Carolyn F. Deacon

Carolyn F. Deacon

Associate Professor

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    ORCID: 0000-0003-2611-5642

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    1. Published

      Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

      Windeløv, Johanne Agerlin, Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Jepsen, Sara Lind, Hornburg, D., Pedersen, Jens, Jensen, E. P., Galsgaard, Katrine Douglas, Winther-Sørensen, Marie, Ørgaard, A., Deacon, Carolyn F., Mann, Matthias, Kissow, Hannelouise, Hartmann, Bolette & Holst, Jens Juul, Oct 2017, In: Diabetologia. 60, 10, p. 2066-2075 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    2. Published

      What do we know about the secretion and degradation of incretin hormones?

      Deacon, Carolyn F., 2005, In: Regulatory Peptides. 128, 2, p. 117-24 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    3. Published

      What Is an L-Cell and How Do We Study the Secretory Mechanisms of the L-Cell?

      Kuhre, Rune Ehrenreich, Deacon, Carolyn F., Holst, Jens Juul & Petersen, N., 2021, In: Frontiers in Endocrinology. 12, 19 p., 694284.

      Research output: Contribution to journal › Review › Research › peer-review

    4. Published

      Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes

      Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., Aug 2005, In: The Journal of clinical endocrinology and metabolism. 90, 8, p. 4888-94 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    5. Published

      Vildagliptin, a dipeptidyl peptidase-IV inhibitor improves model-assessed beta-cell function in patients with type 2 diabetes

      Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Duning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In: J. Clin. Endocrinol. Metab.. 90, p. 4888-4894

      Research output: Contribution to journal › Journal article › Research

    6. Published

      Valine pyrrolidide preserves intact glucose-dependent insulinotropic peptide and improves abnormal glucose tolerance in minipigs with reduced beta-cell mass.

      Larsen, M. O., Rolin, B., Ribel, U., Wilken, M., Deacon, Carolyn F., Svendsen, O., Gotfredsen, C. F. & Carr, R. D., 2003, In: Experimental Diabesity Research. 4, 2, p. 93-105 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    7. Published

      Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose- and non-glucose-induced insulin secretion in patients with type 2 diabetes mellitus

      Aaboe, K., Knop, Filip Krag, Vilsbøll, Tina, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-333 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    8. Published

      Twelve weeks treatment with the DPP-4 inhibitor, sitagliptin, prevents degradation of peptide YY and improves glucose and non-glucose induced insulin secretion in patients with type 2 diabetes mellitus

      Aaboe, K., Knop, Filip Krag, Vilsbøll, T., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S. & Krarup, T. M., 1 Apr 2010, In: Diabetes, Obesity and Metabolism. 12, 4, p. 323-33 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    9. Published

      Twelve weeks treatment with the DPP-4 inhibitor sitagliptin improves glycaemic control, but does not improve GLP-1 secretion, in patients with type 2 diabetes - a randomised trial

      Aaboe, K., Knop, F. K., Vilsbøll, Tina, Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten & Krarup, T., 2009, In: Diabetologia. p. 748

      Research output: Contribution to journal › Conference abstract in journal › Research

    10. Published

      Therapeutic strategies based on glucagon-like peptide 1.

      Deacon, Carolyn F., 2004, In: Diabetes. 53, 9, p. 2181-9 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    11. Published

      The structure of wheat bread influences the postprandial metabolic response in healthy men

      Eelderink, C., Noort, M. W. J., Sozer, N., Koehorst, M., Holst, Jens Juul, Deacon, Carolyn F., Rehfeld, Jens Frederik, Poutanen, K., Vonk, R. J., Oudhuis, L. & Priebe, M. G., Oct 2015, In: Food & Function. 6, 10, p. 3236-48 13 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    12. Published

      The role of efferent cholinergic transmission for the insulinotropic and glucagonostatic effects of GLP-1

      Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Vilsbøll, T., Knop, Filip Krag & Holst, Jens Juul, Sep 2015, In: American Journal of Physiology: Regulatory, Integrative and Comparative Physiology. 309, 5, p. R544-51 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    13. Published

      The reduction in hepatic insulin clearance after oral glucose is not mediated by gastric inhibitory polypeptide (GIP).

      Meier, J. J., Gallwitz, B., Siepmann, N., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Nauck, M. A., 2003, In: Regulatory Peptides. 113, 1-3, p. 95-100 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    14. Published

      The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes

      Zander, M., Madsbad, Sten, Deacon, Carolyn F. & Holst, Jens Juul, Feb 2006, In: Diabetologia. 49, 2, p. 369-74 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    15. Published

      The metabolite generated by dipeptidyl-peptidase 4 metabolism of glucagon-like peptide-1 has no influence on plasma glucose levels in patients with type 2 diabetes

      Zander, M., Madsbad, S., Deacon, Carolyn F. & Holst, Jens Juul, 2006, In: Diabetologia. 49, 2, p. 369-374 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    16. Published

      The major glucagon-like peptide-1 metabolite, GLP-1-(9-36)-amide, does not affect glucose or insulin levels in mice.

