Dan Stærk

Dan Stærk

Head of Department, Visiting professor

ORCID: 0000-0003-0074-298X

Publication year:
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  1. 2024
  2. Published

    Eremane, viscidane and isozizaene diterpenoids from the leaves of Eremophila rigida and their absolute configurations

    Liang, Chao, Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2024, In: Phytochemistry. 219, 16 p., 113972.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Oxetane ring formation in taxol biosynthesis is catalyzed by a bifunctional cytochrome P450 enzyme

    Zhao, Yong, zpm303, zpm303, Xie, Yuman, Duan, Y. T., Andeadelli, A., Pateraki, Irini, Makris, A. M., Pomorski, Thomas Guenther, Stærk, Dan & Kampranis, Sotirios, 2024, In: Journal of the American Chemical Society. 146, p. 801-810

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. 2023
  5. Published

    Biosynthesis and biotechnological production of the anti-obesity agent celastrol

    Zhao, Yong, Hansen, N. L., Duan, Yaotao, Prasad, M., Motawie, Mohammed Saddik, Møller, Birger Lindberg, Pateraki, Irini, Stærk, Dan, Bak, Søren, Miettinen, Karel & Kampranis, Sotirios, 2023, In: Nature Chemistry. 15, p. 1236–1246

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    Characterization of serrulatane diterpenoids in Eremophila phyllopoda subsp. phyllopoda by triple high-resolution α-glucosidase/PTP1B/radical scavenging profiling, NMR spectroscopy, DFT-GIAO NMR, and electronic circular dichroism calculations

    Liang, Chao, Ndi, C., Kjaerulff, Louise, Semple, S., Buirchell, B., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2023, In: Journal of Natural Products. 86, 4, p. 694–709

    Research output: Contribution to journal › Journal article › Research › peer-review

  7. Published

    Identification of new PTP1B-inhibiting decipiene diterpenoid esters from Eremophila clarkei by high-resolution PTP1B inhibition profiling, enzyme kinetics analysis, and molecular docking

    Liang, Chao, Zang, J., Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2023, In: Bioorganic Chemistry. 139, 15 p., 106744.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Orthogonal reversed-phase C18 and pentafluorophenyl HPLC separation for phytochemical profiling of serrulatanes in Eremophila denticulata

    Zhao, Yong, Li, T., Kjaerulff, Louise, Venter, H., Coriani, S., Møller, Birger Lindberg, Semple, S. & Stærk, Dan, 2023, In: Journal of Natural Products. 86, 12, p. 2638-2650

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    Polypharmacology-labeled molecular networking: An analytical technology workflow for accelerated identification of multiple bioactive constituents in complex extracts

    Zhao, Yong, Gericke, Oliver, Li, T., Kjaerulff, Louise, Kongstad, Kenneth Thermann, Heskes, A. M., Møller, Birger Lindberg, Jørgensen, Flemming Steen, Venter, H., Coriani, S., Semple, S. J. & Stærk, Dan, 2023, In: Analytical Chemistry. 95, 9, p. 4381-4389 9 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Semi-synthesis of novel thebaine derivatives with low cytotoxicity and their antibacterial and antihemolytic properties

    Hasanpour, Z., Salehi, P., Aliahmadi, A., Hoseinpour, M., Behboodi, H., Stærk, Dan & Bararjanian, M., 2023, In: Medicinal Chemistry Research. 32, p. 1713–1725

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    The causal mutation leading to sweetness in modern white lupin cultivars

    Mancinotti, Davide, Czepiel, K., Taylor, J. L., Galehshahi, H. G., Møller, L. A., Jensen, M. K., Motawie, Mohammed Saddik, Hufnagel, B., Soriano, A., Yeheyis, L., Kjaerulff, Louise, Péret, B., Stærk, Dan, Wendt, T., Nelson, M. N., Kroc, M. & Geu-Flores, Fernando, 2023, In: Science Advances. 9, 31, 10 p., eadg8866.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. 2022
  13. Published

    Tripterygium wilfordii cytochrome P450s catalyze the methyl shift and epoxidations in the biosynthesis of triptonide

    Hansen, N. L., Kjaerulff, Louise, Heck, Q. K., Forman, Victor, Stærk, Dan, Møller, Birger Lindberg & Andersen-Ranberg, Johan, 2022, In: Nature Communications. 13, 5011.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    A GPCR-based yeast biosensor for biomedical, biotechnological, and point-of-use cannabinoid determination

    Miettinen, Karel, Leelahakorn, Nattawat, Almeida Robles, A. R., Zhao, Yong, Hansen, L. R., Nikolajsen, I. E., Andersen, Jens Bo, Givskov, Michael, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 3664.

