Gitta Wörtwein

Gitta Wörtwein

Associate Professor


  1. 2021
  2. Accepted/In press

    Proinflammatory biomarkers are associated with prediabetes in patients with schizophrenia

    Mller, M., Fredholm, S., Jensen, Mathias Ebbesen, Wörtwein, Gitta, Larsen, J. R., Vilsbøll, Tina, Ødum, Niels & Fink-Jensen, Anders, 2021, (Accepted/In press) In: CNS Spectrums.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2020
  4. Published

    The effect of erythropoietin on electroconvulsive stimulation induced cognitive impairment in rats

    Kjær, K., Jørgensen, Martin Balslev, Hageman, Ida, Miskowiak, Kamilla Woznica & Wörtwein, Gitta, 2020, In: Behavioural Brain Research. 382, 112484.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2019
  6. Published

    G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

    Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In: Neuropharmacology. 161, 107663.

    Research output: Contribution to journalReviewResearchpeer-review

  7. Published

    Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

    Runegaard, A. H., Jensen, Kathrine Louise, Wörtwein, Gitta & Gether, Ulrik, 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

    Jørgensen, Anders, Breitenstein, K., Kalliokoski, Otto, Weimann, A., Henriksen, T., Poulsen, Henrik Enghusen, Jørgensen, Martin Balslev & Wörtwein, Gitta, 2019, In: Acta Neuropsychiatrica. 31, 6, p. 287-293 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. 2018
  10. Published

    Ketogenic Diet suppresses Alcohol Withdrawal Syndrome in Rats

    Dencker, D., Molander, A., Thomsen, M., Schlumberger, C., Wörtwein, Gitta, Weikop, P., Benveniste, H., Volkow, N. D. & Fink-Jensen, Anders, Feb 2018, In: Alcoholism: Clinical and Experimental Research. 42, 2, p. 270-277

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    The circadian oscillator of the cerebral cortex: molecular, biochemical and behavioral effects of deleting the Arntl clock gene in cortical neurons

    Bering, Tenna, Carstensen, Mikkel Bloss, Wörtwein, Gitta, Weikop, P. & Rath, Martin Fredensborg, Feb 2018, In: Cerebral Cortex. 28, 2, p. 644–657

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published
  13. Published

    Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

    Runegaard, A. H., Sørensen, A. T., Fitzpatrick, C. M., Jørgensen, S. H., Petersen, A. V., Hansen, N. W., Weikop, P., Andreasen T., Jesper, Mikkelsen, Jens D., Perrier, Jean-Francois Marie, Woldbye, David Paul Drucker, Rickhag, M., Wörtwein, Gitta & Gether, Ulrik, 2018, In: eNeuro. 5, 3, 26 p., e0345.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

    Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, P., Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, M., 2018, In: eNeuro. 5, 3

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2017
  16. Published

    Erytropoietin behandling kan forbedre kognition ved neuropsykiatriske lidelser

    Kjær, K. S., Hageman, Ida, Wörtwein, Gitta, Jørgensen, Martin Balslev & Miskowiak, Kamilla Woznica, 14 Aug 2017, In: Ugeskrift for Laeger. 179, 22, p. 2-6 5 p., V01170037.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats

    Jørgensen, Anders, Kalliokoski, Otto, Forsberg, K., Breitenstein, K., Weimann, A., Henriksen, T., Hau, Jann, Wörtwein, Gitta, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, Mar 2017, In: Free Radical Biology & Medicine. 104, p. 64-74 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Electroconvulsive stimulation results in long-term survival of newly generated hippocampal neurons in rats

    Olesen, M. V., Wörtwein, Gitta, Folke, J. & Pakkenberg, Bente, Jan 2017, In: Hippocampus. 27, 1, p. 52-60 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

    Runegaard, A. H., Jensen, Kathrine Louise, Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2016
  21. Published

    5-HT2A Receptor Binding in the Frontal Cortex of Parkinson's Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study

    Rasmussen, N. B., Olesen, M. V., Brudek, T., Plenge, P., Klein, A. B., Westin, J. E., Fog, K., Wörtwein, Gitta & Aznar, S., 2016, In: Parkinson’s Disease. 2016, 8 p., 3682936.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels

    Reddy, I. A., Pino, J. A., Weikop, P., Osses, N., Sørensen, G., Bering, T., Valle, C., Bluett, R. J., Erreger, K., Wörtwein, Gitta, Reyes, J. G., Graham, D., Stanwood, G. D., Hackett, T. A., Patel, S., Fink-Jensen, Anders, Torres, G. E. & Galli, A., 2016, In: Translational Psychiatry. 6, 11 p., e809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. 2015
  24. Published

    The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice

    Sorensen, G., Reddy, I. A., Weikop, P., Graham, D. L., Stanwood, G. D., Wörtwein, Gitta, Galli, A. & Fink-Jensen, Anders, 1 Oct 2015, In: Physiology & Behavior. 149, p. 262-268 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Dynamic regulation of cerebral DNA repair genes by psychological stress