      Rolin, B., Deacon, Carolyn F., Carr, R. D. & Ahrén, B., 2004, In: European Journal of Pharmacology. 494, 2-3, p. 283-8 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    17. Published

      The long-acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice.

      Rolin, B., Larsen, M. O., Gotfredsen, C. F., Deacon, Carolyn F., Carr, R. D., Wilken, M. & Knudsen, L. B., 2002, In: American Journal of Physiology: Endocrinology and Metabolism. 283, 4, p. E745-52

      Research output: Contribution to journal › Journal article › Research › peer-review

    18. Published

      The insulinotropic effect of exogenous GLP-1 is not affected by acute vagotomy in anaesthetized pigs

      Veedfald, Simon, Hansen, M., Christensen, L. W., Larsen, S. A. H., Hjøllund, K. R., Plamboeck, A., Hartmann, Bolette, Deacon, Carolyn F. & Holst, Jens Juul, 30 Mar 2016, In: Experimental Physiology. 101, 7, p. 895-912 18 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    19. Published

      The incretin system and its role in type 2 diabetes mellitus

      Holst, Jens Juul, Vilsbøll, Tina & Deacon, Carolyn F., 2008, In: Molecular and Cellular Endocrinology. 297, 1-2, p. 127-136 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    20. Published

      The incretin enhancer vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed -cell function in patients with type 2 diabetes

      Mari, A., Sallas, W. M., He, Y. L., Watson, C., Ligueros-Saylan, M., Dunning, B. E., Deacon, Carolyn F., Holst, Jens Juul & Foley, J. E., 2005, In: Journal of Clinical Endocrinology and Metabolism. 90, p. 4888-4894

      Research output: Contribution to journal › Journal article › Research

    21. Published

      The impact of dipeptidyl peptidase 4 inhibition on incretin effect, glucose tolerance, and gastrointestinal-mediated glucose disposal in healthy subjects

      Rhee, N. A., Østoft, S. H., Holst, Jens Juul, Deacon, Carolyn F., Vilsbøll, T. & Knop, Filip Krag, 16 Jun 2014, In: European Journal of Endocrinology. 171, 3, p. 353-362 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    22. Published

      The glucagonostatic and insulinotropic effects of glucagon-like peptide 1 contribute equally to its glucose-lowering action

      Hare, K. J., Vilsbøll, Tina, Asmar, M., Deacon, Carolyn F., Knop, Filip Krag & Holst, Jens Juul, 1 Jul 2010, In: Diabetes. 59, 7, p. 1765-70 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    23. Published

      The glucagon-like peptide-1 metabolite GLP-1-(9-36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans.

      Meier, J. J., Gethmann, A., Nauck, M. A., Götze, O., Schmitz, F., Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Holst, Jens Juul, 2006, In: American Journal of Physiology: Endocrinology and Metabolism. 290, 6, p. E1118-23

      Research output: Contribution to journal › Journal article › Research › peer-review

    24. Published

      The elimination rates of intact GIP as well as its primary metabolite, GIP 3-42, are similar in type 2 diabetic patients and healthy subjects.

      Vilsbøll, Tina, Agersø, H., Lauritsen, T., Deacon, Carolyn F., Aaboe, K., Madsbad, Sten, Krarup, T. & Holst, Jens Juul, 2006, In: Regulatory Peptides. 137, 3, p. 168-72 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    25. Published

      The effects of sitagliptin on gastric emptying in healthy humans – a randomised controlled study

      Stevens, J., Horowitz, M., Deacon, Carolyn F., Nauck, M., Rayner, C. & Jones, K., 2012, In: Alimentary Pharmacology and Therapeutics. 36, 4, p. 379-390

      Research output: Contribution to journal › Journal article › Research › peer-review

    26. Published

      The effect of dipeptidyl peptidase 4 inhibition on gastric volume, satiation and enteroendocrine secretion in Type 2 diabetes: a double blind, placebo-controlled crossover study.

      Vella, A., Bock, G., Giesler, P. D., Burton, D. B., Serra, D. B., Saylan, M. L., Deacon, Carolyn F., Foley, J. E., Rizza, R. A. & Camilleri, M., 2008, In: Clinical Endocrinology.