    Research output: Contribution to journal › Journal article › Research › peer-review

  15. Published

    A gene cluster in Ginkgo biloba encodes unique multifunctional cytochrome P450s that initiate ginkgolide biosynthesis

    Forman, Victor, Luo, Dan, Geu-Flores, Fernando, Lemcke, René, Nelson, D., Kampranis, Sotirios, Stærk, Dan, Møller, Birger Lindberg & Pateraki, Irini, 2022, In: Nature Communications. 13, 14 p., 5143.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method

    Nordin, E., Steffensen, S. K., Laursen, B. B., Andersson, S., Johansson, J., Åman, P., Hallmans, G., Borre, M., Stærk, Dan, Hanhineva, K., Fomsgaard, I. S. & Landberg, R., 2022, In: Scientific Reports. 12, 14 p., 5260.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Ancient biosynthesis in an oil crop: Glucosinulate profiles in Limnanthes alba and its relatives (Limnanthaceae, Brassicales)

    Agerbirk, Niels, Pattison, David, Mandáková, T., Lysak, M. A., Montaut, S. & Stærk, Dan, 2022, In: Journal of Agricultural and Food Chemistry. 70, p. 1134-1147

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

    Semple, S., Stærk, Dan, Buirchell, B., Fowler, R., Gericke, Oliver, Kjaerulff, Louise, Zhao, Yong, Pedersen, H. A., Petersen, M. J., Rasmussen, L. F., Bredahl, E. K., Pedersen, Gustav Blichfeldt, McNair, Laura M., Ndi, C., Hansen, N. L., Heskes, A., Bayly, M., Loland, Claus Juul, Heinz, Nanna & Møller, Birger Lindberg, 2022, In: Plant Journal. 111, 4, p. 936-953 15866.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    Data-dependent acquisition-mass spectrometry guided isolation of new benzoxazinoids from the roots of Acanthus mollis L.

    Bhattarai, B., Steffensen, S. K., Stærk, Dan, Laursen, B. B. & Fomsgaard, I. S., 2022, In: International Journal of Mass Spectrometry. 474, 10 p., 116815.

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks

    Ignea, C., Raadam, Morten Hessellund, Koutsaviti, A., Zhao, Yong, Duan, Yaotao, Harizani, M., Miettinen, Karel, Georgantea, P., Rosenfeldt, M., Viejo-Ledesma, S. E., Petersen, Mikael Agerlin, Bredie, Wender, Stærk, Dan, Roussis, V., Ioannou, E. & Kampranis, Sotirios, 2022, In: Nature Communications. 13, 16 p., 5188.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    Fremtidens bæredygtige medicin fra naturen: Nye teknologier hjælper med at finde nålen i høstakken

    Stærk, Dan, 2022, In: Pharma. 2022, 2, p. 20-22

    Research output: Contribution to journal › Contribution to newspaper - Newspaper article › Communication

  22. Published

    Investigation of the mechanism and chemistry underlying Staphylococcus aureus' ability to inhibit Pseudomonas aeruginosa growth in vitro

    Kvich, Lasse Andersson, Crone, S. G., Christensen, M. H., Lima, R. D. C. L., Alhede, M., Alhede, M., Stærk, Dan & Bjarnsholt, Thomas, 2022, In: Journal of Bacteriology. 204, 11, 16 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Isolation and structure elucidation of caryophyllane sesquiterpenoids from leaves of Eremophila spathulata

    Bredahl, E. K., Kjaerulff, Louise, Ndi, C., Semple, S., Buirchell, B., Møller, Birger Lindberg & Stærk, Dan, 2022, In: Phytochemistry Letters. 47, p. 156-163

    Research output: Contribution to journal › Journal article › Research › peer-review

