Frederik Vilhardt

Frederik Vilhardt

Associate Professor


  1. 2023
  2. Published

    Targeting NOX2 with Bivalent Small-Molecule p47phox-p22phox Inhibitors

    Zang, J., Peters, F., Cambet, Y., Cifuentes-Pagano, E., Hissabu, M. M. S., Dustin, C. M., Svensson, L. H., Olesen, M. M., Poulsen, M. F. L., Jacobsen, Stig, Tuelung, P. S., Narayanan, Dilip, Langkilde, Annette Eva, Gajhede, Michael, Pagano, P. J., Jaquet, V., Vilhardt, Frederik & Bach, Anders, 2023, In: Journal of Medicinal Chemistry. 66, 21, p. 14963–15005

    Research output: Contribution to journalJournal articlepeer-review

  3. Published

    Translocator protein (TSPO) expression in neoplastic cells and tumor-associated macrophages in meningiomas

    Blum, Nadja Ayo Denna, Mirian, C., Maier, A. D., Mathiesen, Tiit Illimar, Vilhardt, Frederik & Haslund-Vinding, Jeppe Lohfert, 2023, In: Journal of Neuropathology and Experimental Neurology. 82, 12, p. 1020-1032 13 p.

    Research output: Contribution to journalJournal articlepeer-review

  4. 2022
  5. Published

    Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

    Oernbo, E. K., Steffensen, Annette Buur, Khamesi, P. R., Toft-Bertelsen, Trine Lisberg, Barbuskaite, Dagne, Vilhardt, Frederik, Gerkau, N. J., Tritsaris, Katerina, Simonsen, A. H., Lolansen, Sara Diana, Andreassen, Søren Norge, Hasselbalch, Steen, Zeuthen, Thomas, Rose, C. R., Kurtcuoglu, V. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 25 p., 65.

    Research output: Contribution to journalJournal articlepeer-review

  6. Published

    Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters

    Lolansen, Sara Diana, Rostgaard, Nina, Barbuskaite, Dagne, Capion, T., Olsen, M. H., Norager, N. H., Vilhardt, Frederik, Andreassen, Søren Norge, Toft-Bertelsen, Trine Lisberg, Ye, F., Juhler, Marianne, Keep, R. F. & MacAulay, Nanna, 2022, In: Fluids and Barriers of the CNS. 19, 1, 19 p., 62.

    Research output: Contribution to journalJournal articlepeer-review

  7. Published

    The role of systemic inflammatory cells in meningiomas

    Haslund-Vinding, J., Møller, J. R., Ziebell, M., Vilhardt, Frederik & Mathiesen, Tiit Illimar, 2022, In: Neurosurgical Review. 45, p. 1205–1215

    Research output: Contribution to journalReviewpeer-review

  8. Published

    α-synuclein buildup is alleviated via ESCRT-dependent endosomal degradation brought about by p38MAPK inhibition in cells expressing p25α

    Madsen, Helena Borland, Rasmussen, Izabela Zorawska, Bjerregaard-Andersen, K., Rasmussen, M., Olsen, A. & Vilhardt, Frederik, 2022, In: The Journal of Biological Chemistry. 298, 11, 20 p., 102531.

    Research output: Contribution to journalJournal articlepeer-review

  9. 2021
  10. Published

    Meningioma–brain crosstalk: A scoping review

    de Stricker Borch, J., Haslund-Vinding, Jeppe Lohfert, Vilhardt, Frederik, Maier, A. D. & Mathiesen, Tiit Illimar, 2021, In: Cancers. 13, 17, 4267.

    Research output: Contribution to journalReviewpeer-review

  11. Published

    Nicotinamide Adenine Dinucleotide Phosphate Oxidases Are Everywhere in Brain Disease, but Not in Huntington’s Disease?

    Duque Villegas, Luisana Carolina, Nørremølle, Anne, Freude, Kristine & Vilhardt, Frederik, 2021, In: Frontiers in Aging Neuroscience. 13, 20 p., 736734.

    Research output: Contribution to journalReviewpeer-review

  12. Published

    Novel and converging ways of NOX2 and SOD3 in trafficking and redox signaling in macrophages

    Petersen, S. V., Poulsen, Nanna Bach, Matthiesen, C. L. & Vilhardt, Frederik, 2021, In: Antioxidants. 10, 2, p. 1-16 16 p., 172.

