Christoffer Clemmensen

Christoffer Clemmensen

Associate Professor


  1. 2020
  2. Published

    The unidentified hormonal defense against weight gain

    Lund, Jens, Lund, Camilla, Morville, T. H. & Clemmensen, Christoffer, 25 Feb 2020, In : PLOS Biology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Glucometabolic consequences of acute and prolonged inhibition of fatty acid oxidation

    Lundsgaard, Anne-Marie, Fritzen, Andreas Mæchel, Nicolaisen, Trine Sand, Carl, Christian Strini, Sjøberg, Kim A, Raun, Steffen Henning, Klein, Anders Bue, Sanchez-Quant, E., Langer, J., Ørskov, Cathrine, Clemmensen, Christoffer, Tschöp, M. H., Richter, Erik A., Kiens, Bente & Kleinert, Maximilian, 2020, In : Journal of Lipid Research. 61, 1, p. 10-19 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. E-pub ahead of print

    Muscarinic receptors in energy homeostasis: Physiology and pharmacology

    Falk, Sarah, Lund, Camilla & Clemmensen, Christoffer, 2020, In : Basic & Clinical Pharmacology & Toxicology.

    Research output: Contribution to journalReviewResearchpeer-review

  5. Published

    Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity

    Jall, S., De Angelis, M., Lundsgaard, Anne-Marie, Fritzen, Andreas Mæchel, Nicolaisen, Trine Sand, Klein, Anders Bue, Novikoff, A., Sachs, S., Richter, Erik A., Kiens, Bente, Schramm, K., Tschöp, M. H., Stemmer, K., Clemmensen, Christoffer, Müller, T. D. & Kleinert, Maximilian, 2020, In : Diabetologia. 63, 6, p. 1236-1247 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation

    Fischer, K., Fenzl, A., Liu, D., Dyar, K. A., Kleinert, Maximilian, Brielmeier, M., Clemmensen, Christoffer, Fedl, A., Finan, B., Gessner, A., Jastroch, M., Huang, J., Keipert, S., Klingenspor, M., Brüning, J. C., Kneilling, M., Maier, F. C., Othman, A. E., Pichler, B. J., Pramme-Steinwachs, I., Sachs, S., Scheideler, A., Thaiss, W. M., Uhlenhaut, H., Ussar, S., Woods, S. C., Zorn, J., Stemmer, K., Collins, S., Diaz-Meco, M., Moscat, J., Tschöp, M. H. & Müller, T. D., 2020, In : Nature Communications. 11, 1, 13 p., 2306.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. 2019
  8. Published

    Designing Poly-agonists for Treatment of Metabolic Diseases: Challenges and Opportunities

    Petersen, Jonas Odgaard, Strømgaard, Kristian, Frølund, Bente & Clemmensen, Christoffer, 2019, In : Drugs. 79, 11, p. 1187-1197 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Effect of bariatric surgery on plasma GDF15 in humans

    Kleinert, Maximilian, Bojsen-Møller, K. N., Jørgensen, N. B., Svane, M. S., Martinussen, C., Kiens, Bente, Wojtaszewski, Jørgen F P, Madsbad, Sten, Richter, Erik A. & Clemmensen, Christoffer, 2019, In : American Journal of Physiology: Endocrinology and Metabolism. 316, 4, p. E615-E621 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

    Clemmensen, Christoffer, Finan, B., Müller, T. D., DiMarchi, R. D., Tschöp, M. H. & Hofmann, S. M., 2019, In : Nature Reviews Endocrinology. 15, p. 90-104

    Research output: Contribution to journalReviewResearchpeer-review

  11. Published

    GLP-1/dexamethasone inhibits food reward without inducing mood and memory deficits in mice

    Decarie-Spain, L., Fisette, A., Zhu, Z., Yang, B., DiMarchi, R. D., Tschoep, M. H., Finan, B., Fulton, S. & Clemmensen, Christoffer, 2019, In : Neuropharmacology. 151, p. 55-63

