Dorte Frees

Dorte Frees

Associate Professor

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    1 - 50 out of 85Page size: 50
    1. 2024
    2. Published

      Lack of correlation between growth, stress, and virulence phenotypes in strains of Salmonella enterica serovar Enteritidis, S. Typhimurium DT104, S. 4,12, b:- and S. Liverpool

      Olsen, John Elmerdahl, Frees, Dorte, Kyvsgaard, N. C. & Barco, L., 2024, In: Letters in Applied Microbiology. 77, 2, 9 p., ovae015.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      The ClpX chaperone and a hypermorphic FtsA variant with impaired self-interaction are mutually compensatory for coordinating Staphylococcus aureus cell division

      Henriksen, C., Bæk, K. T., Wacnik, K., Gallay, C., Veening, J. W., Foster, S. J. & Frees, Dorte, 2024, In: Molecular Microbiology. 121, 1, p. 98-115

      Research output: Contribution to journal › Journal article › Research › peer-review

    4. 2023
    5. Published

      A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology

      Xu, Lijuan, Henriksen, C., Mebus, Viktor Hundtofte, Guérillot, R., Petersen, A., Jacques, N., Jiang, J. H., Derks, R. J. E., Sánchez-López, E., Giera, M., Leeten, K., Stinear, T. P., Oury, C., Howden, B. P., Peleg, A. Y. & Frees, Dorte, 2023, In: Antimicrobial Agents and Chemotherapy. 67, 6, 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    6. Published

      Clinical Staphylococcus aureus inhibits human T-cell activity through interaction with the PD-1 receptor

      Mellergaard, M., Skovbakke, S. L., Jepsen, S. D., Panagiotopoulou, N., Hansen, A. B. R., Tian, W., Lund, A., Høgh, R. I., Møller, S. H., Guérillot, R., Hayes, A. S., Erikstrup, L. T., Andresen, L., Peleg, A. Y., Larsen, A. R., Stinear, T. P., Handberg, A., Erikstrup, C., Howden, B. P., Goletz, S. & 2 others, Frees, Dorte & Skov, Søren, 2023, In: mBio. 14, 5, 21 p., e01349-23.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. 2022
    8. Published

      A porcine model of subcutaneous Staphylococcus aureus infection: a pilot study

      Nielsen, O. L., Mellergaard, M., Frees, Dorte, Larsen, M. N., Skov, Søren, Olsen, Lisbeth Høier & Reimann, Maria Josefine, 2022, In: APMIS - Journal of Pathology, Microbiology and Immunology. 130, 7, p. 359-370

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Finding New Fundamental Pieces for the Bacterial Cell Division Puzzle

      Frees, Dorte & Ingmer, Hanne, 2022, In: mBio. 13, 4, e0073722.

      Research output: Contribution to journal › Journal article › Research › peer-review

    10. Published

      Rapid in vivo development of resistance to daptomycin in vancomycin-resistant Enterococcus faecium due to genomic alterations

      Mollerup, S., Elmeskov, C., Pinholt, M., Sejersen, T. S., Pedersen, M. S., Worning, P., Frees, Dorte & Westh, Henrik T., 2022, In: FEMS Microbiology Letters. 369, 1, 6 p., 063.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. 2021
    12. Published

      A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse β-Lactam Resistance in MRSA

      Bæk, K. T., Jensen, C., Farha, M. A., Nielsen, T. K., Paknejadi, E., Mebus, Viktor Hundtofte, Vestergaard, M., Brown, E. D. & Frees, Dorte, 2021, In: Frontiers in Molecular Biosciences. 8, 691569.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      Cefoxitin treatment of MRSA leads to a shift in the IL-12/IL-23 production pattern in dendritic cells by a mechanism involving changes in the MAPK signaling

