, 16 p., 26997.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    BMP-2 induces EMT and breast cancer stemness through Rb and CD44

    Huang, P., Chen, A., He, W., Li, Z., Zhang, G., Liu, Z., Liu, G., Liu, X., He, S., Xiao, G., Huang, F., Stenvang, Jan, Brünner, Nils, Hong, A. & Wang, J., 2017, In: Cell Death Discovery. 3, 12 p., 17039.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy: a novel strategy in drug development

    Stenvang, Jan, Kümler, I., Nygård, S. B., Smith, D. H., Nielsen, D., Brünner, Nils & Moreira, José, 2013, In: Frontiers in oncology. 3, 9 p., 313.

    Research output: Contribution to journalReviewResearchpeer-review

  12. Published

    Breast cancer cells with acquired antiestrogen resistance are sensitized to cisplatin-induced cell death

    Yde, C. W., Gyrd-Hansen, Mads, Lykkesfeldt, A. E., Issinger, O. & Stenvang, Jan, Jun 2007, In: Molecular Cancer Therapeutics. 6, 6, p. 1869-1876 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

    Jensen, N. F., Agama, K., Roy, A., Smith, D. H., Pfister, T. D., Rømer, M. U., Zhang, H., Doroshow, J. H., Knudsen, B. R., Stenvang, Jan, Brünner, Nils & Pommier, Y., 2016, In: Journal of Experimental and Clinical Cancer Research (Online). 35, 14 p., 56.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Characterization of resistance to a recombinant hexameric Fas-ligand (APO010) in human cancer cell lines

    Jandu, H., Nielsen, A., Brünner, Nils, Hansen, A., Knudsen, S., Stenvang, Jan & Jensen, P. B., 2020, In: Experimental Hematology. 87, p. 33-41

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance

    Du, P., Huang, P., Huang, X., Li, X., Feng, Z., Li, F., Liang, S., Song, Y., Stenvang, Jan, Brünner, Nils, Yang, H., Ou, Y., Gao, Q. & Li, L., Dec 2017, In: Scientific Reports. 7, 9 p., 15324.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Conserved residues and their role in the structure, function, and stability of acyl-coenzyme A binding protein

    Kragelund, B. B., Poulsen, K., Andersen, K. V., Baldursson, T., Krøll, J. B., Neergård, T. B., Jepsen, J., Roepstorff, P., Kristiansen, Karsten, Poulsen, F. M., Knudsen, J. & Stenvang, Jan, 1999, In: Biochemistry. 38, 8, p. 2386-94 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Downregulation of p21(WAF1/CIP1) and estrogen receptor alpha in MCF-7 cells by antisense oligonucleotides containing locked nucleic acid (LNA)

    Stenvang, Jan, Pfundheller, H. M. & Lykkesfeldt, A. E., 2004, In: Oligonucleotides. 14, 2, p. 147-56 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Drug resistance in colorectal cancer cell lines is partially associated with aneuploidy status in light of profiling gene expression

    Guo, J., Xu, S., Huang, X., Li, L., Zhang, C., Pan, Q., Ren, Z., Zhou, R., Ren, Y., Zi, J., Wu, L., Stenvang, Jan, Brünner, Nils, Wen, B. & Liu, S., 2016, In: Journal of Proteome Research. 15, 11, p. 4047–4059 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Drug transporters in breast cancer: response to anthracyclines and taxanes

    Kümler, I., Stenvang, Jan, Moreira, José, Brünner, Nils & Nielsen, Dorte Lisbet, Sep 2015, In: Expert Review of Anticancer Therapy. 15, 9, p. 1075-1092 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Establishment and characterization of models of chemotherapy resistance in colorectal cancer: towards a predictive signature of chemoresistance

    Jensen, N. F., Stenvang, Jan, Lademann, Mette, Hanáková, B., Belling, Kirstine G, Do, K. N., Viuff, B. M., Nygård, S. B., Gupta, R., Rasmussen, M. H., Tarpgaard, L. S., Hansen, T. P., Budinská, E., Pfeiffer, P., Bosman, F., Tejpar, S., Roth, A., Delorenzi, M., Andersen, C. L., Rømer, M. U. K., Brünner, Nils & Moreira, José, 24 Feb 2015, In: Molecular Oncology. 9, 6, p. 1169-1185 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Four phase 1 trials to evaluate the safety and pharmacokinetic profile of single and repeated dosing of SCO-101 in adult male and female volunteers

