Chuna Ram Choudhary

Chuna Ram Choudhary

professor, group leader

  • Choudhary Group

    Blegdamsvej 3, 2200 København N., Bygning 6, Building: 06-6-14

    Phone: +45 35 32 50 20Mobile: +45 24 42 66 43

  1. 2021
  2. E-pub ahead of print

    Enhancers are activated by p300/CBP activity-dependent PIC assembly, RNAPII recruitment, and pause release

    Narita, Takeo, Ito, S., Higashijima, Yoshiki, Chu, W. K., Neumann, K., Walter, Jonas, Satpathy, S., Liebner, Tim, Hamilton, William, Maskey, E., Prus, G., Shibata, M., Iesmantavicius, V., Brickman, Joshua Mark, Anastassiadis, K., Koseki, H. & Choudhary, Chunaram, 17 Mar 2021, (E-pub ahead of print) In: Molecular Cell.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Proteome dynamics at broken replication forks reveal a distinct ATM-directed repair response suppressing DNA double-strand break ubiquitination

    Nakamura, K., Kustatscher, G., Alabert, C., Hödl, M., Forne, I., Völker-Albert, M., Satpathy, S., Beyer, T. E., Mailand, Niels, Choudhary, Chunaram, Imhof, A., Rappsilber, J. & Groth, Anja, 2021, In: Molecular Cell. 81, 3, 23 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    SIK2 orchestrates actin-dependent host response upon Salmonella infection

    Hahn, M., Covarrubias-Pinto, A., Herhaus, L., Satpathy, S., Klann, K., Boyle, K. B., Münch, C., Rajalingam, K., Randow, F., Choudhary, Chunaram & Dikic, I., 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 19, 10 p., e2024144118.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. 2020
  6. Published

    Equilibrium between nascent and parental MCM proteins protects replicating genomes

    Sedlackova, Hana, Rask, M., Gupta, R., Choudhary, Chunaram, Somyajit, K. & Lukas, Jiri, 2020, In: Nature. 587, p. 297-302 34 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    HBO1 is required for the maintenance of leukaemia stem cells

    MacPherson, L., Anokye, J., Yeung, M. M., Lam, E. Y. N., Chan, Y., Weng, C., Yeh, P., Knezevic, K., Butler, M. S., Hoegl, A., Chan, K., Burr, M. L., Gearing, L. J., Willson, T., Liu, J., Choi, J., Yang, Y., Bilardi, R. A., Falk, H., Nghi Nguyen, Stupple, P. A., Peat, T. S., Zhang, M., De Silva, M., Carrasco-Pozo, C., Avery, V. M., Khoo, S., Dolezal, O., Dennis, M. L., Nuttall, S., Surjadi, R., Newman, J., Ren, B., Leaver, D. J., Sun, Y., Baell, J. B., Dovey, O., Vassiliou, G. S., Grebien, F., Dawson, S., Street, I. P., Monahan, B. J., Burns, C. J., Choudhary, Chunaram, Blewitt, M. E., Voss, A. K., Thomas, T. & Dawson, M. A., 2020, In: Nature. 577, 7789, p. 266-270

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Histone Acetyltransferase MOF Blocks Acquisition of Quiescence in Ground-State ESCs through Activating Fatty Acid Oxidation

    Khoa, L. T. P., Tsan, Y., Mao, F., Kremer, D. M., Sajjakulnukit, P., Zhang, L., Zhou, B., Tong, X., Bhanu, N. V., Choudhary, Chunaram, Garcia, B. A., Yin, L., Smith, G. D., Saunders, T. L., Bielas, S. L., Lyssiotis, C. A. & Dou, Y., 2020, In: Cell Stem Cell. 27, 3, p. 441-458.e10 29 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Sequencing of the First Draft of the Human Acetylome

    Choudhary, Chunaram & Mann, Matthias, 2020, In: Clinical Chemistry. 66, 6, p. 852-853 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. 2019
  11. Published

    Acetylation of intrinsically disordered regions regulates phase separation

    Saito, M., Hess, D., Eglinger, J., Fritsch, A. W., Kreysing, M., Weinert, B. T., Choudhary, Chunaram & Matthias, P., Jan 2019, In: Nature Chemical Biology. 15, 1, p. 51-61

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Analysis and Interpretation of Protein Post-Translational Modification Site Stoichiometry

    Prus, Gabriela Zofia, Hoegl, A., Weinert, B. T. & Choudhary, Chunaram, 2019, In: Trends in Biochemical Sciences. 44, 11, p. 943-960

    Research output: Contribution to journalReviewResearchpeer-review

  13. Published

    Analysis of human acetylation stoichiometry defines mechanistic constraints on protein regulation

    Hansen, B. K., Gupta, R., Baldus, L., Lyon, D., Narita, Takeo, Lammers, M., Choudhary, Chunaram & Weinert, B. T., 2019, In: Nature Communications. 10, 11 p., 1055.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Functions and mechanisms of non-histone protein acetylation

    Narita, Takeo, Weinert, B. T. & Choudhary, Chunaram, 2019, In: Nature Reviews. Molecular Cell Biology. 20, p. 156-174 19 p.

    Research output: Contribution to journalReviewResearchpeer-review

  15. Published

    Proteomic exploration of lysine acetylation signaling

    Choudhary, Chunaram, 2019, In: Molecular & Cellular Proteomics. 18, 8, p. S25 1 p.

