Gitta Wörtwein

Gitta Wörtwein

Associate Professor


  1. Published

    5-HT2A Receptor Binding in the Frontal Cortex of Parkinson's Disease Patients and Alpha-Synuclein Overexpressing Mice: A Postmortem Study

    Rasmussen, N. B., Olesen, M. V., Brudek, T., Plenge, P., Klein, A. B., Westin, J. E., Fog, K., Wörtwein, Gitta & Aznar, S., 2016, In: Parkinson’s Disease. 2016, 8 p., 3682936.

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Published

    A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter

    Rickhag, Karl Mattias, Herborg, Freja, Sørensen, G., Strandfelt, K. N., Andresen, B., Gotfryd, K., Madsen, Kenneth Lindegaard, Vestergaard-Klewe, I., Ammendrup-Johnsen, I., Eriksen, J., Newman, A. H., Füchtbauer, E., Gomeza, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Gether, Ulrik, 2013, In: Nature Communications. 4, p. 1-13 13 p., 1580.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats

    Jørgensen, Anders, Kalliokoski, Otto, Forsberg, K., Breitenstein, K., Weimann, A., Henriksen, T., Hau, Jann, Wörtwein, Gitta, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, Mar 2017, In: Free Radical Biology & Medicine. 104, p. 64-74 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors

    Jeon, J., Dencker, D., Wörtwein, Gitta, Woldbye, David Paul Drucker, Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C., Fink-Jensen, Anders, Wess, J., Jeon, J., Nielsen, D. D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C., Fink-Jensen, Anders & Wess, J., 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2396-405 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels

    Christensen, R., Marcussen, A. B., Wörtwein, Gitta, Knudsen, G. M. & Aznar, S., 2008, In: Experimental Neurology. 210, 1, p. 164-71 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Addiction-Related Effects of DOV 216,303 and Cocaine: A Comparative Study in the Mouse

    Sørensen, G., Husum, H., Brennum, L. T., Bundgaard, C., Montezinho, L. C. P., Mørk, A., Wörtwein, Gitta & Woldbye, David Paul Drucker, Jun 2014, In: Basic & Clinical Pharmacology & Toxicology. 114, 6, p. 451-9 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Adult Brain and Behavioral Effect of Early Life Maternal Deprivation

    Mathe, A. A., El Khoury, A., Gruber, S. H. M., Husum, H., Wörtwein, Gitta & Arlinde, C., 2009, Beyond neuropsychiatric diagnostics: Symptoms not disorders. Palomo, T., Beninger, R. J., Kostzewa, R. M. & Archer, T. (eds.). Mountain Home, TN, USA: F. P. Graham Publishing Co.

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  8. Published

    An allosteric enhancer of M4 muscarinic acetylcholine receptor function inhibits behavioral and neurochemical effects of cocaine

    Nielsen, D. D., Weikop, Pia, Sørensen, G., Woldbye, David Paul Drucker, Wörtwein, Gitta, Wess, J. & Fink-Jensen, Anders, 2012, In: Psychopharmacology. 224, 2, p. 277-87 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Analysis of response patterns during prefrontally ablated rats acquisition of an egocentric spatial task in an 8-arm radialmaze

    Mogensen, J., Montero, A. & Wörtwein, Gitta, 2003, In: Homeostasis. Vol. 42, no.1-2, p. 52-59

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor.

    Fink-Jensen, Anders, Schmidt, L. S., Dencker, D., Schülein, C., Wess, J., Wörtwein, Gitta & Woldbye, David Paul Drucker, 10 Apr 2011, In: European Journal of Pharmacology. 656, 1-3, p. 39-44 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice

    Sørensen, G., Sager, T. N., Petersen, Jørgen Holm, Brennum, L. T., Thøgersen, P., Hee Bengtsen, C., Thomsen, M., Wörtwein, Gitta, Fink-Jensen, Anders & Woldbye, David Paul Drucker, 2008, In: Psychopharmacology. 199, 1, p. 37-46 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat

    Madsen, T. M., Kristjansen, P. E. G., Bolwig, T. G. & Wörtwein, Gitta, 2003, In: Neuroscience. Vol. 119, p. 635-42

