Elisabeth Rexen Ulven

Elisabeth Rexen Ulven

Associate Professor

ORCID: 0000-0003-1243-7587

Publication year:
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1 - 41 out of 41Page size: 500
  1. 2024
  2. Published

    Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

    Dragano, N. R. V., Milbank, E., Haddad-Tóvolli, R., Garrido-Gil, P., Nóvoa, E., Fondevilla, M. F., Capelli, V., Zanesco, A. M., Solon, C., Morari, J., Pires, L., Estevez-Salguero, Á., Beiroa, D., González-García, I., Barca-Mayo, O., Diéguez, C., Nogueiras, R., Labandeira-García, J. L., Rexen Ulven, E., Ulven, T. & 3 others, Claret, M., Velloso, L. A. & López, M., 2024, In: Molecular Metabolism. 79, 13 p., 101840.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Structure-Activity Relationship Studies and Optimization of 4-Hydroxypyridones as GPR84 Agonists

    Ieremias, L., Kaspersen, M. H., Manandhar, Asmita, Schultz-Knudsen, Katrine, Vrettou, C. I., Pokhrel, R., Heidtmann, C. V., Jenkins, L., Kanellou, C., Marsango, S., Li, Y., Bräuner, Hans, Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2024, In: Journal of Medicinal Chemistry. 67, 5, p. 3542-3570

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2023
  5. Published

    Development and Characterization of Potent Succinate Receptor Fluorescent Tracers

    Ciba, Marija, Dibnah, B., Hudson, B. D. & Ulven, Elisabeth Rexen, 2023, In: Journal of Medicinal Chemistry. 66, 13, p. 8951–8974

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists

    Valentini, Alice, Schultz-Knudsen, Katrine, Hansen, A. H., Tsakoumagkou, A., Jenkins, L., Christensen, H. B., Manandhar, Asmita, Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2023, In: Journal of Medicinal Chemistry. 66, 9, p. 6105–6121

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets

    Lorza-Gil, E., Kaiser, G., Carlein, C., Hoffmann, M. D. A., König, G. M., Haug, S., Prates Roma, L., Ulven, Elisabeth Rexen, Ulven, Trond, Kostenis, E., Birkenfeld, A. L., Häring, H. U., Ullrich, S. & Gerst, F., 2023, In: Diabetologia. 66, p. 1501–1515

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Ligand entry pathways control the chemical space recognized by GPR183

    Kjær, Viktoria Madeline Skovgaard, Stępniewski, T. M., Medel-Lacruz, B., Reinmuth, L., Ciba, Marija, Ulven, Elisabeth Rexen, Bonomi, M., Selent, J. & Rosenkilde, Mette, 2023, In: Chemical Science. 14, 39, p. 10671-10683

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. 2022
  10. Published

    Chemogenetics defines a short-chain fatty acid receptor gut-brain axis

    Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, Trond, Hudson, B. D., Ulven, Elisabeth Rexen, Dekker, N., Tobin, A. B. & Milligan, G., 2022, In: eLife. 11, 23 p., e73777.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. 2021
  12. Published

    Acute effects of delayed-release hydrolyzed pine nut oil on glucose tolerance, incretins, ghrelin and appetite in healthy humans

    Sørensen, K. V., Korfitzen, S. S., Kaspersen, M. H., Ulven, Elisabeth Rexen, Ekberg, J. H., Bauer-Brandl, A., Ulven, Trond & Højlund, K., 2021, In: Clinical Nutrition. 40, 4, p. 2169-2179

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Structure-Activity Relationship Explorations and Discovery of a Potent Antagonist for the Free Fatty Acid Receptor 2

    Hansen, A. H., Christensen, H. B., Pandey, S. K., Sergeev, E., Valentini, Alice, Dunlop, J., Dedeo, D., Fratta, S., Hudson, B. D., Milligan, G., Ulven, Trond & Ulven, Elisabeth Rexen, 2021, In: ChemMedChem. 16, 21, p. 3326-3341