    Research output: Contribution to journalReviewpeer-review

  13. Published

    The C-terminal peptide of CCL21 drastically augments CCL21 activity through the dendritic cell lymph node homing receptor CCR7 by interaction with the receptor N-terminus

    Jørgensen, Astrid Sissel, Brandum, E. P., Mikkelsen, J. M., Orfin, K. A., Boilesen, D. R., Egerod, Kristoffer Lihme, Moussouras, N. A., Vilhardt, Frederik, Kalinski, P., Basse, P., Chen, Yen-Hsi, Yang, Zhang, Dwinell, M. B., Volkman, B. F., Veldkamp, C. T., Holst, Peter Johannes, Lahl, K., Goth, C. K., Rosenkilde, Mette & Hjortø, Gertrud Malene, 2021, In: Cellular and Molecular Life Sciences. 78, p. 6963-6978 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  14. 2019
  15. Published

    Evaluating the involvement of cerebral microvascular endothelial Na+/K+-ATPase and Na+-K+-2Cl- co-transporter in electrolyte fluxes in an in vitro blood-brain barrier model of dehydration

    Lykke, K., Assentoft, M., Hørlyck, S., Helms, H. C. C., Stoica, A., Toft-Bertelsen, Trine Lisberg, Tritsaris, Katerina, Vilhardt, Frederik, Larsen, Birger Brodin & MacAulay, Nanna, 2019, In: Journal of Cerebral Blood Flow and Metabolism. 39, 3, p. 497-512

    Research output: Contribution to journalJournal articlepeer-review

  16. Published

    The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response

    Hu, L., Zachariae, E. D., Larsen, U. G., Vilhardt, Frederik & Petersen, S. V., 2019, In: Redox Biology. 26, 9 p., 101268.

    Research output: Contribution to journalJournal articlepeer-review

  17. 2018
  18. Published

    The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development

    Rasmussen, K. K., Skat-Rørdam, Josephine, Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, Frederik, Pedersen, Lotte Bang, Wrana, J. L., Anderson, R. H., Møllgård, Kjeld, Christensen, Søren Tvorup & Larsen, Lars Allan, 2018, In: Scientific Reports. 8, 1, 14 p., 9542.

    Research output: Contribution to journalJournal articlepeer-review

  19. 2017
  20. Published

    Microglia antioxidant systems and redox signaling

    Vilhardt, Frederik, Haslund-Vinding, Jeppe Lohfert, Jaquet, V. & McBean, G., Jun 2017, In: British Journal of Pharmacology. 174, 12, p. 1719-1732 14 p.

    Research output: Contribution to journalReviewpeer-review

  21. Published

    NADPH oxidases in Microglia oxidant production: Activating Receptors, Pharmacology, and Association with Disease

    Haslund-Vinding, Jeppe Lohfert, McBean, G., Jaquet, V. & Vilhardt, Frederik, Jun 2017, In: British Journal of Pharmacology. 174, 12, p. 1733-1749 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  22. Published

    Prelysosomal Compartments in the Unconventional Secretion of Amyloidogenic Seeds

    Borland, H. & Vilhardt, Frederik, 2017, In: International Journal of Molecular Sciences (Online). 18, 1, 227.

    Research output: Contribution to journalReviewpeer-review

  23. Published

    Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

    Rahbek-Clemmensen, T., Lycas, M. D., Erlendsson, Simon, Eriksen, J., Apuschkin, Mia, Vilhardt, Frederik, Jorgensen, T. N., Herborg, Freja & Gether, Ulrik, 2017, In: Nature Communications. 8, 14 p., 740.

    Research output: Contribution to journalJournal articlepeer-review

  24. Published

    The α2β2 isoform combination dominates the astrocytic Na+/K+-ATPase activity and is rendered nonfunctional by the α2.G301R familial hemiplegic migraine type 2-associated mutation

    Stoica, A., Larsen, B. R., Assentoft, M., Holm, R., Holt, L. M., Vilhardt, Frederik, Vilsen, B., Lykke-Hartmann, K., Olsen, M. L. & MacAulay, Nanna, 2017, In: Glia. 65, 11, p. 1777-1793 17 p.

    Research output: Contribution to journalJournal articlepeer-review

  25. 2016
  26. Published

    Reciprocal signals between microglia and neurons regulate alpha-synuclein secretion by exophagy through a neuronal cJU-N-Nterminal kinase-signaling axis

    Christensen, D. P., Ejlerskov, P., Rasmussen, Izabela Zorawska & Vilhardt, Frederik, 8 Mar 2016, In: Journal of Neuroinflammation. 13, 21 p., 59.

    Research output: Contribution to journalJournal articlepeer-review

  27. 2015
  28. Published

    Macropinocytosis is the Entry Mechanism of Amphotropic Murine Leukemia Virus

    Rasmussen, Izabela Zorawska & Vilhardt, Frederik, Feb 2015, In: Journal of Virology. 89, 3, p. 1851-1866 16 p.

    Research output: Contribution to journalJournal articlepeer-review

  29. 2013
  30. Published

    Tubulin Polymerization-promoting Protein (TPPP/p25α) Promotes Unconventional Secretion of α-Synuclein through Exophagy by Impairing Autophagosome-Lysosome Fusion

    Ejlerskov, P., Rasmussen, Izabela Zorawska, Nielsen, T. T., Bergström, A., Tohyama, Y., Jensen, P. H. & Vilhardt, Frederik, 14 Jun 2013, In: The Journal of Biological Chemistry. 288, 24, p. 17313-35 23 p.

    Research output: Contribution to journalJournal articlepeer-review

  31. 2012
  32. Published

    NADPH oxidase is internalized by clathrin-coated pits and localizes to a Rab27A/B GTPase-regulated secretory compartment in activated macrophages

    Ejlerskov, P., Christensen, D. P., Beyaie, D., Burritt, J. B., Paclet, M., Gorlach, A., van Deurs, B. & Vilhardt, Frederik, Feb 2012, In: Journal of Biological Chemistry. 287, 7, p. 4835-52 18 p.