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Associative an nonassociative learning after chronic imipramine in rats

    Mogensen, J., Svendsen, G., Tølbøll Lauritsen, K., Ermens, P., Hasman, A., Elvertorp, S., Plenge, P. K., Mellerup, Erling Thyge & Wörtwein, Gitta, 2003, In: Pharmacology, Biochemistry and Behavior. Vol. 76, p. 197-212

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Characterization of epibatidine binding to medial habenula: potential role in analgesia

    Plenge, P. K., Mellerup, Erling Thyge & Wörtwein, Gitta, 2002, In: Journal of Pharmacology and Experimental Therapeutics. vol. 302, p. 759-65

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Cholecystokinin tetrapeptide effects on HPA axis function and elevated plus maze behaviour in maternally separated and handled rats

    Greisen, M. H., Bolwig, T. G. & Wörtwein, Gitta, 2005, In: Behavioural Brain Research. Vol 161, p. 204-12

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    Cholinergic control of nerve growth factor in adult rats: evidence from cortical cholinergic deafferentation and chronic drug treatment

    Rossner, S., Wörtwein, Gitta, Gu, Z., Yu, J., Schliebs, R., Bigl, V. & Perez-Polo, J., 1998, In: Journal of Neurochemistry. Vol. 69, p. 947-953

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Chronic electroconvulsive stimulation but not chronic restraint stress modulates mRNA expression of voltage-dependent potassium channels Kv7.2 and Kv11.1 in the rat piriform cortex.

    Hjæresen, M., Hageman, Ida, Wörtwein, Gitta, Plenge, P., Jørgensen, Martin Balslev & Wörtwein, Gitta, 2008, In: Brain Research. 1217C, p. 179-184 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage

    Jorgensen, A., Maigaard, K., Wörtwein, Gitta, Hageman, I., Henriksen, T., Weimann, A., Møller, Peter, Loft, Steffen, Hau, Jann, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, 10 Jan 2013, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 40, p. 30-37

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Cortical area in the rat that mediates visual pattern discrimination

    Wörtwein, Gitta, Mogensen, J., Williams, G., Carlos, J. H. & Divac, I., 1994, In: Acta Neurobiologiae Experimentalis. 54, p. 365-376

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Delayed restraint procedure enhances cognitive recovery of spatial function after fimbria-fornix transection

    Gram, M. G., Wogensen, E., Wörtwein, Gitta, Mogensen, J. & Rytter, Hana Malá, 2015, In: Restorative Neurology and Neuroscience. 34, 1, p. 1-17

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    Differential roles for neuropeptide Y Y1 and Y5 receptors in anxiety and sedation

    Sørensen, G., Lindberg, C., Wörtwein, Gitta, Bolwig, T. G., Woldbye, David Paul Drucker & Sørensen, G., 1 Sep 2004, In: Journal of Neuroscience Research. 77, 5, p. 723-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Disruption of the PDZ domain-binding motif of the dopamine transporter uniquely alters nanoscale distribution, dopamine homeostasis, and reward motivation

    Sørensen, G., Rickhag, Karl Mattias, Leo, D., Lycas, Matthew Domenic, Ridderstrøm, P. H., Weikop, P., Lilja, J. H., Reis Rifes, Pedro Goncalo, Herborg, Freja, Woldbye, David Paul Drucker, Wörtwein, Gitta, Gainetdinov, R. R., Fink-Jensen, Anders & Gether, Ulrik, 2021, In: Journal of Biological Chemistry. 297, 6, 101361.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Dynamic regulation of cerebral DNA repair genes by psychological stress

    Forsberg, K., Aalling, Nadia, Wörtwein, Gitta, Loft, Steffen, Møller, Peter, Hau, Jann, Hageman, I., Jørgensen, M. B. & Jørgensen, Anders, 15 Jan 2015, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 778, p. 37-43 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Dyremodeller i neuropsykiatrisk forskning

    Mogensen, J. & Wörtwein, Gitta, 1999, Neuropsykiatriske Aspekter. Danmark, p. 116-123

