Gitta Wörtwein

Gitta Wörtwein

Associate Professor

Member of:

    ORCID: 0000-0001-6981-7885

    Publication year:
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    1 - 50 out of 89Page size: 50
    1. 2022
    2. Published

      Inactivation of the cholinergic M4 receptor results in a disinhibited endophenotype predicting alcohol use

      Molander, A., Thorbek, D. D., Lysne, C., Weikop, Pia, Fink-Jensen, Anders & Wörtwein, Gitta, 2022, In: Behavioural Brain Research. 430, 10 p., 113921.

      Research output: Contribution to journal › Journal article › peer-review

    3. Published

      Proinflammatory biomarkers are associated with prediabetes in patients with schizophrenia

      Mller, M., Fredholm, S., Jensen, M. E., Wörtwein, Gitta, Larsen, J. R., Vilsbøll, Tina, Ødum, Niels & Fink-Jensen, Anders, 2022, In: CNS Spectrums. 27, 3, 8 p.

      Research output: Contribution to journal › Journal article › peer-review

    4. Published

      The role of glucagon-like peptide 1 (GLP-1) in addictive disorders

      Kruse Klausen, M., Thomsen, Morgane, Wörtwein, Gitta & Fink-Jensen, Anders, 2022, In: British Journal of Pharmacology. 179, 4, p. 625-641 17 p.

      Research output: Contribution to journal › Review › peer-review

    5. 2021
    6. Published

      Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

      Sørensen, G., Rickhag, Karl Mattias, Leo, D., Lycas, M. D., Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Reis Rifes, Pedro Goncalo, Herborg, Freja, Woldbye, David Paul Drucker, Wörtwein, Gitta, Gainetdinov, R. R., Fink-Jensen, Anders & Gether, Ulrik, 2021, In: Journal of Biological Chemistry. 297, 6, 101361.

      Research output: Contribution to journal › Journal article › peer-review

    7. 2020
    8. Published

      The effect of erythropoietin on electroconvulsive stimulation induced cognitive impairment in rats

      Kjær, K., Jørgensen, Martin Balslev, Hageman, Ida, Miskowiak, Kamilla & Wörtwein, Gitta, 2020, In: Behavioural Brain Research. 382, 112484.

      Research output: Contribution to journal › Journal article › peer-review

    9. 2019
    10. Published

      G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

      Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In: Neuropharmacology. 161, 107663.

      Research output: Contribution to journal › Review › peer-review

    11. Published

      Initial rewarding effects of cocaine and amphetamine assessed in a day using the single-exposure place preference protocol

      Runegaard, A. H., Jensen, Kathrine Louise, Wörtwein, Gitta & Gether, Ulrik, 2019, In: European Journal of Neuroscience. 50, 3, p. 2156-2163 8 p.

      Research output: Contribution to journal › Journal article › peer-review

    12. Published

      Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats

      Jørgensen, Anders, Breitenstein, K., Kalliokoski, Otto, Weimann, A., Henriksen, T., Poulsen, Henrik Enghusen, Jørgensen, Martin Balslev & Wörtwein, Gitta, 2019, In: Acta Neuropsychiatrica. 31, 6, p. 287-293 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    13. 2018
    14. Published

      Ketogenic Diet suppresses Alcohol Withdrawal Syndrome in Rats

      Dencker, D., Molander, A., Thomsen, M., Schlumberger, C., Wörtwein, Gitta, Weikop, P., Benveniste, H., Volkow, N. D. & Fink-Jensen, Anders, Feb 2018, In: Alcoholism: Clinical and Experimental Research. 42, 2, p. 270-277

      Research output: Contribution to journal › Journal article › peer-review

    15. Published

      The circadian oscillator of the cerebral cortex: molecular, biochemical and behavioral effects of deleting the Arntl clock gene in cortical neurons