    Bergmann, T. K., Stage, T. B., Stenvang, Jan, Christophersen, P., Jacobsen, T. A., Roest, N. L., Vestlev, P. M. & Brünner, Nils, 2020, In: Basic & Clinical Pharmacology & Toxicology. 127, 4, p. 329-337

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Gel-Based Proteomics of Clinical Samples Identifies Potential Serological Biomarkers for Early Detection of Colorectal Cancer

    Thorsen, S. F., Gromova, I., Christensen, I. J., Fredriksson, S., Andersen, C. L., Nielsen, Hans J., Stenvang, Jan & Moreira, José, Dec 2019, In: International Journal of Molecular Sciences (Online). 20, 19 p., 6082.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    High expression of microRNA-625-3p is associated with poor response to first-line oxaliplatin based treatment of metastatic colorectal cancer

    Rasmussen, M. H., Jensen, N. F., Tarpgaard, L. S., Qvortrup, C., Rømer, M. U. K., Stenvang, Jan, Hansen, T. P., Christensen, L. L., Lindebjerg, J., Hansen, F., Jensen, B. V., Hansen, T. F., Pfeiffer, P., Brünner, Nils, Ørntoft, T. F. & Andersen, C. L., 2013, In: Molecular Oncology. 7, 3, p. 637-646 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Homogenous 96-plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability

    Assarsson, E., Lundberg, M., Holmquist, G., Björkesten, J., Thorsen, S. B., Ekman, D., Eriksson, A., Rennel Dickens, E., Ohlsson, S., Edfeldt, G., Andersson, A., Lindstedt, P., Stenvang, Jan, Gullberg, M. & Fredriksson, S., 2014, In: PLOS ONE. 9, 4, 11 p., e95192.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Identification and characterization of a new TIMP-1 binding protein

    Moreira, José, Høeberg, M., Lademann, U. A., Viuff, B. M., Jensen, L. V., Stenvang, Jan, Nygård, S. B., Ørum-Madsen, M. S., Vistesen, M. V., Fuglsang, Anja Thoe, Liu, S. & Brünner, Nils, 2015, In: Cancer Research. 75, 9 suppl., 1 p., Abstract P5-07-08.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  26. Published

    Implications of ABCG2 Expression on Irinotecan Treatment of Colorectal Cancer Patients: A Review

    Nielsen, Dorte Lisbet, Palshof, J. A., Brünner, Nils, Stenvang, Jan & Viuff, B. M., Sep 2017, In: International Journal of Molecular Sciences (Online). 18, 9, 16 p., 1926.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT

    Yde, C. W., Frogne, T., Lykkesfeldt, A. E., Fichtner, I., Issinger, O. G. & Stenvang, Jan, 2007, In: Cancer Letters. 256, 2, p. 229-237 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Inhibition of microRNA function by antimiR oligonucleotides

    Stenvang, Jan, Petri, A., Lindow, M., Obad, S. & Kauppinen, S., 2012, In: Silence. 3, 1, 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Insulin-like growth factor binding protein 2 is a marker for antiestrogen resistant human breast cancer cell lines but is not a major growth regulator

    Juncker-Jensen, A., Lykkesfeldt, A. E., Worm, J., Ralfkiær, U., Espelund, U. & Stenvang, Jan, 1 Aug 2006, In: Growth Hormone and IGF Research. 16, 4, p. 224-239 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties

    Lin, X., Li, J., Yin, G., Zhao, Q., Elias, D., Lykkesfeldt, A., Stenvang, Jan, Brünner, Nils, Wang, J., Yang, H., Bolund, L. & Ditzel, H. J., 2013, In: Breast cancer research : BCR. 15, 6, 17 p., R119.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Integrative analysis of miRNA and gene expression reveals regulatory networks in tamoxifen-resistant breast cancer