    Research output: Chapter in Book/Report/Conference proceedingReport chapterResearch

  25. Published

    Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats

    Thomsen, M., Fink-Jensen, Anders, Woldbye, David Paul Drucker, Wörtwein, Gitta, Sager, T., Holm, R., Pepe, L. & Barak Caine, S., 2008, In: Psychopharmacology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain

    Altar, C. A., Whitehead, R. E., Chen, R., Wörtwein, Gitta & Madsen, T. M., 2003, In: Biological Psychiatry. VOl. 54, no. 7, p. 703-9

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    Effects of maternal separation on neuropetide Y and calcitonin gene-related peptide in "depressed" Flinders Sensitive Line rats: A study of gene-environment interactions

    Wörtwein, Gitta, Husum, H., Andersson, W., Bolwig, T. G. & Mathe, A. A., 2006, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 30, 4, p. 684-693 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Egocentric spatial orientation in a water maze by rats subjected to transection of the fimbria-fornix and/or ablation of the prefrontal cortex

    Mogensen, J., Moustgaard, A., Khan, U., Wörtwein, Gitta & Sandager Nielsen, K., 2005, In: Brain Research Bulletin. 65, 1, p. 41-58

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Electroconvulsive Stimulation, but not Chronic Restraint Stress, Causes Structural Alterations in Adult Rat Hippocampus: A Stereological Study

    Olesen, M. V., Wörtwein, Gitta & Pakkenberg, Bente, Jan 2015, In: Hippocampus. 25, 1, p. 72-80 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Electroconvulsive stimulation results in long-term survival of newly generated hippocampal neurons in rats

    Olesen, M. V., Wörtwein, Gitta, Folke, J. & Pakkenberg, Bente, Jan 2017, In: Hippocampus. 27, 1, p. 52-60 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour

    Hageman, Ida, Nielsen, M., Wörtwein, Gitta, Diemer, N. H. & Jorgensen, M. B., 2009, In: Behavioural Brain Research. 196, 1, p. 71-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Published

    Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala

    Maigaard, K., Hageman, Ida, Jørgensen, A., Jørgensen, Martin Balslev & Wörtwein, Gitta, 2012, In: Neuroscience Letters. 516, 1, p. 24-8 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus

    Hageman, I., Nielsen, M., Wörtwein, Gitta, Diemer, N. H. & Jorgensen, M. B., 2008, In: Stress: The International Journal on the Biology of Stress . 11, 4, p. 282-9 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Enhanced self-administration of alcohol in muscarinic acetylcholine M4 receptor knockout mice

    de la Cour, C., Sørensen, G., Wörtwein, Gitta, Weikop, Pia, Nielsen, D. D., Fink-Jensen, Anders & Molander, A., 5 Jan 2015, In: European Journal of Pharmacology. 746, p. 1-5 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published
  36. Published

    Erytropoietin behandling kan forbedre kognition ved neuropsykiatriske lidelser

    Kjær, K. S., Hageman, Ida, Wörtwein, Gitta, Jørgensen, Martin Balslev & Miskowiak, Kamilla, 14 Aug 2017, In: Ugeskrift for Laeger. 179, 22, p. 2-6 5 p., V01170037.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Escitalopram reduces increased hippocampal cytogenesis in a genetic rat depression model

    Petersén, A., Wörtwein, Gitta, Gruber, S. H. M. & Mathé, A. A., 2008, In: Neuroscience Letters. 436, 3, p. 305-8 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Exacerbated loss of cell survival, neuropeptide Y-immunoreactive (IR) cells, and serotonin-IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line "depressed" rat: Implications for the pathophysiology of depression?