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. 2020
  15. Published

    Structure-Activity Relationship Studies of Tetrahydroquinolone Free Fatty Acid Receptor 3 Modulators

    Ulven, Elisabeth Rexen, Quon, T., Sergeev, E., Barki, N., Brvar, M., Hudson, B. D., Dutta, P., Hansen, A. H., Bielefeldt, L. Ø., Tobin, A. B., McKenzie, C. J., Milligan, G. & Ulven, Trond, 9 Apr 2020, In: Journal of Medicinal Chemistry. 63, 7, p. 3577-3595 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    FFA2-, but not FFA3-agonists inhibit GSIS of human pseudoislets: a comparative study with mouse islets and rat INS-1E cells

    Lorza-Gil, E., Kaiser, G., Ulven, Elisabeth Rexen, Koenig, G. M., Gerst, F., Oquendo, M. B., Birkenfeld, A. L., Haering, H., Kostenis, E., Ulven, Trond & Ullrich, S., 2020, In: Scientific Reports. 10, 1, 11 p., 16497.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2019
  18. Published

    Kan fedtsyrer bruges som medicin?

    Ulven, Elisabeth Rexen, Jul 2019, In: Aktuel Naturvidenskab. 2019, 3, p. 19-22

    Research output: Contribution to journal › Journal article › Communication

  19. 2018
  20. Published

    Dihydropyridine Fluorophores Allow for Specific Detection of Human Antibodies in Serum

    Domljanovic, I., Ulven, Elisabeth Rexen, Ulven, Trond, Thomsen, R. P., Okholm, A. H., Kjems, J., Voss, A., Taskova, M. & Astakhova, K., 31 Jul 2018, In: ACS Omega. 3, 7, p. 7580-7586 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties

    Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Structure-Activity Investigations and Optimisations of Non-metabolite Agonists for the Succinate Receptor 1

    Ulven, Elisabeth Rexen, Trauelsen, Mette, Brvar, M., Lückmann, Michael, Bielefeldt, L. Ø., Jensen, L. K. I., Schwartz, Thue W. & Frimurer, Thomas Michael, 2018, In: Scientific Reports. 8, 1, p. 1-18 10010.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. 2017
  24. Published

    Receptor structure-based discovery of non-metabolite agonists for the succinate receptor GPR91

    Trauelsen, Mette, Ulven, Elisabeth Rexen, Hjorth, Siv Annegrethe, Brvar, M., Monaco, C., Frimurer, Thomas Michael & Schwartz, Thue W., Dec 2017, In: Molecular Metabolism. 6, 12, p. 1585-1596 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Development and Characterization of a Fluorescent Tracer for the Free Fatty Acid Receptor 2 (FFA2/GPR43)

    Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Ulven, Elisabeth Rexen, Milligan, G. & Ulven, Trond, 2017, In: Journal of Medicinal Chemistry. 60, 13, p. 5638-5645 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

    Dragano, N. R. V., Solon, C., Ramalho, A. F., de Moura, R. F., Razolli, D. S., Ulven, Elisabeth Rexen, Goncalves de Azavedo, C. M. B. P., Ulven, Trond & Velloso, L. A., 2017, In: Journal of Neuroinflammation. 14, 91, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Structure-based discovery of novel US28 small molecule ligands with different modes of action

    Lückmann, Michael, Amarandi, R., Papargyri, N., Jakobsen, M. H., Ulven, Elisabeth Rexen, Jensen, Lars Juhl, Pui, A., Schwartz, Thue W., Rosenkilde, Mette & Frimurer, Thomas Michael, 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. 2016

  29. Discovery of a Potent Free Fatty Acid 1 Receptor Agonist with Low Lipophilicity, Low Polar Surface Area and Robust in Vivo Efficacy

    Hansen, S. V. F., Ulven, Elisabeth Rexen, Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G. & Ulven, Trond, 1 Mar 2016, In: Journal of Medicinal Chemistry. 59, 6, p. 2841-2846 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

