Helena Safavi

Helena Safavi

Associate Professor, Guest Researcher

Member of:

    ORCID: 0000-0002-1984-2721

    Publication year:
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    1 - 25 out of 42Page size: 25
    1. 2023
    2. Published

      A toxin-based approach to neuropeptide and peptide hormone discovery

      Koch, Thomas Lund, Torres, Joshua, Baskin, R. P., Salcedo, P. F., Chase, K., Olivera, B. M. & Safavi, Helena, 2023, In: Frontiers in Molecular Neuroscience. 16, 14 p., 1176662.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. 2022
    4. Published

      Integrating Venom Peptide Libraries Into a Phylogenetic and Broader Biological Framework

      Chase, K., Watkins, M., Safavi, Helena & Olivera, B. M., 2022, In: Frontiers in Molecular Biosciences. 9, 16 p., 784419.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Symmetric and asymmetric receptor conformation continuum induced by a new insulin

      Xiong, X., Blakely, A., Kim, J. H., Menting, J. G., Schäfer, I. B., Schubert, H. L., Agrawal, R., Gutmann, T., Delaine, C., Zhang, Y. W., Artik, G. O., Merriman, A., Eckert, D., Lawrence, M. C., Coskun, Ü., Fisher, S. J., Forbes, B. E., Safavi, Helena, Hill, C. P. & Chou, D. H. C., 2022, In: Nature Chemical Biology. 18, 5, p. 511-519

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Unconventional insulins from predators and pathogens

      Laugesen, S. H., Chou, D. H. C. & Safavi, Helena, 2022, In: Nature Chemical Biology. 18, 7, p. 688-697

      Research output: Contribution to journal › Review › Research › peer-review

    7. 2021
    8. Published

      DisCoTune: versatile auxiliary plasmids for the production of disulphide-containing proteins and peptides in the E. coli T7 system

      Bertelsen, A. B., Hackney, Celeste Menuet, Bayer, C. N., Kjelgaard, L. D., Rennig, M., Christensen, B., Sørensen, E. S., Safavi, Helena, Wulff, T., Ellgaard, Lars & Nørholm, M. H. H., 2021, In: Microbial Biotechnology. 14, 6, p. 2566-2580 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. 2020
    10. Published

      A structurally minimized yet fully active insulin based on cone-snail venom insulin principles

      Xiong, X., Menting, J. G., Disotuar, M. M., Smith, N. A., Delaine, C. A., Ghabash, G., Agrawal, R., Wang, X., He, X., Fisher, S. J., MacRaild, C. A., Norton, R. S., Gajewiak, J., Forbes, B. E., Smith, B. J., Safavi, Helena, Olivera, B., Lawrence, M. C. & Chou, D. H. C., 2020, In: Nature Structural and Molecular Biology. 27, p. 615-624

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      Curses or Cures: A Review of the Numerous Benefits Versus the Biosecurity Concerns of Conotoxin Research

      Bjørn-Yoshimoto, Walden, Ramiro, Iris Bea L. , Yandell, M., McIntosh, J. M., Olivera, B. M., Ellgaard, Lars & Safavi, Helena, 2020, In: Biomedicines. 8, 8, 22 p., 235.

      Research output: Contribution to journal › Review › Research › peer-review

    12. Published

      Transcriptomic Profiling Reveals Extraordinary Diversity of Venom Peptides in Unexplored Predatory Gastropods of the Genus Clavus

      Lu, A., Watkins, M., Li, Q., Robinson, S. D., Concepcion, G. P., Yandell, M., Weng, Z., Olivera, B. M., Safavi, Helena & Fedosov, A. E., 2020, In: Genome Biology and Evolution. 12, 5, p. 684-700 17 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. 2019

    14. Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor

      Ahorukomeye, P., Disotuar, M. M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S. D., Flórez Salcedo, P., Smith, N. A., Smith, B. J., Schlegel, A., Forbes, B. E., Olivera, B., Hung-Chieh Chou, D. & Safavi, Helena, 2019, In: eLife. 8, 28 p., e41574.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways

      Safavi, Helena, Brogan, S. E. & Olivera, B. M., 2019, In: Journal of Proteomics. 190, p. 12-20 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework

      Nielsen, L. D., Foged, M. M., Albert, A., Bertelsen, A. B., Søltoft, C. L., Robinson, S. D., Petersen, S. V., Purcell, A. W., Olivera, B. M., Norton, R. S., Vasskog, T., Safavi, Helena, Teilum, Kaare & Ellgaard, Lars, 2019, In: The Journal of Biological Chemistry. 294, 22, p. 8745-8759