      Eld, H. M. S., Nielsen, E. M., Johnsen, Peter Riber, Marengo, M., Kamper, I. W., Frederiksen, L., Bonomi, F., Frees, Dorte, Iametti, S. & Frøkiær, Hanne, 2021, In: Molecular Immunology. 134, p. 1-12 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      Staphylococcal ClpXP protease targets the cellular antioxidant system to eliminate fitness-compromised cells in stationary phase

      Alqarzaee, A. A., Chaudhari, S. S., Islam, M. M., Kumar, V., Zimmerman, M. C., Saha, R., Bayles, K. W., Frees, Dorte & Thomas, V. C., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 47, e2109671118.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. 2020
    16. Published

      Staphylococcus aureus induces cell-surface expression of immune stimulatory NKG2D ligands on human monocytes

      Mellergaard, M., Høgh, R. I., Feilberg, Astrid Lund, Aldana, Blanca, Guérillot, R., Møller, S. H., Hayes, A. S., Panagiotopoulou, N., Frimand, Z., Jepsen, Stine Dam, Hansen, Camilla Hartmann Friis, Andresen, Lars, Larsen, A. R., Peleg, A. Y., Stinear, T. P., Howden, B. P., Waagepetersen, Helle S., Frees, Dorte & Skov, Søren, 2020, In: The Journal of Biological Chemistry. 295, p. 11803-11821

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      A Functional ClpXP Protease is Required for Induction of the Accessory Toxin Genes, tst, sed, and sec

      Schelin, J., Cohn, M. T., Frisk, B. & Frees, Dorte, 2020, In: Toxins. 12, 9, 553.

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      Nisin Damages the Septal Membrane and Triggers DNA Condensation in Methicillin-Resistant Staphylococcus aureus

      Jensen, C., Li, H., Vestergaard, M., Dalsgaard, Anders, Frees, Dorte & Leisner, Jørgen, 2020, In: Frontiers in Microbiology. 11, 8 p., 1007.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      SosA in Staphylococci: an addition to the paradigm of membrane-localized, SOS-induced cell division inhibition in bacteria

      Bojer, Martin Saxtorph, Frees, Dorte & Ingmer, Hanne, 2020, In: Current Genetics. 66, p. 495-499

      Research output: Contribution to journal › Review › Research › peer-review

    20. Published

      The sle1 cell wall amidase is essential for β-lactam resistance in community-acquired methicillin-resistant staphylococcus aureus USA300

      Thalsø-Madsen, I., Torrubia, F. R., Xu, Lijuan, Petersen, A., Jensen, C. & Frees, Dorte, 2020, In: Antimicrobial Agents and Chemotherapy. 64, 1, 15 p., e01931-19.

      Research output: Contribution to journal › Journal article › Research › peer-review

    21. 2019
    22. Published

      Staphylococcus aureus ClpX localizes at the division septum and impacts transcription of genes involved in cell division, T7-secretion, and SaPI5-excision

      Jensen, C., Fosberg, M. J., Thalsø-Madsen, I., Bæk, K. T. & Frees, Dorte, 2019, In: Scientific Reports. 9, 11 p., 16456.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      Antibiotic Resistance and the MRSA Problem

      Vestergaard, M., Frees, Dorte & Ingmer, Hanne, 2019, In: Microbiology Spectrum. 7, 2, 23 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      Fødevaresikkerhed i udvikling

      Ingmer, Hanne, Larsen, M. H., Leisner, Jørgen, Frees, Dorte, Brøndsted, Lone & Dalsgaard, Anders, 2019, In: Dansk Veterinaertidsskrift. 2019, 7, p. 10-13

      Research output: Contribution to journal › Journal article › Communication

    25. Published

      SosA inhibits cell division in Staphylococcus aureus in response to DNA damage

      Bojer, Martin Saxtorph, Wacnik, K., Kjelgaard, P., Gallay, C., Bottomley, A. L., Cohn, M. T., Lindahl, G., Frees, Dorte, Veening, J. W., Foster, S. J. & Ingmer, Hanne, 2019, In: Molecular Microbiology. 112, 4, p. 1116-1130