    Forsberg, K., Aalling, Nadia, Wörtwein, Gitta, Loft, Steffen, Møller, Peter, Hau, Jann, Hageman, I., Jørgensen, M. B. & Jørgensen, Anders, 15 Jan 2015, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 778, p. 37-43 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Enhanced self-administration of alcohol in muscarinic acetylcholine M4 receptor knockout mice

    de la Cour, C., Sørensen, G., Wörtwein, Gitta, Weikop, P., Nielsen, D. D., Fink-Jensen, Anders & Molander, A., 5 Jan 2015, In: European Journal of Pharmacology. 746, p. 1-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Electroconvulsive Stimulation, but not Chronic Restraint Stress, Causes Structural Alterations in Adult Rat Hippocampus: A Stereological Study

    Olesen, M. V., Wörtwein, Gitta & Pakkenberg, Bente, Jan 2015, In: Hippocampus. 25, 1, p. 72-80 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Delayed restraint procedure enhances cognitive recovery of spatial function after fimbria-fornix transection

    Gram, M. G., Wogensen, E., Wörtwein, Gitta, Mogensen, Jesper & Rytter, Hana Malá, 2015, In: Restorative Neurology and Neuroscience. 34, 1, p. 1-17

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    INACTIVATION OF THE CHOLINERGIC M4 RECEPTOR RESULTS IN THE DEVELOPMENT OF A LOW ANXIETY ENDOPHENOTYPE PREDICTING FUTURE ALCOHOL CONSUMPTION

    Dencker, D., Wörtwein, Gitta, Lysne, C., Weikop, P., Fink-Jensen, Anders & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i57-i58 2 p., P-49.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  30. Published

    SUBCHRONIC LOW DOSE EXENDIN-4 PRETREATMENT INHIBITS RELAPSE TO ALCOHOL DRINKING IN HIGH ALCOHOL PREFERING C57BL6 MICE

    Dencker, D., Egecioglu, E., Jerlhag, E., Wörtwein, Gitta, Weikop, P., Fink-Jensen, Anders & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i17-i18 2 p., SY15-2.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  31. 2014
  32. Published

    Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice

    Elbrønd-Bek, H., Olling, J. D., Gøtzsche, C. R., Waterfield, A., Wörtwein, Gitta & Woldbye, David Paul Drucker, 9 Jul 2014, In: Synapse. 68, 10, p. 427-36 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Addiction-Related Effects of DOV 216,303 and Cocaine: A Comparative Study in the Mouse

    Sørensen, G., Husum, H., Brennum, L. T., Bundgaard, C., Montezinho, L. C. P., Mørk, A., Wörtwein, Gitta & Woldbye, David Paul Drucker, Jun 2014, In: Basic & Clinical Pharmacology & Toxicology. 114, 6, p. 451-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. 2013
  35. Published

    Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference

    Sørensen, G., Wörtwein, Gitta, Fink-Jensen, Anders & Woldbye, David Paul Drucker, Apr 2013, In: Pharmacology, Biochemistry and Behavior. 105, p. 151-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage

    Jorgensen, A., Maigaard, K., Wörtwein, Gitta, Hageman, I., Henriksen, T., Weimann, A., Møller, Peter, Loft, Steffen, Hau, Jann, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, 10 Jan 2013, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 40, p. 30-37

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

    Rickhag, K. M., Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, Kamil, Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

    Rickhag, K. M., Owens, W., Winkler, M., Strandfelt, K. N., Rathje, Mette, Sørensen, G., Andresen, B., Madsen, Kenneth Lindegaard, Nygaard Jørgensen, T., Wörtwein, Gitta, Woldbye, David Paul Drucker, Sitte, H. H., Daws, L. C. & Gether, Ulrik, 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. 2012
  40. Published

    Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

    Sørensen, G., Jensen, M., Weikop, P., Nielsen, D. D., Christiansen, S. H. O., Loland, Claus Juul, Bengtsen, C. H., Petersen, Jørgen Holm, Fink-Jensen, Anders, Wörtwein, Gitta & Woldbye, David Paul Drucker, Feb 2012, In: Psychopharmacology. 222, p. 565-577 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

    Nielsen, D. D., Weikop, P., Sørensen, G., Woldbye, David Paul Drucker, Wörtwein, Gitta, Wess, J. & Fink-Jensen, Anders, 2012, In: Psychopharmacology. 224, 2, p. 277-87 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala

    Maigaard, K., Hageman, Ida, Jørgensen, A., Jørgensen, Martin Balslev & Wörtwein, Gitta, 2012, In: Neuroscience Letters. 516, 1, p. 24-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    The effect of subchronic fluoxetine treatment on learning and memory in adolescent rats

    Sass, A. & Wörtwein, Gitta, 2012, In: Behavioural Brain Research. 228, 1, p. 169-75 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    Time course and duration of changes in K(v)7.2 and K(v)11.1 mRNA expression in the hippocampus and piriform cortex following electroconvulsive stimulations

    Hjaeresen, M., Hageman, I., Wörtwein, Gitta & Jørgensen, Martin Balslev, 2012, In: Brain Stimulation. 5, 1, p. 55-60 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. 2011
  46. Published

    Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease

    Dencker, D., Thomsen, M., Wörtwein, Gitta, Weikop, P., Cui, Y., Jeon, J., Wess, J. & Fink-Jensen, Anders, 22 Nov 2011, In: ACS Chemical Neuroscience. 3, 2, p. 80-89 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor.