  24. Published

    Serrulatane diterpenoids from the leaves of Eremophila glabra and their potential as antihyperglycemic drug leads

    Petersen, M. J., Liang, Chao, Kjaerulff, Louise, Ndi, C., Semple, S., Buirchell, B., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2022, In: Phytochemistry. 196, 11 p., 113072.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Serrulatane diterpenoids with unusual side chain modifications from root bark of Eremophila longifolia

    Rasmussen, L. F., Anton, Jennifer, Kjaerulff, Louise, Zhao, Yong, Semple, S. J., Ndi, C., Buirchell, B., Møller, Birger Lindberg & Stærk, Dan, 2022, In: Phytochemistry. 203, 14 p., 113408.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. 2021
  27. Published

    Insects as sources for sustainable peptide drugs against type 2 diabetes

    Didriksen, A. H., Petersen, M. J. & Stærk, Dan, 8 Jun 2021. 1 p.

    Research output: Contribution to conference › Poster › Research

  28. Published

    α-Glucosidase inhibitory activity of plant extracts from the Danish Medicinal Plant Biobank

    Madsen, A. T., Soelberg, Jens & Stærk, Dan, 8 Jun 2021. 1 p.

    Research output: Contribution to conference › Poster › Research

  29. Published

    A systematic review of possible interactions for herbal medicines and dietary supplements used concomitantly with disease-modifying or symptom-alleviating multiple sclerosis drugs

    Petersen, M. J., Bergien, Sofie Olsgaard & Stærk, Dan, 2021, In: Phytotherapy Research. 35, 7, p. 3610-3631

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    An independent evolutionary origin for insect deterrent cucurbitacins in Iberis amara

    Dong, L., Almeida Robles, A. R., Pollier, J., Khakimov, Bekzod, Bassard, J. A., Miettinen, K., Stærk, Dan, Mehran, R., Olsen, C. E., Motawie, Mohammed Saddik, Goossens, A. & Bak, Søren, 2021, In: Molecular Biology and Evolution. 38, 11, p. 4659-4673 15 p., msab213.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Characterization of antidiabetic serrulatane diterpenoids from Eremophila phyllopoda by triple high-resolution α-glucosidase / PTP1B / radical scavenging profiling

    Liang, Chao, Ndi, C., Semple, S., Coriani, S., Møller, Birger Lindberg & Stærk, Dan, 2021. 1 p.

    Research output: Contribution to conference › Poster › Research

  32. Published

    Coupling microplate-based antibacterial assay with liquid chromatography for high-resolution growth inhibition profiling of crude extracts: Validation and proof-of-concept study with Staphylococcus aureus

    Ardalani, H., Anam, S., Kromphardt, K. J. K., Stærk, Dan & Kongstad, Kenneth Thermann, 2021, In: Molecules. 26, 6, 12 p., 1550.

    Research output: Contribution to journal › Journal article › Research › peer-review

  33. Published

    Dual high-resolution α-glucosidase and PTP1B profiling combined with HPLC-PDA-HRMS-SPE-NMR analysis for the identification of potentially antidiabetic chromene meroterpenoids in Rhododendron capitatum

    Liang, Chao, Kjaerulff, Louise, Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 2021, In: Journal of Natural Products. 84, p. 2454-2467

    Research output: Contribution to journal › Journal article › Research › peer-review

  34. Published

    Furolabdane diterpenoids from Pseudodictamnus aucheri (Boiss.) Salmaki & Siadati (Lamiaceae) as chemophenetic markers

    Sadani, S., Sarrafi, Y. & Stærk, Dan, 2021, In: Biochemical Systematics and Ecology. 98, 4 p., 104304.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Isolation and structure elucidation of serrulatane diterpenoids from the roots of Eremophila longifolia

    Rasmussen, L. F., Anton, J., Kjaerulff, Louise & Stærk, Dan, 2021, p. 1.