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Long-Acting Neurotensin Synergizes With Liraglutide to Reverse Obesity Through a Melanocortin-Dependent Pathway

    Ratner, C., He, Z., Grunddal, K. V., Skov, Louise Julie, Hartmann, Bolette, Zhang, F., Feuchtinger, A., Bjerregaard, A., Christoffersen, Christina, Tschöp, M. H., Finan, B., DiMarchi, R. D., Leinninger, G. M., Williams, K. W., Clemmensen, Christoffer & Holst, Birgitte, 2019, In : Diabetes. 68, 6, p. 1329-1340

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice

    Jall, S., Finan, B., Collden, G., Fischer, K., Dong, X., Tschoep, M. H., Mueller, T. D. & Clemmensen, Christoffer, 2019, In : Molecular Metabolism. 23, p. 75-81

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. 2018
  15. Published

    Animal models of obesity and diabetes mellitus

    Kleinert, Maximilian, Clemmensen, Christoffer, Hofmann, S. M., Moore, M. C., Renner, S., Woods, S. C., Huypens, P., Beckers, J., de Angelis, M. H., Schürmann, A., Bakhti, M., Klingenspor, M., Heiman, M., Cherrington, A. D., Ristow, M., Lickert, H., Wolf, E., Havel, P. J., Müller, T. D. & Tschöp, M. H., 2018, In : Nature Reviews Endocrinology. 14, p. 140-162 23 p.

    Research output: Contribution to journalReviewResearchpeer-review

  16. Published

    Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes

    Clemmensen, Christoffer, Jall, S., Kleinert, Maximilian, Quarta, C., Gruber, T., Reber, J., Sachs, S., Fischer, K., Feuchtinger, A., Karlas, A., Simonds, S. E., Grandl, G., Loher, D., Sanchez-Quant, E., Keipert, S., Jastroch, M., Hofmann, S. M., Nascimento, E. B. M., Schrauwen, P., Ntziachristos, V., Cowley, M. A., Finan, B., Müller, T. D. & Tschöp, M. H., 2018, In : Nature Communications. 9, 13 p., 4304.

    Research output: Contribution to journalJournal articleResearchpeer-review

  17. Published

    Divergent effects of resistance and endurance exercise on plasma bile acids, FGF19, and FGF21 in humans

    Morville, T., Sahl, Ronni Eg, Trammell, Sam, Svenningsen, J. S., Gillum, Matthew Paul, Helge, Jørn Wulff & Clemmensen, Christoffer, 2018, In : JCI Insight. 3, 15, p. 1-13 e122737.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Exercise increases circulating GDF15 in humans

    Kleinert, Maximilian, Clemmensen, Christoffer, Sjøberg, Kim A, Carl, Christian Strini, Jeppesen, J. F., Wojtaszewski, Jørgen F P, Kiens, Bente & Richter, Erik A., 2018, In : Molecular Metabolism. 9, p. 187-191 5 p.

    Research output: Contribution to journalLetterResearchpeer-review

  19. Published

    Time-resolved hypothalamic open flow micro-perfusion reveals normal leptin transport across the blood–brain barrier in leptin resistant mice

    Kleinert, Maximilian, Kotzbeck, P., Altendorfer-Kroath, T., Birngruber, T., Tschöp, M. H. & Clemmensen, Christoffer, 2018, In : Molecular Metabolism. 13, p. 77-82 6 p.

