Frederik Vilhardt
Associate Professor
- 2023
- Published
Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors
Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, Stig, Tuelung, P. S., Narayanan, Dilip, Langkilde, Annette Eva, Gajhede, Michael, Pagano, P. J., Jaquet, V., Vilhardt, Frederik & Bach, Anders, 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005Research output: Contribution to journal › Journal article › peer-review
- Published
Translocator protein (TSPO) expression in neoplastic cells and tumor-associated macrophages in meningiomas
Blum, Nadja Ayo Denna, Mirian, C., Maier, A. D., Mathiesen, Tiit Illimar, Vilhardt, Frederik & Haslund-Vinding, Jeppe Lohfert, 2023, In: Journal of Neuropathology and Experimental Neurology. 82, 12, p. 1020-1032 13 p.Research output: Contribution to journal › Journal article › peer-review
- 2022
- Published
Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure
Oernbo, E. K., Steffensen, Annette Buur, Khamesi, P. R., Toft-Bertelsen, Trine Lisberg, Barbuskaite, Dagne, Vilhardt, Frederik, Gerkau, N. J., Tritsaris, Katerina, Simonsen, A. H., Lolansen, Sara Diana, Andreassen, Søren Norge, Hasselbalch, Steen, Zeuthen, Thomas, Rose, C. R., Kurtcuoglu, V. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 25 p., 65.Research output: Contribution to journal › Journal article › peer-review
- Published
Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters
Lolansen, Sara Diana, Rostgaard, Nina, Barbuskaite, Dagne, Capion, T., Olsen, M. H., Norager, N. H., Vilhardt, Frederik, Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Ye, F., Juhler, Marianne, Keep, R. F. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 62.Research output: Contribution to journal › Journal article › peer-review
- Published
The role of systemic inflammatory cells in meningiomas
Haslund-Vinding, J., Møller, J. R., Ziebell, M., Vilhardt, Frederik & Mathiesen, Tiit Illimar, 2022, In: Neurosurgical Review. 45, p. 1205–1215Research output: Contribution to journal › Review › peer-review
- Published
α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α
Madsen, Helena Borland, Rasmussen, Izabela Zorawska, Bjerregaard-Andersen, K., Rasmussen, M., Olsen, A. & Vilhardt, Frederik, 2022, In: The Journal of Biological Chemistry. 298, 11, 20 p., 102531.Research output: Contribution to journal › Journal article › peer-review
- 2021
- Published
Meningioma–brain crosstalk: A scoping review
de Stricker Borch, J., Haslund-Vinding, Jeppe Lohfert, Vilhardt, Frederik, Maier, A. D. & Mathiesen, Tiit Illimar, 2021, In: Cancers. 13, 17, 4267.Research output: Contribution to journal › Review › peer-review
- Published
Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?
Duque Villegas, Luisana Carolina, Nørremølle, Anne, Freude, Kristine & Vilhardt, Frederik, 2021, In: Frontiers in Aging Neuroscience. 13, 20 p., 736734.Research output: Contribution to journal › Review › peer-review
- Published
Novel and converging ways of NOX2 and SOD3 in trafficking and redox signaling in macrophages
Petersen, S. V., Poulsen, Nanna Bach, Matthiesen, C. L. & Vilhardt, Frederik, 2021, In: Antioxidants. 10, 2, p. 1-16 16 p., 172.Research output: Contribution to journal › Review › peer-review
- Published
The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus
Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.Research output: Contribution to journal › Journal article › peer-review
- 2019
- Published
Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration
Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512Research output: Contribution to journal › Journal article › peer-review
- Published
The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response
Hu, L., Zachariae, E. D., Larsen, U. G., Vilhardt, Frederik & Petersen, S. V., 2019, In: Redox Biology. 26, 9 p., 101268.Research output: Contribution to journal › Journal article › peer-review
- 2018
- Published
The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