      Bering, Tenna, Carstensen, M. B., Wörtwein, Gitta, Weikop, Pia & Rath, Martin Fredensborg, Feb 2018, In: Cerebral Cortex. 28, 2, p. 644–657

      Research output: Contribution to journal › Journal article › peer-review

    16. Published

      Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats

      Aalling, Nadia, Hageman, Ida, Miskowiak, Kamilla, Orlowski, D., Wegener, G. & Wörtwein, Gitta, Jan 2018, In: Journal of Neuroscience Research. 96, 1, p. 103–116

      Research output: Contribution to journal › Journal article › peer-review

    17. Published

      Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons

      Runegaard, A. H., Sørensen, Andreas Toft, Fitzpatrick, C. M., Jørgensen, Søren Heide, Petersen, A. V., Hansen, Nikolaj Winther, Weikop, Pia, Andreasen T., Jesper, Mikkelsen, Jens D., Perrier, Jean-Francois Marie, Woldbye, David Paul Drucker, Rickhag, Karl Mattias, Wörtwein, Gitta & Gether, Ulrik, 2018, In: eNeuro. 5, 3, 26 p., e0345.

      Research output: Contribution to journal › Journal article › peer-review

    18. Published

      PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis

      Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, Pia, Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In: eNeuro. 5, 3

      Research output: Contribution to journal › Journal article › peer-review

    19. 2017
    20. Published

      Erytropoietin behandling kan forbedre kognition ved neuropsykiatriske lidelser

      Kjær, K. S., Hageman, Ida, Wörtwein, Gitta, Jørgensen, Martin Balslev & Miskowiak, Kamilla, 14 Aug 2017, In: Ugeskrift for Laeger. 179, 22, p. 2-6 5 p., V01170037.

      Research output: Contribution to journal › Journal article › peer-review

    21. Published

      A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats

      Jørgensen, Anders, Kalliokoski, Otto, Forsberg, K., Breitenstein, K., Weimann, A., Henriksen, T., Hau, Jann, Wörtwein, Gitta, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, Mar 2017, In: Free Radical Biology & Medicine. 104, p. 64-74 11 p.

      Research output: Contribution to journal › Journal article › peer-review

    22. Published

      Electroconvulsive stimulation results in long-term survival of newly generated hippocampal neurons in rats

      Olesen, M. V., Wörtwein, Gitta, Folke, J. & Pakkenberg, Bente, Jan 2017, In: Hippocampus. 27, 1, p. 52-60 9 p.

      Research output: Contribution to journal › Journal article › peer-review

    23. Published

      Subjective perception of cocaine reward in mice assessed by a single exposure place preference (sePP) paradigm

      Runegaard, A. H., Jensen, Kathrine Louise, Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2017, In: Journal of Neuroscience Methods. 289, p. 85-92 8 p.

      Research output: Contribution to journal › Journal article › peer-review

    24. 2016
    25. Published

      5-HT2A Receptor Binding in the Frontal Cortex of Parkinson's Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study

      Rasmussen, N. B., Olesen, M. V., Brudek, T., Plenge, P., Klein, A. B., Westin, J. E., Fog, K., Wörtwein, Gitta & Aznar, S., 2016, In: Parkinson’s Disease. 2016, 8 p., 3682936.

      Research output: Contribution to journal › Journal article › peer-review

    26. Published

      Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels

      Reddy, I. A., Pino, J. A., Weikop, Pia, Osses, N., Sørensen, G., Bering, T., Valle, C., Bluett, R. J., Erreger, K., Wörtwein, Gitta, Reyes, J. G., Graham, D., Stanwood, G. D., Hackett, T. A., Patel, S., Fink-Jensen, Anders, Torres, G. E. & Galli, A., 2016, In: Translational Psychiatry. 6, 11 p., e809.