    Joshi, T., Elias, D., Stenvang, Jan, Alves, C. M. L., Teng, F., Lyng, M. B., Lykkesfeldt, A. E., Brünner, Nils, Wang, J., Gupta, R., Workman, C. T. & Ditzel, H. J., 2016, In: OncoTarget. 7, 35, p. 57239-57253 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. LNA-antisense rivals siRNA for gene silencing

    Stenvang, Jan & Wengel, J., Mar 2004, In: Current Opinion in Drug Discovery & Development. 7, 2, p. 188-94 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Locked nucleic acid: a potent nucleic acid analog in therapeutics and biotechnology

    Stenvang, Jan, Sørensen, M. D. & Wengel, J., 2004, In: Oligonucleotides. 14, 2, p. 130-46 17 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Measuring ERCC1 protein expression in cancer specimens: validation of a novel antibody

    Smith, D. H., Fiehn, A. K., Fogh, L., Christensen, I. J., Hansen, T. P., Stenvang, Jan, Nielsen, Hans J., Nielsen, K. V., Hasselby, J. P., Brünner, Nils & Jensen, S. S., 2014, In: Scientific Reports. 4, p. 1-8 8 p., 4313.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Metagenomic analysis of faecal microbiome as a tool towards targeted non-invasive biomarkers for colorectal cancer

    Yu, J., Feng, Q., Wong, S. H., Zhang, D., Liang, Q. Y., Qin, Y., Tang, L., Zhao, H., Stenvang, Jan, Li, Y., Wang, X., Xu, X., Chen, N., Wu, W. K. K., Al-Aama, J., Nielsen, H. J., Kiilerich, P., Jensen, Benjamin Anderschou Holbech, Yau, T. O., Lan, Z., Jia, H., Li, J., Xiao, L., Lam, T. Y. T., Ng, S. C., Cheng, A. S., Wong, V. W., Chan, F. K. L., Xu, X., Yang, H., Madsen, L., Datz, C., Tilg, H., Wang, J., Brünner, Nils, Kristiansen, Karsten, Arumugam, Mani, Sung, J. J. & Wang, J., 2017, In: Gut. 66, p. 70-78 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Metallopeptidase Inhibitor 1 (TIMP-1) promotes receptor tyrosine kinase c-Kit signaling in colorectal cancer

    Nordgaard, Cathrine, Doll, S., Matos, A. L. D. S. A., Høeberg, M., Kazi, J. U., Friis, S., Stenvang, Jan, Rönnstrand, L., Mann, Matthias & Moreira, José, 2019, In: Molecular Oncology. 13, 12, p. 2646-2662

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte–associated antigen 4

    Sonkoly , E., Janson , P., Majuri , M., Savinko , T., Fyhrquist , N., Eidsmo , L., Xu , N., Meisgen , F., Wei , T., Bradley , M., Stenvang, Jan, Kauppinen , S., Alenius, H., Lauerma , A., Homey , B., Winqvist , O., Ståhle , M. & Pivarcsi , A., 2010, In: Journal of Allergy and Clinical Immunology. 126, 3, p. 581-589.e20 29 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Submitted

    MicroRNA profiling in generated oxaliplatin- and SN-38-resistant colorectal cancer cell lines

    Jensen, N. F., Søkilde, R., Stenvang, Jan, Litman, T., Brünner, Nils & Rømer, M. U. K., 2011, (Submitted). 1 p.

    Research output: Contribution to conferenceConference abstract for conferenceResearch

  39. Published

    MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo

    Eskildsen, T., Taipaleenmäki, H., Stenvang, Jan, Abdallah, B., Ditzel, N., Nossent, A. Y., Bak, Mads, Kauppinen, S. & Kassem, M., 12 Apr 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 15, p. 6139-44 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    MicroRNAs as targets for antisense-based therapeutics

    Stenvang, Jan & Kauppinen, M. S., 2008, In: Expert Opinion on Biological Therapy. 8, 1, p. 59-81 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    MicroRNAs, epigenetics and disease

    Silahtaroglu, Asli & Stenvang, Jan, 2010, In: Essays in Biochemistry. 48, 1, p. 165-185 21 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Modulation of CpG oligodeoxynucleotide-mediated immune stimulation by locked nucleic acid (LNA)