Rasmussen, K. K., Skat-Rørdam, Josephine, Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, Frederik, Pedersen, Lotte Bang, Wrana, J. L., Anderson, R. H., Møllgård, Kjeld, Christensen, Søren Tvorup & Larsen, Lars Allan, 2018, In: Scientific Reports. 8, 1, 14 p., 9542.Research output: Contribution to journal › Journal article › peer-review
- 2017
- Published
Microglia antioxidant systems and redox signaling
Vilhardt, Frederik, Haslund-Vinding, Jeppe Lohfert, Jaquet, V. & McBean, G., Jun 2017, In: British Journal of Pharmacology. 174, 12, p. 1719-1732 14 p.Research output: Contribution to journal › Review › peer-review
- Published
NADPH oxidases in Microglia oxidant production: Activating Receptors, Pharmacology, and Association with Disease
Haslund-Vinding, Jeppe Lohfert, McBean, G., Jaquet, V. & Vilhardt, Frederik, Jun 2017, In: British Journal of Pharmacology. 174, 12, p. 1733-1749 17 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds
Borland, H. & Vilhardt, Frederik, 2017, In: International Journal of Molecular Sciences (Online). 18, 1, 227.Research output: Contribution to journal › Review › peer-review
- Published
Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
Rahbek-Clemmensen, T., Lycas, M. D., Erlendsson, Simon, Eriksen, J., Apuschkin, Mia, Vilhardt, Frederik, Jorgensen, T. N., Herborg, Freja & Gether, Ulrik, 2017, In: Nature Communications. 8, 14 p., 740.Research output: Contribution to journal › Journal article › peer-review
- Published
The α2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation
Stoica, A., Larsen, B. R., Assentoft, M., Holm, R., Holt, L. M., Vilhardt, Frederik, Vilsen, B., Lykke-Hartmann, K., Olsen, M. L. & MacAulay, Nanna, 2017, In: Glia. 65, 11, p. 1777-1793 17 p.Research output: Contribution to journal › Journal article › peer-review
- 2016
- Published
Reciprocal signals between microglia and neurons regulate alpha-synuclein secretion by exophagy through a neuronal cJU-N-Nterminal kinase-signaling axis
Christensen, D. P., Ejlerskov, P., Rasmussen, Izabela Zorawska & Vilhardt, Frederik, 8 Mar 2016, In: Journal of Neuroinflammation. 13, 21 p., 59.Research output: Contribution to journal › Journal article › peer-review
- 2015
- Published
Macropinocytosis is the Entry Mechanism of Amphotropic Murine Leukemia Virus
Rasmussen, Izabela Zorawska & Vilhardt, Frederik, Feb 2015, In: Journal of Virology. 89, 3, p. 1851-1866 16 p.Research output: Contribution to journal › Journal article › peer-review
- 2013
- Published
Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion
Ejlerskov, P., Rasmussen, Izabela Zorawska, Nielsen, T. T., Bergström, A., Tohyama, Y., Jensen, P. H. & Vilhardt, Frederik, 14 Jun 2013, In: The Journal of Biological Chemistry. 288, 24, p. 17313-35 23 p.Research output: Contribution to journal › Journal article › peer-review
- 2012
- Published
NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages
Ejlerskov, P., Christensen, D. P., Beyaie, D., Burritt, J. B., Paclet, M., Gorlach, A., van Deurs, B. & Vilhardt, Frederik, Feb 2012, In: Journal of Biological Chemistry. 287, 7, p. 4835-52 18 p.Research output: Contribution to journal › Journal article › peer-review
- 2011
- Published
Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats
Hultqvist, M., Sareila, O., Vilhardt, Frederik, Norin, U., Olsson, L. M., Olofsson, P., Hellman, U. & Holmdahl, R., 15 Jun 2011, In: Antioxidants & Redox Signaling. 14, 12, p. 2373-83 11 p.Research output: Contribution to journal › Journal article › peer-review
- 2010
- Published
Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells
Parhamifar, L., Sime, W., Yudina, Y., Vilhardt, Frederik, Mörgelin, M. & Sjölander, A., 1 Dec 2010, In: PLoS ONE. 5, 12, p. e14439Research output: Contribution to journal › Journal article › peer-review
- Published
Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia
Rasmussen, Izabela Zorawska, Pedersen, L. H., Byg, L., Suzuki, K., Sumimoto, H. & Vilhardt, Frederik, 1 Sep 2010, In: B M C Immunology. 11, p. 44Research output: Contribution to journal › Journal article › peer-review
- 2008
- Published
Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis.
