Flemming Steen Jørgensen
Professor
Structural Biology
Universitetsparken 2
2100 København Ø
- 2009
- Published
Discovery of ligands for the human intestinal di-/tripeptide transporter (hPEPT1) using af QSAR-assisted virtual screening strategy
Larsen, S. B., Omkvist, D. H., Larsen, Birger Brodin, Nielsen, C. U., Steffansen, B., Olsen, L. & Jørgensen, Flemming Steen, 2009, In: ChemMedChem. 4, 9, p. 1439-1445Research output: Contribution to journal › Journal article › peer-review
- Published
Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands
Poongavanam, V., Hritz, J., Taboureau, O., Olsen, L., Jørgensen, Flemming Steen, Vermeulen, N. P. E. & Oostenbrink, C., 2009, In: Journal of Chemical Information and Modeling. 49, 1, p. 43-52Research output: Contribution to journal › Journal article › peer-review
- 2008
- Published
QSAR models for the human H+/peptide symporter, hPEPT1: Affinity prediction using alignment-independent descriptors
Larsen, S. B., Jørgensen, Flemming Steen & Olsen, L., 2008, In: Journal of Chemical Information and Modeling. 48, 1, p. 233-241Research output: Contribution to journal › Journal article › peer-review
- Published
Risiko for hjerteflimmer afsløres med computermodel
Taboureau, O., Brunak, S. & Jørgensen, Flemming Steen, 2008, In: Lægemiddelforskning. p. 31-33Research output: Contribution to journal › Journal article
- Published
Small angle X-ray scattering study of calreticulin reveals conformational plasticity
Toft, K. N., Larsen, N., Jørgensen, Flemming Steen, Højrup, P., Houen, G. & Vestergaard, Bente, 2008, In: BBA General Subjects. 1784, 9, p. 1265-1270Research output: Contribution to journal › Journal article › peer-review
- Published
Solvent diversity in polymorph screening
Allesø, M., van der Berg, Franciscus Winfried J, Cornett, Claus, Jørgensen, Flemming Steen, Halling-Sørensen, B., Lopez de Diego, H., Hovgaard, L., Aaltonen, J. & Rantanen, Jukka, 2008, In: Journal of Pharmaceutical Sciences. 97, 6, p. 2145-2159Research output: Contribution to journal › Journal article › peer-review
- 2007
- Published
Computational prediction of solubilizers' effect on partitioning
Høst, J., Christensen, I. T., Jørgensen, Flemming Steen, Frøkjær, Sven & Hovgaard, L., 2007, In: Internation Journal of Pharmaceutics. 329, 1-2, p. 46-52Research output: Contribution to journal › Journal article › peer-review
- Published
Determination of protein conformation by isotopically labelled cross-linking and dedicated software: Application to the chaperone, calreticulin
Nielsen, T., Thaysen-Andersen, M., Larsen, N., Jørgensen, Flemming Steen, Houen, G. & Højrup, P., 2007, In: International Journal of Mass Spectrometry. 268, 2-3, p. 217-226Research output: Contribution to journal › Journal article › peer-review
- Published
Study on the binding of Thioflavin T to ß-sheet-rich and non-ß-sheet cavities
Jensen, M. G., Olsen, L., van de Weert, Marco, Flink, J. M., Frøkjær, Sven & Jørgensen, Flemming Steen, 2007, In: Journal of Structural Biology. 158, 3, p. 358-369Research output: Contribution to journal › Journal article › peer-review
- 2006
- Published
Development of a QSAR model for binding of tripeptides and tripeptidomimetics to the human intestinal di-/tripeptide transporter hPEPT1
Andersen, R., Jørgensen, Flemming Steen, Olsen, L., Våbenø, J., Thorn, K., Nielsen, C. U. & Steffansen, B., 2006, In: Pharmaceutical Research. 23, 3, p. 483-92 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Hvad har varme at gøre med lægemidler?