      Research output: Contribution to journal › Journal article › Research › peer-review

    27. Published

      The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on fasting and postprandial glucose turnover in subjects with impaired fasting glucose

      Bock, G., Man, C. D., Micheletto, F., Basu, R., Rn, P. D. G., Laugen, J., Deacon, Carolyn F., Holst, Jens Juul, Toffolo, G., Cobelli, C., Rizza, R. A. & Vella, A., 2010, In: Clinical Endocrinology. 73, p. 189-196

      Research output: Contribution to journal › Journal article › Research › peer-review

    28. Published

      The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose

      Utzschneider, K. M., Tong, J., Montgomery, B., Udayasankar, J., Gerchman, F., Marcovina, S. M., Watson, C. E., Ligueros-Saylan, M. A., Foley, J. E., Holst, Jens Juul, Deacon, Carolyn F. & Kahn, S. E., 2007, In: Diabetes Care. 31, 1, p. 108-113 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    29. Published

      The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients.

      Balas, B., Baig, M. R., Watson, C., Dunning, B. E., Ligueros-Saylan, M., Wang, Y., He, Y., Darland, C., Holst, Jens Juul, Deacon, Carolyn F., Cusi, K., Mari, A., Foley, J. E. & DeFronzo, R. A., 2007, In: Journal of Clinical Endocrinology and Metabolism. 92, 4, p. 1249-55 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    30. Published

      The clinical effects of a carbohydrate-reduced high-protein diet on glycaemic variability in metformin-treated patients with type 2 diabetes mellitus: A randomised controlled study

      Thomsen, M. N., fbg982, fbg982, Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, Sten, Krarup, T., Haugaard, Steen Bendix & Samkani, A., 2020, In: Clinical Nutrition ESPEN. 39, p. 46-52 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    31. Published

      The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial

      Samkani, A., fbg982, fbg982, Anholm, C., Astrup, A., Deacon, Carolyn F., Holst, Jens Juul, Madsbad, S., Boston, R., Krarup, T. & Haugaard, Steen Bendix, 2018, In: Lipids in Health and Disease. 17, 9 p., 295.

      Research output: Contribution to journal › Journal article › Research › peer-review

    32. Published

      The Use of Gastrostomy Tube for the Long-Term Remission of Hyperinsulinemic Hypoglycemia After Roux-en-y Gastric Bypass: A Case Report

      Craig, C., Lamendola, C., Holst, Jens Juul, Deacon, Carolyn F. & McLaughlin, T., 2015, In: AACE Clinical Case Reports. 1, 2, p. e84-e87 4 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    33. Published

      The Effect of Exogenous GLP-1 on Food Intake is Lost in Male Truncally Vagotomized Subjects with Pyloroplasty

      Plamboeck, A., Veedfald, Simon, Deacon, Carolyn F., Hartmann, Bolette, Wettergren, A., Svendsen, Lars Bo, Meisner, S., Hovendahl, C., Vilsbøll, Tina, Knop, Filip Krag & Holst, Jens Juul, 18 Apr 2013, In: American Journal of Physiology: Gastrointestinal and Liver Physiology. 304, p. G1117-G1127 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    34. Published

      The C-terminal extension of exendin-4 provides additional metabolic stability when added to GLP-1, while there is minimal effect of truncating exendin-4 in anaesthetized pigs

      Simonsen, L., Holst, Jens Juul, Madsen, K. & Deacon, Carolyn F., 10 Feb 2013, In: Regulatory Peptides. 181, 10, p. 17-21 5 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    35. Published

      Targeting the intestinal L-cell for obesity and type 2 diabetes treatment

      Albrechtsen, Nicolai Jacob Wewer, Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 1 Jan 2014, In: Expert Review of Endocrinology & Metabolism. 9, 1, p. 61-72 12 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    36. Published

      Suppression of glucagon secretion is lower after oral glucose administration than during intravenous glucose administration in human subjects

      Meier, J. J., Deacon, Carolyn F., Schmidt, W. E., Holst, Jens Juul & Nauck, M. A., 2007, In: Diabetologia. 50, 4, p. 806-813 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    37. Published

      Stimulation of insulin secretion by intravenous bolus injection and continuous infusion of gastric inhibitory polypeptide in patients with type 2 diabetes and healthy control subjects.

      Meier, J. J., Gallwitz, B., Kask, B., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., 2004, In: Diabetes. 53 Suppl 3, p. S220-4

      Research output: Contribution to journal › Journal article › Research › peer-review

    38. Published

      Stability of glucagon-like peptide-1 and glucagon in human plasma

      Albrechtsen, Nicolai Jacob Wewer, Bak, M. J., Hartmann, Bolette, Christensen, L. W., Kuhre, Rune Ehrenreich, Deacon, Carolyn F. & Holst, Jens Juul, 16 Jan 2015, In: Endocrine Connections. 4, 1, p. 50-57 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    39. Published

      Specificity and sensitivity of commercially available assays for glucagon-like peptide-1 (GLP-1): Implications for GLP-1 measurements in clinical studies