    Research output: Contribution to journalLetterResearchpeer-review

  20. 2017
  21. Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity

    Quarta, C., Clemmensen, Christoffer, Zhu, Z., Yang, B., Joseph, S. S., Lutter, D., Yi, C., Graf, E., García-Cáceres, C., Legutko, B., Fischer, K., Brommage, R., Zizzari, P., Franklin, B. S., Krueger, M., Koch, M., Vettorazzi, S., Li, P., Hofmann, S. M., Bakhti, M., Bastidas-Ponce, A., Lickert, H., Strom, T. M., Gailus-Durner, V., Bechmann, I., Perez-Tilve, D., Tuckermann, J., Hrabě de Angelis, M., Sandoval, D., Cota, D., Latz, E., Seeley, R. J., Müller, T. D., DiMarchi, R. D., Finan, B. & Tschöp, M. H., 3 Oct 2017, In : Cell Metabolism. 26, 4, p. 620-632.e6

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. GLP-1/glucagon receptor co-agonism for treatment of obesity

    Sánchez-Garrido, M. A., Brandt, S. J., Clemmensen, Christoffer, Müller, T. D., DiMarchi, R. D. & Tschöp, M. H., Oct 2017, In : Diabetologia. 60, 10, p. 1851-1861 11 p.

    Research output: Contribution to journalReviewResearchpeer-review

  23. Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

    Fischer, K., Ruiz, H. H., Jhun, K., Finan, B., Oberlin, D. J., van der Heide, V., Kalinovich, A. V., Petrovic, N., Wolf, Y., Clemmensen, Christoffer, Shin, A. C., Divanovic, S., Brombacher, F., Glasmacher, E., Keipert, S., Jastroch, M., Nagler, J., Schramm, K., Medrikova, D., Collden, G., Woods, S. C., Herzig, S., Homann, D., Jung, S., Nedergaard, J., Cannon, B., Tschöp, M. H., Müller, T. D. & Buettner, C., May 2017, In : Nature Medicine. 23, 5, p. 623-630 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice

    Jall, S., Sachs, S., Clemmensen, Christoffer, Finan, B., Neff, F., DiMarchi, R. D., Tschöp, M. H., Müller, T. D. & Hofmann, S. M., May 2017, In : Molecular Metabolism. 6, 5, p. 440-446 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. The New Biology and Pharmacology of Glucagon

    Müller, T. D., Finan, B., Clemmensen, Christoffer, DiMarchi, R. D. & Tschöp, M. H., Apr 2017, In : Physiological Reviews. 97, 2, p. 721-766 46 p.

    Research output: Contribution to journalReviewResearchpeer-review

  26. Gut-Brain Cross-Talk in Metabolic Control

    Clemmensen, Christoffer, Müller, T. D., Woods, S. C., Berthoud, H., Seeley, R. J. & Tschöp, M. H., 23 Feb 2017, In : Cell. 168, 5, p. 758-774 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  27. Published

    Emerging poly-agonists for obesity and type 2 diabetes

    Kleinert, Maximilian, Clemmensen, Christoffer, Stemmer, K., Müller, T. D., DiMarchi, R. D. & Tschöp, M. H., 2017, In : Obesity. 25, 10, p. 1647-1649 3 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  28. Published

    Robust GLP-1 secretion by basic L-amino acids does not require the GPRC6A receptor

    Clemmensen, Christoffer, Jørgensen, C. V., Smajilovic, S. & Bräuner-Osborne, Hans, 2017, In : Diabetes, Obesity and Metabolism. 19, 4, p. 599-603

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. 2016
  30. Determination of thyroid hormones in mouse tissues by isotope-dilution microflow liquid chromatography-mass spectrometry method

    De Angelis, M., Giesert, F., Finan, B., Clemmensen, Christoffer, Müller, T. D., Vogt-Weisenhorn, D., Tschöp, M. H. & Schramm, K., 15 Oct 2016, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 1033-1034, p. 413-420 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Fibroblast activation protein (FAP) as a novel metabolic target

    Sánchez-Garrido, M. A., Habegger, K. M., Clemmensen, Christoffer, Holleman, C., Müller, T. D., Perez-Tilve, D., Li, P., Agrawal, A. S., Finan, B., Drucker, D. J., Tschöp, M. H., DiMarchi, R. D. & Kharitonenkov, A., Oct 2016, In : Molecular Metabolism. 5, 10, p. 1015-24 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  32. Unimolecular Polypharmacy for Treatment of Diabetes and Obesity