Olsen, L., Kasper, C., Kastrup, Jette Sandholm Jensen, Gajhede, Michael & Jørgensen, Flemming Steen, 2006, In: Lægemiddelforskning. p. 31-33Research output: Contribution to journal › Journal article
- Published
Identification of a gene on chromosome 12q22 uniquely overexpressed in chronic lymphocytic leukemia
Buhl, A. M., Jurlander, J., Jørgensen, Flemming Steen, Ottesen, A. M., Cowland, J. B., Gjerdrum, L. M., Hansen, B. V. & Leffers, H., 2006, In: Blood. 107, 7, p. 2904-11 8 p.Research output: Contribution to journal › Journal article › peer-review
- Published
In vitro evaluation of N-methyl amide tripeptidomimetics as substrates for the human intestinal di-/tri-peptide transporter hPEPT1
Andersen, R., Nielsen, C. U., Begtrup, M., Jørgensen, Flemming Steen, Larsen, Birger Brodin, Frøkjær, Sven & Steffansen, B., 2006, In: European Journal of Pharmaceutical Sciences. 28, 4, p. 325-35 11 p.Research output: Contribution to journal › Journal article › peer-review
- Published
New leads of metallo-beta-lactamase inhibitors from structure-based pharmacophore design
Olsen, L., Jost, S., Adolph, H., Pettersson, I., Hemmingsen, Lars Bo Stegeager & Jørgensen, Flemming Steen, 2006, In: Bioorganic & Medicinal Chemistry. 14, 8, p. 2627-2635 9 p.Research output: Contribution to journal › Journal article › peer-review
- 2005
- Published
Conformational restrictions in ligand binding to the human intestinal di-/tripeptide transporter: implications for design of hPEPT1 targeted prodrugs
Våbenø, J., Nielsen, C. U., Steffansen, B., Lejon, T., Sylte, I., Jørgensen, Flemming Steen & Luthman, K., 2005, In: Bioorganic & Medicinal Chemistry. 13, 6, p. 1977-88 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Forudsigelser med hjælp fra det virtuelle rum
Andersen, R., Steffansen, B., Jørgensen, Flemming Steen & Nielsen, C. U., 2005, In: Lægemiddelforskning. p. 24-25Research output: Contribution to journal › Journal article
- Published
Prediction methods and databases within chemoinformatics: emphasis on drugs and drug candidates
Jónsdóttir, S. O., Jørgensen, Flemming Steen & Brunak, Søren, 2005, In: Bioinformatics. 21, 10, p. 2145-60 16 p.Research output: Contribution to journal › Journal article › peer-review
- 2004
- Published
Computeren kan forudsige lægemidlers omdannelse
Olsen, L., Bergmann, R. & Jørgensen, Flemming Steen, 2004, In: Lægemiddelforskning 2004.Research output: Contribution to journal › Journal article
- Published
Docking and scoring of metallo-beta-lactamases inhibitors
Olsen, L., Pettersson, I., Hemmingsen, L., Adolph, H. & Jørgensen, Flemming Steen, 2004, In: Journal of Computer - Aided Molecular Design. 18, 4, p. 287-302 16 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones
Kunick, C., Lauenroth, K., Wieking, K., Xie, X., Schultz, C., Gussio, R., Zaharevitz, D., Leost, M., Meijer, L., Weber, A., Jørgensen, Flemming Steen & Lemcke, T., 2004, In: Journal of Medicinal Chemistry. 47, 1, p. 22-36 15 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Homology building as a means to define antigenic epitopes on dihydrofolate reductase (DHFR) from Plasmodium falciparum
Alifrangis, Michael, Christensen, I. T., Jørgensen, Flemming Steen, Rønn, A. M., Weng, J. E., Chen, M., Bygbjerg, Ib Christian, Sirawaraporn, W., Palarasah, Y. & Koch, C., 2004, In: Malaria Journal. 3, p. 16Research output: Contribution to journal › Journal article › peer-review
- Published
Isolation of a library of aromadendranes from Landolphia dulcis and its characterization using the VolSurf approach