Roepstorff, K., Rasmussen, Izabela Zorawska, Sawada, M., Cudre-Maroux, C., Salmon, P., Bokoch, G., van Deurs, B. & Vilhardt, Frederik, 2008, In: Journal of Biological Chemistry. 283, 12, p. 7983-93 10 p.Research output: Contribution to journal › Journal article › peer-review
- 2006
- Published
The role of caveolae and noncaveolar rafts in endocytosis
van Deurs, B., Vilhardt, Frederik, Torgersen, M., Roepstorff, K., Hommelgaard, A. M. & Sandvig, K., 2006, Lipid Rafts and caveolae. Wiley-VCH, p. 69-89Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
- 2005
- Published
Caveolae: Stable Membrane Domains with a Potential for Internalization
Hommelgaard, A. M., Roepstorff, K., Vilhardt, Frederik, Torgersen, M. L., Sandvig, K. & van Deurs, B., 2005, In: Traffic. 6, 9, p. 720-724Research output: Contribution to journal › Journal article › peer-review
- Published
Microglia: phagocyte and glia cell
Vilhardt, Frederik, 2005, In: International Journal of Biochemistry & Cell Biology. 37, p. 17-21Research output: Contribution to journal › Journal article › peer-review
- Published
Retroviral display of urokinase-binding domain fused to amphotropic envelope protein
Boucquey, A., Vilhardt, Frederik, Franco, D., Weber, A. & Horellou, P., 2005, In: Biochemical and Biophysical Research Communications. 331, p. 1485-1493Research output: Contribution to journal › Journal article › peer-review
- 2004
- Published
The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly
Vilhardt, Frederik & van Deurs, B., 2004, In: EMBO Journal. 23, p. 739-748Research output: Contribution to journal › Journal article › peer-review
- 2002
- Published
The HIV-1 Nef protein and phagocyte NADPH oxidase activation
Vilhardt, Frederik, Plastre, O., Sawada, M., Suzuki, K., Wiznerowicz, M., Kiyokawa, E., Trono, D. & Krause, K., 1 Nov 2002, In: Journal of Biological Chemistry. 277, 44, p. 42136-43 8 p.Research output: Contribution to journal › Journal article › peer-review
- 2000
- Published
Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor
Nicoziani, P., Vilhardt, Frederik, Llorente, A., Hilout, L., Courtoy, P. J., Sandvig, K. & van Deurs, B., 2000, In: Molecular Biology of the Cell. 11, p. 481-495Research output: Contribution to journal › Journal article › peer-review
- 1999
- Published
Extraction of cholesterol with methyl-β-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
Rodal, S. K., Skretting, G., Garred, Ø., Vilhardt, Frederik, van Deurs, B. & Sandvig, K., 1999, In: Mol Biol Cell. Vol 10, p. 961-974Research output: Contribution to journal › Journal article › peer-review
- Published
Urokinase-type plasminogen activator receptor is internalized by different mechanisms in polarized and nonpolarized Madin-Darby canine kidney epithelial cells
Vilhardt, Frederik, Nielsen, M., Sandvig, K. & van Deurs, B., 1999, In: Molecular Biology of the Cell. Vol 10, p. 179-195Research output: Contribution to journal › Journal article › peer-review
ID: 9230
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307
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Reciprocal signals between microglia and neurons regulate alpha-synuclein secretion by exophagy through a neuronal cJU-N-Nterminal kinase-signaling axis
Research output: Contribution to journal › Journal article › peer-review
Published -
278
downloads
Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
Research output: Contribution to journal › Journal article › peer-review
Published -
162
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Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds
Research output: Contribution to journal › Review › peer-review
Published