Chuna Ram Choudhary

Chuna Ram Choudhary

professor, group leader

  • Choudhary Group

    Blegdamsvej 3, 2200 København N., Bygning 6, Building: 06-6-14

    Phone: +45 35 32 50 20Mobile: +45 24 42 66 43

  1. 2020
  2. Published

    HBO1 is required for the maintenance of leukaemia stem cells

    MacPherson, L., Anokye, J., Yeung, M. M., Lam, E. Y. N., Chan, Y., Weng, C., Yeh, P., Knezevic, K., Butler, M. S., Hoegl, A., Chan, K., Burr, M. L., Gearing, L. J., Willson, T., Liu, J., Choi, J., Yang, Y., Bilardi, R. A., Falk, H., Nghi Nguyen, Stupple, P. A., Peat, T. S., Zhang, M., De Silva, M., Carrasco-Pozo, C., Avery, V. M., Khoo, S., Dolezal, O., Dennis, M. L., Nuttall, S., Surjadi, R., Newman, J., Ren, B., Leaver, D. J., Sun, Y., Baell, J. B., Dovey, O., Vassiliou, G. S., Grebien, F., Dawson, S., Street, I. P., Monahan, B. J., Burns, C. J., Choudhary, Chuna Ram, Blewitt, M. E., Voss, A. K., Thomas, T. & Dawson, M. A., 2020, In : Nature. 577, 7789, p. 266-270

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. 2019
  4. Published

    Acetylation of intrinsically disordered regions regulates phase separation

    Saito, M., Hess, D., Eglinger, J., Fritsch, A. W., Kreysing, M., Weinert, B. T., Choudhary, Chuna Ram & Matthias, P., Jan 2019, In : Nature Chemical Biology. 15, 1, p. 51-61

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry

    Prus, Gabriela Zofia, Hoegl, A., Weinert, B. T. & Choudhary, Chuna Ram, 2019, In : Trends in Biochemical Sciences. 44, 11, p. 943-960

    Research output: Contribution to journalReviewResearchpeer-review

  6. Published

    Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

    Hansen, B. K., Gupta, R., Baldus, L., Lyon, D., Narita, Takeo, Lammers, M., Choudhary, Chuna Ram & Weinert, B. T., 2019, In : Nature Communications. 10, 11 p., 1055.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Functions and mechanisms of non-histone protein acetylation

    Narita, Takeo, Weinert, B. T. & Choudhary, Chuna Ram, 2019, In : Nature Reviews. Molecular Cell Biology. 20, p. 156-174 19 p.

    Research output: Contribution to journalReviewResearchpeer-review

  8. Published

    Proteomic exploration of lysine acetylation signaling

    Choudhary, Chuna Ram, 2019, In : Molecular & Cellular Proteomics. 18, 8, p. S25 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  9. 2018
  10. Published

    DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

    Gupta, R., Somyajit, Kumar, Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, Dimitris, Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chuna Ram, 2018, In : Cell. 173, 4, p. 972-988

    Research output: Contribution to journalJournal articleResearchpeer-review

  11. Published

    Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint

    Wild, T., Budzowska, Magdalena, Hellmuth, S., Eibes, S., Karemore, Gopal, Barisic, Marin, Stemmann, O. & Choudhary, Chuna Ram, 2018, In : Cell Reports. 25, 9, 18 p., 2317-2328.e5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    STK3 is a therapeutic target for a subset of acute myeloid leukemias

    Camgoz, A., Paszkowski-Rogacz, M., Satpathy, S., Wermke, M., Hamann, M. V., von Bonin, M., Choudhary, Chuna Ram, Knapp, S. & Buchholz, F., 2018, In : OncoTarget. 9, 39, p. 25458-25473 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

    Weinert, B. T., Narita, Takeo, Satpathy, S., Srinivasan, Balaji, Hansen, B. K., Schölz, C., Hamilton, William, Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, Joshua Mark, Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, Chuna Ram, 2018, In : Cell. 174, 1, p. 231-244.e12 27 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

    Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, Niels, Choudhary, Chuna Ram, Bekker-Jensen, Simon Holst, Akutsu, M., Wagner, S. A. & Beli, P., 2018, In : Nature Communications. 9, p. 1-16 16 p., 1017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. 2017
  16. Published

    lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1

    Chakraborty, D., Paszkowski-Rogacz, M., Berger, N., Ding, L., Mircetic, J., Fu, J., Iesmantavicius, V., Choudhary, Chuna Ram, Anastassiadis, K., Stewart, A. F. & Buchholz, F., 12 Dec 2017, In : Cell Reports. 21, 11, p. 3012-3021 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Redox-sensitive alteration of replisome architecture safeguards genome integrity