    Tschöp, M. H., Finan, B., Clemmensen, Christoffer, Gelfanov, V., Perez-Tilve, D., Müller, T. D. & DiMarchi, R. D., 12 Jul 2016, In : Cell Metabolism. 24, 1, p. 51-62 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  33. Unforeseen role for glucocorticoids in combinatorial anti-obesity pharmacology

    Quarta, C. & Clemmensen, Christoffer, Jul 2016, In : Molecular Metabolism. 5, 7, p. 435-6 2 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Reappraisal of GIP Pharmacology for Metabolic Diseases

    Finan, B., Müller, T. D., Clemmensen, Christoffer, Perez-Tilve, D., DiMarchi, R. D. & Tschöp, M. H., May 2016, In : Trends in Molecular Medicine. 22, 5, p. 359-76 18 p.

    Research output: Contribution to journalReviewResearchpeer-review

  35. Renaissance of leptin for obesity therapy

    Quarta, C., Sánchez-Garrido, M. A., Tschöp, M. H. & Clemmensen, Christoffer, May 2016, In : Diabetologia. 59, 5, p. 920-7 8 p.

    Research output: Contribution to journalReviewResearchpeer-review

  36. Hypothalamic leptin action is mediated by histone deacetylase 5

    Kabra, D. G., Pfuhlmann, K., García-Cáceres, C., Schriever, S. C., Casquero García, V., Kebede, A. F., Fuente-Martin, E., Trivedi, C., Heppner, K., Uhlenhaut, N. H., Legutko, B., Kabra, U. D., Gao, Y., Yi, C., Quarta, C., Clemmensen, Christoffer, Finan, B., Müller, T. D., Meyer, C. W., Paez-Pereda, M., Stemmer, K., Woods, S. C., Perez-Tilve, D., Schneider, R., Olson, E. N., Tschöp, M. H. & Pfluger, P. T., 29 Feb 2016, In : Nature Communications. 7, 10782.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Chemical hybridization of glucagon and thyroid hormone optimizes therapeutic impact for metabolic disease

    Finan, B., Clemmensen, Christoffer, Zhu, Z., Stemmer, K., Gauthier, K., Müller, L., De Angelis, M., Moreth, K., Neff, F., Perez-Tilve, D., Fischer, K., Lutter, D., Sánchez-Garrido, M. A., Liu, P., Tuckermann, J., Malehmir, M., Healy, M. E., Weber, A., Heikenwalder, M., Jastroch, M., Kleinert, Maximilian, Jall, S., Brandt, S., Flamant, F., Schramm, K. W., Biebermann, H., Döring, Y., Weber, C., Habegger, K. M., Keuper, M., Gelfanov, V., Liu, F., Köhrle, J., Rozman, J., Fuchs, H., Gailus-Durner, V., Hrabě de Angelis, M., Hofmann, S. M., Yang, B., Tschöp, M. H., Dimarchi, R. & Müller, T. D., 2016, In : Cell. 167, 3, p. 843-857.e1-e14 29 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Current and Emerging Treatment Options in Diabetes Care

    Clemmensen, Christoffer, Müller, T. D., Finan, B., Tschöp, M. H. & DiMarchi, R., 2016, Metabolic Control. Springer, Vol. 233. p. 437-459 23 p. (Handbook of Experimental Pharmacology; No. 233).

    Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

  39. 2015
  40. Published

    Emerging opportunities for the treatment of metabolic diseases: Glucagon-like peptide-1 based multi-agonists

    Finan, B., Clemmensen, Christoffer & Müller, T. D., 15 Dec 2015, In : Molecular and Cellular Endocrinology. 418 Pt 1, p. 42-54 13 p.