    Husum, H., Aznar, S., Hoyer-Hansen, S., Larsen, M. H., Mikkelsen, J. D., Moller, A., Mathe, A. A. & Wörtwein, Gitta, 2006, In: Journal of Neuroscience Research. 84, 6, p. 1292-1302 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice

    Christiansen, S. H. O., Olesen, M. V., Wörtwein, Gitta & Woldbye, David Paul Drucker, 20 Jan 2011, In: Behavioural Brain Research. 216, 2, p. 585-91 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    Functional and neurochemical profile of place learning after L-nitro-arginine in the rat

    Mogensen, J., Wörtwein, Gitta, Hasman, A., Nielsen, P. & Wang, Q., 1995, In: Neurobiology of Learning and Memory. 63, p. 54-65

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    G protein-coupled receptor signaling in VTA dopaminergic neurons bidirectionally regulates the acute locomotor response to amphetamine but does not affect behavioral sensitization

    Runegaard, A. H., Dencker, D., Wörtwein, Gitta & Gether, Ulrik, 2019, In: Neuropharmacology. 161, 107663.

    Research output: Contribution to journalReviewResearchpeer-review

  42. Published

    Gene-environment interaction affects substance P and neurokinin A in the entorhinal cortex and periaqueductal grey in a genetic animal model of depression: implications for the pathophysiology of depression

    Husum, H., Wörtwein, Gitta, Andersson, W., Bolwig, T. G. & Mathé, A. A., 2008, In: International Journal of Neuropsychopharmacology. 11, 1, p. 93-101 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels

    Reddy, I. A., Pino, J. A., Weikop, Pia, Osses, N., Sørensen, G., Bering, T., Valle, C., Bluett, R. J., Erreger, K., Wörtwein, Gitta, Reyes, J. G., Graham, D., Stanwood, G. D., Hackett, T. A., Patel, S., Fink-Jensen, Anders, Torres, G. E. & Galli, A., 2016, In: Translational Psychiatry. 6, 11 p., e809.

    Research output: Contribution to journalJournal articleResearchpeer-review

  44. Published

    INACTIVATION OF THE CHOLINERGIC M4 RECEPTOR RESULTS IN THE DEVELOPMENT OF A LOW ANXIETY ENDOPHENOTYPE PREDICTING FUTURE ALCOHOL CONSUMPTION

    Dencker, D., Wörtwein, Gitta, Lysne, C., Weikop, Pia, Fink-Jensen, Anders & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i57-i58 2 p., P-49.

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  45. Published

    Inactivation of the cholinergic M4 receptor results in a disinhibited endophenotype predicting alcohol use

    Molander, A., Thorbek, D. D., Lysne, C., Weikop, Pia, Fink-Jensen, Anders & Wörtwein, Gitta, 2022, In: Behavioural Brain Research. 430, 10 p., 113921.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Increased adult hippocampal brain-derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats

    Greisen, M. H., Altar, C. A., Bolwig, T. G., Whitehead, R. E. & Wörtwein, Gitta, 2005, In: Journal of Neuroscience Research. 79/6, p. 772-778

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Increased amphetamine-induced locomotor activity, sensitization, and accumbal dopamine release in M5 muscarinic receptor knockout mice

    Schmidt, L. S., Miller, A. D., Lester, D. B., Bay-Richter, C., Schülein, C., Frikke-Schmidt, H., Wess, J., Blaha, C. D., Woldbye, David Paul Drucker, Fink-Jensen, Anders & Wörtwein, Gitta, 2010, In: Psychopharmacology. 207, 4, p. 547-58 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Increased cocaine self-administration in M4 muscarinic acetylcholine receptor knockout mice.

    Schmidt, L. S., Thomsen, M., Weikop, Pia, Nielsen, D. D., Wess, J., Woldbye, David Paul Drucker, Wörtwein, Gitta & Fink-Jensen, Anders, 2011, In: Psychopharmacology. 216, 3, p. 367-378 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Increased dopaminergic activity in socially isolated rats: an electrophysiological study

    Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, Gitta, Steiniger-Brach, B., Sotty, F., Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, G., Steiniger-Brach, B. & Sotty, F., 27 Sep 2010, In: Neuroscience Letters. 482, 2, p. 117-22 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    Increased numbers of orexin/hypocretin neurons in a genetic rat depression model

    Mikrouli, E., Wörtwein, Gitta, Soylu, R., Mathé, A. A. & Petersén, Å., 2011, In: Neuropeptides (Sheffield). 45, 6, p. 401-6 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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