    Research output: Contribution to journalJournal articlepeer-review

  33. 2011
  34. Published

    Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats

    Hultqvist, M., Sareila, O., Vilhardt, Frederik, Norin, U., Olsson, L. M., Olofsson, P., Hellman, U. & Holmdahl, R., 15 Jun 2011, In: Antioxidants & Redox Signaling. 14, 12, p. 2373-83 11 p.

    Research output: Contribution to journalJournal articlepeer-review

  35. 2010
  36. Published

    Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells

    Parhamifar, L., Sime, W., Yudina, Y., Vilhardt, Frederik, Mörgelin, M. & Sjölander, A., 1 Dec 2010, In: PLoS ONE. 5, 12, p. e14439

    Research output: Contribution to journalJournal articlepeer-review

  37. Published

    Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia

    Rasmussen, Izabela Zorawska, Pedersen, L. H., Byg, L., Suzuki, K., Sumimoto, H. & Vilhardt, Frederik, 1 Sep 2010, In: B M C Immunology. 11, p. 44

    Research output: Contribution to journalJournal articlepeer-review

  38. 2008
  39. Published

    Stimulus-dependent regulation of the phagocyte NADPH oxidase by a VAV1, Rac1, and PAK1 signaling axis.

    Roepstorff, K., Rasmussen, Izabela Zorawska, Sawada, M., Cudre-Maroux, C., Salmon, P., Bokoch, G., van Deurs, B. & Vilhardt, Frederik, 2008, In: Journal of Biological Chemistry. 283, 12, p. 7983-93 10 p.

    Research output: Contribution to journalJournal articlepeer-review

  40. 2006
  41. Published

    The role of caveolae and noncaveolar rafts in endocytosis

    van Deurs, B., Vilhardt, Frederik, Torgersen, M., Roepstorff, K., Hommelgaard, A. M. & Sandvig, K., 2006, Lipid Rafts and caveolae. Wiley-VCH, p. 69-89

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

  42. 2005
  43. Published

    Caveolae: Stable Membrane Domains with a Potential for Internalization

    Hommelgaard, A. M., Roepstorff, K., Vilhardt, Frederik, Torgersen, M. L., Sandvig, K. & van Deurs, B., 2005, In: Traffic. 6, 9, p. 720-724

    Research output: Contribution to journalJournal articlepeer-review

  44. Published

    Microglia: phagocyte and glia cell

    Vilhardt, Frederik, 2005, In: International Journal of Biochemistry & Cell Biology. 37, p. 17-21

    Research output: Contribution to journalJournal articlepeer-review

  45. Published

    Retroviral display of urokinase-binding domain fused to amphotropic envelope protein

    Boucquey, A., Vilhardt, Frederik, Franco, D., Weber, A. & Horellou, P., 2005, In: Biochemical and Biophysical Research Communications. 331, p. 1485-1493

    Research output: Contribution to journalJournal articlepeer-review

  46. 2004
  47. Published

    The phagocyte NADPH oxidase depends on cholesterol-enriched membrane microdomains for assembly

    Vilhardt, Frederik & van Deurs, B., 2004, In: EMBO Journal. 23, p. 739-748

    Research output: Contribution to journalJournal articlepeer-review

  48. 2002
  49. Published

    The HIV-1 Nef protein and phagocyte NADPH oxidase activation

    Vilhardt, Frederik, Plastre, O., Sawada, M., Suzuki, K., Wiznerowicz, M., Kiyokawa, E., Trono, D. & Krause, K., 1 Nov 2002, In: Journal of Biological Chemistry. 277, 44, p. 42136-43 8 p.

    Research output: Contribution to journalJournal articlepeer-review

  50. 2000
  51. Published

    Role for dynamin in late endosome dynamics and trafficking of the cation-independent mannose 6-phosphate receptor

    Nicoziani, P., Vilhardt, Frederik, Llorente, A., Hilout, L., Courtoy, P. J., Sandvig, K. & van Deurs, B., 2000, In: Molecular Biology of the Cell. 11, p. 481-495

    Research output: Contribution to journalJournal articlepeer-review

  52. 1999
  53. Published

    Extraction of cholesterol with methyl-β-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles

    Rodal, S. K., Skretting, G., Garred, Ø., Vilhardt, Frederik, van Deurs, B. & Sandvig, K., 1999, In: Mol Biol Cell. Vol 10, p. 961-974

    Research output: Contribution to journalJournal articlepeer-review

  54. Published

    Urokinase-type plasminogen activator receptor is internalized by different mechanisms in polarized and nonpolarized Madin-Darby canine kidney epithelial cells

    Vilhardt, Frederik, Nielsen, M., Sandvig, K. & van Deurs, B., 1999, In: Molecular Biology of the Cell. Vol 10, p. 179-195

    Research output: Contribution to journalJournal articlepeer-review

ID: 9230