    Fink-Jensen, Anders, Schmidt, L. S., Dencker, D., Schülein, C., Wess, J., Wörtwein, Gitta & Woldbye, David Paul Drucker, 10 Apr 2011, In: European Journal of Pharmacology. 656, 1-3, p. 39-44 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice

    Christiansen, S. H. O., Olesen, M. V., Wörtwein, Gitta & Woldbye, David Paul Drucker, 20 Jan 2011, In: Behavioural Brain Research. 216, 2, p. 585-91 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.

    Schmidt, L. S., Thomsen, M., Weikop, P., Nielsen, D. D., Wess, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Fink-Jensen, Anders, 2011, In: Psychopharmacology. 216, 3, p. 367-378 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Increased numbers of orexin/hypocretin neurons in a genetic rat depression model

    Mikrouli, E., Wörtwein, Gitta, Soylu, R., Mathé, A. A. & Petersén, Å., 2011, In: Neuropeptides (Sheffield). 45, 6, p. 401-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline

    Dencker, D., Wörtwein, Gitta, Weikop, P., Jeon, J., Thomsen, M., Sager, T. N., Mørk, A., Woldbye, David Paul Drucker, Wess, J. & Fink-Jensen, Anders, 2011, In: Journal of Neuroscience. 31, 16, p. 5905-8 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    Pharmacological characterization of social isolation-induced hyperactivity

    Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, Gitta & Steiniger-Brach, B., 2011, In: Psychopharmacology. 215, 2, p. 257-66 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. Published

    Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia

    Fabricius, K., Steiniger-Brach, B., Helboe, L., Fink-Jensen, Anders & Wörtwein, Gitta, 2011, In: International Journal of Developmental Neuroscience. 29, 3, p. 347-50 4 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. 2010
  55. Published

    Increased dopaminergic activity in socially isolated rats: an electrophysiological study

    Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, Gitta, Steiniger-Brach, B., Sotty, F., Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, G., Steiniger-Brach, B. & Sotty, F., 27 Sep 2010, In: Neuroscience Letters. 482, 2, p. 117-22 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors

    Jeon, J., Dencker, D., Wörtwein, Gitta, Woldbye, David Paul Drucker, Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C., Fink-Jensen, Anders, Wess, J., Jeon, J., Nielsen, D. D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C., Fink-Jensen, Anders & Wess, J., 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2396-405 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice

    Schmidt, L. S., Miller, A. D., Lester, D. B., Bay-Richter, C., Schülein, C., Frikke-Schmidt, H., Wess, J., Blaha, C. D., Woldbye, David Paul Drucker, Fink-Jensen, Anders & Wörtwein, Gitta, 2010, In: Psychopharmacology. 207, 4, p. 547-58 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. 2009
  59. Published

    Adult Brain and Behavioral Effect of Early Life Maternal Deprivation

    Mathe, A. A., El Khoury, A., Gruber, S. H. M., Husum, H., Wörtwein, Gitta & Arlinde, C., 2009, Beyond neuropsychiatric diagnostics: Symptoms not disorders. Palomo, T., Beninger, R. J., Kostzewa, R. M. & Archer, T. (eds.). Mountain Home, TN, USA: F. P. Graham Publishing Co.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  60. Published

    Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour

    Hageman, Ida, Nielsen, M., Wörtwein, Gitta, Diemer, N. H. & Jorgensen, M. B., 2009, In: Behavioural Brain Research. 196, 1, p. 71-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  61. Published

    Mekanismer ved funktionel restitution efter hjerneskader

    Wörtwein, Gitta, 2009, Klinisk neuropsykologi. Gade, A., Gerlach, C., Starrfelt, R. & Møller Pedersen, P. (eds.). København: Frydenlund Academic, p. 480-488

    Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication

  62. Published

    Neuropeptide Y infusion into the shell region of the rat nucleus accumbens increases extracellular levels of dopamine

    Sørensen, G., Wegener, G., Hasselstrøm, J., Hansen, T. V. O., Wörtwein, Gitta, Fink-Jensen, Anders & Woldbye, David Paul Drucker, 2009, In: NeuroReport. 20, 11, p. 1023-6 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Nortriptyline mediates behavioral effects without affecting hippocampal cytogenesis in a genetic rat depression model

    Petersén, A., Wörtwein, Gitta, Gruber, S. H. M., El-Khoury, A. & Mathé, A. A., 2009, In: Neuroscience Letters. 451, 2, p. 148-51 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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