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      The ClpX chaperone controls autolytic splitting of Staphylococcus aureus daughter cells, but is bypassed by β-lactam antibiotics or inhibitors of WTA biosynthesis

      Jensen, C., Bæk, K. T., Gallay, C., Thalsø-Madsen, I., Xu, Lijuan, Jousselin, A., Ruiz Torrubia, F., Paulander, W., Pereira, A. R., Veening, J. W., Pinho, M. G. & Frees, Dorte, 2019, In: PLOS Pathogens. 15, 9, 27 p., e1008044.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. 2018
    28. Published

      Application of an agr-Specific Antivirulence Compound as Therapy for Staphylococcus aureus-Induced Inflammatory Skin Disease

      Baldry, M., Nakamura, Y., Nakagawa, S., Frees, Dorte, Matsue, H., Nunez, G. & Ingmer, Hanne, 2018, In: Journal of Infectious Diseases. 218, 6, p. 1009-1013

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. 2017
    30. Published

      A porcine subcutaneous Staphylococcus aureus abscess model - a pilot study

      Nielsen, O. L., Larsen, M. N., Frees, Dorte, Pedersen, M. M., Skov, Søren & Olsen, Lisbeth Høier, 2017.

      Research output: Contribution to conference › Conference abstract for conference › Communication

    31. Published

      The ClpXP protease is dispensable for degradation of unfolded proteins in Staphylococcus aureus

      Stahlhut, S. G., Alqarzaee, A. A., Jensen, C., Fisker, N. S., Pereira, A. R., Pinho, M. G., Thomas, V. C. & Frees, Dorte, 2017, In: Scientific Reports. 7, 14 p., 11739.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. 2016
    33. Published

      Norlichexanthone Reduces Virulence Gene Expression and Biofilm Formation in Staphylococcus aureus

      Baldry, M., Nielsen, A., Bojer, Martin Saxtorph, Zhao, Y., Friberg, C., Ifrah, D., Heede, N. G., Larsen, T. O., Frøkiær, Hanne, Frees, Dorte, Zhang, L., Dai, H. & Ingmer, Hanne, 22 Dec 2016, In: PLOS ONE. 11, 12, 16 p., e0168305.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      Rifampin Resistance rpoB Alleles or Multicopy Thioredoxin/Thioredoxin Reductase Suppresses the Lethality of Disruption of the Global Stress Regulator spx in Staphylococcus aureus

      Villanueva, M., Jousselin, A., Baek, K. T., Prados, J., Andrey, D. O., Renzoni, A., Ingmer, Hanne, Frees, Dorte & Kelley, W. L., 1 Oct 2016, In: Journal of Bacteriology. 198, 19, p. 2719-2731 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Ribosomal dimerization factor YfiA is the major protein synthesized after abrupt glucose depletion in Lactococcus lactis

      Breüner, A., Frees, Dorte, Varmanen, P., Boguta, A. M., Hammer, K., Martinussen, J. & Kilstrup, M., Oct 2016, In: Microbiology. 162, 10, p. 1829-1839 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Stress Responses in Staphylococcus aureus

      Frees, Dorte & Ingmer, Hanne, Oct 2016, Staphylococcus: Genetics and Physiology. Somerville, G. A. (ed.). Caister Academic Press, p. 221-248

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    37. Published

      Antigen Uptake during Different Life Stages of Zebrafish (Danio rerio) Using a GFP-Tagged Yersinia ruckeri

      Korbut, R., Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte, Dalsgaard, I. & Jørgensen, Louise von Gersdorff, 12 Jul 2016, In: P L o S One. 11, 7, e0158968.