Stærk, Dan, Skole, B., Jørgensen, Flemming Steen, Budnik, B. A., Ekpe, P. & Jaroszewski, J. W., 2004, In: Journal of Natural Products. 67, 5, p. 799-805 7 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structural analysis of CYP2C9 and CYP2C5 and an evaluation of commonly used molecular modeling techniques
Afzelius, L., Raubacher, F., Karlén, A., Jørgensen, Flemming Steen, Andersson, T. B., Masimirembwa, C. M. & Zamora, I., 2004, In: Drug Metabolism and Disposition. 32, 11, p. 1218-29 12 p.Research output: Contribution to journal › Journal article › peer-review
- 2002
- Published
Human peptide transporters: Therapeutic applications
Nielsen, C. U., Larsen, Birger Brodin, Jørgensen, Flemming Steen, Frøkjær, Sven & Steffansen, B., 1 Sep 2002, In: Expert Opinion on Therapeutic Patents. 12, 9, p. 1329-1350 22 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Assessing the relative importance of the biophysical properties of amino acid substitutions associated with human genetic disease
Terp, B. N., Cooper, D. N., Christensen, I. T., Jørgensen, Flemming Steen, Bross, P. G., Gregersen, Niels Henrik & Krawczak, M., 2002, In: Human Mutation. 20, 2, p. 98-109 12 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structural differences of matrix metalloproteinases with potential implications for inhibitor selectivity examined by the GRID/CPCA approach
Terp, G. E., Cruciani, G., Christensen, I. T. & Jørgensen, Flemming Steen, 2002, In: Journal of Medicinal Chemistry. 45, 13, p. 2675-84 10 p.Research output: Contribution to journal › Journal article › peer-review
- 2001
- Published
A new concept for multidimensional selection of ligand conformations (MultiSelect) and multidimensional scoring (MultiScore) of protein-ligand binding affinities
Terp, G. E., Johansen, B. N., Christensen, I. T. & Jørgensen, Flemming Steen, 2001, In: Journal of Medicinal Chemistry. 44, 14, p. 2333-43 11 p.Research output: Contribution to journal › Journal article › peer-review
- 2000
- Published
Structural differences of matrix metalloproteinases. Homology modeling and energy minimization of enzyme-substrate complexes
Terp, G. E., Christensen, I. T. & Jørgensen, Flemming Steen, 2000, In: Journal of Biomolecular Structure & Dynamics. 17, 6, p. 933-46 14 p.Research output: Contribution to journal › Journal article › peer-review
- 1999
- Published
Towards an understanding of drug resistance in malaria: three-dimensional structure of Plasmodium falciparum dihydrofolate reductase by homology building
Lemcke, T., Christensen, I. T. & Jørgensen, Flemming Steen, 1999, In: Bioorganic & Medicinal Chemistry. 7, 6, p. 1003-11 9 p.Research output: Contribution to journal › Journal article › peer-review
- 1997
- Published
Conformational analysis of six- and twelve-membered ring compounds by molecular dynamics
Christensen, I. T. & Jørgensen, Flemming Steen, 1997, In: Journal of Computer - Aided Molecular Design. 11, 4, p. 385-94 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Molecular mechanics calculations of proteins. Comparison of different energy minimization strategies
Christensen, I. T. & Jørgensen, Flemming Steen, 1997, In: Journal of Biomolecular Structure & Dynamics. 15, 3, p. 473-88 16 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Substrate binding and catalytic mechanism in phospholipase C from Bacillus cereus. a molecular mechanics and molecular dynamics study
da Graça Thrige, D., Buur, J. R. & Jørgensen, Flemming Steen, 1997, In: Biopolymers. 42, 3, p. 319-36 18 p.Research output: Contribution to journal › Journal article › peer-review
- 1996
- Published
Update on protein structure prediction: Results of the 1995 IRBM workshop