    Research output: Contribution to conference › Poster › Research

  36. Published

    Jagten på bioaktive naturstoffer: Sammenkoblet HPLC-PDA-HRMS-SPE-NMR til hurtig identifikation af bioaktive naturstoffer i komplekse blandinger

    Stærk, Dan, 2021, In: Dansk Kemi. 102, 4, p. 40-44

    Research output: Contribution to journal › Contribution to newspaper - Feature article › Communication

  37. Published

    Navigating through chemical space and evolutionary time across the Australian continent in plant genus Eremophila

    Gericke, Oliver, Fowler, R., Heskes, A., Bayly, M., Semple, S., Ndi, C. P., Stærk, Dan, Loland, Claus Juul, Murphy, D. J., Buirchell, B. & Møller, Birger Lindberg, 2021, In: Plant Journal. 108, 2, p. 555-578

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Phytochemical investigation of Eremophila spp.

    Bredahl, E. K., Ergin, Y., Kjaerulff, Louise & Stærk, Dan, 2021, p. 1.

    Research output: Contribution to conference › Poster › Research

  39. Published

    Reversal of ABCG2/BCRP-mediated multidrug resistance by 5,3’,5’-trihydroxy-3,6,7,4’-tetramethoxyflavone isolated from the Australian desert plant Eremophila galeata Chinnock

    Petersen, M. J., Lund, X. L., Semple, S. J., Buirchell, B., Franzyk, Henrik, Gajhede, Michael, Kongstad, Kenneth Thermann, Stenvang, Jan & Stærk, Dan, 2021, In: Biomolecules. 11, 10, 19 p., 1534.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    Semi-synthesis of novel buprenorphine derivatives and their anti-nociceptive properties and dependency potential

    Hasanpour, Z., Salehi, P., Bunch, Lennart, Khoramjouy, M., Bararjanian, M., Stærk, Dan & Faizi, M., 2021, In: Canadian Journal of Chemistry. 99, 11, p. 910-919

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. 2020
  42. Published

    Evaluation of the antidiabetic potential of Psidium guajava L. (Myrtaceae) using assays for α-glucosidase, α-amylase, muscle glucose uptake, liver glucose production and triglyceride accumulation in adipocytes

    Beidokhti, M. N., Eid, H. M., Villavicencio, M. L. S., Jäger, A. K., Lobbens, E. S., Rasoanaivo, P. R., McNair, Laura M., Haddad, P. S. & Stærk, Dan, 17 Apr 2020, In: Journal of Ethnopharmacology. 257, 8 p., 112877.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Structure elucidation of prenyl- and geranyl substituted coumarins in Gerbera piloselloides by NMR spectroscopy, electronic circular dichroism calculations, and single crystal X-ray crystallography

    Li, T., Ma, X., Fedotov, D., Kjaerulff, Louise, Frydenvang, Karla Andrea, Coriani, S., Hansen, Paul Robert, Kongstad, Kenneth Thermann & Stærk, Dan, 8 Apr 2020, In: Molecules. 25, 25 p., 1706.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    PTP1B-inhibiting branched-chain fatty acid dimers from Eremophila oppositifolia subsp. angustifolia identified by high-resolution PTP1B inhibition profiling and HPLC-PDA-HRMS-SPE-NMR analysis

    Pedersen, H. A., Ndi, C., Semple, S. J., Buirchell, B., Møller, Birger Lindberg & Stærk, Dan, 7 Apr 2020, In: Journal of Natural Products. 83, p. 1598-1610

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    4-Benzyloxylonchocarpin and muracatanes A-C from Ranunculus muricatus L. and their biological effects

    Hussain, H., Ali, I., Wang, D., Mamadalieva, N. Z., Hussain, W., Csuk, R., Loesche, A., Fischer, L., Stærk, Dan, Anam, S., AlZain, M. N., Mushtaq, M., Ul-Haq, Z., Ullah, R., Noman, O. M., Abbas, G. & Green, I. R., 2020, In: Biomolecules. 10, 11, 15 p., 1562.