      Bak, M. J., Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Knop, Filip Krag, Vilsbøll, Tina, Jørgensen, N. B., Hartmann, Bolette, Deacon, Carolyn F., Dragsted, Lars Ove & Holst, Jens Juul, 2014, In: Diabetes, Obesity and Metabolism. 16, 11, p. 1155-1164 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    40. Published

      Specificity and sensitivity of commercially available assays for glucagon and oxyntomodulin measurement in humans

      Bak, M. J., Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens, Hartmann, Bolette, Christensen, M., Vilsbøll, T., Knop, F. K., Deacon, Carolyn F., Dragsted, Lars Ove & Holst, Jens Juul, 2014, In: European Journal of Endocrinology. 170, 4, p. 529-538 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    41. Published

      Small intestinal glucose delivery affects the glucose-lowering effect of acute vildagliptin in type 2 diabetes

      Wu, T., Zhang, X., Trahair, L., Bound, M., Little, T., Deacon, Carolyn F., Horowitz, M., Jones, K. & Rayner, C., 2016, In: Journal of Clinical Endocrinology and Metabolism. 101, 12, p. 4769-4778

      Research output: Contribution to journal › Journal article › Research › peer-review

    42. Published

      Similar insulin secretory response to a gastric inhibitory polypeptide bolus injection at euglycemia in first-degree relatives of patients with type 2 diabetes and control subjects.

      Meier, J. J., Nauck, M. A., Siepmann, N., Greulich, M., Holst, Jens Juul, Deacon, Carolyn F., Schmidt, W. E. & Gallwitz, B., 2003, In: Metabolism - Clinical and Experimental. 52, 12, p. 1579-85 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    43. Published

      Signs of a Glucose- and Insulin-Independent Gut-Bone Axis and Aberrant Bone Homeostasis in Type 1 Diabetes

      Hartmann, Bolette, Longo, M., Mathiesen, D. S., Hare, Kristine Juul, Jørgensen, Niklas Rye, Esposito, K., Deacon, Carolyn F., Vilsbøll, Tina, Holst, Jens Juul & Knop, Filip Krag, 2024, In: Journal of Clinical Endocrinology and Metabolism. 109, 1, p. e259-e265 7 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    44. Published

      Sensory nerve desensitization by resiniferatoxin improves glucose tolerance and increases insulin secretion in Zucker Diabetic Fatty rats and is associated with reduced plasma activity of dipeptidyl peptidase IV.

      Gram, D. X., Hansen, A. J., Deacon, Carolyn F., Brand, C. L., Ribel, U., Wilken, M., Carr, R. D., Svendsen, O. & Ahrén, B., 2005, In: European Journal of Pharmacology. 509, 2-3, p. 211-7 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    45. Published

      Secretion, degradation, and elimination of glucagon-like peptide 1 and gastric inhibitory polypeptide in patients with chronic renal insufficiency and healthy control subjects.

      Meier, J. J., Nauck, M. A., Kranz, D., Holst, Jens Juul, Deacon, Carolyn F., Gaeckler, D., Schmidt, W. E. & Gallwitz, B., 2004, In: Diabetes. 53, 3, p. 654-62 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    46. Published

      Secretion of incretin hormones and the insulinotropic effect of gastric inhibitory polypeptide in women with a history of gestational diabetes

      Meier, J. J., Gallwitz, B., Askenas, M., Vollmer, K., Deacon, Carolyn F., Holst, Jens Juul, Schmidt, W. E. & Nauck, M. A., Sep 2005, In: Diabetologia. 48, 9, p. 1872-81 10 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    47. Published

      Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes.

      Nauck, M. A., El-Ouaghlidi, A., Gabrys, B., Hücking, K., Holst, Jens Juul, Deacon, Carolyn F., Gallwitz, B., Schmidt, W. E. & Meier, J. J., 2004, In: Regulatory Peptides. 122, 3, p. 209-17 8 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    48. Published

      Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: what is up, what is down?

      Nauck, M. A., Vardarli, I., Deacon, Carolyn F., Holst, Jens Juul & Meier, J., 2011, In: Diabetologia. 54, 1, p. 10-18 9 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    49. Published

      Secretion and dipeptidyl peptidase-4-mediated metabolism of incretin hormones after a mixed meal or glucose ingestion in obese compared to lean, nondiabetic men

      Carr, R. D., Larsen, M. O., Jelic, K., Lindgren, O., Vikman, J., Holst, Jens Juul, Deacon, Carolyn F. & Ahrén, B., 2010, In: Journal of Clinical Endocrinology and Metabolism. 95, 2, p. 872-8 6 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

    50. Published

      Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes

      Deacon, Carolyn F. & Holst, Jens Juul, 2009, In: Advances in Therapy. 26, 5, p. 488-99 11 p.

      Research output: Contribution to journal › Journal article › Research › peer-review

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