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Copresence of tet(K) and tet(M) in Livestock-Associated Methicillin-Resistant Staphylococcus aureus Clonal Complex 398 Is Associated with Increased Fitness during Exposure to Sublethal Concentrations of Tetracycline

      Larsen, J., Clasen, J., Hansen, J. E., Paulander, W., Petersen, A., Larsen, A. R. & Frees, Dorte, Jul 2016, In: Antimicrobial Agents and Chemotherapy. 60, 7, p. 4401-4403

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Antigen uptake in zebrafish (Danio rerio) at different life stages

      Korbut, R., Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Jørgensen, Louise von Gersdorff, 2016.

      Research output: Contribution to conference › Conference abstract for conference › Research

    40. Published

      The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone

      Baek, K. T., Bowman, L., Millership, C., Sogaard, M. D., Kaever, V., Siljamaki, P., Savijoki, K., Varmanen, P., Nyman, T. A., Grundling, A. & Frees, Dorte, 2016, In: mBio (Print). 7, 4, 11 p., 01228.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. 2015
    42. Published

      Stepwise decrease in daptomycin susceptibility in clinical Staphylococcus aureus isolates associated with an initial mutation in rpoB and a compensatory inactivation of the clpX gene

      Bæk, K. T., Thøgersen, L., Mogensen, R. G., Pedersen, M. M., Thomsen, Line Elnif, Petersen, A., Skov, Søren, Cameron, D. R., Peleg, A. Y. & Frees, Dorte, Nov 2015, In: Antimicrobial Agents and Chemotherapy. 59, 11, p. 6983-6991 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Proteomic analyses of iron-responsive, Clp-dependent changes in Staphylococcus aureus

      Farrand, A. J., Friedman, D. B., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., Apr 2015, In: Pathogens and Disease. 73, 3, 6 p., ftv004.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Antigen uptake in zebrafish

      Jørgensen, Louise von Gersdorff, Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Buchmann, Kurt, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research

    45. Published

      Antigen uptake in zebrafish (Danio rerio)

      Jørgensen, Louise von Gersdorff, Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Buchmann, Kurt, 2015.

      Research output: Contribution to conference › Conference abstract for conference › Research

    46. Published

      Antigen uptake in zebrafish (Danio rerio)

      Jørgensen, Louise von Gersdorff, Mehrdana, Foojan, Kania, Per, Larsen, M. H., Frees, Dorte & Buchmann, Kurt, 2015.

      Research output: Contribution to conference › Poster › Research

    47. 2014
    48. Published

      Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

      Frees, Dorte, Gerth, U. & Ingmer, Hanne, 2014, In: International Journal of Medical Microbiology. 304, 2, p. 142-149 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Solonamide B inhibits quorum sensing and reduces Staphylococcus aureus mediated killing of human neutrophils

      Nielsen, A., Månsson, M., Bojer, Martin Saxtorph, Gram, L., Larsen, T. O., Novick, R. P., Frees, Dorte, Frøkiær, Hanne & Ingmer, Hanne, 2014, In: P L o S One. 9, 1, p. e84992 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      β-lactam resistance in methicillin-resistant Staphylococcus aureus USA300 is increased by inactivation of the ClpXP protease

      Bæk, K. T., Gründling, A., Mogensen, R. G., Thøgersen, L., Petersen, A., Paulander, W. E. A. & Frees, Dorte, 2014, In: Antimicrobial Agents and Chemotherapy. 58, 8, p. 4593-4603 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    51. 2013
    52. Published

      Bacterial proteases and virulence

      Frees, Dorte, Brøndsted, Lone & Ingmer, Hanne, 2013, Regulated proteolysis in microorganisms. Dougan, D. A. (ed.). Springer, p. 161-192 32 p. (Subcellular biochemistry, Vol. 66).

      Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

    53. Published

      Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing

      Bæk, K. T., Frees, Dorte, Renzoni, A., Barras, C., Rodriguez, N., Manzano, C. & Kelley, W. L., 2013, In: P L o S One. 8, 9, 16 p., e77122.

