Irene Gallina
Assistant professor
Duxin Group
Blegdamsvej 3B, 2200 København N., Bygning 6, Building: 06-3-42
Current research
DNA-protein crosslinks (DPCs) are common DNA lesions caused by widely used chemotherapeutics, like cisplatin, but also by byproducts of the cellular metabolism, such as aldehydes. If left urepaired DPCs are likely to promote genome instability, predisposing for cancer and aging. Using Xenopus egg extract as a model system, I aim to identify the key factors required for processing DPCs, and to delineate their mechanisms of action. This will be instrumental for understanding how a very common and toxic lesion like a DPC is recognized and repaired also in humans.
ID: 19186342
Most downloads
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279
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Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
227
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Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
201
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Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts
Research output: Contribution to journal › Journal article › Research › peer-review
Published