    Vollmer, J., Uhlmann, E., Stenvang, Jan, Schetter, C., Jurk, M., Wader, T., Wüllner, M. & Krieg, A. M., 2004, In: Oligonucleotides. 14, 1, p. 23-31 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Molecular Profiling of Docetaxel-Resistant Prostate Cancer Cells Identifies Multiple Mechanisms of Therapeutic Resistance

    Lima, T. S., Iglesias Gato, Diego, De Oliveira Souza, Luciano, Stenvang, Jan, Lima, D. S., Røder, Martin Andreas, Brasso, K. & Moreira, José, 2021, In: Cancers. 13, 19 p.

    Research output: Contribution to journalJournal articleResearch

  44. Published

    Molecular characterization of irinotecan (SN-38) resistant human breast cancer cell lines

    Jandu, H., Aluzaité, K., Fogh, L., Thrane, S. W., Noer, Julie Boertmann, Proszek, J., Nguyen Do, K., Hansen, S. N., Damsgaard-Hansen, B., Nielsen, Signe Lykke, Stougaard, M., Knudsen, B. R., Moreira, José, Hamerlik, P., Gajjar, M., Smid, M., Martens, J., Foekens, J., Pommier, Y., Brünner, Nils, Rasmussen, A. S. & Stenvang, Jan, 22 Jan 2016, In: B M C Cancer. 16, 13 p., 34.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    Multiplexed homogeneous proximity ligation assays for high throughput protein biomarker research in serological material

    Lundberg, M., Thorsen, S. B., Assarsson, E., Villablanca, A., Tran, B., Gee, N., Knowles, M., Nielsen, B. E. S., Couto, E. G., Martin, R., Nilsson, O., Fermer, C., Schlingemann, J., Christensen, I. J., Nielsen, Hans J., Ekstrom, B., Andersson, C., Gustafsson, M., Brünner, Nils, Stenvang, Jan & Fredriksson, S., Apr 2011, In: Molecular and Cellular Proteomics. 10

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    New use for old drugs: Epirubicin in colorectal cancer

    Tarpgaard, L. S., Qvortrup, C., Nielsen, S. L., Stenvang, Jan, Detlefsen, S., Brünner, Nils & Pfeiffer, P., 2021, In: Acta Oncologica. 3 p.

    Research output: Contribution to journalLetterResearchpeer-review

  47. Published

    No effect of ablation of surfactant protein-D on acute cerebral infarction in mice

    Lambertsen, K. L., Østergaard, K., Clausen, B. H., Hansen, S., Stenvang, Jan, Thorsen, S. B., Meldgaard, M., Kristensen, B. W., Hansen, P. B. L., Sørensen, G. L. & Finsen, B., 2014, In: Journal of Neuroinflammation. 11, 13 p., 123.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Pharmacodynamic modelling reveals synergistic interaction between docetaxel and SCO-101 in a docetaxel-resistant triple negative breast cancer cell line

    Nøhr-Nielsen, A., Bagger, Sofie Otzen, Brünner, Nils, Stenvang, Jan & Lund, Trine Meldgaard, 2020, In: European Journal of Pharmaceutical Sciences. 148, 10 p., 105315.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Plasma levels of the MMP-9:TIMP-1 complex as prognostic biomarker in breast cancer: a retrospective study

    Thorsen, S. B., Christensen, S. L. T., Würtz, S. Ø., Lundberg, M., Nielsen, B. E. S., Jensen, L. V., Knowles, M., Gee, N., Fredriksson, S., Møller, S., Brünner, Nils, Rasmussen, A. S. & Stenvang, Jan, 2013, In: B M C Cancer. 13, 12 p., 598.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Progesterone receptor isoform A may regulate the effects of neoadjuvant aglepristone in canine mammary carcinoma

    Guil-Luna, S., Stenvang, Jan, Brünner, Nils, De Andrés, F. J., Rollón, E., Domingo, V., Sánchez-Céspedes, R., Millán, Y. & Mulas, J. M. D. L., 2014, In: B M C Veterinary Research. 10, 8 p., 296.

    Research output: Contribution to journalJournal articleResearchpeer-review

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