      Research output: Contribution to journal › Journal article › Research › peer-review

    54. Published

      Regulation of host hemoglobin binding by the Staphylococcus aureus Clp proteolytic system

      Farrand, A. J., Reniere, M. L., Ingmer, Hanne, Frees, Dorte & Skaar, E. P., 2013, In: Journal of Bacteriology. 195, 22, p. 5041-5050 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    55. Published

      The role of Serpine-1 and Tissue inhibitor of metalloproteinase type-1 in early host responses to Staphylococcus aureus intracutaneous infection of mice

      Harslund, J. L. F., Frees, Dorte, Leifsson, Páll S., Offenberg, H. K., Rømer, M. U. K., Brünner, N. & Olsen, John Elmerdahl, 2013, In: Pathogens and Disease. 68, 3, p. 96-104 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    56. Published

      Therapy of haematogenous osteomyelitis: a comparative study in a porcine model and Angolan children

      Jensen, Louise Kruse, Koch, J., Kirketerp-Møller, K., Wamsler, O. J., Nielsen, O. L., Leifsson, Páll S., Frees, Dorte, Aalbæk, Bent & Jensen, Henrik Elvang, 2013, In: In Vivo. 27, 3, p. 305-312 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    57. Published

      Trapping and proteomic identification of cellular substrates of the ClpP protease in Staphylococcus aureus

      Feng, J., Michalik, S., Varming, A. N., Andersen, J. H., Albrecht, D., Jelsbak, L., Krieger, S., Ohlsen, K., Hecker, M., Gerth, U., Ingmer, Hanne & Frees, Dorte, 2013, In: Journal of Proteome Research. 12, 2, p. 547-558 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    58. 2012
    59. Published

      Solonamide B Inhibits Quorum Sensing and reduces Staphylococcus aureus mediated killing of Human Neutrophils

      Nielsen, A., Månsson, M., Gram, L., Larsen, T. O., Phipps, R. K., Frees, Dorte, Frøkiær, Hanne & Ingmer, Hanne, Aug 2012.

      Research output: Contribution to conference › Poster › Research

    60. Published

      A porcine model of heamatogenous osteomyelitis: pathogenesis and pathology

      Jensen, Louise Kruse, Koch, J., Frees, Dorte, Aalbæk, Bent, Nielsen, O. L., Leifsson, Páll S., Buelund, Lene Elisabeth, Svalastoga, Eiliv Lars & Jensen, Henrik Elvang, 2012. 1 p.

      Research output: Contribution to conference › Poster › Research

    61. Published

      Antibiotic-mediated selection of quorum-sensing-negative Staphylococcus aureus

      Paulander, W. E. A., Varming, A. N., Bæk, K. T., Haaber, J. K., Frees, Dorte & Ingmer, Hanne, 2012, In: mBio. 3, 6, p. e00459-12 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    62. Published

      Local osteogenic expression of cyclooxygenase-2 and systemic response in porcine models of osteomyelitis

      Jensen, Louise Kruse, Iburg, T. M., Nielsen, O. L., Leifsson, Páll S., Dahl-Pedersen, Kirstin, Koch, J., Frees, Dorte, Aalbæk, Bent, Heegaard, P. M. H. & Jensen, Henrik Elvang, 2012, In: Prostaglandins & Other Lipid Mediators. 97, 3-4, p. 103-108 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    63. Published

      New insights into Staphylococcus aureus stress tolerance and virulence regulation from an analysis of the role of the ClpP protease in the strains Newman, COL, and SA564

      Frees, Dorte, Andersen, J. H., Hemmingsen, L., Koskenniemi, K., Bæk, K. T., Muhammed, Musemma Kedir, Gudeta, D. D., Nyman, T. A., Sukura, A., Varmanen, P. & Savijoki, K., 2012, In: Journal of Proteome Research. 11, 1, p. 95-108 14 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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