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Antidiabetic xanthones with α-glucosidase inhibitory activities from an endophytic Penicillium canescens

    Malik, A., Ardalani, H., Anam, S., McNair, Laura M., Kromphardt, K. J. K., Frandsen, R. J. N., Franzyk, Henrik, Stærk, Dan & Kongstad, Kenneth Thermann, 2020, In: Fitoterapia. 142, 8 p., 104522.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Identification of Amaryllidaceae alkaloids in larvae of the ‘lily borer’ moth Brithys crini

    Nair, J. J., Andresen, A. L., Papenfus, H., Stærk, Dan & van Staden, J., 2020, In: South African Journal of Botany. 131, p. 351-359

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Integrating pathway elucidation with yeast engineering to produce polpunonic acid the precursor of the anti-obesity agent celastrol

    Hansen, N. L., Miettinen, Karel, Zhao, Yong, Ignea, C., Andreadeli, A., Raadam, Morten Hessellund, Makris, A. M., Møller, Birger Lindberg, Stærk, Dan, Bak, Søren & Kampranis, Sotirios, 2020, In: Microbial Cell Factories. 19, 17 p., 15.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Isolation, structure elucidation and PTP1B inhibitory activity of serrulatane diterpenoids from the roots of Myoporum insulare

    Kjaerulff, Louise, Jensen, A. B. J., Ndi, C., Semple, S. J., Møller, Birger Lindberg & Stærk, Dan, 2020, In: Phytochemistry Letters. 39, p. 49-56

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Nerylneryl diphosphate is the precursor of serrulatane, viscidane and cembrane-type diterpenoids in Eremophila species

    Gericke, Oliver, Hansen, N. L., Pedersen, G. B., Kjaerulff, Louise, Luo, Dan, Stærk, Dan, Møller, Birger Lindberg, Pateraki, Irini & Heskes, A., 2020, In: B M C Plant Biology. 20, 15 p., 91.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Potential of Myrtus communis Linn. as a bifunctional food: Dual high-resolution PTP1B and α-glucosidase inhibition profiling combined with HPLC-HRMS and NMR for identification of antidiabetic triterpenoids and phloroglucinol derivatives

    Liang, Chao, Stærk, Dan & Kongstad, Kenneth Thermann, 2020, In: Journal of Functional Foods. 64, 10 p., 103623.

    Research output: Contribution to journal › Journal article › Research › peer-review

  52. Published

    Structure elucidation and absolute configuration determination of nortriterpenoids from Picramnia glazioviana

    Gimenes, L., Luna-Dulcey, L., Batista Junior, J. M., dos Santos Junior, F. M., Popolin, C. P., Cominetti, M. R., Fernandes, J. B. & Stærk, Dan, 2020, In: Journal of Natural Products. 83, p. 1859-1876

    Research output: Contribution to journal › Journal article › Research › peer-review

  53. 2019
  54. Published

    High resolution techniques: General discussion

    Adair, E., Afonso, C., Bell, N. G. A., Davies, A. N., Delsuc, M. A., Godfrey, R., Goodacre, R., Hawkes, J. A., Hertkorn, N., Jones, D., Lameiras, P., Le Guennec, A., Lubben, A., Nilsson, M., Paša-Tolić, L., Richards, J., Rodgers, R. P., Rüger, C. P., Schmitt-Kopplin, P., Schoenmakers, P. J. & 8 others, Sidebottom, P., Stærk, Dan, Summerfield, S., Uhrín, D., Van Delft, P., Van Der Hooft, J. J. J., Van Zelst, F. H. M. & Zherebker, A., 1 Jan 2019, In: Faraday Discussions. 218, p. 247-267 21 p.

    Research output: Contribution to journal › Comment/debate › Research › peer-review

  55. Published

    2(5H)-Furanone sesquiterpenes from Eremophila bignoniiflora: High-resolution inhibition profiling and PTP1B inhibitory activity

    Zhao, Yong, Kjaerulff, Louise, Kongstad, Kenneth Thermann, Heskes, A. M., Møller, Birger Lindberg & Stærk, Dan, 2019, In: Phytochemistry. 166, p. 1-8 112054.

    Research output: Contribution to journal › Journal article › Research › peer-review

  56. Published

    19F-substituted amino acids as an alternative to fluorophore labels: monitoring of degradation and cellular uptake of analogues of penetratin by 19F NMR

    Christensen, M. V., Kongstad, Kenneth Thermann, Sondergaard, T. E., Stærk, Dan, Nielsen, Hanne Mørck, Franzyk, Henrik & Wimmer, R., 2019, In: Journal of Biomolecular N M R. 73, p. 167-182

    Research output: Contribution to journal › Journal article › Research › peer-review

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ID: 1299056