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. 2018

    18. Conopeptides promote itch through human itch receptor hMgprX1

      Espino, S. S., Robinson, S. D., Safavi, Helena, Gajewiak, J., Yang, W., Olivera, B. M. & Liu, Q., 2018, In: Toxicon. 154, p. 28-34 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Discovery of Novel Conotoxin Candidates Using Machine Learning

      Li, Q., Watkins, M., Robinson, S. D., Safavi, Helena & Yandell, M., 2018, In: Toxins. 10, 12, 503.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins

      O'Brien, H., Kanemura, S., Okumura, M., Baskin, R. P., Bandyopadhyay, P. K., Olivera, B. M., Ellgaard, Lars, Inaba, K. & Safavi, Helena, 2018, In: International Journal of Molecular Sciences . 19, 11, 15 p., 3418.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. Published

      Evolutionary Adaptations to Cysteine-rich Peptide Folding

      Safavi, Helena, Foged, M. M. & Ellgaard, Lars, 2018, Oxidative Folding of Proteins: Basic Principles, Cellular Regulation and Engineering . Feige, M. J. (ed.). Royal Society of Chemistry, p. 99-128 30 p. (Chemical Biology, Vol. 9).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    22. 2017
    23. Published

      Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study

      Olivera, B. M., Raghuraman, S., Schmidt, E. W. & Safavi, Helena, Oct 2017, In: Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 203, 9, p. 717-735 19 p.

      Research output: Contribution to journal › Review › Research › peer-review

    24. Published

      Hormone-like peptides in the venoms of marine cone snails

      Robinson, S. D., Li, Q., Bandyopadhyay, P. K., Gajewiak, J., Yandell, M., Papenfuss, A. T., Purcell, A. W., Norton, R. S. & Safavi, Helena, 1 Apr 2017, In: General and Comparative Endocrinology. 244, p. 11-18 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus

      Li, Q., Barghi, N., Lu, A., Fedosov, A. E., Bandyopadhyay, P. K., Lluisma, A. O., Concepcion, G. P., Yandell, M., Olivera, B. M. & Safavi, Helena, 2017, In: Genome Biology and Evolution. 9, 9, p. 2211-2225 15 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Isolation and characterization of Conohyal-P1, a hyaluronidase from the injected venom of Conus purpurascens

      Möller, C., Clark, E., Safavi, Helena, DeCaprio, A. & Marí, F., 2017, In: Journal of Proteomics. 164, p. 73-84 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea

      Robinson, S. D., Li, Q., Lu, A., Bandyopadhyay, P. K., Yandell, M., Olivera, B. M. & Safavi, Helena, 2017, In: Marine Drugs. 15, 5, 145.

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Venom peptides as pharmacological tools and therapeutics for diabetes

      Robinson, S. D. & Safavi, Helena, 2017, In: Neuropharmacology. 127, p. 79-86 8 p.

      Research output: Contribution to journal › Review › Research › peer-review

    29. 2016

    30. A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold

      Robinson, S. D., Chhabra, S., Belgi, A., Chittoor, B., Safavi, Helena, Robinson, A. J., Papenfuss, A. T., Purcell, A. W. & Norton, R. S., 2016, In: Structure. 24, 2, p. 293-299 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin

      Menting, J. G., Gajewiak, J., MacRaild, C. A., Chou, D. H., Disotuar, M. M., Smith, N. A., Miller, C., Erchegyi, J., Rivier, J. E., Olivera, B. M., Forbes, B. E., Smith, B. J., Norton, R. S., Safavi, Helena & Lawrence, M. C., 2016, In: Nature Structural and Molecular Biology. 23, 10, p. 916-920 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. A prominent role of PDIA6 in processing of misfolded proinsulin

      Gorasia, D. G., Dudek, N. L., Safavi, Helena, Perez, R. A., Schittenhelm, R. B., Saunders, P. M., Wee, S., Mangum, J. E., Hubbard, M. J. & Purcell, A. W., 2016, In: B B A - Reviews on Cancer. 1864, 6, p. 715-723 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      Insulin as a weapon

      Robinson, S. D. & Safavi, Helena, 2016, In: Toxicon. 123, p. 56-61 6 p.

      Research output: Contribution to journal › Review › Research › peer-review

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