      Research output: Contribution to journal › Journal article › peer-review

    27. 2015
    28. Published

      The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice

      Sorensen, G., Reddy, I. A., Weikop, Pia, Graham, D. L., Stanwood, G. D., Wörtwein, Gitta, Galli, A. & Fink-Jensen, Anders, 1 Oct 2015, In: Physiology & Behavior. 149, p. 262-268 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    29. Published

      Dynamic regulation of cerebral DNA repair genes by psychological stress

      Forsberg, K., Aalling, Nadia, Wörtwein, Gitta, Loft, Steffen, Møller, Peter, Hau, Jann, Hageman, I., Jørgensen, M. B. & Jørgensen, Anders, 15 Jan 2015, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 778, p. 37-43 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    30. Published

      Enhanced self-administration of alcohol in muscarinic acetylcholine M4 receptor knockout mice

      de la Cour, C., Sørensen, G., Wörtwein, Gitta, Weikop, Pia, Nielsen, D. D., Fink-Jensen, Anders & Molander, A., 5 Jan 2015, In: European Journal of Pharmacology. 746, p. 1-5 5 p.

      Research output: Contribution to journal › Journal article › peer-review

    31. Published

      Electroconvulsive Stimulation, but not Chronic Restraint Stress, Causes Structural Alterations in Adult Rat Hippocampus: A Stereological Study

      Olesen, M. V., Wörtwein, Gitta & Pakkenberg, Bente, Jan 2015, In: Hippocampus. 25, 1, p. 72-80 8 p.

      Research output: Contribution to journal › Journal article › peer-review

    32. Published

      Delayed restraint procedure enhances cognitive recovery of spatial function after fimbria-fornix transection

      Gram, M. G., Wogensen, E., Wörtwein, Gitta, Mogensen, J. & Rytter, Hana Malá, 2015, In: Restorative Neurology and Neuroscience. 34, 1, p. 1-17

      Research output: Contribution to journal › Journal article › peer-review

    33. Published

      INACTIVATION OF THE CHOLINERGIC M4 RECEPTOR RESULTS IN THE DEVELOPMENT OF A LOW ANXIETY ENDOPHENOTYPE PREDICTING FUTURE ALCOHOL CONSUMPTION

      Dencker, D., Wörtwein, Gitta, Lysne, C., Weikop, Pia, Fink-Jensen, Anders & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i57-i58 2 p., P-49.

      Research output: Contribution to journal › Conference abstract in journal › peer-review

    34. Published

      SUBCHRONIC LOW DOSE EXENDIN-4 PRETREATMENT INHIBITS RELAPSE TO ALCOHOL DRINKING IN HIGH ALCOHOL PREFERING C57BL6 MICE

      Dencker, D., Egecioglu, E., Jerlhag, E., Wörtwein, Gitta, Weikop, Pia, Fink-Jensen, Anders & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i17-i18 2 p., SY15-2.

      Research output: Contribution to journal › Conference abstract in journal › peer-review

    35. 2014
    36. Published

      Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice

      Elbrønd-Bek, H., Olling, J. D., Gøtzsche, C. R., Waterfield, A., Wörtwein, Gitta & Woldbye, David Paul Drucker, 9 Jul 2014, In: Synapse. 68, 10, p. 427-36 10 p.

      Research output: Contribution to journal › Journal article › peer-review

    37. Published

      Addiction-Related Effects of DOV 216,303 and Cocaine: A Comparative Study in the Mouse

      Sørensen, G., Husum, H., Brennum, L. T., Bundgaard, C., Montezinho, L. C. P., Mørk, A., Wörtwein, Gitta & Woldbye, David Paul Drucker, Jun 2014, In: Basic & Clinical Pharmacology & Toxicology. 114, 6, p. 451-9 9 p.

      Research output: Contribution to journal › Journal article › peer-review

    38. 2013
    39. Published

      Neuropeptide Y Y5 receptor antagonism causes faster extinction and attenuates reinstatement in cocaine-induced place preference

      Sørensen, G., Wörtwein, Gitta, Fink-Jensen, Anders & Woldbye, David Paul Drucker, Apr 2013, In: Pharmacology, Biochemistry and Behavior. 105, p. 151-6 6 p.