    Research output: Contribution to journalReviewResearchpeer-review

  41. Published

    Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice

    Clemmensen, Christoffer, Finan, B., Fischer, K., Tom, R. Z., Legutko, B., Sehrer, L., Heine, D., Grassl, N., Meyer, C. W., Henderson, B., Hofmann, S. M., Tschöp, M. H., Van der Ploeg, L. H. T. & Müller, T. D., Mar 2015, In : EMBO Molecular Medicine. 7, 3, p. 288-98 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

    Finan, B., Yang, B., Ottaway, N., Smiley, D. L., Ma, T., Clemmensen, Christoffer, Chabenne, J., Zhang, L., Habegger, K. M., Fischer, K., Campbell, J. E., Sandoval, D., Seeley, R. J., Bleicher, K., Uhles, S., Riboulet, W., Funk, J., Hertel, C., Belli, S., Sebokova, E., Conde-Knape, K., Konkar, A., Drucker, D. J., Gelfanov, V., Pfluger, P. T., Müller, T. D., Perez-Tilve, D., DiMarchi, R. D. & Tschöp, M. H., Jan 2015, In : Nature Medicine. 21, 1, p. 27-36 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. 2014
  44. Published

    FXR is a molecular target for the effects of vertical sleeve gastrectomy

    Ryan, K. K., Tremaroli, V., Clemmensen, Christoffer, Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F. & Seeley, R. J., 8 May 2014, In : Nature. 509, 7499, p. 183-8 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  45. Published

    GLP-1/glucagon coagonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet

    Clemmensen, Christoffer, Chabenne, J., Finan, B., Sullivan, L., Fischer, K., Küchler, D., Sehrer, L., Ograjsek, T., Hofmann, S. M., Schriever, S. C., Pfluger, P. T., Pinkstaff, J., Tschöp, M. H., Dimarchi, R. & Müller, T. D., Apr 2014, In : Diabetes. 63, 4, p. 1422-7 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Loss of melanocortin-4 receptor function attenuates HPA responses to psychological stress

    Ryan, K. K., Mul, J. D., Clemmensen, Christoffer, Egan, A. E., Begg, D. P., Halcomb, K., Seeley, R. J., Herman, J. P. & Ulrich-Lai, Y. M., Apr 2014, In : Psychoneuroendocrinology. 42, p. 98-105 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    The G protein-coupled receptor, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function

    Clemmensen, Christoffer, Smajilovic, S., Wellendorph, Petrine & Bräuner-Osborne, Hans, 2014, In : British Journal of Pharmacology. 171, 5, p. 1129-1141

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    The Pentapeptide RM-131 Promotes Food Intake and Adiposity in Wildtype Mice but Not in Mice Lacking the Ghrelin Receptor

    Fischer, K., Finan, B., Clemmensen, Christoffer, van der Ploeg, L. H. T., Tschöp, M. H. & Müller, T. D., 2014, In : Frontiers in Nutrition. 1, p. 31

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. 2013
  50. Published

    Enhanced voluntary wheel running in GPRC6A receptor knockout mice

    Clemmensen, Christoffer, Pehmøller, C., Klein, Anders Bue, Ratner, C., Wojtaszewski, Jørgen F P & Bräuner-Osborne, Hans, 2013, In : Physiology & Behavior. 118, p. 144-151 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  51. Published

    Increased susceptibility to diet-induced obesity in GPRC6A receptor knockout mice

    Clemmensen, Christoffer, Smajilovic, S., Madsen, A. N., Klein, Anders Bue, Holst, Birgitte & Bräuner-Osborne, Hans, 2013, In : Journal of Endocrinology. 217, 2, p. 151-60 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published

    The L-alpha-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release

    Smajilovic, S., Clemmensen, Christoffer, Johansen, L. D., Wellendorph, Petrine, Holst, Jens Juul, Thams, P. G., Ogo, E. & Bräuner-Osborne, Hans, 2013, In : Amino Acids. 44, 2, p. 383-390 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  53. 2012
  54. Published

    L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances

    Clemmensen, Christoffer, Madsen, A. N., Smajilovic, S., Holst, Birgitte & Bräuner-Osborne, Hans, 2012, In : Amino Acids. 43, 3, p. 1265-1275

    Research output: Contribution to journalJournal articleResearchpeer-review

ID: 16824492