    Research output: Contribution to journalConference abstract in journalResearch

  16. 2018
  17. Published

    DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

    Gupta, R., Somyajit, K., Narita, Takeo, Maskey, E., Stanlie, A., Kremer, M., Typas, Dimitris, Lammers, M., Mailand, Niels, Nussenzweig, A., Lukas, Jiri & Choudhary, Chunaram, 2018, In: Cell. 173, 4, p. 972-988

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint

    Wild, T., Budzowska, M., Hellmuth, S., Eibes, S., Karemore, Gopal, Barisic, Marin, Stemmann, O. & Choudhary, Chunaram, 2018, In: Cell Reports. 25, 9, 18 p., 2317-2328.e5.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    STK3 is a therapeutic target for a subset of acute myeloid leukemias

    Camgoz, A., Paszkowski-Rogacz, M., Satpathy, S., Wermke, M., Hamann, M. V., von Bonin, M., Choudhary, Chunaram, Knapp, S. & Buchholz, F., 2018, In: OncoTarget. 9, 39, p. 25458-25473 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  20. Published

    Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome

    Weinert, B. T., Narita, Takeo, Satpathy, S., Srinivasan, Balaji, Hansen, B. K., Schölz, C., Hamilton, William, Zucconi, B. E., Wang, W. W., Liu, W. R., Brickman, Joshua Mark, Kesicki, E. A., Lai, A., Bromberg, K. D., Cole, P. A. & Choudhary, Chunaram, 2018, In: Cell. 174, 1, p. 231-244.e12 27 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  21. Published

    p38-MK2 signaling axis regulates RNA metabolism after UV-light-induced DNA damage

    Borisova, M. E., Voigt, A., Tollenaere, M. A. X., Sahu, S. K., Juretschke, T., Kreim, N., Mailand, Niels, Choudhary, Chunaram, Bekker-Jensen, Simon Holst, Akutsu, M., Wagner, S. A. & Beli, P., 2018, In: Nature Communications. 9, p. 1-16 16 p., 1017.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. 2017
  23. Published

    lncRNA Panct1 Maintains Mouse Embryonic Stem Cell Identity by Regulating TOBF1 Recruitment to Oct-Sox Sequences in Early G1

    Chakraborty, D., Paszkowski-Rogacz, M., Berger, N., Ding, L., Mircetic, J., Fu, J., Iesmantavicius, V., Choudhary, Chunaram, Anastassiadis, K., Stewart, A. F. & Buchholz, F., 12 Dec 2017, In: Cell Reports. 21, 11, p. 3012-3021 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Redox-sensitive alteration of replisome architecture safeguards genome integrity

    Somyajit, K., Gupta, R., Sedlackova, Hana, Neelsen, K. J., Ochs, F., Rask, M., Choudhary, Chunaram & Lukas, Jiri, 10 Nov 2017, In: Science. 358, 6364, p. 797-802 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours

    Lasko, L. M., Jakob, C. G., Edalji, R. P., Qiu, W., Montgomery, D., Digiammarino, E. L., Hansen, T. M., Risi, R. M., Frey, R., Manaves, V., Shaw, B., Algire, M., Hessler, P., Lam, L. T., Uziel, T., Faivre, E., Ferguson, D., Buchanan, F. G., Martin, R. L., Torrent, M., Chiang, G. G., Karukurichi, K., Langston, J. W., Weinert, B. T., Choudhary, Chunaram, de Vries, P., Van Drie, J. H., McElligott, D., Kesicki, E., Marmorstein, R., Sun, C., Cole, P. A., Rosenberg, S. H., Michaelides, M. R., Lai, A. & Bromberg, K. D., 5 Oct 2017, In: Nature. 550, 7674, p. 128-132 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Accurate quantification of site-specific acetylation stoichiometry reveals the impact of sirtuin deacetylase CobB on the E. coli acetylome

    Weinert, B. T., Satpathy, S., Hansen, B. K., Lyon, D., Jensen, Lars Juhl & Choudhary, Chunaram, May 2017, In: Molecular and Cellular Proteomics. 16, p. 759-769

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. 2016
  28. Published

    SPATA2 links CYLD to the TNF-α receptor signaling complex and modulates the receptor signaling outcomes

    Wagner, S. A., Satpathy, S., Beli, P. & Choudhary, Chunaram, 1 Sep 2016, In: E M B O Journal. 35, 17, p. 1868-1884

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Deubiquitylating enzyme USP9x regulates hippo pathway activity by controlling angiomotin protein turnover

    Nguyen, T. H., Andrejeva, D., Gupta, R., Choudhary, Chunaram, Hong, X., Eichhorn, P. J., Loya, Anand Chainsukh & Cohen, S. M., 29 Mar 2016, In: Cell Discovery. 2, 13 p., 16001.

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    The Spindle Assembly Checkpoint Is Not Essential for Viability of Human Cells with Genetically Lowered APC/C Activity

    Wild, T., Larsen, M. S. Y., Narita, Takeo, Schou, J., Nilsson, Jakob & Choudhary, Chunaram, 1 Mar 2016, In: Cell Reports. 14, 8, p. 1829-40 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

    Starnes, L. M., Su, D., Pikkupeura, Laura Maarit, Weinert, B. T., Santos, M. A., Mund, Andreas, Soria, R., Cho, Y., Pozdnyakova, I., Kubec Højfeldt, M., Lages Lino Vala, A., Yang, W., López-Méndez, B., Lee, J., Peng, W., Yuan, J., Ge, K., Montoya, Guillermo, Nussenzweig, A., Choudhary, Chunaram & Daniel, J. A., 15 Jan 2016, In: Genes & Development. 30, 2, p. 149-163 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

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ID: 13781159