      Research output: Contribution to journal › Journal article › peer-review

    40. Published

      Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage

      Jorgensen, A., Maigaard, K., Wörtwein, Gitta, Hageman, I., Henriksen, T., Weimann, A., Møller, Peter, Loft, Steffen, Hau, Jann, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, 10 Jan 2013, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 40, p. 30-37

      Research output: Contribution to journal › Journal article › peer-review

    41. Published

      A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

      Rickhag, Karl Mattias, Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.

      Research output: Contribution to journal › Journal article › peer-review

    42. Published

      Membrane permeable C-terminal dopamine transporter peptides attenuate amphetamine-evoked dopamine release.

      Rickhag, Karl Mattias, Owens, W., Winkler, M., Strandfelt, K. N., Rathje, Mette, Sørensen, G., Andresen, B., Madsen, Kenneth Lindegaard, Nygaard Jørgensen, T., Wörtwein, Gitta, Woldbye, David Paul Drucker, Sitte, H. H., Daws, L. C. & Gether, Ulrik, 2013, In: Journal of Biological Chemistry. 288, p. 27534-44 11 p.

      Research output: Contribution to journal › Journal article › peer-review

    43. 2012
    44. Published

      Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.

      Sørensen, G., Jensen, M., Weikop, Pia, Nielsen, D. D., Christiansen, S. H. O., Loland, Claus Juul, Bengtsen, C. H., Petersen, Jørgen Holm, Fink-Jensen, Anders, Wörtwein, Gitta & Woldbye, David Paul Drucker, Feb 2012, In: Psychopharmacology. 222, p. 565-577 13 p.

      Research output: Contribution to journal › Journal article › peer-review

    45. Published

      An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

      Nielsen, D. D., Weikop, Pia, Sørensen, G., Woldbye, David Paul Drucker, Wörtwein, Gitta, Wess, J. & Fink-Jensen, Anders, 2012, In: Psychopharmacology. 224, 2, p. 277-87 11 p.

      Research output: Contribution to journal › Journal article › peer-review

    46. Published

      Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala

      Maigaard, K., Hageman, Ida, Jørgensen, A., Jørgensen, Martin Balslev & Wörtwein, Gitta, 2012, In: Neuroscience Letters. 516, 1, p. 24-8 5 p.

      Research output: Contribution to journal › Journal article › peer-review

    47. Published

      The effect of subchronic fluoxetine treatment on learning and memory in adolescent rats

      Sass, A. & Wörtwein, Gitta, 2012, In: Behavioural Brain Research. 228, 1, p. 169-75 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    48. Published

      Time course and duration of changes in K(v)7.2 and K(v)11.1 mRNA expression in the hippocampus and piriform cortex following electroconvulsive stimulations

      Hjaeresen, M., Hageman, I., Wörtwein, Gitta & Jørgensen, Martin Balslev, 2012, In: Brain Stimulation. 5, 1, p. 55-60 6 p.

      Research output: Contribution to journal › Journal article › peer-review

    49. 2011
    50. Published

      Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease

      Dencker, D., Thomsen, M., Wörtwein, Gitta, Weikop, Pia, Cui, Y., Jeon, J., Wess, J. & Fink-Jensen, Anders, 22 Nov 2011, In: ACS Chemical Neuroscience. 3, 2, p. 80-89 10 p.

      Research output: Contribution to journal › Journal article › peer-review

    51. Published

      Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor.

      Fink-Jensen, Anders, Schmidt, L. S., Dencker, D., Schülein, C., Wess, J., Wörtwein, Gitta & Woldbye, David Paul Drucker, 10 Apr 2011, In: European Journal of Pharmacology. 656, 1-3, p. 39-44 6 p.

      Research output: Contribution to journal › Journal article › peer-review

    52. Published

      Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice

      Christiansen, S. H. O., Olesen, M. V., Wörtwein, Gitta & Woldbye, David Paul Drucker, 20 Jan 2011, In: Behavioural Brain Research. 216, 2, p. 585-91 7 p.