    Somyajit, Kumar, Gupta, R., Sedlackova, Hana, Neelsen, K. J., Ochs, F., Rask, M., Choudhary, Chuna Ram & Lukas, Jiri, 10 Nov 2017, In : Science. 358, 6364, p. 797-802 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

    Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., Shaw, B., Algire, M., Hessler, P., Lam, L. T., Uziel, T., Faivre, E., Ferguson, D., Buchanan, F. G., Martin, R. L., Torrent, M., Chiang, G. G., Karukurichi, K., Langston, J. W., Weinert, B. T., Choudhary, Chuna Ram, de Vries, P., Van Drie, J. H., McElligott, D., Kesicki, E., Marmorstein, R., Sun, C., Cole, P. A., Rosenberg, S. H., Michaelides, M. R., Lai, A. & Bromberg, K. D., 5 Oct 2017, In : Nature. 550, 7674, p. 128-132 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome

    Weinert, B. T., Satpathy, S., Hansen, B. K., Lyon, D., Jensen, Lars Juhl & Choudhary, Chuna Ram, May 2017, In : Molecular and Cellular Proteomics. 16, p. 759-769

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. 2016
  21. Published

    SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes

    Wagner, S. A., Satpathy, S., Beli, P. & Choudhary, Chuna Ram, 1 Sep 2016, In : E M B O Journal. 35, 17, p. 1868-1884

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover

    Nguyen, T. H., Andrejeva, D., Gupta, R., Choudhary, Chuna Ram, Hong, X., Eichhorn, P. J., Loya, Anand Chainsukh & Cohen, S. M., 29 Mar 2016, In : Cell Discovery. 2, 13 p., 16001.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity

    Wild, T., Larsen, M. S. Y., Narita, Takeo, Schou, J., Nilsson, Jakob & Choudhary, Chuna Ram, 1 Mar 2016, In : Cell Reports. 14, 8, p. 1829-40 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

    Starnes, L. M., Su, D., Pikkupeura, Laura Maarit, Weinert, B. T., Santos, M. A., Mund, Andreas, Soria, R., Cho, Y., Pozdnyakova, I., Kubec Højfeldt, M., Lages Lino Vala, A., Yang, W., López-Méndez, B., Lee, J., Peng, W., Yuan, J., Ge, K., Montoya, Guillermo, Nussenzweig, A., Choudhary, Chuna Ram & Daniel, J. A., 15 Jan 2016, In : Genes & Development. 30, 2, p. 149-163 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance

    Pinela da Silva, S. C., Altmannova, V., Luke-Glaser, S., Henriksen, P., Gallina, Irene, Yang, X., Choudhary, Chuna Ram, Luke, B., Krejci, L. & Lisby, Michael, 2016, In : Genes & Development. 30, 6, p. 700-717 18 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. 2015
  27. Published

    Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage

    Thorslund, T., Ripplinger, A., Hoffmann, Saskia, Wild, T., Uckelmann, M., Villumsen, B., Narita, Takeo, Sixma, T. K., Choudhary, Chuna Ram, Bekker-Jensen, Simon Holst & Mailand, Niels, 19 Nov 2015, In : Nature. 527, 7578, p. 389-93 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  28. Published

    Analysis of acetylation stoichiometry suggests that SIRT3 repairs nonenzymatic acetylation lesions

    Weinert, B. T., Moustafa, T., Iesmantavicius, V., Zechner, R. & Choudhary, Chuna Ram, 3 Nov 2015, In : E M B O Journal. 34, 21, p. 2620-2632 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Avoiding abundance bias in the functional annotation of posttranslationally modified proteins

    Schölz, C., Lyon, D., Refsgaard, J. C., Jensen, Lars Juhl, Choudhary, Chuna Ram & Weinert, B. T., Nov 2015, In : Nature Methods. 12, p. 1003-4 2 p.

    Research output: Contribution to journalComment/debateResearchpeer-review

  30. Published

    Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits

    Acosta-Alvear, D., Cho, M. Y., Wild, T., Buchholz, T. J., Lerner, A. G., Simakova, O., Hahn, J., Korde, N., Landgren, O., Maric, I., Choudhary, Chuna Ram, Walter, P., Weissman, J. S. & Kampmann, M., 1 Sep 2015, In : eLife. 4, p. 1-19 e08153.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Systems Analyses Reveal Shared and Diverse Attributes of Oct4 Regulation in Pluripotent Cells

    Ding, L., Paszkowski-Rogacz, M., Winzi, M., Chakraborty, D., Theis, M., Singh, S., Ciotta, G., Poser, I., Roguev, A., Chu, W. K., Choudhary, Chuna Ram, Mann, Matthias, Stewart, A. F., Krogan, N. & Buchholz, F., 26 Aug 2015, In : Cell Systems. 1, 2, p. 141-151 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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