Hubbard, T., Tramontano, A., Barton, G., Jones, D., Sippl, M., Valencia, A., Lesk, A., Moult, J., Rost, B., Sander, C., Schneider, R., Lahm, A., Leplae, R., Buta, C., Eisenstein, M., Fjellstrom, O., Floeckner, H., Grossmann, JG., Hansen, J., Citterich, MH. & 12 others, , 1996, In: Folding and Design. 1, 3, p. R55-R63Research output: Contribution to journal › Journal article › peer-review
- 1995
- Published
Crystallization and preliminary X-ray analysis of a PNA-DNA complex
Kastrup, Jette Sandholm Jensen, Pilgaard, M., Jørgensen, Flemming Steen, Nielsen, Peter E. & Rasmussen, H. B., 1995, In: FEBS Letters. 363, 1-2, p. 115-117 3 p.Research output: Contribution to journal › Journal article › peer-review
- 1994
- Published
GABAA receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects
Krogsgaard-Larsen, Povl, Frølund, Bente, Jørgensen, Flemming Steen & Schousboe, Arne, 1994, In: Journal of Medicinal Chemistry. 37, 16, p. 2489-505 17 p.Research output: Contribution to journal › Journal article › peer-review
- 1993
- Published
Conformational analysis and molecular modelling of a partial GABA(A) agonist and a glycine antagonist related to the GABA(A) agonist, THIP
Byberg Buur, J. R., Hjeds, H., Krogsgaard-Larsen, Povl & Jørgensen, Flemming Steen, 1 Dec 1993, In: Drug Design and Discovery. 10, 3, p. 213-229 17 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Conservation of a helix-stabilizing dipole moment in the PP-fold family of regulatory peptides
Bjørnholm, B., Jørgensen, Flemming Steen & Schwartz, Thue W., 1993, In: Biochemistry. 32, 12, p. 2954-9 6 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Three-dimensional structures of human phospholipase A2 from pancreas and synovial fluid by model building
Christensen, I. T., Jørgensen, Flemming Steen, Svensson, L. A. & Högberg, T., 1993, In: Drug Design and Discovery. 10, 2, p. 101-13 13 p.Research output: Contribution to journal › Journal article › peer-review
- 1992
- Published
AMPA receptor agonists: structural, conformational and stereochemical aspects
Hansen, J., Jørgensen, Flemming Steen, Lund, Trine Meldgaard, Nielsen, Birgitte, Reinhardt, A., Breum, I., Brehm, L. & Krogsgaard-Larsen, Povl, 1992, Excitatory Amino Acid Receptors. Krogsgaard-Larsen, P. & Hansen, J. J. (eds.). Ellis Horwood: Chichester, 30 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Conformational analysis of the fungicide fenpropimorph by molecular mechanics calculations and NMR spectroscopy
Kastrup, Jette Sandholm Jensen, Jørgensen, Flemming Steen, Klemmensen, P. D., Hacksell, U. & Petersson, I., 1992, In: Journal of Pesticide Science. 36, p. 309-318 10 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Substrate-enzyme interactions and catalytic mechanism in phospholipase C: a molecular modeling study using the GRID program
Byberg, J. R., Jørgensen, Flemming Steen, Hansen, S. & Hough, E., 1992, In: Proteins: Structure, Function, and Bioinformatics. 12, 4, p. 331-8 8 p.Research output: Contribution to journal › Journal article › peer-review
- 1991
- Published
Conformational and pharmacological characterization of 4-AHCP, a bicyclic homologue of the excitatory amino acid receptor agonist AMPA
Lund, Trine Meldgaard, Madsen, Ulf, Ebert, B., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1991, In: Med. Chem. Res. 1, p. 136-141 6 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Excitatory amino acid receptors: multiplicity and structural requirements for activation and blockade
Krogsgaard-Larsen, Povl, Lund, Trine Meldgaard, Jørgensen, Flemming Steen & Brehn, L., 1991, Excitatory amino acids and synaptic function. Wheal, H. & Thomson, A. (eds.). London: Academic Press, p. 1-17 17 p. (Excitatory Amino Acids and Synaptic Transmission, Academic Press, London).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- Published