      Research output: Contribution to journal › Journal article › peer-review

    53. Published

      Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.

      Schmidt, L. S., Thomsen, M., Weikop, Pia, Nielsen, D. D., Wess, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Fink-Jensen, Anders, 2011, In: Psychopharmacology. 216, 3, p. 367-378 12 p.

      Research output: Contribution to journal › Journal article › peer-review

    54. Published

      Increased numbers of orexin/hypocretin neurons in a genetic rat depression model

      Mikrouli, E., Wörtwein, Gitta, Soylu, R., Mathé, A. A. & Petersén, Å., 2011, In: Neuropeptides (Sheffield). 45, 6, p. 401-6 6 p.

      Research output: Contribution to journal › Journal article › peer-review

    55. Published

      Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline

      Dencker, D., Wörtwein, Gitta, Weikop, Pia, Jeon, J., Thomsen, M., Sager, T. N., Mørk, A., Woldbye, David Paul Drucker, Wess, J. & Fink-Jensen, Anders, 2011, In: Journal of Neuroscience. 31, 16, p. 5905-8 4 p.

      Research output: Contribution to journal › Journal article › peer-review

    56. Published

      Pharmacological characterization of social isolation-induced hyperactivity

      Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, Gitta & Steiniger-Brach, B., 2011, In: Psychopharmacology. 215, 2, p. 257-66 10 p.

      Research output: Contribution to journal › Journal article › peer-review

    57. Published

      Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia

      Fabricius, K., Steiniger-Brach, B., Helboe, L., Fink-Jensen, Anders & Wörtwein, Gitta, 2011, In: International Journal of Developmental Neuroscience. 29, 3, p. 347-50 4 p.

      Research output: Contribution to journal › Journal article › peer-review

    58. 2010
    59. Published

      Increased dopaminergic activity in socially isolated rats: an electrophysiological study

      Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, Gitta, Steiniger-Brach, B., Sotty, F., Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, G., Steiniger-Brach, B. & Sotty, F., 27 Sep 2010, In: Neuroscience Letters. 482, 2, p. 117-22 6 p.

      Research output: Contribution to journal › Journal article › peer-review

    60. Published

      A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors

      Jeon, J., Dencker, D., Wörtwein, Gitta, Woldbye, David Paul Drucker, Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C., Fink-Jensen, Anders, Wess, J., Jeon, J., Nielsen, D. D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C., Fink-Jensen, Anders & Wess, J., 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2396-405 10 p.

      Research output: Contribution to journal › Journal article › peer-review

    61. Published

      Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice

      Schmidt, L. S., Miller, A. D., Lester, D. B., Bay-Richter, C., Schülein, C., Frikke-Schmidt, H., Wess, J., Blaha, C. D., Woldbye, David Paul Drucker, Fink-Jensen, Anders & Wörtwein, Gitta, 2010, In: Psychopharmacology. 207, 4, p. 547-58 11 p.

      Research output: Contribution to journal › Journal article › peer-review

    62. 2009
    63. Published

      Adult Brain and Behavioral Effect of Early Life Maternal Deprivation

      Mathe, A. A., El Khoury, A., Gruber, S. H. M., Husum, H., Wörtwein, Gitta & Arlinde, C., 2009, Beyond neuropsychiatric diagnostics: Symptoms not disorders. Palomo, T., Beninger, R. J., Kostzewa, R. M. & Archer, T. (eds.). Mountain Home, TN, USA: F. P. Graham Publishing Co.

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research

    64. Published

      Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour

      Hageman, Ida, Nielsen, M., Wörtwein, Gitta, Diemer, N. H. & Jorgensen, M. B., 2009, In: Behavioural Brain Research. 196, 1, p. 71-7 6 p.

      Research output: Contribution to journal › Journal article › peer-review

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