    Due-Hansen, M. E., Pandey, S. K., Ulven, Elisabeth Rexen, Andersen, R., Hansen, S. V. F. & Ulven, Trond, 2016, In: Organic & Biomolecular Chemistry. 14, 2, p. 430-433 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Development and Characterization of a Potent Free Fatty Acid Receptor 1 (FFA1) Fluorescent Tracer

    Ulven, Elisabeth Rexen, Hudson, B. D., Hansen, A. H., Milligan, G. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 10, p. 4849-4858 10 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Non-Acidic Free Fatty Acid Receptor 4 Agonists with Antidiabetic Activity

    Goncalves de Azavedo, C. M. B. P., Watterson, K. R., Wargent, E. T., Hansen, S. V. F., Hudson, B. D., Kępczyńska, M. A., Dunlop, J., Shimpukade, B., Ulven, Elisabeth Rexen, Milligan, G., Stocker, C. J. & Ulven, Trond, 2016, In: Journal of Medicinal Chemistry. 59, 19, p. 8868-8878 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. 2015
  34. Published

    Dietary Fatty Acids and Their Potential for Controlling Metabolic Diseases Through Activation of FFA4/GPR120

    Ulven, Trond & Ulven, Elisabeth Rexen, 17 Jul 2015, In: Annual Review of Nutrition. 35, p. 239-263 25 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases

    Ulven, Elisabeth Rexen, Watterson, K. R., Stocker, C. J., Sokol, E., Jenkins, L., Simon, K., Grundmann, M., Petersen, R. K., Wargent, E. T., Hudson, B. D., Kostenis, E., Ejsing, C. S., Cawthorne, M. A., Milligan, G. & Ulven, T., 2015, In: British Journal of Nutrition. 113, 11, p. 1677-1688 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. 2014

  37. Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands

    Hudson, B. D., Ulven, Elisabeth Rexen, Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, Trond & Milligan, G., Aug 2014, In: Molecular Pharmacology. 86, 2, p. 200-210 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. 2013

  39. In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469

    Urban, C., Hamacher, A., Partke, H. J., Roden, M., Schinner, S., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Gohlke, H. & Kassack, M. U., 17 Jul 2013, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 386, 12, p. 1021-2030 1010 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Defining the molecular basis for the first potent and selective orthosteric agonists of the FFA2 free fatty acid receptor

    Hudson, B. D., Due-Hansen, M. E., Ulven, Elisabeth Rexen, Hansen, A., Mackenzie, A. E., Murdoch, H., Pandey, S. K., Ward, R. J., Marquez, R., Tikhonova, I. G., Ulven, Trond & Milligan, G., 14 Jun 2013, In: Journal of Biological Chemistry. 288, p. 17296-17312 17 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Discovery of TUG-770

    Ulven, Elisabeth Rexen, Hansen, S. V. F., Urban, C., Hudson, B. D., Wargent, E. T., Grundmann, M., Jenkins, L., Zaibi, M., Stocker, C. J., Ullrich, S., Kostenis, E., Kassack, M. U., Milligan, G., Cawthorne, M. A. & Ulven, Trond, 9 May 2013, In: A C S Medicinal Chemistry Letters. 4, 5, p. 441-445 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability

    Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schmidt, J., Hansen, S. V. F., Hudson, B. D., Zaibi, M., Markussen, S. B., Hagesaether, E., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 14 Feb 2013, In: Journal of Medicinal Chemistry. 56, 3, p. 982-992 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Reevaluation of Fatty acid receptor 1 (FFAR1/GPR40) as drug target for the stimulation of insulin secretion in humans

    Wagner, R., Kaiser, G., Gerst, F., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Grundmann, M., Machicao, F., Peter, A., Kostenis, E., Ulven, Trond, Fritsche, A., Häring, H. & Ullrich, S., 1 Feb 2013, In: Diabetes. 62, 6, p. 2106-2111 6 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Mucus can change the permeation rank order of drug candidates