Primary structure and conformational analysis of peptide methionine-tyrosine, a peptide related to neuropeptide Y and peptide YY isolated from lamprey intestine
Conlon, J. M., Bjørnholm, B., Jørgensen, Flemming Steen, Youson, J. H. & Schwartz, T. W., 1991, In: European Journal of Biochemistry. 199, 2, p. 293-8 6 p.Research output: Contribution to journal › Journal article › peer-review
- 1990
- Published
Relationship between structure, conformational flexibility, and biological activity of agonists and antagonists at the N-methyl-D-aspartic acid subtype of excitatory amino acid receptors
Madsen, Ulf, Brehm, L., Schaumburg, K., Jørgensen, Flemming Steen & Krogsgaard-Larsen, Povl, 1990, In: Journal of Medicinal Chemistry. 33, 1, p. 374-80 7 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Structural and stereochemical requirements for interactions with subtypes of central excitatory amino acid receptors
Brehm, L., Christensen, I. T., Nielsen, Birgitte, Reinhardt, A., Ebert, B., Madsen, Ulf, Jørgensen, Flemming Steen, Hansen, J. J. & Krogsgaard-Larsen, Povl, 1990, Frontiers in Drug Research; Alfred Benzon Symposium 28. Jensen, B., Jørgensen, F. S. & Kofod, H. (eds.). Copenhagen: Munksgaard , p. 92-105 14 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
- 1989
- Published
3D-QSAR. Towards a quantitative three-dimensional description of muscarinic agonists.
Lagersted, A. & Jørgensen, Flemming Steen, 1 Jan 1989, In: Progress in Clinical and Biological Research. 291, p. 333-336 4 p.Research output: Contribution to journal › Journal article › peer-review
- Published
Heterocyclic muscarinic agonists: Structural and therapeutic aspects
Krogsgaard-Larsen, Povl, Jensen, B., Falch, E. & Jørgensen, Flemming Steen, 1 Jan 1989, In: Drugs of the Future. 14, 6, p. 541-561 21 p.Research output: Contribution to journal › Journal article › peer-review
- 1988
- Published
Conformational analysis of peri-interactions in napththalene derivatives. Ring inversion in CH2–X–CH2-bridged peri-naphthalenes
Anderson, J. E. & Jørgensen, Flemming Steen, 1 Apr 1988, In: Journal of the Chemical Society. Perkin Transactions 2 (2001). 1988, 4, p. 469-471 3 p.Research output: Contribution to journal › Journal article › peer-review
- Published
peri-Interaction, ortho-interaction, and barriers to internal rotation. A dynamic nuclear magnetic resonance and molecular mechanics investigation of 1,2-dineopentylbenzene and 1,8-dineopentylnaphthalene
Anderson, J. E., Barkel, D. J. & Jørgensen, Flemming Steen, 1 Feb 1988, In: Journal of the Chemical Society. Perkin Transactions 2 (2001). 2, p. 199-202 4 p.Research output: Contribution to journal › Journal article › peer-review
ID: 1302104
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1964
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Forbedret optagelse af lægemidler i organismen: computeren viser vejen
Research output: Contribution to journal › Journal article
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1911
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Synthesis and antiangiogenic activity of N-alkylated levamisole derivatives
Research output: Contribution to journal › Journal article › peer-review
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1525
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Design of prodrugs targeting the intestinal di/tri‐peptide transporter hPEPT1 (SLC15A1
Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
Published