    Hagesaether, E., Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 2013, In: International Journal of Pharmaceutics. 452, 1-2, p. 276-282 7 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. The Pharmacology of TUG-891, a Potent and Selective Agonist of the Free Fatty Acid Receptor 4 (FFA4/GPR120), Demonstrates Both Potential Opportunity and Possible Challenges to Therapeutic Agonism

    Hudson, B. D., Shimpukade, B., Mackenzie, A. E., Butcher, A. J., Pediani, J. D., Ulven, Elisabeth Rexen, Heathcote, H., Tobin, A. B., Ulven, Trond & Milligan, G., 2013, In: Molecular Pharmacology. 84, 5, p. 710-725 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. 2012

  47. Chemically engineering ligand selectivity at the free fatty acid receptor 2 based on pharmacological variation between species orthologs

    Hudson, B. D., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Kostenis, E., Adams, D. R., Ulven, Trond & Milligan, G., 2012, In: F A S E B Journal. 26, 12, p. 4951-4965 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists

    Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Grundmann, M., Schröder, R., Hudson, B. D., Milligan, G., Cawthorne, M. A., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2012, In: Journal of Medicinal Chemistry. 55, 14, p. 6624-6628 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. 2011

  50. Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

    Schmidt, J., Smith, N. J., Ulven, Elisabeth Rexen, Tikhonova, I. G., Grundmann, M., Hudson, B. D., Ward, R. J., Drewke, C., Milligan, G., Kostenis, E. & Ulven, Trond, 10 Jan 2011, In: Journal of Biological Chemistry. 286, 12, p. 10628-10640 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Conjugated Linoleic Acids Mediate Insulin Release through Islet G Protein-coupled Receptor FFA1/GPR40

    Schmidt, J., Liebscher, K., Merten, N., Grundmann, M., Mielenz, M., Sauerwein, H., Ulven, Elisabeth Rexen, Due-Hansen, M. E., Ulven, Trond, Ullrich, S., Gomeza, J., Drewke, C. & Kostenis, E., 2011, In: Journal of Biological Chemistry. 286, 14, p. 11890-11894 5 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Identification of a potent and selective free fatty acid receptor 1 (FFA1/GPR40) agonist with favorable physicochemical and in vitro ADME properties

    Ulven, Elisabeth Rexen, Urban, C., Grundmann, M., Due-Hansen, M. E., Hagesaether, E., Schmidt, J., Pardo, L., Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2011, In: Journal of Medicinal Chemistry. 54, 19, p. 6691-6703 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. 2010

  54. A Rapid and Efficient Sonogashira Protocol and Improved Synthesis of Free Fatty Acid 1 (FFA1) Receptor Agonists

    Ulven, Elisabeth Rexen, Due-Hansen, M. E. & Ulven, Trond, 19 Feb 2010, In: Journal of Organic Chemistry. 75, 4, p. 1301-1304 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  55. Published

    Structure-activity study of dihydrocinnamic acids and discovery of the potent FFA1 (GPR40) agonist TUG-469

    Ulven, Elisabeth Rexen, Due-Hansen, M. E., Urban, C., Merten, N., Pfleiderer, M., Karlsen, K. K., Rasmussen, S. S., Steensgaard, M., Hamacher, A., Schmidt, J., Drewke, C., Petersen, R. K., Kristiansen, Karsten, Ullrich, S., Kostenis, E., Kassack, M. U. & Ulven, Trond, 2010, In: ACS Medicinal Chemistry Letters. 1, 7, p. 345-349 5 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  56. 2008
  57. Published

    Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes

    Ulven, Elisabeth Rexen, Urban, C., Merten, N., Liebscher, K., Karlsen, K. K., Hamacher, A., Spinrath, A., Bond, A. D., Drewke, C., Ullrich, S., Kassack, M. U., Kostenis, E. & Ulven, Trond, 27 Nov 2008, In: Journal of Medicinal Chemistry. 51, 22, p. 7061-4 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

ID: 201719978